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{{ | '''Splicing factor, arginine/serine-rich 3''' is a [[protein]] that in humans is encoded by the ''SFRS3'' [[gene]].<ref name="pmid1577277">{{cite journal |author1=Zahler AM |author2=Lane WS |author3=Stolk JA |author4=Roth MB | title = SR proteins: a conserved family of pre-mRNA splicing factors | journal = Genes Dev | volume = 6 | issue = 5 | pages = 837–47 |date=Jun 1992 | pmid = 1577277 | pmc = | doi =10.1101/gad.6.5.837 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SFRS3 splicing factor, arginine/serine-rich 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6428| accessdate = }}</ref> | ||
}} | |||
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==Browser View== | |||
[http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg18&knownGene=pack&hgFind.matches=uc003omj.1, UCSC Genome Browser View] | |||
[http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003omj.1&hgg_prot=P84103&hgg_type=knownGene&db=hg18, UCSC Gene details page] | |||
==Interactions== | |||
SFRS3 has been shown to [[Protein-protein interaction|interact]] with [[RBM7]].<ref name=pmid12634307>{{cite journal |last=Guo |first=Taylor B |authorlink= |author2=Boros Laszlo G |author3=Chan Kam C |author4=Hikim Amiya P Sinha |author5=Hudson Alan P |author6=Swerdloff Ronald S |author7=Mitchell Aaron P |author8=Salameh Wael A |year=2003|title=Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors |journal=J. Androl. |volume=24 |issue=2 |pages=204–14 |publisher= |location = United States| issn = 0196-3635| pmid = 12634307 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | doi=10.1002/j.1939-4640.2003.tb02664.x}}</ref> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal |author1=Ayane M |author2=Preuss U |author3=Köhler G |author4=Nielsen PJ |title=A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs. |journal=Nucleic Acids Res. |volume=19 |issue= 6 |pages= 1273–8 |year= 1991 |pmid= 2030943 |doi=10.1093/nar/19.6.1273 | pmc=333853 }} | ||
*{{cite journal |author1=Gui JF |author2=Lane WS |author3=Fu XD |title=A serine kinase regulates intracellular localization of splicing factors in the cell cycle. |journal=Nature |volume=369 |issue= 6482 |pages= 678–82 |year= 1994 |pmid= 8208298 |doi= 10.1038/369678a0 |bibcode=1994Natur.369..678G }} | |||
*{{cite journal | | *{{cite journal |author1=Cáceres JF |author2=Screaton GR |author3=Krainer AR |title=A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm. |journal=Genes Dev. |volume=12 |issue= 1 |pages= 55–66 |year= 1998 |pmid= 9420331 |doi=10.1101/gad.12.1.55 | pmc=316398 }} | ||
*{{cite journal | | *{{cite journal |author1=Zhang WJ |author2=Wu JY |title=Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing. |journal=Mol. Cell. Biol. |volume=18 |issue= 2 |pages= 676–84 |year= 1998 |pmid= 9447963 |doi= | pmc=108778 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Tripodis N, Mason R, Humphray SJ, etal |title=Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex. |journal=Genome Res. |volume=8 |issue= 6 |pages= 631–43 |year= 1999 |pmid= 9647638 |doi= 10.1101/gr.8.6.631| pmc=310739 }} | ||
*{{cite journal | *{{cite journal |vauthors=Papoutsopoulou S, Nikolakaki E, Chalepakis G, etal |title=SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1. |journal=Nucleic Acids Res. |volume=27 |issue= 14 |pages= 2972–80 |year= 1999 |pmid= 10390541 |doi=10.1093/nar/27.14.2972 | pmc=148514 }} | ||
*{{cite journal | *{{cite journal |author1=Barnard DC |author2=Patton JG |title=Identification and characterization of a novel serine-arginine-rich splicing regulatory protein. |journal=Mol. Cell. Biol. |volume=20 |issue= 9 |pages= 3049–57 |year= 2000 |pmid= 10757789 |doi=10.1128/MCB.20.9.3049-3057.2000 | pmc=85584 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Shnyreva M, Schullery DS, Suzuki H, etal |title=Interaction of two multifunctional proteins. Heterogeneous nuclear ribonucleoprotein K and Y-box-binding protein. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 15498–503 |year= 2000 |pmid= 10809782 |doi=10.1074/jbc.275.20.15498 }} | ||
*{{cite journal | *{{cite journal |vauthors=Elliott DJ, Bourgeois CF, Klink A, etal |title=A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 11 |pages= 5717–22 |year= 2000 |pmid= 10823932 |doi=10.1073/pnas.97.11.5717 | pmc=18499 |bibcode=2000PNAS...97.5717E }} | ||
*{{cite journal | *{{cite journal |author1=Huang Y |author2=Steitz JA |title=Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA. |journal=Mol. Cell |volume=7 |issue= 4 |pages= 899–905 |year= 2001 |pmid= 11336712 |doi=10.1016/S1097-2765(01)00233-7 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Andersen JS, Lyon CE, Fox AH, etal |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 }} | ||
*{{cite journal | *{{cite journal |author1=Barnard DC |author2=Li J |author3=Peng R |author4=Patton JG |title=Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins. |journal=RNA |volume=8 |issue= 4 |pages= 526–33 |year= 2002 |pmid= 11991645 |doi=10.1017/S1355838202029928 | pmc=1370273 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }} | ||
*{{cite journal | *{{cite journal |vauthors=Guo TB, Boros LG, Chan KC, etal |title=Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors. |journal=J. Androl. |volume=24 |issue= 2 |pages= 204–14 |year= 2003 |pmid= 12634307 |doi= 10.1002/j.1939-4640.2003.tb02664.x}} | ||
