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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Serine/threonine-protein kinase SRPK2''' is an [[enzyme]] that in humans is encoded by the ''SRPK2'' [[gene]].<ref name="pmid8208298">{{cite journal | vauthors = Gui JF, Lane WS, Fu XD | title = A serine kinase regulates intracellular localization of splicing factors in the cell cycle | journal = Nature | volume = 369 | issue = 6482 | pages = 678–82 | date = Jul 1994 | pmid = 8208298 | pmc =  | doi = 10.1038/369678a0 }}</ref><ref name="pmid9472028">{{cite journal | vauthors = Wang HY, Lin W, Dyck JA, Yeakley JM, Songyang Z, Cantley LC, Fu XD | title = SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells | journal = J Cell Biol | volume = 140 | issue = 4 | pages = 737–50 | date = Mar 1998 | pmid = 9472028 | pmc = 2141757 | doi = 10.1083/jcb.140.4.737 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SRPK2 SFRS protein kinase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6733| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = SFRS protein kinase 2
| HGNCid = 11306
| Symbol = SRPK2
| AltSymbols =; FLJ36101; SFRSK2
| OMIM = 602980
| ECnumber = 
| Homologene = 40660
| MGIid = 1201408
| GeneAtlas_image1 = PBB_GE_SRPK2_203182_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SRPK2_203181_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_SRPK2_214931_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000245 |text = spliceosome assembly}} {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6733
    | Hs_Ensembl = ENSG00000135250
    | Hs_RefseqProtein = NP_872633
    | Hs_RefseqmRNA = NM_182691
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 104544060
    | Hs_GenLoc_end = 104816577
    | Hs_Uniprot = P78362
    | Mm_EntrezGene = 20817
    | Mm_Ensembl = ENSMUSG00000062604
    | Mm_RefseqmRNA = NM_009274
    | Mm_RefseqProtein = NP_033300
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 23019360
    | Mm_GenLoc_end = 23077091
    | Mm_Uniprot = Q3TEK9
  }}
}}
'''SFRS protein kinase 2''', also known as '''SRPK2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SRPK2 SFRS protein kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6733| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
SRPK2 has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
* [[ASF/SF2]]<ref name = pmid9472028/><ref name = pmid12565863>{{cite journal | vauthors = Umehara H, Nishii Y, Morishima M, Kakehi Y, Kioka N, Amachi T, Koizumi J, Hagiwara M, Ueda K | title = Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A | journal = Biochem. Biophys. Res. Commun. | volume = 301 | issue = 2 | pages = 324–9 | date = Feb 2003 | pmid = 12565863 | doi =  10.1016/s0006-291x(02)03017-6}}</ref><ref name = pmid10196197>{{cite journal | vauthors = Koizumi J, Okamoto Y, Onogi H, Mayeda A, Krainer AR, Hagiwara M | title = The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs) | journal = J. Biol. Chem. | volume = 274 | issue = 16 | pages = 11125–31 | date = Apr 1999 | pmid = 10196197 | doi = 10.1074/jbc.274.16.11125}}</ref> and
| section_title =  
* [[U2AF2]].<ref name = pmid9472028 /><ref name = pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M|authorlink30=Huda Zoghbi | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref>
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Bedford MT, Chan DC, Leder P | title = FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands. | journal = EMBO J. | volume = 16 | issue = 9 | pages = 2376–83 | year = 1997 | pmid = 9171351 | pmc = 1169838 | doi = 10.1093/emboj/16.9.2376 }}
| citations =
* {{cite journal | vauthors = Kuroyanagi N, Onogi H, Wakabayashi T, Hagiwara M | title = Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles. | journal = Biochem. Biophys. Res. Commun. | volume = 242 | issue = 2 | pages = 357–64 | year = 1998 | pmid = 9446799 | doi = 10.1006/bbrc.1997.7913 }}
*{{cite journal | author=Gui JF, Lane WS, Fu XD |title=A serine kinase regulates intracellular localization of splicing factors in the cell cycle. |journal=Nature |volume=369 |issue= 6482 |pages= 678-82 |year= 1994 |pmid= 8208298 |doi= 10.1038/369678a0 }}
* {{cite journal | vauthors = Koizumi J, Okamoto Y, Onogi H, Mayeda A, Krainer AR, Hagiwara M | title = The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs) | journal = J. Biol. Chem. | volume = 274 | issue = 16 | pages = 11125–31 | year = 1999 | pmid = 10196197 | doi = 10.1074/jbc.274.16.11125 }}
*{{cite journal  | author=Bedford MT, Chan DC, Leder P |title=FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands. |journal=EMBO J. |volume=16 |issue= 9 |pages= 2376-83 |year= 1997 |pmid= 9171351 |doi= 10.1093/emboj/16.9.2376 }}
* {{cite journal | vauthors = Daub H, Blencke S, Habenberger P, Kurtenbach A, Dennenmoser J, Wissing J, Ullrich A, Cotten M | title = Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein | journal = J. Virol. | volume = 76 | issue = 16 | pages = 8124–37 | year = 2002 | pmid = 12134018 | pmc = 155132 | doi = 10.1128/JVI.76.16.8124-8137.2002 }}
*{{cite journal | author=Kuroyanagi N, Onogi H, Wakabayashi T, Hagiwara M |title=Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles. |journal=Biochem. Biophys. Res. Commun. |volume=242 |issue= 2 |pages= 357-64 |year= 1998 |pmid= 9446799 |doi= 10.1006/bbrc.1997.7913 }}
* {{cite journal | vauthors = Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC | title = Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry | journal = Anal. Chem. | volume = 76 | issue = 10 | pages = 2763–72 | year = 2004 | pmid = 15144186 | doi = 10.1021/ac035352d }}
*{{cite journal | author=Wang HY, Lin W, Dyck JA, ''et al.'' |title=SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. |journal=J. Cell Biol. |volume=140 |issue= 4 |pages= 737-50 |year= 1998 |pmid= 9472028 |doi=  }}
* {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nat. Biotechnol. | volume = 23 | issue = 1 | pages = 94–101 | year = 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 }}
*{{cite journal  | author=Koizumi J, Okamoto Y, Onogi H, ''et al.'' |title=The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs). |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 11125-31 |year= 1999 |pmid= 10196197 |doi= }}
* {{cite journal | vauthors = Zheng Y, Fu XD, Ou JH | title = Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein | journal = Virology | volume = 342 | issue = 1 | pages = 150–8 | year = 2005 | pmid = 16122776 | doi = 10.1016/j.virol.2005.07.030 }}
*{{cite journal | author=Daub H, Blencke S, Habenberger P, ''et al.'' |title=Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein. |journal=J. Virol. |volume=76 |issue= 16 |pages= 8124-37 |year= 2002 |pmid= 12134018 |doi= }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Brill LM, Salomon AR, Ficarro SB, ''et al.'' |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763-72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal | author=Zheng Y, Fu XD, Ou JH |title=Suppression of hepatitis B virus replication by SRPK1 and SRPK2 via a pathway independent of the phosphorylation of the viral core protein. |journal=Virology |volume=342 |issue= 1 |pages= 150-8 |year= 2005 |pmid= 16122776 |doi= 10.1016/j.virol.2005.07.030 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 16:32, 8 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine/threonine-protein kinase SRPK2 is an enzyme that in humans is encoded by the SRPK2 gene.[1][2][3]

