SPDEF: Difference between revisions
Jump to navigation
Jump to search
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +)) |
imported>Bibcode Bot m (Adding 0 arxiv eprint(s), 1 bibcode(s) and 0 doi(s). Did it miss something? Report bugs, errors, and suggestions at User talk:Bibcode Bot) |
||
| (One intermediate revision by one other user not shown) | |||
| Line 1: | Line 1: | ||
{{Infobox_gene}} | |||
{{ | '''SAM pointed domain-containing Ets transcription factor''' is a [[protein]] that in humans is encoded by the ''SPDEF'' [[gene]].<ref name="pmid10625666">{{cite journal |author1=Oettgen P |author2=Finger E |author3=Sun Z |author4=Akbarali Y |author5=Thamrongsak U |author6=Boltax J |author7=Grall F |author8=Dube A |author9=Weiss A |author10=Brown L |author11=Quinn G |author12=Kas K |author13=Endress G |author14=Kunsch C |author15=Libermann TA | title = PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression | journal = J Biol Chem | volume = 275 | issue = 2 | pages = 1216–25 |date=February 2000 | pmid = 10625666 | pmc = | doi =10.1074/jbc.275.2.1216 }}</ref><ref name="pmid6857767">{{cite journal |author1=Johannessen JV |author2=Finseth I | title = Electron micrographs in five minutes | journal = Ultrastruct Pathol | volume = 4 | issue = 1 | pages = 97–100 |date=July 1983 | pmid = 6857767 | pmc = | doi =10.3109/01913128309140576 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SPDEF SAM pointed domain containing ets transcription factor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25803| accessdate = }}</ref> | ||
}} | |||
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --> | <!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --> | ||
{{PBB_Summary | {{PBB_Summary | ||
| section_title = | | section_title = | ||
| summary_text = PDEF is an ETS transcription factor expressed in prostate epithelial cells. It acts as an androgen-independent transactivator of PSA (MIM 176820) expression.[supplied by OMIM]<ref name="entrez" | | summary_text = PDEF is an ETS transcription factor expressed in prostate epithelial cells. It acts as an androgen-independent transactivator of PSA (MIM 176820) expression.[supplied by OMIM]<ref name="entrez"/> | ||
}} | }} | ||
==Interactions== | |||
SPDEF has been shown to [[Protein-protein interaction|interact]] with [[NKX3-1]].<ref name=pmid11809674>{{cite journal |last=Chen |first=Hui |authorlink= |author2=Nandi Asit K |author3=Li Xiang |author4=Bieberich Charles J |date=January 2002 |title=NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter |journal=Cancer Res. |volume=62 |issue=2 |pages=338–40 |publisher= |location = United States| issn = 0008-5472| pmid = 11809674 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> | |||
The Protein Kinase CK2 has been shown to control the stability of PDEF.<ref>{{cite journal |last=Chisholm |first=Christine |authorlink= |author2=Padmanabhan Achuth |author3=Guan Bin |author4=Li Xiang |author5=Kalra Simran |author6=Bieberich Charles J |date= 2010 |title=Protein Kinase CK2 regulates the stability of prostate derived Ets factor |journal= The Open Cancer Journal |volume=3 | pages=109–115 |publisher= Bentham Science|doi=10.2174/1874079001003010109}}http://www.benthamscience.com/open/tocj/articles/V003/SI0022TOCJ/109TOCJ.pdf</ref> | |||
Needed for the differentiation of both pulmonary and intestinal goblet cells | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | author=Lance V |title=Studies on the annual reproductive cycle of the female cobra, Naja naja. Seasonal variation in plasma inorganic ions. |journal=Comparative | *{{cite journal | author=Lance V |title=Studies on the annual reproductive cycle of the female cobra, Naja naja. Seasonal variation in plasma inorganic ions. |journal=Comparative Biochemistry and Physiology A |volume=53 |issue= 3 |pages= 285–9 |year= 1976 |pmid= 2437 |doi=10.1016/S0300-9629(76)80037-0 }} | ||
*{{cite journal |author1=Yamada N |author2=Tamai Y |author3=Miyamoto H |author4=Nozaki M |title=Cloning and expression of the mouse Pse gene encoding a novel Ets family member. |journal=Gene |volume=241 |issue= 2 |pages= 267–74 |year= 2000 |pmid= 10675039 |doi=10.1016/S0378-1119(99)00484-9 }} | |||
*{{cite journal |author1=Chen H |author2=Nandi AK |author3=Li X |author4=Bieberich CJ |title=NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter. |journal=Cancer Res. |volume=62 |issue= 2 |pages= 338–40 |year= 2002 |pmid= 11809674 |doi= }} | |||
*{{cite journal | | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }} | ||
