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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Serine palmitoyltransferase, long chain base subunit 2''', also known as '''SPTLC2''', is a [[protein]] which in humans is encoded by the ''SPTLC2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SPTLC2 serine palmitoyltransferase, long chain base subunit 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9517| accessdate = }}</ref><ref name="pmid8921873">{{cite journal | vauthors = Nagiec MM, Lester RL, Dickson RC | title = Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase | journal = Gene | volume = 177 | issue = 1-2 | pages = 237–41 | date = October 1996 | pmid = 8921873 | doi = 10.1016/0378-1119(96)00309-5 }}</ref><ref name="pmid9363775">{{cite journal | vauthors = Weiss B, Stoffel W | title = Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis | journal = European Journal of Biochemistry / FEBS | volume = 249 | issue = 1 | pages = 239–47 | date = October 1997 | pmid = 9363775 | doi = 10.1111/j.1432-1033.1997.00239.x }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a long chain base subunit of [[serine C-palmitoyltransferase|serine palmitoyltransferase]]. Serine palmitoyltransferase, which consists of two different subunits, is the initial enzyme in [[sphingolipid]] biosynthesis. It catalyzes the [[pyridoxal phosphate|pyridoxal 5'-phosphate]] dependent condensation of L-[[serine]] and [[palmitoyl CoA]] to 3-oxosphinganine. Mutations in this gene were identified in patients with [[hereditary sensory neuropathy]] type I. [[Alternative splicing|Alternatively spliced]] variants encoding different [[protein isoform|isoforms]] have been identified.<ref name="entrez" />
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Serine palmitoyltransferase, long chain base subunit 2
| HGNCid = 11278
| Symbol = SPTLC2
| AltSymbols =; KIAA0526; LCB2; SPT2
| OMIM = 605713
| ECnumber = 
| Homologene = 21610
| MGIid = 108074
| GeneAtlas_image1 = PBB_GE_SPTLC2_203127_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SPTLC2_203128_at_tn.png
| Function = {{GNF_GO|id=GO:0004758 |text = serine C-palmitoyltransferase activity}} {{GNF_GO|id=GO:0008415 |text = acyltransferase activity}} {{GNF_GO|id=GO:0016769 |text = transferase activity, transferring nitrogenous groups}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0009058 |text = biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9517
    | Hs_Ensembl = ENSG00000100596
    | Hs_RefseqProtein = NP_004854
    | Hs_RefseqmRNA = NM_004863
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 77043025
    | Hs_GenLoc_end = 77152863
    | Hs_Uniprot = O15270
    | Mm_EntrezGene = 20773
    | Mm_Ensembl = ENSMUSG00000021036
    | Mm_RefseqmRNA = NM_011479
    | Mm_RefseqProtein = NP_035609
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 88196992
    | Mm_GenLoc_end = 88277333
    | Mm_Uniprot = Q3UT78
  }}
}}
'''Serine palmitoyltransferase, long chain base subunit 2''', also known as '''SPTLC2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SPTLC2 serine palmitoyltransferase, long chain base subunit 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9517| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== References ==
{{PBB_Summary
{{reflist}}
| section_title =  
| summary_text = This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. Alternatively spliced variants encoding different isoforms have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: SPTLC2 serine palmitoyltransferase, long chain base subunit 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9517| accessdate = }}</ref>
}}


