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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Semaphorin-3C''' is a [[protein]] that in humans is encoded by the ''SEMA3C'' [[gene]].<ref name="pmid7748561">{{cite journal | vauthors = Püschel AW, Adams RH, Betz H | title = Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension | journal = Neuron | volume = 14 | issue = 5 | pages = 941–8 | date = May 1995 | pmid = 7748561 | pmc =  | doi = 10.1016/0896-6273(95)90332-1 }}</ref><ref name="pmid9168980">{{cite journal | vauthors = Mangasser-Stephan K, Dooley S, Welter C, Mutschler W, Hanselmann RG | title = Identification of human semaphorin E gene expression in rheumatoid synovial cells by mRNA differential display | journal = Biochemical and Biophysical Research Communications | volume = 234 | issue = 1 | pages = 153–6 | date = May 1997 | pmid = 9168980 | pmc = | doi = 10.1006/bbrc.1997.6607 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10512| accessdate = }}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== References ==
{{GNF_Protein_box
{{reflist}}
| image = 
| image_source = 
| PDB =
| Name = Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
| HGNCid = 10725
| Symbol = SEMA3C
| AltSymbols =; SEMAE; SemE
| OMIM = 602645
| ECnumber = 
| Homologene = 36201
| MGIid = 107557
| GeneAtlas_image1 = PBB_GE_SEMA3C_203788_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SEMA3C_203789_s_at_tn.png
| Function = {{GNF_GO|id=GO:0030215 |text = semaphorin receptor binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0042493 |text = response to drug}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10512
    | Hs_Ensembl = ENSG00000075223
    | Hs_RefseqProtein = NP_006370
    | Hs_RefseqmRNA = NM_006379
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 80209791
    | Hs_GenLoc_end = 80386603
    | Hs_Uniprot = Q99985
    | Mm_EntrezGene = 20348
    | Mm_Ensembl = ENSMUSG00000028780
    | Mm_RefseqmRNA = NM_013657
    | Mm_RefseqProtein = NP_038685
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 17086640
    | Mm_GenLoc_end = 17242094
    | Mm_Uniprot = Q6NXW7
  }}
}}
'''Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C''', also known as '''SEMA3C''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10512| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Further reading ==
{{PBB_Summary
| section_title =
| summary_text =
}}
 
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC | title = Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening | journal = Genomics | volume = 23 | issue = 1 | pages = 42–50 | date = September 1994 | pmid = 7829101 | doi = 10.1006/geno.1994.1457 }}
| citations =
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Püschel AW, Adams RH, Betz H |title=Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. |journal=Neuron |volume=14 |issue= 5 |pages= 941-8 |year= 1995 |pmid= 7748561 |doi=  }}
* {{cite journal | vauthors = Chen H, Chédotal A, He Z, Goodman CS, Tessier-Lavigne M | title = Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III | journal = Neuron | volume = 19 | issue = 3 | pages = 547–59 | date = September 1997 | pmid = 9331348 | doi = 10.1016/S0896-6273(00)80371-2 }}
*{{cite journal  | author=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, ''et al.'' |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. |journal=Genomics |volume=23 |issue= 1 |pages= 42-50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457 }}
* {{cite journal | vauthors = Yamada T, Endo R, Gotoh M, Hirohashi S | title = Identification of semaphorin E as a non-MDR drug resistance gene of human cancers | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 26 | pages = 14713–8 | date = December 1997 | pmid = 9405678 | pmc = 25101 | doi = 10.1073/pnas.94.26.14713 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Galani E, Sgouros J, Petropoulou C, Janinis J, Aravantinos G, Dionysiou-Asteriou D, Skarlos D, Gonos E | title = Correlation of MDR-1, nm23-H1 and H Sema E gene expression with histopathological findings and clinical outcome in ovarian and breast cancer patients | journal = Anticancer Research | volume = 22 | issue = 4 | pages = 2275–80 | year = 2002 | pmid = 12174914 | doi =  }}
*{{cite journal  | author=Mangasser-Stephan K, Dooley S, Welter C, ''et al.'' |title=Identification of human semaphorin E gene expression in rheumatoid synovial cells by mRNA differential display. |journal=Biochem. Biophys. Res. Commun. |volume=234 |issue= 1 |pages= 153-6 |year= 1997 |pmid= 9168980 |doi= 10.1006/bbrc.1997.6607 }}
* {{cite journal | vauthors = Rieger J, Wick W, Weller M | title = Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins | journal = Glia | volume = 42 | issue = 4 | pages = 379–89 | date = June 2003 | pmid = 12730958 | doi = 10.1002/glia.10210 }}
*{{cite journal | author=Chen H, Chédotal A, He Z, ''et al.'' |title=Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. |journal=Neuron |volume=19 |issue= 3 |pages= 547-59 |year= 1997 |pmid= 9331348 |doi= }}
* {{cite journal | vauthors = Miller LE, Weidler C, Falk W, Angele P, Schaumburger J, Schölmerich J, Straub RH | title = Increased prevalence of semaphorin 3C, a repellent of sympathetic nerve fibers, in the synovial tissue of patients with rheumatoid arthritis | journal = Arthritis and Rheumatism | volume = 50 | issue = 4 | pages = 1156–63 | date = April 2004 | pmid = 15077297 | doi = 10.1002/art.20110 }}
*{{cite journal | author=Yamada T, Endo R, Gotoh M, Hirohashi S |title=Identification of semaphorin E as a non-MDR drug resistance gene of human cancers. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 26 |pages= 14713-8 |year= 1998 |pmid= 9405678 |doi= }}
* {{cite journal | vauthors = Beckers J, Herrmann F, Rieger S, Drobyshev AL, Horsch M, Hrabé de Angelis M, Seliger B | title = Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis | journal = International Journal of Cancer | volume = 114 | issue = 4 | pages = 590–7 | date = April 2005 | pmid = 15609325 | doi = 10.1002/ijc.20798 }}
*{{cite journal | author=Galani E, Sgouros J, Petropoulou C, ''et al.'' |title=Correlation of MDR-1, nm23-H1 and H Sema E gene expression with histopathological findings and clinical outcome in ovarian and breast cancer patients. |journal=Anticancer Res. |volume=22 |issue= 4 |pages= 2275-80 |year= 2002 |pmid= 12174914 |doi=  }}
* {{cite journal|authorlink1=James G. Herman | vauthors = Herman JG, Meadows GG | title = Increased class 3 semaphorin expression modulates the invasive and adhesive properties of prostate cancer cells | journal = International Journal of Oncology | volume = 30 | issue = 5 | pages = 1231–8 | date = May 2007 | pmid = 17390026 | doi = 10.3892/ijo.30.5.1231 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal  | author=Rieger J, Wick W, Weller M |title=Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins. |journal=Glia |volume=42 |issue= 4 |pages= 379-89 |year= 2003 |pmid= 12730958 |doi= 10.1002/glia.10210 }}
*{{cite journal | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal  | author=Miller LE, Weidler C, Falk W, ''et al.'' |title=Increased prevalence of semaphorin 3C, a repellent of sympathetic nerve fibers, in the synovial tissue of patients with rheumatoid arthritis. |journal=Arthritis Rheum. |volume=50 |issue= 4 |pages= 1156-63 |year= 2004 |pmid= 15077297 |doi= 10.1002/art.20110 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Beckers J, Herrmann F, Rieger S, ''et al.'' |title=Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis. |journal=Int. J. Cancer |volume=114 |issue= 4 |pages= 590-7 |year= 2005 |pmid= 15609325 |doi= 10.1002/ijc.20798 }}
*{{cite journal | author=Herman JG, Meadows GG |title=Increased class 3 semaphorin expression modulates the invasive and adhesive properties of prostate cancer cells. |journal=Int. J. Oncol. |volume=30 |issue= 5 |pages= 1231-8 |year= 2007 |pmid= 17390026 |doi= }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{gene-7-stub}}
{{WikiDoc Sources}}

