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{{Infobox_gene}}
{{PBB_Controls
'''SH2 domain-containing adapter protein B''' is a [[protein]] that in humans is encoded by the ''SHB'' [[gene]].<ref name="pmid7713524">{{cite journal | vauthors = Yulug IG, Hillermann R, Fisher EM | title = The SHB adaptor protein maps to human chromosome 9 | journal = Genomics | volume = 24 | issue = 3 | pages = 615–7 | date = Dec 1994 | pmid = 7713524 | pmc = | doi = 10.1006/geno.1994.1681 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SHB Src homology 2 domain containing adaptor protein B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6461| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Src homology 2 domain containing adaptor protein B
| HGNCid = 10838
| Symbol = SHB
| AltSymbols =; RP11-3J10.8; bA3J10.2
| OMIM = 600314
| ECnumber = 
| Homologene = 74458
| MGIid = 98294
| GeneAtlas_image1 = PBB_GE_SHB_204657_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SHB_204656_at_tn.png
| Function = {{GNF_GO|id=GO:0005070 |text = SH3/SH2 adaptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0042100 |text = B cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6461
    | Hs_Ensembl = ENSG00000107338
    | Hs_RefseqProtein = NP_003019
    | Hs_RefseqmRNA = NM_003028
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 37909131
    | Hs_GenLoc_end = 38059249
    | Hs_Uniprot = Q15464
    | Mm_EntrezGene = 230126
    | Mm_Ensembl = ENSMUSG00000044813
    | Mm_RefseqmRNA = XM_131399
    | Mm_RefseqProtein = XP_131399
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 45444379
    | Mm_GenLoc_end = 45551430
    | Mm_Uniprot = Q6PD21
  }}
}}
'''Src homology 2 domain containing adaptor protein B''', also known as '''SHB''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SHB Src homology 2 domain containing adaptor protein B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6461| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
SHB (gene) has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[EPS8]],<ref name = pmid7537362/>
* [[Fibroblast growth factor receptor 1]],<ref name = pmid7537362>{{cite journal | vauthors = Karlsson T, Songyang Z, Landgren E, Lavergne C, Di Fiore PP, Anafi M, Pawson T, Cantley LC, Claesson-Welsh L, Welsh M | title = Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins | journal = Oncogene | volume = 10 | issue = 8 | pages = 1475–83 | date = Apr 1995 | pmid = 7537362 | doi =  }}</ref>
* [[Linker of activated T cells]],<ref name = pmid10488157>{{cite journal | vauthors = Lindholm CK, Gylfe E, Zhang W, Samelson LE, Welsh M | title = Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells | journal = The Journal of Biological Chemistry | volume = 274 | issue = 39 | pages = 28050–7 | date = Sep 1999 | pmid = 10488157 | doi =  10.1074/jbc.274.39.28050}}</ref><ref name = pmid12084069>{{cite journal | vauthors = Lindholm CK, Henriksson ML, Hallberg B, Welsh M | title = Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells | journal = European Journal of Biochemistry / FEBS | volume = 269 | issue = 13 | pages = 3279–88 | date = Jul 2002 | pmid = 12084069 | doi =  10.1046/j.1432-1033.2002.03008.x}}</ref>
* [[Lymphocyte cytosolic protein 2]],<ref name = pmid12084069/>
* [[PIK3R1]],<ref name = pmid7537362/>
* [[Src (gene) | Src]],<ref name = pmid7537362/>
* [[VAV1]],<ref name = pmid12084069/> and
* [[ZAP-70]].<ref name = pmid12084069/>
{{Div col end}}
