SGOL1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Shugoshin-like 1''' is a [[protein]] that in humans is encoded by the ''SGOL1'' [[gene]].<ref name="pmid12747765">{{cite journal | vauthors = Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, Jäger D, Chen YT, Mackay A, O'Hare MJ, Old LJ | title = Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression | journal = Cancer Immunity | volume = 1 | issue =  | pages = 4 | date = Mar 2001 | pmid = 12747765 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SGOL1 shugoshin-like 1 (S. pombe)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=151648| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Model organisms==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Shugoshin-like 1 (S. pombe)
| HGNCid = 25088
| Symbol = SGOL1
| AltSymbols =; NY-BR-85; Sgo1
| OMIM = 609168
| ECnumber = 
| Homologene = 23642
| MGIid = 1919665
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000775 |text = chromosome, pericentric region}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0045132 |text = meiotic chromosome segregation}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 151648
    | Hs_Ensembl = ENSG00000129810
    | Hs_RefseqProtein = NP_001012409
    | Hs_RefseqmRNA = NM_001012409
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 20177091
    | Hs_GenLoc_end = 20202687
    | Hs_Uniprot = Q5FBB7
    | Mm_EntrezGene = 72415
    | Mm_Ensembl = ENSMUSG00000023940
    | Mm_RefseqmRNA = NM_028232
    | Mm_RefseqProtein = NP_082508
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 53140989
    | Mm_GenLoc_end = 53154241
    | Mm_Uniprot = Q9CXH7
  }}
}}
'''Shugoshin-like 1 (S. pombe)''', also known as '''SGOL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SGOL1 shugoshin-like 1 (S. pombe)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=151648| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{| class="wikitable sortable collapsible collapsed" border="1" cellpadding="2" style="float: right;" |
{{PBB_Summary
|+ ''Sgol1'' knockout mouse phenotype
| section_title =
|-
| summary_text =
! Characteristic!! Phenotype
}}