==References==
== Further reading ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Takeda J, Yano H, Eng S, Zeng Y, Bell GI | title = A molecular inventory of human pancreatic islets: sequence analysis of 1000 cDNA clones | journal = Human Molecular Genetics | volume = 2 | issue = 11 | pages = 1793–8 | date = November 1993 | pmid = 7506601 | doi = 10.1093/hmg/2.11.1793 }}
| citations =
* {{cite journal | vauthors = Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M | title = Generation and analysis of 280,000 human expressed sequence tags | journal = Genome Research | volume = 6 | issue = 9 | pages = 807–28 | date = September 1996 | pmid = 8889549 | doi = 10.1101/gr.6.9.807 }}
*{{cite journal | author=Takeda J, Yano H, Eng S, ''et al.'' |title=A molecular inventory of human pancreatic islets: sequence analysis of 1000 cDNA clones. |journal=Hum. Mol. Genet. |volume=2 |issue= 11 |pages= 1793-8 |year= 1994 |pmid= 7506601 |doi= }}
* {{cite journal | vauthors = Nagiec MM, Lester RL, Dickson RC | title = Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase | journal = Gene | volume = 177 | issue = 1-2 | pages = 237–41 | date = October 1996 | pmid = 8921873 | doi = 10.1016/0378-1119(96)00309-5 }}
*{{cite journal | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi= }}
* {{cite journal | vauthors = Weiss B, Stoffel W | title = Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis | journal = European Journal of Biochemistry / FEBS | volume = 249 | issue = 1 | pages = 239–47 | date = October 1997 | pmid = 9363775 | doi = 10.1111/j.1432-1033.1997.00239.x }}
*{{cite journal | author=Nagiec MM, Lester RL, Dickson RC |title=Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase. |journal=Gene |volume=177 |issue= 1-2 |pages= 237-41 |year= 1996 |pmid= 8921873 |doi= }}
* {{cite journal | vauthors = Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 1 | pages = 31–9 | date = February 1998 | pmid = 9628581 | doi = 10.1093/dnares/5.1.31 }}
*{{cite journal | author=Weiss B, Stoffel W |title=Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis. |journal=Eur. J. Biochem. |volume=249 |issue= 1 |pages= 239-47 |year= 1997 |pmid= 9363775 |doi= }}
* {{cite journal | vauthors = Hanada K, Hara T, Nishijima M | title = Purification of the serine palmitoyltransferase complex responsible for sphingoid base synthesis by using affinity peptide chromatography techniques | journal = The Journal of Biological Chemistry | volume = 275 | issue = 12 | pages = 8409–15 | date = March 2000 | pmid = 10722674 | doi = 10.1074/jbc.275.12.8409 }}
*{{cite journal | author=Nagase T, Ishikawa K, Miyajima N, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31-9 |year= 1998 |pmid= 9628581 |doi= }}
* {{cite journal | vauthors = Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ | title = Shotgun sequencing of the human transcriptome with ORF expressed sequence tags | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 7 | pages = 3491–6 | date = March 2000 | pmid = 10737800 | pmc = 16267 | doi = 10.1073/pnas.97.7.3491 }}
*{{cite journal | author=Hanada K, Hara T, Nishijima M |title=Purification of the serine palmitoyltransferase complex responsible for sphingoid base synthesis by using affinity peptide chromatography techniques. |journal=J. Biol. Chem. |volume=275 |issue= 12 |pages= 8409-15 |year= 2000 |pmid= 10722674 |doi= }}
* {{cite journal | vauthors = Dawkins JL, Brahmbhatt S, Auer-Grumbach M, Wagner K, Hartung HP, Verhoeven K, Timmerman V, De Jonghe P, Kennerson M, LeGuern E, Nicholson GA | title = Exclusion of serine palmitoyltransferase long chain base subunit 2 (SPTLC2) as a common cause for hereditary sensory neuropathy | journal = Neuromuscular Disorders | volume = 12 | issue = 7-8 | pages = 656–8 | date = October 2002 | pmid = 12207934 | doi = 10.1016/S0960-8966(02)00015-9 }}
*{{cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi= }}
* {{cite journal | vauthors = Stachowitz S, Alessandrini F, Abeck D, Ring J, Behrendt H | title = Permeability barrier disruption increases the level of serine palmitoyltransferase in human epidermis | journal = The Journal of Investigative Dermatology | volume = 119 | issue = 5 | pages = 1048–52 | date = November 2002 | pmid = 12445191 | doi = 10.1046/j.1523-1747.2002.19524.x }}
*{{cite journal | author=Dawkins JL, Brahmbhatt S, Auer-Grumbach M, ''et al.'' |title=Exclusion of serine palmitoyltransferase long chain base subunit 2 (SPTLC2) as a common cause for hereditary sensory neuropathy. |journal=Neuromuscul. Disord. |volume=12 |issue= 7-8 |pages= 656-8 |year= 2002 |pmid= 12207934 |doi= }}
* {{cite journal |authorlink30=Huda Zoghbi| vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Stachowitz S, Alessandrini F, Abeck D, ''et al.'' |title=Permeability barrier disruption increases the level of serine palmitoyltransferase in human epidermis. |journal=J. Invest. Dermatol. |volume=119 |issue= 5 |pages= 1048-52 |year= 2003 |pmid= 12445191 |doi= 10.1046/j.1523-1747.2002.19524.x }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Chen M, Han G, Dietrich CR, Dunn TM, Cahoon EB | title = The essential nature of sphingolipids in plants as revealed by the functional identification and characterization of the Arabidopsis LCB1 subunit of serine palmitoyltransferase | journal = The Plant Cell | volume = 18 | issue = 12 | pages = 3576–93 | date = December 2006 | pmid = 17194770 | pmc = 1785403 | doi = 10.1105/tpc.105.040774 }}
*{{cite journal  | author=Heilig R, Eckenberg R, Petit JL, ''et al.'' |title=The DNA sequence and analysis of human chromosome 14. |journal=Nature |volume=421 |issue= 6923 |pages= 601-7 |year= 2003 |pmid= 12508121 |doi= 10.1038/nature01348 }}
* {{cite journal | vauthors = Hornemann T, Wei Y, von Eckardstein A | title = Is the mammalian serine palmitoyltransferase a high-molecular-mass complex? | journal = The Biochemical Journal | volume = 405 | issue = 1 | pages = 157–64 | date = July 2007 | pmid = 17331073 | pmc = 1925250 | doi = 10.1042/BJ20070025 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Chen M, Han G, Dietrich CR, ''et al.'' |title=The essential nature of sphingolipids in plants as revealed by the functional identification and characterization of the Arabidopsis LCB1 subunit of serine palmitoyltransferase. |journal=Plant Cell |volume=18 |issue= 12 |pages= 3576-93 |year= 2007 |pmid= 17194770 |doi= 10.1105/tpc.105.040774 }}
*{{cite journal | author=Hornemann T, Wei Y, von Eckardstein A |title=Is the mammalian serine palmitoyltransferase a high-molecular-mass complex? |journal=Biochem. J. |volume=405 |issue= 1 |pages= 157-64 |year= 2007 |pmid= 17331073 |doi= 10.1042/BJ20070025 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Acyltransferases}}
{{WikiDoc Sources}}
 
