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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{Infobox_gene}}
{{GNF_Protein_box
'''Kunitz-type protease inhibitor 2''' is an [[enzyme inhibitor]] that in humans is encoded by the ''SPINT2'' [[gene]].<ref name="pmid9115294">{{cite journal | vauthors = Marlor CW, Delaria KA, Davis G, Muller DK, Greve JM, Tamburini PP | title = Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domains | journal = The Journal of Biological Chemistry | volume = 272 | issue = 18 | pages = 12202–8 | date = May 1997 | pmid = 9115294 | pmc =  | doi = 10.1074/jbc.272.18.12202 }}</ref><ref name="pmid9346890">{{cite journal | vauthors = Kawaguchi T, Qin L, Shimomura T, Kondo J, Matsumoto K, Denda K, Kitamura N | title = Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor | journal = The Journal of Biological Chemistry | volume = 272 | issue = 44 | pages = 27558–64 | date = Oct 1997 | pmid = 9346890 | pmc =  | doi = 10.1074/jbc.272.44.27558 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SPINT2 serine peptidase inhibitor, Kunitz type, 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10653| accessdate = }}</ref>
| image = 
SPINT2 is a [[transmembrane protein]] with two extracellular [[Kunitz domain|Kunitz domains]] to inhibit [[Serine protease|serine proteases]]. This gene is a presumed [[Tumor suppressor gene|tumor suppressor]] by inhibiting HGF activator which prevents the formation of active [[hepatocyte growth factor]]. [[Mutation|Mutations]] in SPINT2 could result in [[congenital sodium diarrhea]] (CSD).
| image_source = 
| PDB =
| Name = Serine peptidase inhibitor, Kunitz type, 2
| HGNCid = 11247
| Symbol = SPINT2
| AltSymbols =; HAI-2; HAI2; Kop; PB
| OMIM = 605124
| ECnumber = 
| Homologene = 7955
| MGIid = 1338031
| GeneAtlas_image1 = PBB_GE_SPINT2_210715_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004867 |text = serine-type endopeptidase inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
  | Process = {{GNF_GO|id=GO:0006928 |text = cell motility}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10653
    | Hs_Ensembl = ENSG00000167642
    | Hs_RefseqProtein = NP_066925
    | Hs_RefseqmRNA = NM_021102
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 43447007
    | Hs_GenLoc_end = 43474927
    | Hs_Uniprot = O43291
    | Mm_EntrezGene = 20733
    | Mm_Ensembl = ENSMUSG00000074227
    | Mm_RefseqmRNA = NM_011464
    | Mm_RefseqProtein = NP_035594
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 28965097
    | Mm_GenLoc_end = 28990672
    | Mm_Uniprot = Q9WU03
  }}
}}
'''Serine peptidase inhibitor, Kunitz type, 2''', also known as '''SPINT2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SPINT2 serine peptidase inhibitor, Kunitz type, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10653| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== References ==
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
{{reflist}}
{{reflist|2}}
 
==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Morelle W, Capon C, Balduyck M, Sautiere P, Kouach M, Michalski C, Fournet B, Mizon J | title = Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor | journal = European Journal of Biochemistry / FEBS | volume = 221 | issue = 2 | pages = 881–8 | date = Apr 1994 | pmid = 7513643 | doi = 10.1111/j.1432-1033.1994.tb18803.x }}
| citations =
* {{cite journal | vauthors = Mizon C, Balduyck M, Albani D, Michalski C, Burnouf T, Mizon J | title = Development of an enzyme-linked immunosorbent assay for human plasma inter-alpha-trypsin inhibitor (ITI) using specific antibodies against each of the H1 and H2 heavy chains | journal = Journal of Immunological Methods | volume = 190 | issue = 1 | pages = 61–70 | date = Mar 1996 | pmid = 8601712 | doi = 10.1016/0022-1759(95)00257-X }}