==References==
|-
{{reflist|2}}
| [[Homozygote]] viability || bgcolor="#C40000"|Abnormal
==Further reading==
|-
{{refbegin | 2}}
| [[Recessive]] lethal study || bgcolor="#C40000"|Abnormal
{{PBB_Further_reading
|-
| citations =  
| Body weight || bgcolor="#488ED3"|Normal
*{{cite journal | author=Wang X, Dai W |title=Shugoshin, a guardian for sister chromatid segregation. |journal=Exp. Cell Res. |volume=310 |issue= 1 |pages= 1-9 |year= 2005 |pmid= 16112668 |doi= 10.1016/j.yexcr.2005.07.018 }}
|-
*{{cite journal | author=Fu G, Ding X, Yuan K, ''et al.'' |title=Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis. |journal=Cell Res. |volume=17 |issue= 7 |pages= 608-18 |year= 2007 |pmid= 17621308 |doi= 10.1038/cr.2007.55 }}
| [[Open Field (animal test)|Anxiety]] || bgcolor="#488ED3"|Normal
*{{cite journal | author=Pouwels J, Kukkonen AM, Lan W, ''et al.'' |title=Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1. |journal=Cell Cycle |volume=6 |issue= 13 |pages= 1579-85 |year= 2007 |pmid= 17617734 |doi= }}
|-
*{{cite journal | author=Fu G, Hua S, Ward T, ''et al.'' |title=D-box is required for the degradation of human Shugoshin and chromosome alignment. |journal=Biochem. Biophys. Res. Commun. |volume=357 |issue= 3 |pages= 672-8 |year= 2007 |pmid= 17448445 |doi= 10.1016/j.bbrc.2007.03.204 }}
| Neurological assessment || bgcolor="#488ED3"|Normal
*{{cite journal | author=Yang Y, Wang X, Dai W |title=Human Sgo1 is an excellent target for induction of apoptosis of transformed cells. |journal=Cell Cycle |volume=5 |issue= 8 |pages= 896-901 |year= 2006 |pmid= 16628005 |doi= }}
|-
*{{cite journal | author=Tang Z, Shu H, Qi W, ''et al.'' |title=PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. |journal=Dev. Cell |volume=10 |issue= 5 |pages= 575-85 |year= 2006 |pmid= 16580887 |doi= 10.1016/j.devcel.2006.03.010 }}
| Grip strength || bgcolor="#488ED3"|Normal
*{{cite journal | author=Kitajima TS, Sakuno T, Ishiguro K, ''et al.'' |title=Shugoshin collaborates with protein phosphatase 2A to protect cohesin. |journal=Nature |volume=441 |issue= 7089 |pages= 46-52 |year= 2006 |pmid= 16541025 |doi= 10.1038/nature04663 }}
|-
*{{cite journal | author=McGuinness BE, Hirota T, Kudo NR, ''et al.'' |title=Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells. |journal=PLoS Biol. |volume=3 |issue= 3 |pages= e86 |year= 2006 |pmid= 15737064 |doi= 10.1371/journal.pbio.0030086 }}
| [[Hot plate test|Hot plate]] || bgcolor="#488ED3"|Normal
*{{cite journal | author=Kitajima TS, Hauf S, Ohsugi M, ''et al.'' |title=Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localization. |journal=Curr. Biol. |volume=15 |issue= 4 |pages= 353-9 |year= 2005 |pmid= 15723797 |doi= 10.1016/j.cub.2004.12.044 }}
|-
*{{cite journal | author=Tang Z, Sun Y, Harley SE, ''et al.'' |title=Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 52 |pages= 18012-7 |year= 2005 |pmid= 15604152 |doi= 10.1073/pnas.0408600102 }}
| [[Dysmorphology]] || bgcolor="#488ED3"|Normal
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
|-
*{{cite journal  | author=Scanlan MJ, Gout I, Gordon CM, ''et al.'' |title=Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. |journal=Cancer Immun. |volume=1 |issue=  |pages= 4 |year= 2003 |pmid= 12747765 |doi=  }}
| [[Indirect calorimetry]] || bgcolor="#488ED3"|Normal
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
|-
}}
| [[Glucose tolerance test]] || bgcolor="#488ED3"|Normal
|-
| [[Auditory brainstem response]] || bgcolor="#488ED3"|Normal
|-
| [[Dual-energy X-ray absorptiometry|DEXA]] || bgcolor="#488ED3"|Normal
|-
| [[Radiography]] || bgcolor="#488ED3"|Normal
|-
| Body temperature || bgcolor="#488ED3"|Normal
|-
| Eye morphology || bgcolor="#488ED3"|Normal
|-
| [[Clinical chemistry]] || bgcolor="#488ED3"|Normal
|-
| [[Blood plasma|Plasma]] [[immunoglobulin]]s || bgcolor="#488ED3"|Normal
|-
| [[Haematology]] || bgcolor="#488ED3"|Normal
|-
| [[Peripheral blood lymphocyte]]s || bgcolor="#C40000"|Abnormal<ref name="Peripheral blood lymphocytes">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBRY/peripheral-blood-lymphocytes/ |title=Peripheral blood lymphocytes data for Sgol1 |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| [[Micronucleus test]] || bgcolor="#488ED3"|Normal
|-
| Heart weight || bgcolor="#488ED3"|Normal
|-
| Skin Histopathology || bgcolor="#488ED3"|Normal
|-
| Brain histopathology || bgcolor="#488ED3"|Normal
|-
| Eye Histopathology || bgcolor="#488ED3"|Normal
|-
| ''[[Salmonella]]'' infection || bgcolor="#488ED3"|Normal<ref name="''Salmonella'' infection">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBRY/salmonella-challenge/ |title=''Salmonella'' infection data for Sgol1 |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| ''[[Citrobacter]]'' infection || bgcolor="#488ED3"|Normal<ref name="''Citrobacter'' infection">{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBRY/citrobacter-challenge/ |title=''Citrobacter'' infection data for Sgol1 |publisher=Wellcome Trust Sanger Institute}}</ref>
|-
| colspan=2; style="text-align: center;" | All tests and analysis from<ref name="mgp_reference">{{cite journal | doi = 10.1111/j.1755-3768.2010.4142.x | title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice | year = 2010 | author = Gerdin AK | journal = Acta Ophthalmologica | volume = 88 | pages =  925–7 }}</ref><ref>[http://www.sanger.ac.uk/mouseportal/ Mouse Resources Portal], Wellcome Trust Sanger Institute.</ref>
|}
[[Model organism]]s have been used in the study of SGOL1 function. A conditional [[knockout mouse]] line, called ''Sgol1<sup>tm1a(EUCOMM)Wtsi</sup>''<ref name="allele_ref">{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Sgol1 |title=International Knockout Mouse Consortium}}</ref><ref name="mgi_allele_ref">{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4433385 |title=Mouse Genome Informatics}}</ref> has been generated.<ref name="pmid21677750">{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}</ref><ref name="mouse_library">{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}</ref><ref name="mouse_for_all_reasons">{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}</ref>
 