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Karlsson T, Songyang Z, Landgren E, Lavergne C, Di Fiore PP, Anafi M, Pawson T, Cantley LC, Claesson-Welsh L, Welsh M | title = Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins | journal = Oncogene | volume = 10 | issue = 8 | pages = 1475–83 | date = Apr 1995 | pmid = 7537362 | doi =  }}
| citations =
* {{cite journal | vauthors = Welsh M, Mares J, Karlsson T, Lavergne C, Bréant B, Claesson-Welsh L | title = Shb is a ubiquitously expressed Src homology 2 protein | journal = Oncogene | volume = 9 | issue = 1 | pages = 19–27 | date = Jan 1994 | pmid = 8302579 | doi =  }}
*{{cite journal | author=Karlsson T, Songyang Z, Landgren E, ''et al.'' |title=Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins. |journal=Oncogene |volume=10 |issue= 8 |pages= 1475-83 |year= 1995 |pmid= 7537362 |doi=  }}
* {{cite journal | vauthors = Karlsson T, Welsh M | title = Apoptosis of NIH3T3 cells overexpressing the Src homology 2 domain protein Shb | journal = Oncogene | volume = 13 | issue = 5 | pages = 955–61 | date = Sep 1996 | pmid = 8806685 | doi =  }}
*{{cite journal | author=Yulug IG, Hillermann R, Fisher EM |title=The SHB adaptor protein maps to human chromosome 9. |journal=Genomics |volume=24 |issue= 3 |pages= 615-7 |year= 1995 |pmid= 7713524 |doi= 10.1006/geno.1994.1681 }}
* {{cite journal | vauthors = Welsh M, Songyang Z, Frantz JD, Trüb T, Reedquist KA, Karlsson T, Miyazaki M, Cantley LC, Band H, Shoelson SE | title = Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins | journal = Oncogene | volume = 16 | issue = 7 | pages = 891–901 | date = Feb 1998 | pmid = 9484780 | doi = 10.1038/sj.onc.1201607 }}
*{{cite journal  | author=Welsh M, Mares J, Karlsson T, ''et al.'' |title=Shb is a ubiquitously expressed Src homology 2 protein. |journal=Oncogene |volume=9 |issue= 1 |pages= 19-27 |year= 1994 |pmid= 8302579 |doi=  }}
* {{cite journal | vauthors = Karlsson T, Kullander K, Welsh M | title = The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- and nerve growth factor-dependent differentiation signals in PC12 cells | journal = Cell Growth & Differentiation | volume = 9 | issue = 9 | pages = 757–66 | date = Sep 1998 | pmid = 9751119 | doi =  }}
*{{cite journal | author=Karlsson T, Welsh M |title=Apoptosis of NIH3T3 cells overexpressing the Src homology 2 domain protein Shb. |journal=Oncogene |volume=13 |issue= 5 |pages= 955-61 |year= 1996 |pmid= 8806685 |doi=  }}
* {{cite journal | vauthors = Lindholm CK, Gylfe E, Zhang W, Samelson LE, Welsh M | title = Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells | journal = The Journal of Biological Chemistry | volume = 274 | issue = 39 | pages = 28050–7 | date = Sep 1999 | pmid = 10488157 | doi = 10.1074/jbc.274.39.28050 }}
*{{cite journal | author=Welsh M, Songyang Z, Frantz JD, ''et al.'' |title=Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins. |journal=Oncogene |volume=16 |issue= 7 |pages= 891-901 |year= 1998 |pmid= 9484780 |doi= 10.1038/sj.onc.1201607 }}
* {{cite journal | vauthors = Dixelius J, Larsson H, Sasaki T, Holmqvist K, Lu L, Engström A, Timpl R, Welsh M, Claesson-Welsh L | title = Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis | journal = Blood | volume = 95 | issue = 11 | pages = 3403–11 | date = Jun 2000 | pmid = 10828022 | doi =  }}
*{{cite journal | author=Karlsson T, Kullander K, Welsh M |title=The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- and nerve growth factor-dependent differentiation signals in PC12 cells. |journal=Cell Growth Differ. |volume=9 |issue= 9 |pages= 757-66 |year= 1998 |pmid= 9751119 |doi=  }}
