SLK (gene): Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''STE20-like serine/threonine-protein kinase''' is an [[enzyme]] that in humans is encoded by the ''SLK'' [[gene]].<ref name="pmid3526554">{{cite journal | vauthors = Celenza JL, Carlson M | title = A yeast gene that is essential for release from glucose repression encodes a protein kinase | journal = Science | volume = 233 | issue = 4769 | pages = 1175–80 | date = Sep 1986 | pmid = 3526554 | pmc =  | doi = 10.1126/science.3526554 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLK STE20-like kinase (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9748| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_SLK_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2j51.
| PDB = {{PDB2|2j51}}, {{PDB2|2jfl}}, {{PDB2|2jfm}}, {{PDB2|2uv2}}
| Name = STE20-like kinase (yeast)
| HGNCid = 11088
| Symbol = SLK
| AltSymbols =; KIAA0204; STK2; MGC133067; bA16H23.1; se20-9
| OMIM = 
| ECnumber = 
| Homologene = 22515
| MGIid = 103241
| GeneAtlas_image1 = PBB_GE_SLK_206874_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SLK_206875_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004518 |text = nuclease activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006289 |text = nucleotide-excision repair}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006915 |text = apoptosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9748
    | Hs_Ensembl = ENSG00000065613
    | Hs_RefseqProtein = NP_055535
    | Hs_RefseqmRNA = NM_014720
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 105716949
    | Hs_GenLoc_end = 105778981
    | Hs_Uniprot = Q9H2G2
    | Mm_EntrezGene = 20874
    | Mm_Ensembl = ENSMUSG00000025060
    | Mm_RefseqmRNA = NM_009289
    | Mm_RefseqProtein = NP_033315
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 47632989
    | Mm_GenLoc_end = 47697119
    | Mm_Uniprot = O54988
  }}
}}
'''STE20-like kinase (yeast)''', also known as '''SLK''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLK STE20-like kinase (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9748| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
SLK (gene) has been shown to [[Protein-protein interaction|interact]] with [[PDZK1]].<ref name=pmid14531806>{{cite journal | vauthors = Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H | title = PDZK1: I. a major scaffolder in brush borders of proximal tubular cells | journal = Kidney International | volume = 64 | issue = 5 | pages = 1733–45 | date = Nov 2003 | pmid = 14531806 | doi = 10.1046/j.1523-1755.2003.00266.x }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Yan Y, Nguyen H, Dalmasso G, Sitaraman SV, Merlin D | title = Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform | journal = Biochimica et Biophysica Acta | volume = 1769 | issue = 2 | pages = 106–16 | date = Feb 2007 | pmid = 17321610 | pmc = 1865517 | doi = 10.1016/j.bbaexp.2007.01.003 }}
| citations =
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Yan Y, Nguyen H, Dalmasso G, ''et al.'' |title=Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform. |journal=Biochim. Biophys. Acta |volume=1769 |issue= 2 |pages= 106-16 |year= 2007 |pmid= 17321610 |doi= 10.1016/j.bbaexp.2007.01.003 }}
* {{cite journal | vauthors = Chaar Z, O'reilly P, Gelman I, Sabourin LA | title = v-Src-dependent down-regulation of the Ste20-like kinase SLK by casein kinase II | journal = The Journal of Biological Chemistry | volume = 281 | issue = 38 | pages = 28193–9 | date = Sep 2006 | pmid = 16837460 | doi = 10.1074/jbc.M605665200 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
* {{cite journal | vauthors = Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H | title = PDZK1: I. a major scaffolder in brush borders of proximal tubular cells | journal = Kidney International | volume = 64 | issue = 5 | pages = 1733–45 | date = Nov 2003 | pmid = 14531806 | doi = 10.1046/j.1523-1755.2003.00266.x }}
*{{cite journal | author=Chaar Z, O'reilly P, Gelman I, Sabourin LA |title=v-Src-dependent down-regulation of the Ste20-like kinase SLK by casein kinase II. |journal=J. Biol. Chem. |volume=281 |issue= 38 |pages= 28193-9 |year= 2006 |pmid= 16837460 |doi= 10.1074/jbc.M605665200 }}
* {{cite journal | vauthors = Nakayama M, Kikuno R, Ohara O | title = Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs | journal = Genome Research | volume = 12 | issue = 11 | pages = 1773–84 | date = Nov 2002 | pmid = 12421765 | pmc = 187542 | doi = 10.1101/gr.406902 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Dan I, Watanabe NM, Kusumi A | title = The Ste20 group kinases as regulators of MAP kinase cascades | journal = Trends in Cell Biology | volume = 11 | issue = 5 | pages = 220–30 | date = May 2001 | pmid = 11316611 | doi = 10.1016/S0962-8924(01)01980-8 }}
