SFRS12: Difference between revisions

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Latest revision as of 06:13, 11 September 2017

Splicing factor, arginine/serine-rich 12 is a protein that in humans is encoded by the SFRS12 gene.^[1]^[2]

SFRS12 belongs to the superfamily of serine/arginine-rich (SR) splicing factors. It modulates splice site selection by regulating the activities of other SR proteins (Barnard et al., 2002).[supplied by OMIM]^[2]

References

↑ Zhang DL, Sun XJ, Ling LJ, Chen RS, Ma DL (Jun 2002). "[Molecular cloning, characterization, chromosomal assignment, genomic organization and verification of SFRS12(SRrp508), a novel member of human SR protein superfamily and a human homolog of rat SRrp86]". Yi Chuan Xue Bao. 29 (5): 377–83. PMID 12043562.
↑ ^2.0 ^2.1 "Entrez Gene: SFRS12 splicing factor, arginine/serine-rich 12".

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Heese K, Fujita M, Akatsu H, et al. (2005). "The splicing regulatory protein p18SRP is down-regulated in Alzheimer's disease brain". J. Mol. Neurosci. 24 (2): 269–76. doi:10.1385/JMN:24:2:269. PMID 15456940.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Peng R, Dye BT, Pérez I, et al. (2002). "PSF and p54nrb bind a conserved stem in U5 snRNA". RNA. 8 (10): 1334–47. doi:10.1017/S1355838202022070. PMC 1370341. PMID 12403470.
Li J, Barnard DC, Patton JG (2002). "A unique glutamic acid-lysine (EK) domain acts as a splicing inhibitor". J. Biol. Chem. 277 (42): 39485–92. doi:10.1074/jbc.M201784200. PMID 12183448.
Rappsilber J, Ryder U, Lamond AI, Mann M (2002). "Large-scale proteomic analysis of the human spliceosome". Genome Res. 12 (8): 1231–45. doi:10.1101/gr.473902. PMC 186633. PMID 12176931.
Barnard DC, Li J, Peng R, Patton JG (2002). "Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins". RNA. 8 (4): 526–33. doi:10.1017/S1355838202029928. PMC 1370273. PMID 11991645.
Barnard DC, Patton JG (2000). "Identification and characterization of a novel serine-arginine-rich splicing regulatory protein". Mol. Cell. Biol. 20 (9): 3049–57. doi:10.1128/MCB.20.9.3049-3057.2000. PMC 85584. PMID 10757789.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[pmid12043562-1] Zhang DL, Sun XJ, Ling LJ, Chen RS, Ma DL (Jun 2002). "[Molecular cloning, characterization, chromosomal assignment, genomic organization and verification of SFRS12(SRrp508), a novel member of human SR protein superfamily and a human homolog of rat SRrp86]". Yi Chuan Xue Bao. 29 (5): 377–83. PMID 12043562.

[entrez-2] 2.0 ^2.1 "Entrez Gene: SFRS12 splicing factor, arginine/serine-rich 12".

[1]

[2]