* {{cite journal | vauthors = Hooshmand-Rad R, Lu L, Heldin CH, Claesson-Welsh L, Welsh M | title = Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization | journal = Experimental Cell Research | volume = 257 | issue = 2 | pages = 245–54 | date = Jun 2000 | pmid = 10837138 | doi = 10.1006/excr.2000.4896 }}
*{{cite journal | author=Lindholm CK, Gylfe E, Zhang W, ''et al.'' |title=Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells. |journal=J. Biol. Chem. |volume=274 |issue= 39 |pages= 28050-7 |year= 1999 |pmid= 10488157 |doi= }}
* {{cite journal | vauthors = Lu L, Annerén C, Reedquist KA, Bos JL, Welsh M | title = NGF-Dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway | journal = Experimental Cell Research | volume = 259 | issue = 2 | pages = 370–7 | date = Sep 2000 | pmid = 10964504 | doi = 10.1006/excr.2000.4984 }}
*{{cite journal | author=Dixelius J, Larsson H, Sasaki T, ''et al.'' |title=Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis. |journal=Blood |volume=95 |issue= 11 |pages= 3403-11 |year= 2000 |pmid= 10828022 |doi=  }}
* {{cite journal | vauthors = Diakonova M, Gunter DR, Herrington J, Carter-Su C | title = SH2-Bbeta is a Rac-binding protein that regulates cell motility | journal = The Journal of Biological Chemistry | volume = 277 | issue = 12 | pages = 10669–77 | date = Mar 2002 | pmid = 11786545 | doi = 10.1074/jbc.M111138200 }}
*{{cite journal | author=Hooshmand-Rad R, Lu L, Heldin CH, ''et al.'' |title=Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization. |journal=Exp. Cell Res. |volume=257 |issue= 2 |pages= 245-54 |year= 2000 |pmid= 10837138 |doi= 10.1006/excr.2000.4896 }}
* {{cite journal | vauthors = Lindholm CK, Henriksson ML, Hallberg B, Welsh M | title = Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells | journal = European Journal of Biochemistry / FEBS | volume = 269 | issue = 13 | pages = 3279–88 | date = Jul 2002 | pmid = 12084069 | doi = 10.1046/j.1432-1033.2002.03008.x }}
*{{cite journal | author=Lu L, Annerén C, Reedquist KA, ''et al.'' |title=NGF-Dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway. |journal=Exp. Cell Res. |volume=259 |issue= 2 |pages= 370-7 |year= 2000 |pmid= 10964504 |doi= 10.1006/excr.2000.4984 }}
* {{cite journal | vauthors = Cross MJ, Lu L, Magnusson P, Nyqvist D, Holmqvist K, Welsh M, Claesson-Welsh L | title = The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells | journal = Molecular Biology of the Cell | volume = 13 | issue = 8 | pages = 2881–93 | date = Aug 2002 | pmid = 12181353 | pmc = 117949 | doi = 10.1091/mbc.E02-02-0103 }}
*{{cite journal | author=Diakonova M, Gunter DR, Herrington J, Carter-Su C |title=SH2-Bbeta is a Rac-binding protein that regulates cell motility. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10669-77 |year= 2002 |pmid= 11786545 |doi= 10.1074/jbc.M111138200 }}
* {{cite journal | vauthors = Lindholm CK | title = IL-2 receptor signaling through the Shb adapter protein in T and NK cells | journal = Biochemical and Biophysical Research Communications | volume = 296 | issue = 4 | pages = 929–36 | date = Aug 2002 | pmid = 12200137 | doi = 10.1016/S0006-291X(02)02016-8 }}
*{{cite journal | author=Lindholm CK, Henriksson ML, Hallberg B, Welsh M |title=Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells. |journal=Eur. J. Biochem. |volume=269 |issue= 13 |pages= 3279-88 |year= 2002 |pmid= 12084069 |doi= }}
* {{cite journal | vauthors = Holmqvist K, Cross M, Riley D, Welsh M | title = The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells | journal = Cellular Signalling | volume = 15 | issue = 2 | pages = 171–9 | date = Feb 2003 | pmid = 12464388 | doi = 10.1016/S0898-6568(02)00076-1 }}