*{{cite journal | author=Morelle W, Capon C, Balduyck M, ''et al.'' |title=Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor. |journal=Eur. J. Biochem. |volume=221 |issue= 2 |pages= 881-8 |year= 1994 |pmid= 7513643 |doi= }}
* {{cite journal | vauthors = Gress TM, Müller-Pillasch F, Geng M, Zimmerhackl F, Zehetner G, Friess H, Büchler M, Adler G, Lehrach H | title = A pancreatic cancer-specific expression profile | journal = Oncogene | volume = 13 | issue = 8 | pages = 1819–30 | date = Oct 1996 | pmid = 8895530 | doi =  }}
*{{cite journal | author=Mizon C, Balduyck M, Albani D, ''et al.'' |title=Development of an enzyme-linked immunosorbent assay for human plasma inter-alpha-trypsin inhibitor (ITI) using specific antibodies against each of the H1 and H2 heavy chains. |journal=J. Immunol. Methods |volume=190 |issue= 1 |pages= 61-70 |year= 1996 |pmid= 8601712 |doi= }}
* {{cite journal | vauthors = Shimomura T, Denda K, Kitamura A, Kawaguchi T, Kito M, Kondo J, Kagaya S, Qin L, Takata H, Miyazawa K, Kitamura N | title = Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor | journal = The Journal of Biological Chemistry | volume = 272 | issue = 10 | pages = 6370–6 | date = Mar 1997 | pmid = 9045658 | doi = 10.1074/jbc.272.10.6370 }}
*{{cite journal | author=Gress TM, Müller-Pillasch F, Geng M, ''et al.'' |title=A pancreatic cancer-specific expression profile. |journal=Oncogene |volume=13 |issue= 8 |pages= 1819-30 |year= 1996 |pmid= 8895530 |doi=  }}
* {{cite journal | vauthors = Blom AM, Thuveson M, Fries E | title = Intracellular coupling of bikunin and the heavy chain of rat pre-alpha-inhibitor in COS-1 cells | journal = The Biochemical Journal | volume = 328 ( Pt 1) | issue = Pt 1 | pages = 185–91 | date = Nov 1997 | pmid = 9359851 | pmc = 1218904 | doi =  }}
*{{cite journal | author=Shimomura T, Denda K, Kitamura A, ''et al.'' |title=Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor. |journal=J. Biol. Chem. |volume=272 |issue= 10 |pages= 6370-6 |year= 1997 |pmid= 9045658 |doi= }}
* {{cite journal | vauthors = Müller-Pillasch F, Wallrapp C, Bartels K, Varga G, Friess H, Büchler M, Adler G, Gress TM | title = Cloning of a new Kunitz-type protease inhibitor with a putative transmembrane domain overexpressed in pancreatic cancer | journal = Biochimica et Biophysica Acta | volume = 1395 | issue = 1 | pages = 88–95 | date = Jan 1998 | pmid = 9434156 | doi = 10.1016/s0167-4781(97)00129-2 }}
*{{cite journal | author=Marlor CW, Delaria KA, Davis G, ''et al.'' |title=Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domains. |journal=J. Biol. Chem. |volume=272 |issue= 18 |pages= 12202-8 |year= 1997 |pmid= 9115294 |doi=  }}
* {{cite journal | vauthors = Kataoka H, Shimomura T, Kawaguchi T, Hamasuna R, Itoh H, Kitamura N, Miyazawa K, Koono M | title = Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment | journal = The Journal of Biological Chemistry | volume = 275 | issue = 51 | pages = 40453–62 | date = Dec 2000 | pmid = 11013244 | doi = 10.1074/jbc.M006412200 }}
*{{cite journal | author=Kawaguchi T, Qin L, Shimomura T, ''et al.'' |title=Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor. |journal=J. Biol. Chem. |volume=272 |issue= 44 |pages= 27558-64 |year= 1997 |pmid= 9346890 |doi= }}
* {{cite journal | vauthors = Itoh H, Kataoka H, Yamauchi M, Naganuma S, Akiyama Y, Nuki Y, Shimomura T, Miyazawa K, Kitamura N, Koono M | title = Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes | journal = Biochemical and Biophysical Research Communications | volume = 288 | issue = 2 | pages = 390–9 | date = Oct 2001 | pmid = 11606055 | doi = 10.1006/bbrc.2001.5767 }}
*{{cite journal | author=Blom AM, Thuveson M, Fries E |title=Intracellular coupling of bikunin and the heavy chain of rat pre-alpha-inhibitor in COS-1 cells. |journal=Biochem. J. |volume=328 ( Pt 1) |issue= |pages= 185-91 |year= 1998 |pmid= 9359851 |doi= }}
