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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Secretogranin III''', also known as '''SCG3''', is a [[protein]] which in humans is encoded by the ''SCG3''  [[gene]].<ref name="pmid12098761">{{cite journal | vauthors = Rong YP, Liu F, Zeng LC, Ma WJ, Wei DZ, Han ZG | title = Cloning and characterization of a novel human secretory protein: secretogranin III | journal = Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica | volume = 34 | issue = 4 | pages = 411–7 | date = July 2002 | pmid = 12098761 | doi =  | url = http://www.abbs.info/fulltxt/eng/34040411.htm }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SCG3 secretogranin III| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29106| accessdate = }}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Secretogranin III
| HGNCid = 13707
| Symbol = SCG3
| AltSymbols =; FLJ90833; SGIII
| OMIM = 
| ECnumber = 
| Homologene = 7526
| MGIid = 103032
| GeneAtlas_image1 = PBB_GE_SCG3_219196_at_tn.png
| Function =  
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 29106
    | Hs_Ensembl = ENSG00000104112
    | Hs_RefseqProtein = NP_037375
    | Hs_RefseqmRNA = NM_013243
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 49760842
    | Hs_GenLoc_end = 49800514
    | Hs_Uniprot = Q8WXD2
    | Mm_EntrezGene = 20255
    | Mm_Ensembl = ENSMUSG00000032181
    | Mm_RefseqmRNA = NM_009130
    | Mm_RefseqProtein = NP_033156
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 75429283
    | Mm_GenLoc_end = 75469926
    | Mm_Uniprot = Q3UTT1
  }}
}}
'''Secretogranin III''', also known as '''SCG3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SCG3 secretogranin III| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29106| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the [[chromogranin]]/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown.<ref name="entrez">{{cite web | title = Entrez Gene: SCG3 secretogranin III| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29106| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Huttner WB, Gerdes HH, Rosa P | title = The granin (chromogranin/secretogranin) family | journal = Trends in Biochemical Sciences | volume = 16 | issue = 1 | pages = 27–30 | date = January 1991 | pmid = 2053134 | doi = 10.1016/0968-0004(91)90012-K }}
| citations =
* {{cite journal | vauthors = Ozawa H, Takata K | title = The granin family--its role in sorting and secretory granule formation | journal = Cell Structure and Function | volume = 20 | issue = 6 | pages = 415–20 | date = December 1995 | pmid = 8825061 | doi = 10.1247/csf.20.415 }}
*{{cite journal | author=Huttner WB, Gerdes HH, Rosa P |title=The granin (chromogranin/secretogranin) family. |journal=Trends Biochem. Sci. |volume=16 |issue= 1 |pages= 27-30 |year= 1991 |pmid= 2053134 |doi= }}
* {{cite journal | vauthors = Dopazo A, Lovenberg TW, Danielson PE, Ottiger HP, Sutcliffe JG | title = Primary structure of mouse secretogranin III and its absence from deficient mice | journal = Journal of Molecular Neuroscience | volume = 4 | issue = 4 | pages = 225–33 | year = 1994 | pmid = 7917832 | doi = 10.1007/BF02821554 }}
*{{cite journal | author=Ozawa H, Takata K |title=The granin family--its role in sorting and secretory granule formation. |journal=Cell Struct. Funct. |volume=20 |issue= 6 |pages= 415-20 |year= 1996 |pmid= 8825061 |doi= }}
* {{cite journal | vauthors = Holthuis JC, Jansen EJ, Martens GJ | title = Secretogranin III is a sulfated protein undergoing proteolytic processing in the regulated secretory pathway | journal = The Journal of Biological Chemistry | volume = 271 | issue = 30 | pages = 17755–60 | date = July 1996 | pmid = 8663421 | doi = 10.1074/jbc.271.30.17755 }}
*{{cite journal | author=Dopazo A, Lovenberg TW, Danielson PE, ''et al.'' |title=Primary structure of mouse secretogranin III and its absence from deficient mice. |journal=J. Mol. Neurosci. |volume=4 |issue= 4 |pages= 225-33 |year= 1994 |pmid= 7917832 |doi= }}
* {{cite journal | vauthors = Rong YP, Liu F, Zeng LC, Ma WJ, Wei DZ, Han ZG | title = Cloning and characterization of a novel human secretory protein: secretogranin III | journal = Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica | volume = 34 | issue = 4 | pages = 411–7 | date = July 2002 | pmid = 12098761 | doi =  }}