Interactions

SRPK2 has been shown to interact with:

References

  1. ↑ Gui JF, Lane WS, Fu XD (Jul 1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle". Nature. 369 (6482): 678–82. doi:10.1038/369678a0. PMID 8208298.
  2. ↑ 2.0 2.1 2.2 Wang HY, Lin W, Dyck JA, Yeakley JM, Songyang Z, Cantley LC, Fu XD (Mar 1998). "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells". J Cell Biol. 140 (4): 737–50. doi:10.1083/jcb.140.4.737. PMC 2141757. PMID 9472028.
  3. ↑ "Entrez Gene: SRPK2 SFRS protein kinase 2".
  4. ↑ Umehara H, Nishii Y, Morishima M, Kakehi Y, Kioka N, Amachi T, Koizumi J, Hagiwara M, Ueda K (Feb 2003). "Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A". Biochem. Biophys. Res. Commun. 301 (2): 324–9. doi:10.1016/s0006-291x(02)03017-6. PMID 12565863.
  5. ↑ Koizumi J, Okamoto Y, Onogi H, Mayeda A, Krainer AR, Hagiwara M (Apr 1999). "The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs)". J. Biol. Chem. 274 (16): 11125–31. doi:10.1074/jbc.274.16.11125. PMID 10196197.
  6. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading


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