* {{cite journal | vauthors = Suzuki M, Kobayashi H, Fujie M, Nishida T, Takigawa M, Kanayama N, Terao T | title = Kunitz-type protease inhibitor bikunin disrupts phorbol ester-induced oligomerization of CD44 variant isoforms containing epitope v9 and subsequently suppresses expression of urokinase-type plasminogen activator in human chondrosarcoma cells | journal = The Journal of Biological Chemistry | volume = 277 | issue = 10 | pages = 8022–32 | date = Mar 2002 | pmid = 11777908 | doi = 10.1074/jbc.M108545200 }}
*{{cite journal | author=Müller-Pillasch F, Wallrapp C, Bartels K, ''et al.'' |title=Cloning of a new Kunitz-type protease inhibitor with a putative transmembrane domain overexpressed in pancreatic cancer. |journal=Biochim. Biophys. Acta |volume=1395 |issue= 1 |pages= 88-95 |year= 1998 |pmid= 9434156 |doi= }}
* {{cite journal | vauthors = Kobayashi H, Suzuki M, Kanayama N, Nishida T, Takigawa M, Terao T | title = Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade | journal = European Journal of Biochemistry / FEBS | volume = 269 | issue = 16 | pages = 3945–57 | date = Aug 2002 | pmid = 12180971 | doi = 10.1046/j.1432-1033.2002.03068.x }}
*{{cite journal | author=Kataoka H, Shimomura T, Kawaguchi T, ''et al.'' |title=Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment. |journal=J. Biol. Chem. |volume=275 |issue= 51 |pages= 40453-62 |year= 2001 |pmid= 11013244 |doi= 10.1074/jbc.M006412200 }}
* {{cite journal | vauthors = Mizon C, Piva F, Queyrel V, Balduyck M, Hachulla E, Mizon J | title = Urinary bikunin determination provides insight into proteinase/proteinase inhibitor imbalance in patients with inflammatory diseases | journal = Clinical Chemistry and Laboratory Medicine | volume = 40 | issue = 6 | pages = 579–86 | date = Jun 2002 | pmid = 12211652 | doi = 10.1515/CCLM.2002.100 }}
*{{cite journal | author=Itoh H, Kataoka H, Yamauchi M, ''et al.'' |title=Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes. |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 2 |pages= 390-9 |year= 2001 |pmid= 11606055 |doi= 10.1006/bbrc.2001.5767 }}
* {{cite journal | vauthors = Isogai R, Matsukura A, Aragane Y, Maeda A, Matsukura M, Yudate T, Sugihara K, Takahashi M, Aisu K, Tezuka T | title = Quantitative analysis of bikunin-laden mast cells in follicular eruptions and chronic skin lesions of atopic dermatitis | journal = Archives of Dermatological Research | volume = 294 | issue = 9 | pages = 387–92 | date = Dec 2002 | pmid = 12522575 | doi = 10.1007/s00403-002-0336-9 }}
*{{cite journal | author=Suzuki M, Kobayashi H, Fujie M, ''et al.'' |title=Kunitz-type protease inhibitor bikunin disrupts phorbol ester-induced oligomerization of CD44 variant isoforms containing epitope v9 and subsequently suppresses expression of urokinase-type plasminogen activator in human chondrosarcoma cells. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8022-32 |year= 2002 |pmid= 11777908 |doi= 10.1074/jbc.M108545200 }}
* {{cite journal | vauthors = Yamauchi M, Itoh H, Naganuma S, Koono M, Hasui Y, Osada Y, Kataoka H | title = Expression of hepatocyte growth factor activator inhibitor type 2 (HAI-2) in human testis: identification of a distinct transcription start site for the HAI-2 gene in testis | journal = Biological Chemistry | volume = 383 | issue = 12 | pages = 1953–7 | date = Dec 2002 | pmid = 12553733 | doi = 10.1515/BC.2002.220 }}
*{{cite journal | author=Kobayashi H, Suzuki M, Kanayama N, ''et al.'' |title=Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade. |journal=Eur. J. Biochem. |volume=269 |issue= 16 |pages= 3945-57 |year= 2002 |pmid= 12180971 |doi= }}
* {{cite journal | vauthors = Suzuki M, Kobayashi H, Tanaka Y, Hirashima Y, Kanayama N, Takei Y, Saga Y, Suzuki M, Itoh H, Terao T | title = Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cell line by overexpression of bikunin | journal = International Journal of Cancer | volume = 104 | issue = 3 | pages = 289–302 | date = Apr 2003 | pmid = 12569552 | doi = 10.1002/ijc.10950 }}