*{{cite journal | | *{{cite journal |vauthors=Thompson HG, Harris JW, Wold BJ, etal |title=p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells. |journal=Oncogene |volume=22 |issue= 15 |pages= 2322–33 |year= 2003 |pmid= 12700667 |doi= 10.1038/sj.onc.1206325 }} | ||
*{{cite journal | *{{cite journal |vauthors=Feldman RJ, Sementchenko VI, Gayed M, etal |title=Pdef expression in human breast cancer is correlated with invasive potential and altered gene expression. |journal=Cancer Res. |volume=63 |issue= 15 |pages= 4626–31 |year= 2003 |pmid= 12907642 |doi= }} | ||
*{{cite journal | *{{cite journal |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ghadersohi A, Odunsi K, Lele S, etal |title=Prostate derived Ets transcription factor shows better tumor-association than other cancer-associated molecules. |journal=Oncol. Rep. |volume=11 |issue= 2 |pages= 453–8 |year= 2004 |pmid= 14719083 |doi= 10.3892/or.11.2.453}} | ||
*{{cite journal | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal | *{{cite journal |author1=Chen H |author2=Bieberich CJ |title=Structural and functional analysis of domains mediating interaction between NKX-3.1 and PDEF. |journal=J. Cell. Biochem. |volume=94 |issue= 1 |pages= 168–77 |year= 2005 |pmid= 15523673 |doi= 10.1002/jcb.20297 }} | ||
*{{cite journal | *{{cite journal |vauthors=Wang Y, Feng L, Said M, etal |title=Analysis of the 2.0 A crystal structure of the protein-DNA complex of the human PDEF Ets domain bound to the prostate specific antigen regulatory site. |journal=Biochemistry |volume=44 |issue= 19 |pages= 7095–106 |year= 2005 |pmid= 15882048 |doi= 10.1021/bi047352t }} | ||
*{{cite journal | | *{{cite journal |vauthors=Fowler M, Borazanci E, McGhee L, etal |title=RUNX1 (AML-1) and RUNX2 (AML-3) cooperate with prostate-derived Ets factor to activate transcription from the PSA upstream regulatory region. |journal=J. Cell. Biochem. |volume=97 |issue= 1 |pages= 1–17 |year= 2006 |pmid= 16237704 |doi= 10.1002/jcb.20664 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gunawardane RN, Sgroi DC, Wrobel CN, etal |title=Novel role for PDEF in epithelial cell migration and invasion. |journal=Cancer Res. |volume=65 |issue= 24 |pages= 11572–80 |year= 2006 |pmid= 16357167 | pmc=2919290 |doi= 10.1158/0008-5472.CAN-05-1196 }} | ||
*{{cite journal | *{{cite journal |vauthors=Rodabaugh KJ, Mhawech-Fauceglia P, Groth J, etal |title=Prostate-derived Ets factor is overexpressed in serous epithelial ovarian tumors. |journal=Int. J. Gynecol. Pathol. |volume=26 |issue= 1 |pages= 10–5 |year= 2007 |pmid= 17197890 |doi= 10.1097/01.pgp.0000225386.41244.bd }} | ||
*{{cite journal | *{{cite journal |vauthors=Park KS, Korfhagen TR, Bruno MD, etal |title=SPDEF regulates goblet cell hyperplasia in the airway epithelium. |journal=J. Clin. Invest. |volume=117 |issue= 4 |pages= 978–88 |year= 2007 |pmid= 17347682 |doi= 10.1172/JCI29176 | pmc=1810569 }} | ||
*{{cite journal | |||
*{{cite journal | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=25803}} | |||
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. --> | |||
{{PBB_Controls | |||
| update_page = yes | |||
| require_manual_inspection = no | |||
| update_protein_box = yes | |||
| update_summary = yes | |||
| update_citations = yes | |||
}} | |||
{{ | {{gene-6-stub}} | ||
Latest revision as of 04:43, 26 June 2018
| VALUE_ERROR (nil) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Aliases | |||||||
| External IDs | GeneCards: [1] | ||||||
| Orthologs | |||||||
| Species | Human | Mouse | |||||
| Entrez |
|
| |||||
| Ensembl |
|
| |||||
| UniProt |
|
| |||||
| RefSeq (mRNA) |
|
| |||||
| RefSeq (protein) |
|
| |||||
| Location (UCSC) | n/a | n/a | |||||
| PubMed search | n/a | n/a | |||||
| Wikidata | |||||||
| |||||||
SAM pointed domain-containing Ets transcription factor is a protein that in humans is encoded by the SPDEF gene.[1][2][3]
PDEF is an ETS transcription factor expressed in prostate epithelial cells. It acts as an androgen-independent transactivator of PSA (MIM 176820) expression.[supplied by OMIM][3]
Interactions
SPDEF has been shown to interact with NKX3-1.[4]
The Protein Kinase CK2 has been shown to control the stability of PDEF.[5] Needed for the differentiation of both pulmonary and intestinal goblet cells
References
- ↑ Oettgen P; Finger E; Sun Z; Akbarali Y; Thamrongsak U; Boltax J; Grall F; Dube A; Weiss A; Brown L; Quinn G; Kas K; Endress G; Kunsch C; Libermann TA (February 2000). "PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression". J Biol Chem. 275 (2): 1216–25. doi:10.1074/jbc.275.2.1216. PMID 10625666.