*{{cite journal | author=Cross MJ, Lu L, Magnusson P, ''et al.'' |title=The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells. |journal=Mol. Biol. Cell |volume=13 |issue= 8 |pages= 2881-93 |year= 2003 |pmid= 12181353 |doi= 10.1091/mbc.E02-02-0103 }}
* {{cite journal | vauthors = Welsh N, Makeeva N, Welsh M | title = Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins | journal = Molecular Medicine | volume = 8 | issue = 11 | pages = 695–704 | date = Nov 2002 | pmid = 12520086 | pmc = 2039954 | doi = }}
*{{cite journal | author=Lindholm CK |title=IL-2 receptor signaling through the Shb adapter protein in T and NK cells. |journal=Biochem. Biophys. Res. Commun. |volume=296 |issue= 4 |pages= 929-36 |year= 2002 |pmid= 12200137 |doi= }}
* {{cite journal | vauthors = Holmqvist K, Cross MJ, Rolny C, Hägerkvist R, Rahimi N, Matsumoto T, Claesson-Welsh L, Welsh M | title = The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration | journal = The Journal of Biological Chemistry | volume = 279 | issue = 21 | pages = 22267–75 | date = May 2004 | pmid = 15026417 | doi = 10.1074/jbc.M312729200 }}
*{{cite journal | author=Holmqvist K, Cross M, Riley D, Welsh M |title=The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells. |journal=Cell. Signal. |volume=15 |issue= 2 |pages= 171-9 |year= 2003 |pmid= 12464388 |doi= }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Welsh N, Makeeva N, Welsh M |title=Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins. |journal=Mol. Med. |volume=8 |issue= 11 |pages= 695-704 |year= 2003 |pmid= 12520086 |doi= }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Holmqvist K, Cross MJ, Rolny C, ''et al.'' |title=The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22267-75 |year= 2004 |pmid= 15026417 |doi= 10.1074/jbc.M312729200 }}
*{{cite journal  | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369-74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{gene-9-stub}}
{{WikiDoc Sources}}

Latest revision as of 06:18, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

SH2 domain-containing adapter protein B is a protein that in humans is encoded by the SHB gene.[1][2]


Interactions

SHB (gene) has been shown to interact with:

References

  1. ↑ Yulug IG, Hillermann R, Fisher EM (Dec 1994). "The SHB adaptor protein maps to human chromosome 9". Genomics. 24 (3): 615–7. doi:10.1006/geno.1994.1681. PMID 7713524.
  2. ↑ "Entrez Gene: SHB Src homology 2 domain containing adaptor protein B".
  3. ↑ 3.0 3.1 3.2 3.3 Karlsson T, Songyang Z, Landgren E, Lavergne C, Di Fiore PP, Anafi M, Pawson T, Cantley LC, Claesson-Welsh L, Welsh M (Apr 1995). "Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins". Oncogene. 10 (8): 1475–83. PMID 7537362.
  4. ↑ Lindholm CK, Gylfe E, Zhang W, Samelson LE, Welsh M (Sep 1999). "Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells". The Journal of Biological Chemistry. 274 (39): 28050–7. doi:10.1074/jbc.274.39.28050. PMID 10488157.
  5. ↑ 5.0 5.1 5.2 5.3 Lindholm CK, Henriksson ML, Hallberg B, Welsh M (Jul 2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells". European Journal of Biochemistry / FEBS. 269 (13): 3279–88. doi:10.1046/j.1432-1033.2002.03008.x. PMID 12084069.

Further reading

  • Karlsson T, Songyang Z, Landgren E, Lavergne C, Di Fiore PP, Anafi M, Pawson T, Cantley LC, Claesson-Welsh L, Welsh M (Apr 1995). "Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins". Oncogene. 10 (8): 1475–83. PMID 7537362.
