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{{Infobox_gene}}
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'''Semenogelin-2''' is a [[protein]] that in humans is encoded by the ''SEMG2'' [[gene]].<ref name="pmid1517240">{{cite journal | vauthors = Ulvsback M, Lazure C, Lilja H, Spurr NK, Rao VV, Loffler C, Hansmann I, Lundwall A | title = Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20 | journal = J Biol Chem | volume = 267 | issue = 25 | pages = 18080–4 |date=Oct 1992 | pmid = 1517240 | pmc =  | doi =  }}</ref><ref name="pmid9523691">{{cite journal | vauthors = Peter A, Lilja H, Lundwall A, Malm J | title = Semenogelin I and semenogelin II, the major gel-forming proteins in human semen, are substrates for transglutaminase | journal = Eur J Biochem | volume = 252 | issue = 2 | pages = 216–21 |date=Apr 1998 | pmid = 9523691 | pmc =  | doi =10.1046/j.1432-1327.1998.2520216.x }}</ref><ref name="entrez"/>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Semenogelin II
| HGNCid = 10743
| Symbol = SEMG2
| AltSymbols =; SGII
| OMIM = 182141
| ECnumber =
| Homologene = 88473
| MGIid =
  | GeneAtlas_image1 = PBB_GE_SEMG2_216030_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}}  
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0030141 |text = secretory granule}}
| Process = {{GNF_GO|id=GO:0019953 |text = sexual reproduction}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6407
    | Hs_Ensembl = ENSG00000124157
    | Hs_RefseqProtein = NP_002999
    | Hs_RefseqmRNA = NM_003008
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 43283355
    | Hs_GenLoc_end = 43286513
    | Hs_Uniprot = Q02383
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot =   
  }}
}}
'''Semenogelin II''', also known as '''SEMG2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SEMG2 semenogelin II| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6407| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20.<ref name="entrez">{{cite web | title = Entrez Gene: SEMG2 semenogelin II| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6407| accessdate = }}</ref>
| summary_text = The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20.<ref name="entrez">{{cite web | title = Entrez Gene: SEMG2 semenogelin II| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6407| accessdate = }}</ref>
}}
}}
==See also==
*[[Semenogelin]]