- ↑ Johannessen JV; Finseth I (July 1983). "Electron micrographs in five minutes". Ultrastruct Pathol. 4 (1): 97–100. doi:10.3109/01913128309140576. PMID 6857767.
- ↑ 3.0 3.1 "Entrez Gene: SPDEF SAM pointed domain containing ets transcription factor".
- ↑ Chen, Hui; Nandi Asit K; Li Xiang; Bieberich Charles J (January 2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter". Cancer Res. United States. 62 (2): 338–40. ISSN 0008-5472. PMID 11809674.
- ↑ Chisholm, Christine; Padmanabhan Achuth; Guan Bin; Li Xiang; Kalra Simran; Bieberich Charles J (2010). "Protein Kinase CK2 regulates the stability of prostate derived Ets factor". The Open Cancer Journal. Bentham Science. 3: 109–115. doi:10.2174/1874079001003010109.http://www.benthamscience.com/open/tocj/articles/V003/SI0022TOCJ/109TOCJ.pdf
Further reading
- Lance V (1976). "Studies on the annual reproductive cycle of the female cobra, Naja naja. Seasonal variation in plasma inorganic ions". Comparative Biochemistry and Physiology A. 53 (3): 285–9. doi:10.1016/S0300-9629(76)80037-0. PMID 2437.
- Yamada N; Tamai Y; Miyamoto H; Nozaki M (2000). "Cloning and expression of the mouse Pse gene encoding a novel Ets family member". Gene. 241 (2): 267–74. doi:10.1016/S0378-1119(99)00484-9. PMID 10675039.
- Chen H; Nandi AK; Li X; Bieberich CJ (2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter". Cancer Res. 62 (2): 338–40. PMID 11809674.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Thompson HG, Harris JW, Wold BJ, et al. (2003). "p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells". Oncogene. 22 (15): 2322–33. doi:10.1038/sj.onc.1206325. PMID 12700667.
- Feldman RJ, Sementchenko VI, Gayed M, et al. (2003). "Pdef expression in human breast cancer is correlated with invasive potential and altered gene expression". Cancer Res. 63 (15): 4626–31. PMID 12907642.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Ghadersohi A, Odunsi K, Lele S, et al. (2004). "Prostate derived Ets transcription factor shows better tumor-association than other cancer-associated molecules". Oncol. Rep. 11 (2): 453–8. doi:10.3892/or.11.2.453. PMID 14719083.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Chen H; Bieberich CJ (2005). "Structural and functional analysis of domains mediating interaction between NKX-3.1 and PDEF". J. Cell. Biochem. 94 (1): 168–77. doi:10.1002/jcb.20297. PMID 15523673.
- Wang Y, Feng L, Said M, et al. (2005). "Analysis of the 2.0 A crystal structure of the protein-DNA complex of the human PDEF Ets domain bound to the prostate specific antigen regulatory site". Biochemistry. 44 (19): 7095–106. doi:10.1021/bi047352t. PMID 15882048.
- Fowler M, Borazanci E, McGhee L, et al. (2006). "RUNX1 (AML-1) and RUNX2 (AML-3) cooperate with prostate-derived Ets factor to activate transcription from the PSA upstream regulatory region". J. Cell. Biochem. 97 (1): 1–17. doi:10.1002/jcb.20664. PMID 16237704.
- Gunawardane RN, Sgroi DC, Wrobel CN, et al. (2006). "Novel role for PDEF in epithelial cell migration and invasion". Cancer Res. 65 (24): 11572–80. doi:10.1158/0008-5472.CAN-05-1196. PMC 2919290. PMID 16357167.
- Rodabaugh KJ, Mhawech-Fauceglia P, Groth J, et al. (2007). "Prostate-derived Ets factor is overexpressed in serous epithelial ovarian tumors". Int. J. Gynecol. Pathol. 26 (1): 10–5. doi:10.1097/01.pgp.0000225386.41244.bd. PMID 17197890.
- Park KS, Korfhagen TR, Bruno MD, et al. (2007). "SPDEF regulates goblet cell hyperplasia in the airway epithelium". J. Clin. Invest. 117 (4): 978–88. doi:10.1172/JCI29176. PMC 1810569. PMID 17347682.
 | This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it. |