SFXN1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
(Added recent information from a high impact journal. Reference was included.)
 
(One intermediate revision by one other user not shown)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Sideroflexin-1''' is a [[protein]] that in humans is encoded by the ''SFXN1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SFXN1 sideroflexin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=94081| accessdate = }}</ref> According to Nora Kory et al., ''SFXN1'' gene product has mitochondrial serine transporter activity<ref>{{Cite journal|last=Kory|first=Nora|last2=Wyant|first2=Gregory A.|last3=Prakash|first3=Gyan|last4=Bos|first4=Jelmi uit de|last5=Bottanelli|first5=Francesca|last6=Pacold|first6=Michael E.|last7=Chan|first7=Sze Ham|last8=Lewis|first8=Caroline A.|last9=Wang|first9=Tim|date=2018-11-16|title=SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism|url=http://science.sciencemag.org/content/362/6416/eaat9528|journal=Science|language=en|volume=362|issue=6416|pages=eaat9528|doi=10.1126/science.aat9528|issn=0036-8075|pmid=30442778}}</ref>.
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Sideroflexin 1
| HGNCid = 16085
| Symbol = SFXN1
| AltSymbols =; FLJ12876
| OMIM = 
| ECnumber = 
| Homologene = 41494
| MGIid = 2137677
| GeneAtlas_image1 = PBB_GE_SFXN1_218392_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0008324 |text = cation transmembrane transporter activity}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005743 |text = mitochondrial inner membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006812 |text = cation transport}} {{GNF_GO|id=GO:0006826 |text = iron ion transport}} {{GNF_GO|id=GO:0030218 |text = erythrocyte differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 94081
    | Hs_Ensembl = ENSG00000164466
    | Hs_RefseqProtein = NP_073591
    | Hs_RefseqmRNA = NM_022754
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 174851713
    | Hs_GenLoc_end = 174888290
    | Hs_Uniprot = Q9H9B4
    | Mm_EntrezGene = 14057
    | Mm_Ensembl = ENSMUSG00000021474
    | Mm_RefseqmRNA = NM_027324
    | Mm_RefseqProtein = NP_081600
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 54081490
    | Mm_GenLoc_end = 54117966
    | Mm_Uniprot = Q8BPC9
  }}
}}
'''Sideroflexin 1''', also known as '''SFXN1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SFXN1 sideroflexin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=94081| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Line 55: Line 9:


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Kaplan RS, Mayor JA |title=Structure, function and regulation of the tricarboxylate transport protein from rat liver mitochondria. |journal=J. Bioenerg. Biomembr. |volume=25 |issue= 5 |pages= 503-14 |year= 1994 |pmid= 8132490 |doi=  }}
*{{cite journal  | vauthors=Kaplan RS, Mayor JA |title=Structure, function and regulation of the tricarboxylate transport protein from rat liver mitochondria. |journal=J. Bioenerg. Biomembr. |volume=25 |issue= 5 |pages= 503–14 |year= 1994 |pmid= 8132490 |doi=10.1007/BF01108407 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 }}
*{{cite journal | author=Fleming MD, Campagna DR, Haslett JN, ''et al.'' |title=A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. |journal=Genes Dev. |volume=15 |issue= 6 |pages= 652-7 |year= 2001 |pmid= 11274051 |doi= 10.1101/gad.873001 }}
*{{cite journal   |vauthors=Fleming MD, Campagna DR, Haslett JN, etal |title=A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice |journal=Genes Dev. |volume=15 |issue= 6 |pages= 652–7 |year= 2001 |pmid= 11274051 |doi= 10.1101/gad.873001 | pmc=312659 }}
*{{cite journal | author=Zara V, Giudetti AM, Siculella L, ''et al.'' |title=Covariance of tricarboxylate carrier activity and lipogenesis in liver of polyunsaturated fatty acid (n-6) fed rats. |journal=Eur. J. Biochem. |volume=268 |issue= 22 |pages= 5734-9 |year= 2001 |pmid= 11722557 |doi=  }}
*{{cite journal   |vauthors=Zara V, Giudetti AM, Siculella L, etal |title=Covariance of tricarboxylate carrier activity and lipogenesis in liver of polyunsaturated fatty acid (n-6) fed rats |journal=Eur. J. Biochem. |volume=268 |issue= 22 |pages= 5734–9 |year= 2001 |pmid= 11722557 |doi=10.1046/j.0014-2956.2001.02508.x }}
*{{cite journal | author=Miyake S, Yamashita T, Taniguchi M, ''et al.'' |title=Identification and characterization of a novel mitochondrial tricarboxylate carrier. |journal=Biochem. Biophys. Res. Commun. |volume=295 |issue= 2 |pages= 463-8 |year= 2002 |pmid= 12150972 |doi=  }}
*{{cite journal   |vauthors=Miyake S, Yamashita T, Taniguchi M, etal |title=Identification and characterization of a novel mitochondrial tricarboxylate carrier |journal=Biochem. Biophys. Res. Commun. |volume=295 |issue= 2 |pages= 463–8 |year= 2002 |pmid= 12150972 |doi=10.1016/S0006-291X(02)00694-0 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Giudetti AM, Sabetta S, di Summa R, ''et al.'' |title=Differential effects of coconut oil- and fish oil-enriched diets on tricarboxylate carrier in rat liver mitochondria. |journal=J. Lipid Res. |volume=44 |issue= 11 |pages= 2135-41 |year= 2004 |pmid= 14634051 |doi= 10.1194/jlr.M300237-JLR200 }}
*{{cite journal   |vauthors=Giudetti AM, Sabetta S, di Summa R, etal |title=Differential effects of coconut oil- and fish oil-enriched diets on tricarboxylate carrier in rat liver mitochondria |journal=J. Lipid Res. |volume=44 |issue= 11 |pages= 2135–41 |year= 2004 |pmid= 14634051 |doi= 10.1194/jlr.M300237-JLR200 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal   |vauthors=Bouwmeester T, Bauch A, Ruffner H, etal |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal  | author=Siculella L, Damiano F, Sabetta S, Gnoni GV |title=n-6 PUFAs downregulate expression of the tricarboxylate carrier in rat liver by transcriptional and posttranscriptional mechanisms. |journal=J. Lipid Res. |volume=45 |issue= 7 |pages= 1333-40 |year= 2005 |pmid= 15060089 |doi= 10.1194/jlr.M400061-JLR200 }}
*{{cite journal  | vauthors=Siculella L, Damiano F, Sabetta S, Gnoni GV |title=n-6 PUFAs downregulate expression of the tricarboxylate carrier in rat liver by transcriptional and posttranscriptional mechanisms |journal=J. Lipid Res. |volume=45 |issue= 7 |pages= 1333–40 |year= 2005 |pmid= 15060089 |doi= 10.1194/jlr.M400061-JLR200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal   |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }}
*{{cite journal | author=Siculella L, Sabetta S, Damiano F, ''et al.'' |title=Different dietary fatty acids have dissimilar effects on activity and gene expression of mitochondrial tricarboxylate carrier in rat liver. |journal=FEBS Lett. |volume=578 |issue= 3 |pages= 280-4 |year= 2005 |pmid= 15589833 |doi= 10.1016/j.febslet.2004.11.014 }}
*{{cite journal   |vauthors=Siculella L, Sabetta S, Damiano F, etal |title=Different dietary fatty acids have dissimilar effects on activity and gene expression of mitochondrial tricarboxylate carrier in rat liver |journal=FEBS Lett. |volume=578 |issue= 3 |pages= 280–4 |year= 2005 |pmid= 15589833 |doi= 10.1016/j.febslet.2004.11.014 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal   |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{WikiDoc Sources}}
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
 
{{gene-5-stub}}

Latest revision as of 16:11, 21 November 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sideroflexin-1 is a protein that in humans is encoded by the SFXN1 gene.[1] According to Nora Kory et al., SFXN1 gene product has mitochondrial serine transporter activity[2].


References

  1. ↑ "Entrez Gene: SFXN1 sideroflexin 1".
  2. ↑ Kory, Nora; Wyant, Gregory A.; Prakash, Gyan; Bos, Jelmi uit de; Bottanelli, Francesca; Pacold, Michael E.; Chan, Sze Ham; Lewis, Caroline A.; Wang, Tim (2018-11-16). "SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism". Science. 362 (6416): eaat9528. doi:10.1126/science.aat9528. ISSN 0036-8075. PMID 30442778.

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=SFXN1&oldid=1532828"