*{{cite journal | author=Mizon C, Piva F, Queyrel V, ''et al.'' |title=Urinary bikunin determination provides insight into proteinase/proteinase inhibitor imbalance in patients with inflammatory diseases. |journal=Clin. Chem. Lab. Med. |volume=40 |issue= 6 |pages= 579-86 |year= 2003 |pmid= 12211652 |doi= }}
* {{cite journal | vauthors = Suzuki M, Kobayashi H, Tanaka Y, Hirashima Y, Kanayama N, Takei Y, Saga Y, Suzuki M, Itoh H, Terao T | title = Bikunin target genes in ovarian cancer cells identified by microarray analysis | journal = The Journal of Biological Chemistry | volume = 278 | issue = 17 | pages = 14640–6 | date = Apr 2003 | pmid = 12571229 | doi = 10.1074/jbc.M300239200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Schuster JM, Longo M, Nelson PS | title = Differential expression of bikunin (HAI-2/PB), a proposed mediator of glioma invasion, by demethylation treatment | journal = Journal of Neuro-Oncology | volume = 64 | issue = 3 | pages = 219–25 | date = Sep 2003 | pmid = 14558597 | doi = 10.1023/A:1025674227750 }}
*{{cite journal | author=Isogai R, Matsukura A, Aragane Y, ''et al.'' |title=Quantitative analysis of bikunin-laden mast cells in follicular eruptions and chronic skin lesions of atopic dermatitis. |journal=Arch. Dermatol. Res. |volume=294 |issue= 9 |pages= 387-92 |year= 2003 |pmid= 12522575 |doi= 10.1007/s00403-002-0336-9 }}
* {{cite journal | vauthors = Fukai K, Yokosuka O, Chiba T, Hirasawa Y, Tada M, Imazeki F, Kataoka H, Saisho H | title = Hepatocyte growth factor activator inhibitor 2/placental bikunin (HAI-2/PB) gene is frequently hypermethylated in human hepatocellular carcinoma | journal = Cancer Research | volume = 63 | issue = 24 | pages = 8674–9 | date = Dec 2003 | pmid = 14695180 | doi =  }}
*{{cite journal | author=Yamauchi M, Itoh H, Naganuma S, ''et al.'' |title=Expression of hepatocyte growth factor activator inhibitor type 2 (HAI-2) in human testis: identification of a distinct transcription start site for the HAI-2 gene in testis. |journal=Biol. Chem. |volume=383 |issue= 12 |pages= 1953-7 |year= 2003 |pmid= 12553733 |doi= }}
*{{cite journal | author=Suzuki M, Kobayashi H, Tanaka Y, ''et al.'' |title=Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cell line by overexpression of bikunin. |journal=Int. J. Cancer |volume=104 |issue= 3 |pages= 289-302 |year= 2003 |pmid= 12569552 |doi= 10.1002/ijc.10950 }}
*{{cite journal  | author=Suzuki M, Kobayashi H, Tanaka Y, ''et al.'' |title=Bikunin target genes in ovarian cancer cells identified by microarray analysis. |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 14640-6 |year= 2003 |pmid= 12571229 |doi= 10.1074/jbc.M300239200 }}
*{{cite journal  | author=Schuster JM, Longo M, Nelson PS |title=Differential expression of bikunin (HAI-2/PB), a proposed mediator of glioma invasion, by demethylation treatment. |journal=J. Neurooncol. |volume=64 |issue= 3 |pages= 219-25 |year= 2003 |pmid= 14558597 |doi=  }}
*{{cite journal  | author=Fukai K, Yokosuka O, Chiba T, ''et al.'' |title=Hepatocyte growth factor activator inhibitor 2/placental bikunin (HAI-2/PB) gene is frequently hypermethylated in human hepatocellular carcinoma. |journal=Cancer Res. |volume=63 |issue= 24 |pages= 8674-9 |year= 2004 |pmid= 14695180 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{gene-19-stub}}

Latest revision as of 21:01, 20 February 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Kunitz-type protease inhibitor 2 is an enzyme inhibitor that in humans is encoded by the SPINT2 gene.[1][2][3] SPINT2 is a transmembrane protein with two extracellular Kunitz domains to inhibit serine proteases. This gene is a presumed tumor suppressor by inhibiting HGF activator which prevents the formation of active hepatocyte growth factor. Mutations in SPINT2 could result in congenital sodium diarrhea (CSD).