Latest revision as of 15:20, 9 December 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

n/a

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UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Semaphorin-3C is a protein that in humans is encoded by the SEMA3C gene.[1][2][3]

References

  1. ↑ Püschel AW, Adams RH, Betz H (May 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron. 14 (5): 941–8. doi:10.1016/0896-6273(95)90332-1. PMID 7748561.
  2. ↑ Mangasser-Stephan K, Dooley S, Welter C, Mutschler W, Hanselmann RG (May 1997). "Identification of human semaphorin E gene expression in rheumatoid synovial cells by mRNA differential display". Biochemical and Biophysical Research Communications. 234 (1): 153–6. doi:10.1006/bbrc.1997.6607. PMID 9168980.
  3. ↑ "Entrez Gene: SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C".

Further reading

  • Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (September 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
  • Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Chen H, Chédotal A, He Z, Goodman CS, Tessier-Lavigne M (September 1997). "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III". Neuron. 19 (3): 547–59. doi:10.1016/S0896-6273(00)80371-2. PMID 9331348.
  • Yamada T, Endo R, Gotoh M, Hirohashi S (December 1997). "Identification of semaphorin E as a non-MDR drug resistance gene of human cancers". Proceedings of the National Academy of Sciences of the United States of America. 94 (26): 14713–8. doi:10.1073/pnas.94.26.14713. PMC 25101. PMID 9405678.
  • Galani E, Sgouros J, Petropoulou C, Janinis J, Aravantinos G, Dionysiou-Asteriou D, Skarlos D, Gonos E (2002). "Correlation of MDR-1, nm23-H1 and H Sema E gene expression with histopathological findings and clinical outcome in ovarian and breast cancer patients". Anticancer Research. 22 (4): 2275–80. PMID 12174914.
  • Rieger J, Wick W, Weller M (June 2003). "Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins". Glia. 42 (4): 379–89. doi:10.1002/glia.10210. PMID 12730958.
  • Miller LE, Weidler C, Falk W, Angele P, Schaumburger J, Schölmerich J, Straub RH (April 2004). "Increased prevalence of semaphorin 3C, a repellent of sympathetic nerve fibers, in the synovial tissue of patients with rheumatoid arthritis". Arthritis and Rheumatism. 50 (4): 1156–63. doi:10.1002/art.20110. PMID 15077297.
  • Beckers J, Herrmann F, Rieger S, Drobyshev AL, Horsch M, Hrabé de Angelis M, Seliger B (April 2005). "Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis". International Journal of Cancer. 114 (4): 590–7. doi:10.1002/ijc.20798. PMID 15609325.
  • Herman JG, Meadows GG (May 2007). "Increased class 3 semaphorin expression modulates the invasive and adhesive properties of prostate cancer cells". International Journal of Oncology. 30 (5): 1231–8. doi:10.3892/ijo.30.5.1231. PMID 17390026.
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