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Ulvsbäck M, Lazure C, Lilja H, ''et al.'' |title=Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20. |journal=J. Biol. Chem. |volume=267 |issue= 25 |pages= 18080-4 |year= 1992 |pmid= 1517240 |doi=  }}
*{{cite journal  | vauthors=Lilja H, Lundwall A |title=Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 10 |pages= 4559–63 |year= 1992 |pmid= 1584792 |doi=10.1073/pnas.89.10.4559 | pmc=49122  }}
*{{cite journal | author=Lilja H, Lundwall A |title=Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 10 |pages= 4559-63 |year= 1992 |pmid= 1584792 |doi=  }}
*{{cite journal   |vauthors=Schneider K, Kausler W, Tripier D, etal |title=[Isolation and structure determination of two peptides occurring in human seminal plasma] |journal=Biol. Chem. Hoppe-Seyler |volume=370 |issue= 4 |pages= 353–6 |year= 1989 |pmid= 2757795 |doi=  }}
*{{cite journal  | author=Schneider K, Kausler W, Tripier D, ''et al.'' |title=[Isolation and structure determination of two peptides occurring in human seminal plasma] |journal=Biol. Chem. Hoppe-Seyler |volume=370 |issue= 4 |pages= 353-6 |year= 1989 |pmid= 2757795 |doi=  }}
*{{cite journal  | author=Lundwall A |title=The structure of the semenogelin gene locus--nucleotide sequence of the intergenic and the flanking DNA |journal=Eur. J. Biochem. |volume=235 |issue= 3 |pages= 466–70 |year= 1996 |pmid= 8654389 |doi=10.1111/j.1432-1033.1996.00466.x }}
*{{cite journal | author=Lundwall A |title=The structure of the semenogelin gene locus--nucleotide sequence of the intergenic and the flanking DNA. |journal=Eur. J. Biochem. |volume=235 |issue= 3 |pages= 466-70 |year= 1996 |pmid= 8654389 |doi= }}
*{{cite journal   |vauthors=Malm J, Hellman J, Magnusson H, etal |title=Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II |journal=Eur. J. Biochem. |volume=238 |issue= 1 |pages= 48–53 |year= 1996 |pmid= 8665951 |doi=10.1111/j.1432-1033.1996.0048q.x  }}
*{{cite journal  | author=Malm J, Hellman J, Magnusson H, ''et al.'' |title=Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II. |journal=Eur. J. Biochem. |volume=238 |issue= 1 |pages= 48-53 |year= 1996 |pmid= 8665951 |doi=  }}
*{{cite journal  | vauthors=Kise H, Nishioka J, Kawamura J, Suzuki K |title=Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor |journal=Eur. J. Biochem. |volume=238 |issue= 1 |pages= 88–96 |year= 1996 |pmid= 8665956 |doi=10.1111/j.1432-1033.1996.0088q.x }}
*{{cite journal | author=Kise H, Nishioka J, Kawamura J, Suzuki K |title=Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor. |journal=Eur. J. Biochem. |volume=238 |issue= 1 |pages= 88-96 |year= 1996 |pmid= 8665956 |doi=  }}
*{{cite journal   |vauthors=Bjartell A, Malm J, Moller C, etal |title=Distribution and tissue expression of semenogelin I and II in man as demonstrated by in situ hybridization and immunocytochemistry |journal=J. Androl. |volume=17 |issue= 1 |pages= 17–26 |year= 1997 |pmid= 8833737 |doi=  }}
*{{cite journal  | author=Bjartell A, Malm J, Moller C, ''et al.'' |title=Distribution and tissue expression of semenogelin I and II in man as demonstrated by in situ hybridization and immunocytochemistry. |journal=J. Androl. |volume=17 |issue= 1 |pages= 17-26 |year= 1997 |pmid= 8833737 |doi=  }}
*{{cite journal  | vauthors=Ulvsbäck M, Lundwall A |title=Cloning of the semenogelin II gene of the rhesus monkey. Duplications of 360 bp extend the coding region in man, rhesus monkey and baboon |journal=Eur. J. Biochem. |volume=245 |issue= 1 |pages= 25–31 |year= 1997 |pmid= 9128720 |doi=10.1111/j.1432-1033.1997.00025.x }}
*{{cite journal  | author=Ulvsbäck M, Lundwall A |title=Cloning of the semenogelin II gene of the rhesus monkey. Duplications of 360 bp extend the coding region in man, rhesus monkey and baboon. |journal=Eur. J. Biochem. |volume=245 |issue= 1 |pages= 25-31 |year= 1997 |pmid= 9128720 |doi=  }}
*{{cite journal  | vauthors=Lövgren J, Airas K, Lilja H |title=Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors |journal=Eur. J. Biochem. |volume=262 |issue= 3 |pages= 781–9 |year= 1999 |pmid= 10411640 |doi=10.1046/j.1432-1327.1999.00433.x }}
*{{cite journal  | author=Peter A, Lilja H, Lundwall A, Malm J |title=Semenogelin I and semenogelin II, the major gel-forming proteins in human semen, are substrates for transglutaminase. |journal=Eur. J. Biochem. |volume=252 |issue= 2 |pages= 216-21 |year= 1998 |pmid= 9523691 |doi= }}
*{{cite journal  | vauthors=Malm J, Hellman J, Hogg P, Lilja H |title=Enzymatic action of prostate-specific antigen (PSA or hK3): substrate specificity and regulation by Zn(2+), a tight-binding inhibitor |journal=Prostate |volume=45 |issue= 2 |pages= 132–9 |year= 2000 |pmid= 11027412 |doi=10.1002/1097-0045(20001001)45:2<132::AID-PROS7>3.0.CO;2-3  }}
*{{cite journal | author=Lövgren J, Airas K, Lilja H |title=Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors. |journal=Eur. J. Biochem. |volume=262 |issue= 3 |pages= 781-9 |year= 1999 |pmid= 10411640 |doi= }}