*{{cite journal | *{{cite journal |vauthors=Tai HH, Geisterfer M, Bell JC, etal |title=CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins. |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 1 |pages= 170–6 |year= 2003 |pmid= 12890497 |doi=10.1016/S0006-291X(03)01354-8 }} | ||
*{{cite journal | *{{cite journal |vauthors=Li J, Hawkins IC, Harvey CD, etal |title=Regulation of alternative splicing by SRrp86 and its interacting proteins. |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7437–47 |year= 2003 |pmid= 14559993 |doi=10.1128/MCB.23.21.7437-7447.2003 | pmc=207616 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | ||
*{{cite journal | *{{cite journal |vauthors=Dettwiler S, Aringhieri C, Cardinale S, etal |title=Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization. |journal=J. Biol. Chem. |volume=279 |issue= 34 |pages= 35788–97 |year= 2005 |pmid= 15169763 |doi= 10.1074/jbc.M403927200 }} | ||
*{{cite journal | *{{cite journal |author1=Lehner B |author2=Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 | pmc=442147 }} | ||
*{{cite journal | | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
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{{gene-6-stub}} | |||
Latest revision as of 04:33, 26 June 2018
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| External IDs | GeneCards: [1] | ||||||
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| Species | Human | Mouse | |||||
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| Location (UCSC) | n/a | n/a | |||||
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Splicing factor, arginine/serine-rich 3 is a protein that in humans is encoded by the SFRS3 gene.[1][2]
Browser View
Interactions
SFRS3 has been shown to interact with RBM7.[3]
References
- ↑ Zahler AM; Lane WS; Stolk JA; Roth MB (Jun 1992). "SR proteins: a conserved family of pre-mRNA splicing factors". Genes Dev. 6 (5): 837–47. doi:10.1101/gad.6.5.837. PMID 1577277.
- ↑ "Entrez Gene: SFRS3 splicing factor, arginine/serine-rich 3".
- ↑ Guo, Taylor B; Boros Laszlo G; Chan Kam C; Hikim Amiya P Sinha; Hudson Alan P; Swerdloff Ronald S; Mitchell Aaron P; Salameh Wael A (2003). "Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors". J. Androl. United States. 24 (2): 204–14. doi:10.1002/j.1939-4640.2003.tb02664.x. ISSN 0196-3635. PMID 12634307.
Further reading
- Ayane M; Preuss U; Köhler G; Nielsen PJ (1991). "A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs". Nucleic Acids Res. 19 (6): 1273–8. doi:10.1093/nar/19.6.1273. PMC 333853. PMID 2030943.
- Gui JF; Lane WS; Fu XD (1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. Bibcode:1994Natur.369..678G. doi:10.1038/369678a0. PMID 8208298.
- Cáceres JF; Screaton GR; Krainer AR (1998). "A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm". Genes Dev. 12 (1): 55–66. doi:10.1101/gad.12.1.55. PMC 316398. PMID 9420331.
- Zhang WJ; Wu JY (1998). "Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing". Mol. Cell. Biol. 18 (2): 676–84. PMC 108778. PMID 9447963.
- Tripodis N, Mason R, Humphray SJ, et al. (1999). "Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex". Genome Res. 8 (6): 631–43. doi:10.1101/gr.8.6.631. PMC 310739. PMID 9647638.
- Papoutsopoulou S, Nikolakaki E, Chalepakis G, et al. (1999). "SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1". Nucleic Acids Res. 27 (14): 2972–80. doi:10.1093/nar/27.14.2972. PMC 148514. PMID 10390541.
- Barnard DC; Patton JG (2000). "Identification and characterization of a novel serine-arginine-rich splicing regulatory protein". Mol. Cell. Biol. 20 (9): 3049–57. doi:10.1128/MCB.20.9.3049-3057.2000. PMC 85584. PMID 10757789.
- Shnyreva M, Schullery DS, Suzuki H, et al. (2000). "Interaction of two multifunctional proteins. Heterogeneous nuclear ribonucleoprotein K and Y-box-binding protein". J. Biol. Chem. 275 (20): 15498–503. doi:10.1074/jbc.275.20.15498. PMID 10809782.
- Elliott DJ, Bourgeois CF, Klink A, et al. (2000). "A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection". Proc. Natl. Acad. Sci. U.S.A. 97 (11): 5717–22. Bibcode:2000PNAS...97.5717E. doi:10.1073/pnas.97.11.5717. PMC 18499. PMID 10823932.
- Huang Y; Steitz JA (2001). "Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA". Mol. Cell. 7 (4): 899–905. doi:10.1016/S1097-2765(01)00233-7. PMID 11336712.
- Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
- Barnard DC; Li J; Peng R; Patton JG (2002). "Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins". RNA. 8 (4): 526–33. doi:10.1017/S1355838202029928. PMC 1370273. PMID 11991645.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Guo TB, Boros LG, Chan KC, et al. (2003). "Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors". J. Androl. 24 (2): 204–14. doi:10.1002/j.1939-4640.2003.tb02664.x. PMID 12634307.
- Tai HH, Geisterfer M, Bell JC, et al. (2003). "CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins". Biochem. Biophys. Res. Commun. 308 (1): 170–6. doi:10.1016/S0006-291X(03)01354-8. PMID 12890497.
- Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Dettwiler S, Aringhieri C, Cardinale S, et al. (2005). "Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization". J. Biol. Chem. 279 (34): 35788–97. doi:10.1074/jbc.M403927200. PMID 15169763.
- Lehner B; Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
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