Male and female animals underwent a standardized [[phenotypic screen]] to determine the effects of deletion.<ref name="mgp_reference" /><ref name="pmid21722353">{{cite journal | vauthors = van der Weyden L, White JK, Adams DJ, Logan DW | title = The mouse genetics toolkit: revealing function and mechanism | journal = Genome Biology | volume = 12 | issue = 6 | pages = 224 | year = 2011 | pmid = 21722353 | pmc = 3218837 | doi = 10.1186/gb-2011-12-6-224 }}</ref> Twenty six tests were carried out on [[mutant]] mice and three significant abnormalities were observed. No [[homozygous]] [[mutant]] embryos were identified during gestation, and thus none survived until [[weaning]]. The remaining tests were carried out on [[heterozygous]] mutant adult mice and a decreased regulatory [[T cell]] number was observed in male animals.<ref name="mgp_reference" />
 
== Mechanisms ==
 
A physical mechanism that guarantees the accurate segregation of [[sister chromatids]] during [[mitosis]] arises from the ring shaped [[cohesin]] complex consisting of 4 subunits ([[SMC1A]]/[[SMC1B|B]], [[SMC3]], [[RAD21|SCC1]], and [[STAG1|SA1]]/[[STAG2|2]] in humans).  This complex encircles the two sister chromatids and resists the pulling force of [[microtubule]]s.<ref>{{cite journal | vauthors = Nasmyth K, Haering CH | title = Cohesin: its roles and mechanisms | journal = Annual Review of Genetics | volume = 43 | pages = 525–58 | pmid = 19886810 | doi = 10.1146/annurev-genet-102108-134233 }}</ref> The characteristic X-shape chromosomes are formed due to the [[centromeric]] cohesin protected by Shugoshin-[[PP2A]] complex.<ref>{{cite journal | vauthors = Kitajima TS, Sakuno T, Ishiguro K, Iemura S, Natsume T, Kawashima SA, Watanabe Y | title = Shugoshin collaborates with protein phosphatase 2A to protect cohesin | journal = Nature | volume = 441 | issue = 7089 | pages = 46–52 | date = May 2006 | pmid = 16541025 | doi = 10.1038/nature04663 }}</ref>
 
[[Kinetochore]] localization of Sgo1-PP2A is dependent upon phosphorylation on [[histone H2A]] of [[nucleosome]], which is the important substrate of spindle checkpoint kinase [[BUB1]].<ref>{{cite journal | vauthors = Kawashima SA, Yamagishi Y, Honda T, Ishiguro K, Watanabe Y | title = Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin | journal = Science | volume = 327 | issue = 5962 | pages = 172–7 | date = Jan 2010 | pmid = 19965387 | doi = 10.1126/science.1180189 }}</ref> Centromeric cohesin and H2A-pT120 specify two distinct pools of Sgo1-PP2A at inner centromeres and kinetochores respectively,<ref>{{cite journal | vauthors = Liu H, Jia L, Yu H | title = Phospho-H2A and cohesin specify distinct tension-regulated Sgo1 pools at kinetochores and inner centromeres | journal = Current Biology | volume = 23 | issue = 19 | pages = 1927–33 | date = Oct 2013 | pmid = 24055156 | doi = 10.1016/j.cub.2013.07.078 }}</ref> while the [[CDK1]]/cyclin B phosphorylation on Sgo1 is essential for Sgo1-PP2A to protect centromeric cohesin, not only for bringing PP2A to cohesin,<ref>{{cite journal | vauthors = Liu H, Rankin S, Yu H | title = Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis | journal = Nature Cell Biology | volume = 15 | issue = 1 | pages = 40–9 | date = Jan 2013 | pmid = 23242214 | doi = 10.1038/ncb2637 | pmc=3531828}}</ref> but also physically shield out the negative regulator [[WAPAL]] from cohesin.<ref>{{cite journal | vauthors = Hara K, Zheng G, Qu Q, Liu H, Ouyang Z, Chen Z, Tomchick DR, Yu H | title = Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion | journal = Nature Structural & Molecular Biology | volume = 21 | issue = 10 | pages = 864–70 | date = Oct 2014 | pmid = 25173175 | doi = 10.1038/nsmb.2880 | pmc=4190070}}</ref>
 
