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{{Infobox_gene}}
'''SH2 domain-containing protein 2A''' is a [[protein]] that in humans is encoded by the ''SH2D2A'' [[gene]].<ref name="pmid9468509">{{cite journal |author1=Spurkland A |author2=Brinchmann JE |author3=Markussen G |author4=Pedeutour F |author5=Munthe E |author6=Lea T |author7=Vartdal F |author8=Aasheim HC | title = Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites | journal = J Biol Chem | volume = 273 | issue = 8 | pages = 4539–46 |date=March 1998 | pmid = 9468509 | pmc =  | doi =10.1074/jbc.273.8.4539  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SH2D2A SH2 domain protein 2A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9047| accessdate = }}</ref>
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==Interactions==
SH2D2A has been shown to [[Protein-protein interaction|interact]] with [[MAP3K2]].<ref name=pmid11073940>{{cite journal |last=Sun |first=W |authorlink= |author2=Kesavan K |author3=Schaefer B C |author4=Garrington T P |author5=Ware M |author6=Johnson N L |author7=Gelfand E W |author8=Johnson G L  |date=February 2001 |title=MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway |journal=J. Biol. Chem. |volume=276 |issue=7 |pages=5093–100 |publisher= |location = United States| issn = 0021-9258| pmid = 11073940 |doi = 10.1074/jbc.M003719200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
==References==
{{Reflist}}
==Further reading==
{{Refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  |author1=Marti F |author2=Lapinski PE |author3=King PD |title=The emerging role of the T cell-specific adaptor (TSAd) protein as an autoimmune disease-regulator in mouse and man. |journal=Immunol. Lett. |volume=97 |issue= 2 |pages= 165–70 |year= 2005 |pmid= 15752554 |doi= 10.1016/j.imlet.2004.10.019 }}
*{{cite journal  |author1=Maruyama K |author2=Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal  |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
*{{cite journal  |author1=Choi YB |author2=Kim CK |author3=Yun Y |title=Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation. |journal=J. Immunol. |volume=163 |issue= 10 |pages= 5242–9 |year= 1999 |pmid= 10553045 |doi=  }}
*{{cite journal  |vauthors=Rajagopal K, Sommers CL, Decker DC, etal |title=RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation. |journal=J. Exp. Med. |volume=190 |issue= 11 |pages= 1657–68 |year= 2000 |pmid= 10587356 |doi=10.1084/jem.190.11.1657  | pmc=2195727  }}
*{{cite journal  |vauthors=Wu LW, Mayo LD, Dunbar JD, etal |title=VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor. |journal=J. Biol. Chem. |volume=275 |issue= 9 |pages= 6059–62 |year= 2000 |pmid= 10692392 |doi=10.1074/jbc.275.9.6059  }}
*{{cite journal  |vauthors=Dai KZ, Vergnaud G, Ando A, etal |title=The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd) is localized centromeric to the CD1 gene cluster on human Chromosome 1. |journal=Immunogenetics |volume=51 |issue= 3 |pages= 179–85 |year= 2000 |pmid= 10752626 |doi=10.1007/s002510050029  }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  |vauthors=Smerdel A, Dai KZ, Lorentzen AR, etal |title=Genetic association between juvenile rheumatoid arthritis and polymorphism in the SH2D2A gene. |journal=Genes Immun. |volume=5 |issue= 4 |pages= 310–2 |year= 2005 |pmid= 15129233 |doi= 10.1038/sj.gene.6364093 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  |vauthors=Rush J, Moritz A, Lee KA, etal |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal  |vauthors=Matsumoto T, Bohman S, Dixelius J, etal |title=VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis. |journal=EMBO J. |volume=24 |issue= 13 |pages= 2342–53 |year= 2005 |pmid= 15962004 |doi= 10.1038/sj.emboj.7600709  | pmc=1173150 }}
*{{cite journal  |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G }}
*{{cite journal  |vauthors=Park D, Park I, Lee D, etal |title=The adaptor protein Lad associates with the G protein beta subunit and mediates chemokine-dependent T-cell migration. |journal=Blood |volume=109 |issue= 12 |pages= 5122–8 |year= 2007 |pmid= 17327418 |doi= 10.1182/blood-2005-10-061838 }}
}}
{{Refend}}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = SH2 domain protein 2A
| HGNCid = 10821
| Symbol = SH2D2A
| AltSymbols =; F2771; TSAd
| OMIM = 604514
| ECnumber = 
| Homologene = 2958
| MGIid = 1351596