*{{cite journal | author=Holthuis JC, Jansen EJ, Martens GJ |title=Secretogranin III is a sulfated protein undergoing proteolytic processing in the regulated secretory pathway. |journal=J. Biol. Chem. |volume=271 |issue= 30 |pages= 17755-60 |year= 1996 |pmid= 8663421 |doi= }}
* {{cite journal | vauthors = Hosaka M, Watanabe T, Sakai Y, Uchiyama Y, Takeuchi T | title = Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells | journal = Molecular Biology of the Cell | volume = 13 | issue = 10 | pages = 3388–99 | date = October 2002 | pmid = 12388744 | pmc = 129953 | doi = 10.1091/mbc.02-03-0040 }}
*{{cite journal | author=Rong YP, Liu F, Zeng LC, ''et al.'' |title=Cloning and characterization of a novel human secretory protein: secretogranin III. |journal=Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao |volume=34 |issue= 4 |pages= 411-7 |year= 2002 |pmid= 12098761 |doi=  }}
* {{cite journal | vauthors = Sakai Y, Hosaka M, Hira Y, Harumi T, Ohsawa Y, Wang H, Takeuchi T, Uchiyama Y, Watanabe T | title = Immunocytochemical localization of secretogranin III in the anterior lobe of male rat pituitary glands | journal = The Journal of Histochemistry and Cytochemistry | volume = 51 | issue = 2 | pages = 227–38 | date = February 2003 | pmid = 12533531 | doi = 10.1177/002215540305100211 }}
*{{cite journal | author=Hosaka M, Watanabe T, Sakai Y, ''et al.'' |title=Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells. |journal=Mol. Biol. Cell |volume=13 |issue= 10 |pages= 3388-99 |year= 2003 |pmid= 12388744 |doi= 10.1091/mbc.02-03-0040 }}
* {{cite journal | vauthors = Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A | title = The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment | journal = Genome Research | volume = 13 | issue = 10 | pages = 2265–70 | date = October 2003 | pmid = 12975309 | pmc = 403697 | doi = 10.1101/gr.1293003 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Hosaka M, Suda M, Sakai Y, Izumi T, Watanabe T, Takeuchi T | title = Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A | journal = The Journal of Biological Chemistry | volume = 279 | issue = 5 | pages = 3627–34 | date = January 2004 | pmid = 14597614 | doi = 10.1074/jbc.M310104200 }}
*{{cite journal  | author=Sakai Y, Hosaka M, Hira Y, ''et al.'' |title=Immunocytochemical localization of secretogranin III in the anterior lobe of male rat pituitary glands. |journal=J. Histochem. Cytochem. |volume=51 |issue= 2 |pages= 227-38 |year= 2003 |pmid= 12533531 |doi= }}
* {{cite journal | vauthors = Sakai Y, Hosaka M, Yoshinaga A, Hira Y, Harumi T, Watanabe T | title = Immunocytochemical localization of secretogranin III in the endocrine pancreas of male rats | journal = Archives of Histology and Cytology | volume = 67 | issue = 1 | pages = 57–64 | date = March 2004 | pmid = 15125023 | doi = 10.1679/aohc.67.57 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
* {{cite journal | vauthors = Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T | title = Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries | journal = DNA Research | volume = 12 | issue = 2 | pages = 117–26 | year = 2007 | pmid = 16303743 | doi = 10.1093/dnares/12.2.117 }}
*{{cite journal | author=Hosaka M, Suda M, Sakai Y, ''et al.'' |title=Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A. |journal=J. Biol. Chem. |volume=279 |issue= 5 |pages= 3627-34 |year= 2004 |pmid= 14597614 |doi= 10.1074/jbc.M310104200 }}
* {{cite journal | vauthors = Tanabe A, Yanagiya T, Iida A, Saito S, Sekine A, Takahashi A, Nakamura T, Tsunoda T, Kamohara S, Nakata Y, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Funahashi T, Miyazaki S, Tokunaga K, Hamaguchi K, Shimada T, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Sakata T, Matsuzawa Y, Kamatani N, Nakamura Y, Hotta K | title = Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 92 | issue = 3 | pages = 1145–54 | date = March 2007 | pmid = 17200173 | doi = 10.1210/jc.2006-1808 }}
*{{cite journal | author=Sakai Y, Hosaka M, Yoshinaga A, ''et al.'' |title=Immunocytochemical localization of secretogranin III in the endocrine pancreas of male rats. |journal=Arch. Histol. Cytol. |volume=67 |issue= 1 |pages= 57-64 |year= 2004 |pmid= 15125023 |doi=  }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal | author=Tanabe A, Yanagiya T, Iida A, ''et al.'' |title=Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity. |journal=J. Clin. Endocrinol. Metab. |volume=92 |issue= 3 |pages= 1145-54 |year= 2007 |pmid= 17200173 |doi= 10.1210/jc.2006-1808 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{gene-15-stub}}
{{WikiDoc Sources}}