== References ==
{{reflist|33em}}
 
== Further reading ==
{{refbegin|33em}}
* {{cite journal | vauthors = Wang X, Dai W | title = Shugoshin, a guardian for sister chromatid segregation | journal = Experimental Cell Research | volume = 310 | issue = 1 | pages = 1–9 | date = Oct 2005 | pmid = 16112668 | doi = 10.1016/j.yexcr.2005.07.018 }}
* {{cite journal | vauthors = Fu G, Ding X, Yuan K, Aikhionbare F, Yao J, Cai X, Jiang K, Yao X | title = Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis | journal = Cell Research | volume = 17 | issue = 7 | pages = 608–18 | date = Jul 2007 | pmid = 17621308 | doi = 10.1038/cr.2007.55 }}
* {{cite journal | vauthors = Pouwels J, Kukkonen AM, Lan W, Daum JR, Gorbsky GJ, Stukenberg T, Kallio MJ | title = Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1 | journal = Cell Cycle | volume = 6 | issue = 13 | pages = 1579–85 | date = Jul 2007 | pmid = 17617734 | doi = 10.4161/cc.6.13.4442 }}
* {{cite journal | vauthors = Fu G, Hua S, Ward T, Ding X, Yang Y, Guo Z, Yao X | title = D-box is required for the degradation of human Shugoshin and chromosome alignment | journal = Biochemical and Biophysical Research Communications | volume = 357 | issue = 3 | pages = 672–8 | date = Jun 2007 | pmid = 17448445 | doi = 10.1016/j.bbrc.2007.03.204 }}
* {{cite journal | vauthors = Yang Y, Wang X, Dai W | title = Human Sgo1 is an excellent target for induction of apoptosis of transformed cells | journal = Cell Cycle | volume = 5 | issue = 8 | pages = 896–901 | date = Apr 2006 | pmid = 16628005 | doi = 10.4161/cc.5.8.2691 }}
* {{cite journal | vauthors = Tang Z, Shu H, Qi W, Mahmood NA, Mumby MC, Yu H | title = PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation | journal = Developmental Cell | volume = 10 | issue = 5 | pages = 575–85 | date = May 2006 | pmid = 16580887 | doi = 10.1016/j.devcel.2006.03.010 }}
* {{cite journal | vauthors = Kitajima TS, Sakuno T, Ishiguro K, Iemura S, Natsume T, Kawashima SA, Watanabe Y | title = Shugoshin collaborates with protein phosphatase 2A to protect cohesin | journal = Nature | volume = 441 | issue = 7089 | pages = 46–52 | date = May 2006 | pmid = 16541025 | doi = 10.1038/nature04663 }}
* {{cite journal | vauthors = McGuinness BE, Hirota T, Kudo NR, Peters JM, Nasmyth K | title = Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells | journal = PLoS Biology | volume = 3 | issue = 3 | pages = e86 | date = Mar 2005 | pmid = 15737064 | pmc = 1054882 | doi = 10.1371/journal.pbio.0030086 }}
* {{cite journal | vauthors = Kitajima TS, Hauf S, Ohsugi M, Yamamoto T, Watanabe Y | title = Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localization | journal = Current Biology | volume = 15 | issue = 4 | pages = 353–9 | date = Feb 2005 | pmid = 15723797 | doi = 10.1016/j.cub.2004.12.044 }}
* {{cite journal | vauthors = Tang Z, Sun Y, Harley SE, Zou H, Yu H | title = Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 52 | pages = 18012–7 | date = Dec 2004 | pmid = 15604152 | pmc = 539817 | doi = 10.1073/pnas.0408600102 }}
{{refend}}
{{refend}}


