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{{Infobox_gene}}
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'''SLAM family member 6''' is a [[protein]] that in humans is encoded by the ''SLAMF6'' [[gene]].<ref name="pmid11489943">{{cite journal | vauthors = Bottino C, Falco M, Parolini S, Marcenaro E, Augugliaro R, Sivori S, Landi E, Biassoni R, Notarangelo LD, Moretta L, Moretta A | title = NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease | journal = J Exp Med | volume = 194 | issue = 3 | pages = 235–46 |date=Aug 2001 | pmid = 11489943 | pmc = 2193462 | doi =10.1084/jem.194.3.235 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLAMF6 SLAM family member 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114836| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SLAMF6_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2if7.
| PDB = {{PDB2|2if7}}
| Name = SLAM family member 6
| HGNCid = 21392
| Symbol = SLAMF6
| AltSymbols =; KALI; KALIb; Ly108; MGC104953; NTB-A; NTBA; SF2000
| OMIM = 606446
| ECnumber = 
| Homologene = 49945
| MGIid = 1353620
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process =  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 114836
    | Hs_Ensembl = ENSG00000162739
    | Hs_RefseqProtein = NP_443163
    | Hs_RefseqmRNA = NM_052931
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 158721444
    | Hs_GenLoc_end = 158759676
    | Hs_Uniprot = Q96DU3
    | Mm_EntrezGene = 30925
    | Mm_Ensembl = ENSMUSG00000015314
    | Mm_RefseqmRNA = NM_030710
    | Mm_RefseqProtein = NP_109635
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 173754190
    | Mm_GenLoc_end = 173785627
    | Mm_Uniprot = Q18PJ0
  }}
}}
'''SLAM family member 6''', also known as '''SLAMF6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLAMF6 SLAM family member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114836| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.<ref name="entrez">{{cite web | title = Entrez Gene: SLAMF6 SLAM family member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114836| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a type I [[transmembrane protein]], belonging to the [[CD2]] subfamily of the [[immunoglobulin superfamily]]. This encoded protein is expressed on [[Natural killer]] (NK), [[T lymphocyte|T]], and [[B lymphocytes]]. It undergoes [[tyrosine phosphorylation]] and associates with the Src homology 2 domain-containing protein ([[SH2D1A]]) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from [[X-linked lymphoproliferative disease|X-linked lymphoproliferative]] patients.<ref name="entrez">{{cite web | title = Entrez Gene: SLAMF6 SLAM family member 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114836| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Claus M, Meinke S, Bhat R, Watzl C |title=Regulation of NK cell activity by 2B4, NTB-A and CRACC. |journal=Front. Biosci. |volume=13 |issue=  |pages= 956-65 |year= 2007 |pmid= 17981603 |doi=  }}
*{{cite journal  | vauthors=Claus M, Meinke S, Bhat R, Watzl C |title=Regulation of NK cell activity by 2B4, NTB-A and CRACC. |journal=Front. Biosci. |volume=13 |issue=  13|pages= 956–65 |year= 2007 |pmid= 17981603 |doi=10.2741/2735 }}
*{{cite journal | author=Hercend T, Meuer S, Brennan A, ''et al.'' |title=Natural killer-like function of activated T lymphocytes: differential blocking effects of monoclonal antibodies specific for a 90-kDa clonotypic structure. |journal=Cell. Immunol. |volume=86 |issue= 2 |pages= 381-92 |year= 1984 |pmid= 6610481 |doi=  }}
*{{cite journal   |vauthors=Hercend T, Meuer S, Brennan A, etal |title=Natural killer-like function of activated T lymphocytes: differential blocking effects of monoclonal antibodies specific for a 90-kDa clonotypic structure |journal=Cell. Immunol. |volume=86 |issue= 2 |pages= 381–92 |year= 1984 |pmid= 6610481 |doi=10.1016/0008-8749(84)90393-9 }}
*{{cite journal | author=Kong G, Dalton M, Wardenburg JB, ''et al.'' |title=Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function. |journal=Mol. Cell. Biol. |volume=16 |issue= 9 |pages= 5026-35 |year= 1996 |pmid= 8756661 |doi=  }}
*{{cite journal   |vauthors=Kong G, Dalton M, Wardenburg JB, etal |title=Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function |journal=Mol. Cell. Biol. |volume=16 |issue= 9 |pages= 5026–35 |year= 1996 |pmid= 8756661 |doi= | pmc=231504 }}
*{{cite journal  | author=Lee YJ, Luisiri P, Clark MR |title=A novel complex, p40/42, is constitutively associated with the B cell antigen receptor and phosphorylated upon receptor stimulation. |journal=J. Immunol. |volume=157 |issue= 9 |pages= 3828-37 |year= 1996 |pmid= 8892612 |doi=  }}
*{{cite journal  | vauthors=Lee YJ, Luisiri P, Clark MR |title=A novel complex, p40/42, is constitutively associated with the B cell antigen receptor and phosphorylated upon receptor stimulation |journal=J. Immunol. |volume=157 |issue= 9 |pages= 3828–37 |year= 1996 |pmid= 8892612 |doi=  }}
*{{cite journal | author=Gray CW, Ward RV, Karran E, ''et al.'' |title=Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response. |journal=Eur. J. Biochem. |volume=267 |issue= 18 |pages= 5699-710 |year= 2000 |pmid= 10971580 |doi=  }}
*{{cite journal   |vauthors=Gray CW, Ward RV, Karran E, etal |title=Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response |journal=Eur. J. Biochem. |volume=267 |issue= 18 |pages= 5699–710 |year= 2000 |pmid= 10971580 |doi=10.1046/j.1432-1327.2000.01589.x }}