*{{cite journal   |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal | author=Malm J, Hellman J, Hogg P, Lilja H |title=Enzymatic action of prostate-specific antigen (PSA or hK3): substrate specificity and regulation by Zn(2+), a tight-binding inhibitor. |journal=Prostate |volume=45 |issue= 2 |pages= 132-9 |year= 2000 |pmid= 11027412 |doi=  }}
*{{cite journal   |vauthors=Brillard-Bourdet M, Réhault S, Juliano L, etal |title=Amidolytic activity of prostatic acid phosphatase on human semenogelins and semenogelin-derived synthetic substrates |journal=Eur. J. Biochem. |volume=269 |issue= 1 |pages= 390–5 |year= 2002 |pmid= 11784334 |doi=10.1046/j.0014-2956.2001.02667.x }}
*{{cite journal  | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal  | vauthors=Lundwall A, Bjartell A, Olsson AY, Malm J |title=Semenogelin I and II, the predominant human seminal plasma proteins, are also expressed in non-genital tissues |journal=Mol. Hum. Reprod. |volume=8 |issue= 9 |pages= 805–10 |year= 2003 |pmid= 12200457 |doi=10.1093/molehr/8.9.805  }}
*{{cite journal | author=Brillard-Bourdet M, Réhault S, Juliano L, ''et al.'' |title=Amidolytic activity of prostatic acid phosphatase on human semenogelins and semenogelin-derived synthetic substrates. |journal=Eur. J. Biochem. |volume=269 |issue= 1 |pages= 390-5 |year= 2002 |pmid= 11784334 |doi=  }}
*{{cite journal   |vauthors=Ek P, Malm J, Lilja H, etal |title=Exogenous protein kinases A and C, but not endogenous prostasome-associated protein kinase, phosphorylate semenogelins I and II from human semen |journal=J. Androl. |volume=23 |issue= 6 |pages= 806–14 |year= 2003 |pmid= 12399526 |doi=  }}
*{{cite journal | author=Lundwall A, Bjartell A, Olsson AY, Malm J |title=Semenogelin I and II, the predominant human seminal plasma proteins, are also expressed in non-genital tissues. |journal=Mol. Hum. Reprod. |volume=8 |issue= 9 |pages= 805-10 |year= 2003 |pmid= 12200457 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Ek P, Malm J, Lilja H, ''et al.'' |title=Exogenous protein kinases A and C, but not endogenous prostasome-associated protein kinase, phosphorylate semenogelins I and II from human semen. |journal=J. Androl. |volume=23 |issue= 6 |pages= 806-14 |year= 2003 |pmid= 12399526 |doi=  }}
*{{cite journal   |vauthors=Yoshida K, Yamasaki T, Yoshiike M, etal |title=Quantification of seminal plasma motility inhibitor/semenogelin in human seminal plasma |journal=J. Androl. |volume=24 |issue= 6 |pages= 878–84 |year= 2004 |pmid= 14581514 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Jensen-Seaman MI, Li WH |title=Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen |journal=J. Mol. Evol. |volume=57 |issue= 3 |pages= 261–70 |year= 2004 |pmid= 14629036 |doi= 10.1007/s00239-003-2474-x }}
*{{cite journal | author=Yoshida K, Yamasaki T, Yoshiike M, ''et al.'' |title=Quantification of seminal plasma motility inhibitor/semenogelin in human seminal plasma. |journal=J. Androl. |volume=24 |issue= 6 |pages= 878-84 |year= 2004 |pmid= 14581514 |doi= }}
*{{cite journal   |vauthors=Dorus S, Evans PD, Wyckoff GJ, etal |title=Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity |journal=Nat. Genet. |volume=36 |issue= 12 |pages= 1326–9 |year= 2005 |pmid= 15531881 |doi= 10.1038/ng1471 }}
*{{cite journal | author=Jensen-Seaman MI, Li WH |title=Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen. |journal=J. Mol. Evol. |volume=57 |issue= 3 |pages= 261-70 |year= 2004 |pmid= 14629036 |doi= 10.1007/s00239-003-2474-x }}
*{{cite journal   |vauthors=Jonsson M, Linse S, Frohm B, etal |title=Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen |journal=Biochem. J. |volume=387 |issue= Pt 2 |pages= 447–53 |year= 2005 |pmid= 15563730 |doi= 10.1042/BJ20041424 | pmc=1134973 }}
*{{cite journal | author=Dorus S, Evans PD, Wyckoff GJ, ''et al.'' |title=Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity. |journal=Nat. Genet. |volume=36 |issue= 12 |pages= 1326-9 |year= 2005 |pmid= 15531881 |doi= 10.1038/ng1471 }}
*{{cite journal  | author=Jonsson M, Linse S, Frohm B, ''et al.'' |title=Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen. |journal=Biochem. J. |volume=387 |issue= Pt 2 |pages= 447-53 |year= 2005 |pmid= 15563730 |doi= 10.1042/BJ20041424 }}
}}
}}
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Latest revision as of 06:06, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Semenogelin-2 is a protein that in humans is encoded by the SEMG2 gene.[1][2][3]

The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20.[3]

See also

References

  1. ↑ Ulvsback M, Lazure C, Lilja H, Spurr NK, Rao VV, Loffler C, Hansmann I, Lundwall A (Oct 1992). "Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20". J Biol Chem. 267 (25): 18080–4. PMID 1517240.
  2. ↑ Peter A, Lilja H, Lundwall A, Malm J (Apr 1998). "Semenogelin I and semenogelin II, the major gel-forming proteins in human semen, are substrates for transglutaminase". Eur J Biochem. 252 (2): 216–21. doi:10.1046/j.1432-1327.1998.2520216.x. PMID 9523691.
  3. ↑ 3.0 3.1 "Entrez Gene: SEMG2 semenogelin II".

Further reading



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