@@ Line 1: / Line 1: @@
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+'''Splicing factor, arginine/serine-rich 12''' is a [[protein]] that in humans is encoded by the ''SFRS12'' [[gene]].<ref name="pmid12043562">{{cite journal | vauthors = Zhang DL, Sun XJ, Ling LJ, Chen RS, Ma DL | title = [Molecular cloning, characterization, chromosomal assignment, genomic organization and verification of SFRS12(SRrp508), a novel member of human SR protein superfamily and a human homolog of rat SRrp86] | journal = Yi Chuan Xue Bao | volume = 29 | issue = 5 | pages = 377–83 |date=Jun 2002 | pmid = 12043562 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SFRS12 splicing factor, arginine/serine-rich 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=140890| accessdate = }}</ref>
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- | image =
- | image_source =
- | PDB =
- | Name = Splicing factor, arginine/serine-rich 12
- | HGNCid = 17882
- | Symbol = SFRS12
- | AltSymbols =; DKFZp564B176; MGC133045; SRrp508; SRrp86
- | OMIM = 609268
- | ECnumber =
- | Homologene = 10581
- | MGIid = 2145245
- | GeneAtlas_image1 = PBB_GE_SFRS12_212721_at_tn.png
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}}
- | Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
-  | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 140890
-    | Hs_Ensembl = ENSG00000153914
-    | Hs_RefseqProtein = NP_001070667
-    | Hs_RefseqmRNA = NM_001077199
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 5
-    | Hs_GenLoc_start = 65475802
-    | Hs_GenLoc_end = 65515199
-    | Hs_Uniprot = Q8WXA9
-    | Mm_EntrezGene = 218543
-    | Mm_Ensembl = ENSMUSG00000032621
-    | Mm_RefseqmRNA = NM_172592
-    | Mm_RefseqProtein = NP_766180
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 13
-    | Mm_GenLoc_start = 104861997
-    | Mm_GenLoc_end = 104884964
-    | Mm_Uniprot = Q6P3Z1
-  }}
-}}
-'''Splicing factor, arginine/serine-rich 12''', also known as '''SFRS12''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SFRS12 splicing factor, arginine/serine-rich 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=140890| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
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-| summary_text = SFRS12 belongs to the superfamily of serine/arginine-rich (SR) splicing factors. It modulates splice site selection by regulating the activities of other SR proteins (Barnard et al., 2002).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SFRS12 splicing factor, arginine/serine-rich 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=140890| accessdate = }}</ref>
+| summary_text = SFRS12 belongs to the superfamily of serine/arginine-rich (SR) splicing factors. It modulates splice site selection by regulating the activities of other SR proteins (Barnard et al., 2002).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SFRS12 splicing factor, arginine/serine-rich 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=140890| accessdate = }}</ref>
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
+*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134  | pmc=1847948 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Heese K, Fujita M, Akatsu H, ''et al.'' |title=The splicing regulatory protein p18SRP is down-regulated in Alzheimer's disease brain. |journal=J. Mol. Neurosci. |volume=24 |issue= 2 |pages= 269-76 |year= 2005 |pmid= 15456940 |doi=  }}
+*{{cite journal   |vauthors=Heese K, Fujita M, Akatsu H, etal |title=The splicing regulatory protein p18SRP is down-regulated in Alzheimer's disease brain. |journal=J. Mol. Neurosci. |volume=24 |issue= 2 |pages= 269–76 |year= 2005 |pmid= 15456940 |doi=10.1385/JMN:24:2:269  }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Li J, Hawkins IC, Harvey CD, ''et al.'' |title=Regulation of alternative splicing by SRrp86 and its interacting proteins. |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7437-47 |year= 2003 |pmid= 14559993 |doi=  }}
+*{{cite journal   |vauthors=Li J, Hawkins IC, Harvey CD, etal |title=Regulation of alternative splicing by SRrp86 and its interacting proteins. |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7437–47 |year= 2003 |pmid= 14559993 |doi=10.1128/MCB.23.21.7437-7447.2003  | pmc=207616  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Peng R, Dye BT, Pérez I, ''et al.'' |title=PSF and p54nrb bind a conserved stem in U5 snRNA. |journal=RNA |volume=8 |issue= 10 |pages= 1334-47 |year= 2002 |pmid= 12403470 |doi=  }}
+*{{cite journal   |vauthors=Peng R, Dye BT, Pérez I, etal |title=PSF and p54nrb bind a conserved stem in U5 snRNA. |journal=RNA |volume=8 |issue= 10 |pages= 1334–47 |year= 2002 |pmid= 12403470 |doi=10.1017/S1355838202022070  | pmc=1370341  }}
-*{{cite journal  | author=Li J, Barnard DC, Patton JG |title=A unique glutamic acid-lysine (EK) domain acts as a splicing inhibitor. |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39485-92 |year= 2002 |pmid= 12183448 |doi= 10.1074/jbc.M201784200 }}
+*{{cite journal  | vauthors=Li J, Barnard DC, Patton JG |title=A unique glutamic acid-lysine (EK) domain acts as a splicing inhibitor. |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39485–92 |year= 2002 |pmid= 12183448 |doi= 10.1074/jbc.M201784200 }}
-*{{cite journal  | author=Rappsilber J, Ryder U, Lamond AI, Mann M |title=Large-scale proteomic analysis of the human spliceosome. |journal=Genome Res. |volume=12 |issue= 8 |pages= 1231-45 |year= 2002 |pmid= 12176931 |doi= 10.1101/gr.473902 }}
+*{{cite journal  | vauthors=Rappsilber J, Ryder U, Lamond AI, Mann M |title=Large-scale proteomic analysis of the human spliceosome. |journal=Genome Res. |volume=12 |issue= 8 |pages= 1231–45 |year= 2002 |pmid= 12176931 |doi= 10.1101/gr.473902  | pmc=186633 }}
-*{{cite journal  | author=Zhang DL, Sun XJ, Ling LJ, ''et al.'' |title=[Molecular cloning, characterization, chromosomal assignment, genomic organization and verification of SFRS12(SRrp508), a novel member of human SR protein superfamily and a human homolog of rat SRrp86] |journal=Yi Chuan Xue Bao |volume=29 |issue= 5 |pages= 377-83 |year= 2002 |pmid= 12043562 |doi=  }}
+*{{cite journal  | vauthors=Barnard DC, Li J, Peng R, Patton JG |title=Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins. |journal=RNA |volume=8 |issue= 4 |pages= 526–33 |year= 2002 |pmid= 11991645 |doi=10.1017/S1355838202029928  | pmc=1370273  }}
-*{{cite journal  | author=Barnard DC, Li J, Peng R, Patton JG |title=Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins. |journal=RNA |volume=8 |issue= 4 |pages= 526-33 |year= 2002 |pmid= 11991645 |doi=  }}
+*{{cite journal  | vauthors=Barnard DC, Patton JG |title=Identification and characterization of a novel serine-arginine-rich splicing regulatory protein. |journal=Mol. Cell. Biol. |volume=20 |issue= 9 |pages= 3049–57 |year= 2000 |pmid= 10757789 |doi=10.1128/MCB.20.9.3049-3057.2000  | pmc=85584  }}
-*{{cite journal  | author=Barnard DC, Patton JG |title=Identification and characterization of a novel serine-arginine-rich splicing regulatory protein. |journal=Mol. Cell. Biol. |volume=20 |issue= 9 |pages= 3049-57 |year= 2000 |pmid= 10757789 |doi=  }}
 }}
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SFRS12: Difference between revisions

Latest revision as of 06:13, 11 September 2017

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