References

  1. ↑ Marlor CW, Delaria KA, Davis G, Muller DK, Greve JM, Tamburini PP (May 1997). "Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domains". The Journal of Biological Chemistry. 272 (18): 12202–8. doi:10.1074/jbc.272.18.12202. PMID 9115294.
  2. ↑ Kawaguchi T, Qin L, Shimomura T, Kondo J, Matsumoto K, Denda K, Kitamura N (Oct 1997). "Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor". The Journal of Biological Chemistry. 272 (44): 27558–64. doi:10.1074/jbc.272.44.27558. PMID 9346890.
  3. ↑ "Entrez Gene: SPINT2 serine peptidase inhibitor, Kunitz type, 2".

Further reading

  • Morelle W, Capon C, Balduyck M, Sautiere P, Kouach M, Michalski C, Fournet B, Mizon J (Apr 1994). "Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor". European Journal of Biochemistry / FEBS. 221 (2): 881–8. doi:10.1111/j.1432-1033.1994.tb18803.x. PMID 7513643.
  • Mizon C, Balduyck M, Albani D, Michalski C, Burnouf T, Mizon J (Mar 1996). "Development of an enzyme-linked immunosorbent assay for human plasma inter-alpha-trypsin inhibitor (ITI) using specific antibodies against each of the H1 and H2 heavy chains". Journal of Immunological Methods. 190 (1): 61–70. doi:10.1016/0022-1759(95)00257-X. PMID 8601712.
  • Gress TM, Müller-Pillasch F, Geng M, Zimmerhackl F, Zehetner G, Friess H, Büchler M, Adler G, Lehrach H (Oct 1996). "A pancreatic cancer-specific expression profile". Oncogene. 13 (8): 1819–30. PMID 8895530.
  • Shimomura T, Denda K, Kitamura A, Kawaguchi T, Kito M, Kondo J, Kagaya S, Qin L, Takata H, Miyazawa K, Kitamura N (Mar 1997). "Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor". The Journal of Biological Chemistry. 272 (10): 6370–6. doi:10.1074/jbc.272.10.6370. PMID 9045658.
  • Blom AM, Thuveson M, Fries E (Nov 1997). "Intracellular coupling of bikunin and the heavy chain of rat pre-alpha-inhibitor in COS-1 cells". The Biochemical Journal. 328 ( Pt 1) (Pt 1): 185–91. PMC 1218904. PMID 9359851.
  • Müller-Pillasch F, Wallrapp C, Bartels K, Varga G, Friess H, Büchler M, Adler G, Gress TM (Jan 1998). "Cloning of a new Kunitz-type protease inhibitor with a putative transmembrane domain overexpressed in pancreatic cancer". Biochimica et Biophysica Acta. 1395 (1): 88–95. doi:10.1016/s0167-4781(97)00129-2. PMID 9434156.