{{protein-stub}}
[[Category:Genes mutated in mice]]
{{WikiDoc Sources}}

Latest revision as of 06:15, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Shugoshin-like 1 is a protein that in humans is encoded by the SGOL1 gene.[1][2]

Model organisms

Model organisms have been used in the study of SGOL1 function. A conditional knockout mouse line, called Sgol1tm1a(EUCOMM)Wtsi[8][9] has been generated.[10][11][12]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[6][13] Twenty six tests were carried out on mutant mice and three significant abnormalities were observed. No homozygous mutant embryos were identified during gestation, and thus none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice and a decreased regulatory T cell number was observed in male animals.[6]

Mechanisms

A physical mechanism that guarantees the accurate segregation of sister chromatids during mitosis arises from the ring shaped cohesin complex consisting of 4 subunits (SMC1A/B, SMC3, SCC1, and SA1/2 in humans). This complex encircles the two sister chromatids and resists the pulling force of microtubules.[14] The characteristic X-shape chromosomes are formed due to the centromeric cohesin protected by Shugoshin-PP2A complex.[15]

Kinetochore localization of Sgo1-PP2A is dependent upon phosphorylation on histone H2A of nucleosome, which is the important substrate of spindle checkpoint kinase BUB1.[16] Centromeric cohesin and H2A-pT120 specify two distinct pools of Sgo1-PP2A at inner centromeres and kinetochores respectively,[17] while the CDK1/cyclin B phosphorylation on Sgo1 is essential for Sgo1-PP2A to protect centromeric cohesin, not only for bringing PP2A to cohesin,[18] but also physically shield out the negative regulator WAPAL from cohesin.[19]

References

  1. ↑ Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, Jäger D, Chen YT, Mackay A, O'Hare MJ, Old LJ (Mar 2001). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immunity. 1: 4. PMID 12747765.
  2. ↑ "Entrez Gene: SGOL1 shugoshin-like 1 (S. pombe)".
  3. ↑ "Peripheral blood lymphocytes data for Sgol1". Wellcome Trust Sanger Institute.
  4. ↑ "Salmonella infection data for Sgol1". Wellcome Trust Sanger Institute.
  5. ↑ "Citrobacter infection data for Sgol1". Wellcome Trust Sanger Institute.
  6. ↑ 6.0 6.1 6.2 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  7. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  8. ↑ "International Knockout Mouse Consortium".
  9. ↑ "Mouse Genome Informatics".
  10. ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  11. ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  12. ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  13. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.
  14. ↑ Nasmyth K, Haering CH. "Cohesin: its roles and mechanisms". Annual Review of Genetics. 43: 525–58. doi:10.1146/annurev-genet-102108-134233. PMID 19886810.
  15. ↑ Kitajima TS, Sakuno T, Ishiguro K, Iemura S, Natsume T, Kawashima SA, Watanabe Y (May 2006). "Shugoshin collaborates with protein phosphatase 2A to protect cohesin". Nature. 441 (7089): 46–52. doi:10.1038/nature04663. PMID 16541025.
  16. ↑ Kawashima SA, Yamagishi Y, Honda T, Ishiguro K, Watanabe Y (Jan 2010). "Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin". Science. 327 (5962): 172–7. doi:10.1126/science.1180189. PMID 19965387.
  17. ↑ Liu H, Jia L, Yu H (Oct 2013). "Phospho-H2A and cohesin specify distinct tension-regulated Sgo1 pools at kinetochores and inner centromeres". Current Biology. 23 (19): 1927–33. doi:10.1016/j.cub.2013.07.078. PMID 24055156.
  18. ↑ Liu H, Rankin S, Yu H (Jan 2013). "Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis". Nature Cell Biology. 15 (1): 40–9. doi:10.1038/ncb2637. PMC 3531828. PMID 23242214.
  19. ↑ Hara K, Zheng G, Qu Q, Liu H, Ouyang Z, Chen Z, Tomchick DR, Yu H (Oct 2014). "Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion". Nature Structural & Molecular Biology. 21 (10): 864–70. doi:10.1038/nsmb.2880. PMC 4190070. PMID 25173175.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=SGOL1&oldid=1413179"