Latest revision as of 05:58, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Secretogranin III, also known as SCG3, is a protein which in humans is encoded by the SCG3 gene.[1][2]

Function

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown.[2]

References

  1. ↑ Rong YP, Liu F, Zeng LC, Ma WJ, Wei DZ, Han ZG (July 2002). "Cloning and characterization of a novel human secretory protein: secretogranin III". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 34 (4): 411–7. PMID 12098761.
  2. ↑ 2.0 2.1 "Entrez Gene: SCG3 secretogranin III".

Further reading

  • Huttner WB, Gerdes HH, Rosa P (January 1991). "The granin (chromogranin/secretogranin) family". Trends in Biochemical Sciences. 16 (1): 27–30. doi:10.1016/0968-0004(91)90012-K. PMID 2053134.
  • Ozawa H, Takata K (December 1995). "The granin family--its role in sorting and secretory granule formation". Cell Structure and Function. 20 (6): 415–20. doi:10.1247/csf.20.415. PMID 8825061.
  • Dopazo A, Lovenberg TW, Danielson PE, Ottiger HP, Sutcliffe JG (1994). "Primary structure of mouse secretogranin III and its absence from deficient mice". Journal of Molecular Neuroscience. 4 (4): 225–33. doi:10.1007/BF02821554. PMID 7917832.
  • Holthuis JC, Jansen EJ, Martens GJ (July 1996). "Secretogranin III is a sulfated protein undergoing proteolytic processing in the regulated secretory pathway". The Journal of Biological Chemistry. 271 (30): 17755–60. doi:10.1074/jbc.271.30.17755. PMID 8663421.
  • Rong YP, Liu F, Zeng LC, Ma WJ, Wei DZ, Han ZG (July 2002). "Cloning and characterization of a novel human secretory protein: secretogranin III". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 34 (4): 411–7. PMID 12098761.
  • Hosaka M, Watanabe T, Sakai Y, Uchiyama Y, Takeuchi T (October 2002). "Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells". Molecular Biology of the Cell. 13 (10): 3388–99. doi:10.1091/mbc.02-03-0040. PMC 129953. PMID 12388744.
  • Sakai Y, Hosaka M, Hira Y, Harumi T, Ohsawa Y, Wang H, Takeuchi T, Uchiyama Y, Watanabe T (February 2003). "Immunocytochemical localization of secretogranin III in the anterior lobe of male rat pituitary glands". The Journal of Histochemistry and Cytochemistry. 51 (2): 227–38. doi:10.1177/002215540305100211. PMID 12533531.
  • Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Hosaka M, Suda M, Sakai Y, Izumi T, Watanabe T, Takeuchi T (January 2004). "Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A". The Journal of Biological Chemistry. 279 (5): 3627–34. doi:10.1074/jbc.M310104200. PMID 14597614.
  • Sakai Y, Hosaka M, Yoshinaga A, Hira Y, Harumi T, Watanabe T (March 2004). "Immunocytochemical localization of secretogranin III in the endocrine pancreas of male rats". Archives of Histology and Cytology. 67 (1): 57–64. doi:10.1679/aohc.67.57. PMID 15125023.
  • Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Tanabe A, Yanagiya T, Iida A, Saito S, Sekine A, Takahashi A, Nakamura T, Tsunoda T, Kamohara S, Nakata Y, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Funahashi T, Miyazaki S, Tokunaga K, Hamaguchi K, Shimada T, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Sakata T, Matsuzawa Y, Kamatani N, Nakamura Y, Hotta K (March 2007). "Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity". The Journal of Clinical Endocrinology and Metabolism. 92 (3): 1145–54. doi:10.1210/jc.2006-1808. PMID 17200173.
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