  • Kataoka H, Shimomura T, Kawaguchi T, Hamasuna R, Itoh H, Kitamura N, Miyazawa K, Koono M (Dec 2000). "Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment". The Journal of Biological Chemistry. 275 (51): 40453–62. doi:10.1074/jbc.M006412200. PMID 11013244.
  • Itoh H, Kataoka H, Yamauchi M, Naganuma S, Akiyama Y, Nuki Y, Shimomura T, Miyazawa K, Kitamura N, Koono M (Oct 2001). "Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes". Biochemical and Biophysical Research Communications. 288 (2): 390–9. doi:10.1006/bbrc.2001.5767. PMID 11606055.
  • Suzuki M, Kobayashi H, Fujie M, Nishida T, Takigawa M, Kanayama N, Terao T (Mar 2002). "Kunitz-type protease inhibitor bikunin disrupts phorbol ester-induced oligomerization of CD44 variant isoforms containing epitope v9 and subsequently suppresses expression of urokinase-type plasminogen activator in human chondrosarcoma cells". The Journal of Biological Chemistry. 277 (10): 8022–32. doi:10.1074/jbc.M108545200. PMID 11777908.
  • Kobayashi H, Suzuki M, Kanayama N, Nishida T, Takigawa M, Terao T (Aug 2002). "Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade". European Journal of Biochemistry / FEBS. 269 (16): 3945–57. doi:10.1046/j.1432-1033.2002.03068.x. PMID 12180971.
  • Mizon C, Piva F, Queyrel V, Balduyck M, Hachulla E, Mizon J (Jun 2002). "Urinary bikunin determination provides insight into proteinase/proteinase inhibitor imbalance in patients with inflammatory diseases". Clinical Chemistry and Laboratory Medicine. 40 (6): 579–86. doi:10.1515/CCLM.2002.100. PMID 12211652.
  • Isogai R, Matsukura A, Aragane Y, Maeda A, Matsukura M, Yudate T, Sugihara K, Takahashi M, Aisu K, Tezuka T (Dec 2002). "Quantitative analysis of bikunin-laden mast cells in follicular eruptions and chronic skin lesions of atopic dermatitis". Archives of Dermatological Research. 294 (9): 387–92. doi:10.1007/s00403-002-0336-9. PMID 12522575.
  • Yamauchi M, Itoh H, Naganuma S, Koono M, Hasui Y, Osada Y, Kataoka H (Dec 2002). "Expression of hepatocyte growth factor activator inhibitor type 2 (HAI-2) in human testis: identification of a distinct transcription start site for the HAI-2 gene in testis". Biological Chemistry. 383 (12): 1953–7. doi:10.1515/BC.2002.220. PMID 12553733.
  • Suzuki M, Kobayashi H, Tanaka Y, Hirashima Y, Kanayama N, Takei Y, Saga Y, Suzuki M, Itoh H, Terao T (Apr 2003). "Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cell line by overexpression of bikunin". International Journal of Cancer. 104 (3): 289–302. doi:10.1002/ijc.10950. PMID 12569552.
  • Suzuki M, Kobayashi H, Tanaka Y, Hirashima Y, Kanayama N, Takei Y, Saga Y, Suzuki M, Itoh H, Terao T (Apr 2003). "Bikunin target genes in ovarian cancer cells identified by microarray analysis". The Journal of Biological Chemistry. 278 (17): 14640–6. doi:10.1074/jbc.M300239200. PMID 12571229.
  • Schuster JM, Longo M, Nelson PS (Sep 2003). "Differential expression of bikunin (HAI-2/PB), a proposed mediator of glioma invasion, by demethylation treatment". Journal of Neuro-Oncology. 64 (3): 219–25. doi:10.1023/A:1025674227750. PMID 14558597.
  • Fukai K, Yokosuka O, Chiba T, Hirasawa Y, Tada M, Imazeki F, Kataoka H, Saisho H (Dec 2003). "Hepatocyte growth factor activator inhibitor 2/placental bikunin (HAI-2/PB) gene is frequently hypermethylated in human hepatocellular carcinoma". Cancer Research. 63 (24): 8674–9. PMID 14695180.


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