| GeneAtlas_image1 = PBB_GE_SH2D2A_207351_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005070 |text = SH3/SH2 adaptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9047
    | Hs_Ensembl = ENSG00000027869
    | Hs_RefseqProtein = NP_003966
    | Hs_RefseqmRNA = NM_003975
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 155042659
    | Hs_GenLoc_end = 155053278
    | Hs_Uniprot = Q9NP31
    | Mm_EntrezGene = 27371
    | Mm_Ensembl = ENSMUSG00000028071
    | Mm_RefseqmRNA = NM_001025571
    | Mm_RefseqProtein = NP_001020742
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 87932938
    | Mm_GenLoc_end = 87941649
    | Mm_Uniprot = Q3TA00
  }}
}}
'''SH2 domain protein 2A''', also known as '''SH2D2A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SH2D2A SH2 domain protein 2A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9047| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Marti F, Lapinski PE, King PD |title=The emerging role of the T cell-specific adaptor (TSAd) protein as an autoimmune disease-regulator in mouse and man. |journal=Immunol. Lett. |volume=97 |issue= 2 |pages= 165-70 |year= 2005 |pmid= 15752554 |doi= 10.1016/j.imlet.2004.10.019 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Spurkland A, Brinchmann JE, Markussen G, ''et al.'' |title=Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites. |journal=J. Biol. Chem. |volume=273 |issue= 8 |pages= 4539-46 |year= 1998 |pmid= 9468509 |doi=  }}
*{{cite journal  | author=Choi YB, Kim CK, Yun Y |title=Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation. |journal=J. Immunol. |volume=163 |issue= 10 |pages= 5242-9 |year= 1999 |pmid= 10553045 |doi=  }}
*{{cite journal  | author=Rajagopal K, Sommers CL, Decker DC, ''et al.'' |title=RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation. |journal=J. Exp. Med. |volume=190 |issue= 11 |pages= 1657-68 |year= 2000 |pmid= 10587356 |doi=  }}
*{{cite journal  | author=Wu LW, Mayo LD, Dunbar JD, ''et al.'' |title=VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor. |journal=J. Biol. Chem. |volume=275 |issue= 9 |pages= 6059-62 |year= 2000 |pmid= 10692392 |doi=  }}
*{{cite journal  | author=Dai KZ, Vergnaud G, Ando A, ''et al.'' |title=The SH2D2A gene encoding the T-cell-specific adapter protein (TSAd) is localized centromeric to the CD1 gene cluster on human Chromosome 1. |journal=Immunogenetics |volume=51 |issue= 3 |pages= 179-85 |year= 2000 |pmid= 10752626 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Smerdel A, Dai KZ, Lorentzen AR, ''et al.'' |title=Genetic association between juvenile rheumatoid arthritis and polymorphism in the SH2D2A gene. |journal=Genes Immun. |volume=5 |issue= 4 |pages= 310-2 |year= 2005 |pmid= 15129233 |doi= 10.1038/sj.gene.6364093 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal  | author=Matsumoto T, Bohman S, Dixelius J, ''et al.'' |title=VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis. |journal=EMBO J. |volume=24 |issue= 13 |pages= 2342-53 |year= 2005 |pmid= 15962004 |doi= 10.1038/sj.emboj.7600709 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | author=Park D, Park I, Lee D, ''et al.'' |title=The adaptor protein Lad associates with the G protein beta subunit and mediates chemokine-dependent T-cell migration. |journal=Blood |volume=109 |issue= 12 |pages= 5122-8 |year= 2007 |pmid= 17327418 |doi= 10.1182/blood-2005-10-061838 }}
}}
{{refend}}


{{protein-stub}}
{{Gene-1-stub}}
{{WikiDoc Sources}}

Latest revision as of 04:34, 26 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

SH2 domain-containing protein 2A is a protein that in humans is encoded by the SH2D2A gene.[1][2]

Interactions

SH2D2A has been shown to interact with MAP3K2.[3]

References

  1. ↑ Spurkland A; Brinchmann JE; Markussen G; Pedeutour F; Munthe E; Lea T; Vartdal F; Aasheim HC (March 1998). "Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites". J Biol Chem. 273 (8): 4539–46. doi:10.1074/jbc.273.8.4539. PMID 9468509.
  2. ↑ "Entrez Gene: SH2D2A SH2 domain protein 2A".
  3. ↑ Sun, W; Kesavan K; Schaefer B C; Garrington T P; Ware M; Johnson N L; Gelfand E W; Johnson G L (February 2001). "MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway". J. Biol. Chem. United States. 276 (7): 5093–100. doi:10.1074/jbc.M003719200. ISSN 0021-9258. PMID 11073940.

Further reading



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