*{{cite journal  | author=Deloukas P, Earthrowl ME, Grafham DV, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375-81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }}
* {{cite journal | vauthors = Eichmuller S, Usener D, Dummer R, Stein A, Thiel D, Schadendorf D | title = Serological detection of cutaneous T-cell lymphoma-associated antigens | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 2 | pages = 629–34 | date = Jan 2001 | pmid = 11149944 | pmc = 14639 | doi = 10.1073/pnas.021386498 }}
*{{cite journal  | author=Gisler SM, Pribanic S, Bacic D, ''et al.'' |title=PDZK1: I. a major scaffolder in brush borders of proximal tubular cells. |journal=Kidney Int. |volume=64 |issue= 5 |pages= 1733-45 |year= 2004 |pmid= 14531806 |doi= 10.1046/j.1523-1755.2003.00266.x }}
* {{cite journal | vauthors = Yamada E, Tsujikawa K, Itoh S, Kameda Y, Kohama Y, Yamamoto H | title = Molecular cloning and characterization of a novel human STE20-like kinase, hSLK | journal = Biochimica et Biophysica Acta | volume = 1495 | issue = 3 | pages = 250–62 | date = Feb 2000 | pmid = 10699464 | doi = 10.1016/S0167-4889(99)00164-0 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Sabourin LA, Tamai K, Seale P, Wagner J, Rudnicki MA | title = Caspase 3 cleavage of the Ste20-related kinase SLK releases and activates an apoptosis-inducing kinase domain and an actin-disassembling region | journal = Molecular and Cellular Biology | volume = 20 | issue = 2 | pages = 684–96 | date = Jan 2000 | pmid = 10611247 | pmc = 85169 | doi = 10.1128/MCB.20.2.684-696.2000 }}
*{{cite journal  | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773-84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 }}
* {{cite journal | vauthors = Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N | title = Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain | journal = DNA Research | volume = 3 | issue = 5 | pages = 321–9, 341–54 | date = Oct 1996 | pmid = 9039502 | doi = 10.1093/dnares/3.5.321 }}
*{{cite journal | author=Dan I, Watanabe NM, Kusumi A |title=The Ste20 group kinases as regulators of MAP kinase cascades. |journal=Trends Cell Biol. |volume=11 |issue= 5 |pages= 220-30 |year= 2001 |pmid= 11316611 |doi= }}
*{{cite journal | author=Eichmuller S, Usener D, Dummer R, ''et al.'' |title=Serological detection of cutaneous T-cell lymphoma-associated antigens. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 2 |pages= 629-34 |year= 2001 |pmid= 11149944 |doi= 10.1073/pnas.021386498 }}
*{{cite journal | author=Yamada E, Tsujikawa K, Itoh S, ''et al.'' |title=Molecular cloning and characterization of a novel human STE20-like kinase, hSLK. |journal=Biochim. Biophys. Acta |volume=1495 |issue= 3 |pages= 250-62 |year= 2000 |pmid= 10699464 |doi= }}
*{{cite journal | author=Sabourin LA, Tamai K, Seale P, ''et al.'' |title=Caspase 3 cleavage of the Ste20-related kinase SLK releases and activates an apoptosis-inducing kinase domain and an actin-disassembling region. |journal=Mol. Cell. Biol. |volume=20 |issue= 2 |pages= 684-96 |year= 2000 |pmid= 10611247 |doi= }}
*{{cite journal | author=Nagase T, Seki N, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. |journal=DNA Res. |volume=3 |issue= 5 |pages= 321-9, 341-54 |year= 1997 |pmid= 9039502 |doi= }}
*{{cite journal  | author=Celenza JL, Carlson M |title=A yeast gene that is essential for release from glucose repression encodes a protein kinase. |journal=Science |volume=233 |issue= 4769 |pages= 1175-80 |year= 1986 |pmid= 3526554 |doi=  }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=9748}}


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Latest revision as of 06:37, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

STE20-like serine/threonine-protein kinase is an enzyme that in humans is encoded by the SLK gene.[1][2]

Interactions

SLK (gene) has been shown to interact with PDZK1.[3]

References

  1. ↑ Celenza JL, Carlson M (Sep 1986). "A yeast gene that is essential for release from glucose repression encodes a protein kinase". Science. 233 (4769): 1175–80. doi:10.1126/science.3526554. PMID 3526554.
  2. ↑ "Entrez Gene: SLK STE20-like kinase (yeast)".
  3. ↑ Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.

Further reading


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