  • Welsh M, Mares J, Karlsson T, Lavergne C, Bréant B, Claesson-Welsh L (Jan 1994). "Shb is a ubiquitously expressed Src homology 2 protein". Oncogene. 9 (1): 19–27. PMID 8302579.
  • Karlsson T, Welsh M (Sep 1996). "Apoptosis of NIH3T3 cells overexpressing the Src homology 2 domain protein Shb". Oncogene. 13 (5): 955–61. PMID 8806685.
  • Welsh M, Songyang Z, Frantz JD, Trüb T, Reedquist KA, Karlsson T, Miyazaki M, Cantley LC, Band H, Shoelson SE (Feb 1998). "Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins". Oncogene. 16 (7): 891–901. doi:10.1038/sj.onc.1201607. PMID 9484780.
  • Karlsson T, Kullander K, Welsh M (Sep 1998). "The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- and nerve growth factor-dependent differentiation signals in PC12 cells". Cell Growth & Differentiation. 9 (9): 757–66. PMID 9751119.
  • Lindholm CK, Gylfe E, Zhang W, Samelson LE, Welsh M (Sep 1999). "Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells". The Journal of Biological Chemistry. 274 (39): 28050–7. doi:10.1074/jbc.274.39.28050. PMID 10488157.
  • Dixelius J, Larsson H, Sasaki T, Holmqvist K, Lu L, Engström A, Timpl R, Welsh M, Claesson-Welsh L (Jun 2000). "Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis". Blood. 95 (11): 3403–11. PMID 10828022.
  • Hooshmand-Rad R, Lu L, Heldin CH, Claesson-Welsh L, Welsh M (Jun 2000). "Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization". Experimental Cell Research. 257 (2): 245–54. doi:10.1006/excr.2000.4896. PMID 10837138.
  • Lu L, Annerén C, Reedquist KA, Bos JL, Welsh M (Sep 2000). "NGF-Dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway". Experimental Cell Research. 259 (2): 370–7. doi:10.1006/excr.2000.4984. PMID 10964504.
  • Diakonova M, Gunter DR, Herrington J, Carter-Su C (Mar 2002). "SH2-Bbeta is a Rac-binding protein that regulates cell motility". The Journal of Biological Chemistry. 277 (12): 10669–77. doi:10.1074/jbc.M111138200. PMID 11786545.
  • Lindholm CK, Henriksson ML, Hallberg B, Welsh M (Jul 2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells". European Journal of Biochemistry / FEBS. 269 (13): 3279–88. doi:10.1046/j.1432-1033.2002.03008.x. PMID 12084069.
  • Cross MJ, Lu L, Magnusson P, Nyqvist D, Holmqvist K, Welsh M, Claesson-Welsh L (Aug 2002). "The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells". Molecular Biology of the Cell. 13 (8): 2881–93. doi:10.1091/mbc.E02-02-0103. PMC 117949. PMID 12181353.
  • Lindholm CK (Aug 2002). "IL-2 receptor signaling through the Shb adapter protein in T and NK cells". Biochemical and Biophysical Research Communications. 296 (4): 929–36. doi:10.1016/S0006-291X(02)02016-8. PMID 12200137.
  • Holmqvist K, Cross M, Riley D, Welsh M (Feb 2003). "The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells". Cellular Signalling. 15 (2): 171–9. doi:10.1016/S0898-6568(02)00076-1. PMID 12464388.
  • Welsh N, Makeeva N, Welsh M (Nov 2002). "Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins". Molecular Medicine. 8 (11): 695–704. PMC 2039954. PMID 12520086.
  • Holmqvist K, Cross MJ, Rolny C, Hägerkvist R, Rahimi N, Matsumoto T, Claesson-Welsh L, Welsh M (May 2004). "The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration". The Journal of Biological Chemistry. 279 (21): 22267–75. doi:10.1074/jbc.M312729200. PMID 15026417.
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