*{{cite journal | author=Bottino C, Falco M, Parolini S, ''et al.'' |title=NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease. |journal=J. Exp. Med. |volume=194 |issue= 3 |pages= 235-46 |year= 2001 |pmid= 11489943 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Del Valle JM, Engel P, Martín M |title=The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2) |journal=J. Biol. Chem. |volume=278 |issue= 19 |pages= 17430–7 |year= 2003 |pmid= 12621057 |doi= 10.1074/jbc.M301569200 }}
*{{cite journal  | author=Del Valle JM, Engel P, Martín M |title=The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2). |journal=J. Biol. Chem. |volume=278 |issue= 19 |pages= 17430-7 |year= 2003 |pmid= 12621057 |doi= 10.1074/jbc.M301569200 }}
*{{cite journal  | vauthors=Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC |title=Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation |journal=J. Immunol. |volume=171 |issue= 5 |pages= 2485–95 |year= 2003 |pmid= 12928397 |doi= 10.4049/jimmunol.171.5.2485}}
*{{cite journal | author=Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC |title=Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation. |journal=J. Immunol. |volume=171 |issue= 5 |pages= 2485-95 |year= 2003 |pmid= 12928397 |doi=  }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal   |vauthors=Valdez PA, Wang H, Seshasayee D, etal |title=NTB-A, a new activating receptor in T cells that regulates autoimmune disease |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 18662–9 |year= 2004 |pmid= 14988414 |doi= 10.1074/jbc.M312313200 }}
*{{cite journal  | author=Valdez PA, Wang H, Seshasayee D, ''et al.'' |title=NTB-A, a new activating receptor in T cells that regulates autoimmune disease. |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 18662-9 |year= 2004 |pmid= 14988414 |doi= 10.1074/jbc.M312313200 }}
*{{cite journal  | vauthors=Flaig RM, Stark S, Watzl C |title=Cutting edge: NTB-A activates NK cells via homophilic interaction |journal=J. Immunol. |volume=172 |issue= 11 |pages= 6524–7 |year= 2004 |pmid= 15153464 |doi= 10.4049/jimmunol.172.11.6524}}
*{{cite journal  | author=Flaig RM, Stark S, Watzl C |title=Cutting edge: NTB-A activates NK cells via homophilic interaction. |journal=J. Immunol. |volume=172 |issue= 11 |pages= 6524-7 |year= 2004 |pmid= 15153464 |doi= }}
*{{cite journal  | vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504  | pmc=2286551 }}
*{{cite journal | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Stark S, Watzl C |title=2B4 (CD244), NTB-A and CRACC (CS1) stimulate cytotoxicity but no proliferation in human NK cells |journal=Int. Immunol. |volume=18 |issue= 2 |pages= 241–7 |year= 2006 |pmid= 16410313 |doi= 10.1093/intimm/dxh358 }}
*{{cite journal | author=Stark S, Watzl C |title=2B4 (CD244), NTB-A and CRACC (CS1) stimulate cytotoxicity but no proliferation in human NK cells. |journal=Int. Immunol. |volume=18 |issue= 2 |pages= 241-7 |year= 2006 |pmid= 16410313 |doi= 10.1093/intimm/dxh358 }}
*{{cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | vauthors=Eissmann P, Watzl C |title=Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A-mediated activation of human NK cells |journal=J. Immunol. |volume=177 |issue= 5 |pages= 3170–7 |year= 2006 |pmid= 16920955 |doi= 10.4049/jimmunol.177.5.3170}}
*{{cite journal | author=Eissmann P, Watzl C |title=Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A-mediated activation of human NK cells. |journal=J. Immunol. |volume=177 |issue= 5 |pages= 3170-7 |year= 2006 |pmid= 16920955 |doi= }}
*{{cite journal   |vauthors=Cao E, Ramagopal UA, Fedorov A, etal |title=NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family |journal=Immunity |volume=25 |issue= 4 |pages= 559–70 |year= 2006 |pmid= 17045824 |doi= 10.1016/j.immuni.2006.06.020 }}
*{{cite journal  | author=Cao E, Ramagopal UA, Fedorov A, ''et al.'' |title=NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family. |journal=Immunity |volume=25 |issue= 4 |pages= 559-70 |year= 2006 |pmid= 17045824 |doi= 10.1016/j.immuni.2006.06.020 }}
*{{cite journal  | vauthors=Banerjee P, Feuer G, Barker E |title=Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous natural killer cell-mediated cytotoxicity despite the reduction of major histocompatibility complex class I molecules on infected cells |journal=J. Virol. |volume=81 |issue= 18 |pages= 9707–17 |year= 2007 |pmid= 17609265 |doi= 10.1128/JVI.00887-07  | pmc=2045425 }}
*{{cite journal | author=Banerjee P, Feuer G, Barker E |title=Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous natural killer cell-mediated cytotoxicity despite the reduction of major histocompatibility complex class I molecules on infected cells. |journal=J. Virol. |volume=81 |issue= 18 |pages= 9707-17 |year= 2007 |pmid= 17609265 |doi= 10.1128/JVI.00887-07 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=114836}}
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Latest revision as of 18:18, 20 February 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

SLAM family member 6 is a protein that in humans is encoded by the SLAMF6 gene.[1][2]

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.[2]

References

  1. Bottino C, Falco M, Parolini S, Marcenaro E, Augugliaro R, Sivori S, Landi E, Biassoni R, Notarangelo LD, Moretta L, Moretta A (Aug 2001). "NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease". J Exp Med. 194 (3): 235–46. doi:10.1084/jem.194.3.235. PMC 2193462. PMID 11489943.
  2. 2.0 2.1 "Entrez Gene: SLAMF6 SLAM family member 6".

Further reading