 
 
{{gene-14-stub}}

Latest revision as of 02:20, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine palmitoyltransferase, long chain base subunit 2, also known as SPTLC2, is a protein which in humans is encoded by the SPTLC2 gene.[1][2][3]

This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the initial enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal 5'-phosphate dependent condensation of L-serine and palmitoyl CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. Alternatively spliced variants encoding different isoforms have been identified.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: SPTLC2 serine palmitoyltransferase, long chain base subunit 2".
  2. ↑ Nagiec MM, Lester RL, Dickson RC (October 1996). "Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase". Gene. 177 (1–2): 237–41. doi:10.1016/0378-1119(96)00309-5. PMID 8921873.
  3. ↑ Weiss B, Stoffel W (October 1997). "Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis". European Journal of Biochemistry / FEBS. 249 (1): 239–47. doi:10.1111/j.1432-1033.1997.00239.x. PMID 9363775.

Further reading

  • Takeda J, Yano H, Eng S, Zeng Y, Bell GI (November 1993). "A molecular inventory of human pancreatic islets: sequence analysis of 1000 cDNA clones". Human Molecular Genetics. 2 (11): 1793–8. doi:10.1093/hmg/2.11.1793. PMID 7506601.
  • Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (September 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
  • Nagiec MM, Lester RL, Dickson RC (October 1996). "Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase". Gene. 177 (1–2): 237–41. doi:10.1016/0378-1119(96)00309-5. PMID 8921873.
  • Weiss B, Stoffel W (October 1997). "Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis". European Journal of Biochemistry / FEBS. 249 (1): 239–47. doi:10.1111/j.1432-1033.1997.00239.x. PMID 9363775.
  • Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (February 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
  • Hanada K, Hara T, Nishijima M (March 2000). "Purification of the serine palmitoyltransferase complex responsible for sphingoid base synthesis by using affinity peptide chromatography techniques". The Journal of Biological Chemistry. 275 (12): 8409–15. doi:10.1074/jbc.275.12.8409. PMID 10722674.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (March 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Dawkins JL, Brahmbhatt S, Auer-Grumbach M, Wagner K, Hartung HP, Verhoeven K, Timmerman V, De Jonghe P, Kennerson M, LeGuern E, Nicholson GA (October 2002). "Exclusion of serine palmitoyltransferase long chain base subunit 2 (SPTLC2) as a common cause for hereditary sensory neuropathy". Neuromuscular Disorders. 12 (7–8): 656–8. doi:10.1016/S0960-8966(02)00015-9. PMID 12207934.
  • Stachowitz S, Alessandrini F, Abeck D, Ring J, Behrendt H (November 2002). "Permeability barrier disruption increases the level of serine palmitoyltransferase in human epidermis". The Journal of Investigative Dermatology. 119 (5): 1048–52. doi:10.1046/j.1523-1747.2002.19524.x. PMID 12445191.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Chen M, Han G, Dietrich CR, Dunn TM, Cahoon EB (December 2006). "The essential nature of sphingolipids in plants as revealed by the functional identification and characterization of the Arabidopsis LCB1 subunit of serine palmitoyltransferase". The Plant Cell. 18 (12): 3576–93. doi:10.1105/tpc.105.040774. PMC 1785403. PMID 17194770.
  • Hornemann T, Wei Y, von Eckardstein A (July 2007). "Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?". The Biochemical Journal. 405 (1): 157–64. doi:10.1042/BJ20070025. PMC 1925250. PMID 17331073.


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