ST3GAL3: Difference between revisions
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{{ | '''ST3 beta-galactoside alpha-2,3-sialyltransferase 3''', also known as '''ST3GAL3''', is a [[protein]] which in humans is encoded by the ''ST3GAL3'' [[gene]].<ref name="pmid8333853">{{cite journal | vauthors = Kitagawa H, Paulson JC | title = Cloning and expression of human Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase | journal = Biochemical and Biophysical Research Communications | volume = 194 | issue = 1 | pages = 375–82 | date = Jul 1993 | pmid = 8333853 | doi = 10.1006/bbrc.1993.1830 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6487| accessdate = }}</ref> | ||
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== Function == | |||
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of [[sialic acid]] from CMP-sialic acid to [[galactose]]-containing [[enzyme substrate|substrate]]s. The encoded protein is normally found in the [[Golgi apparatus]] but can be [[proteolysis|proteolytically]] processed to a soluble form. This protein is a member of [[glycosyltransferase]] family 29. Multiple transcript variants encoding several different isoforms have been found for this gene.<ref name="entrez"/> | |||
Mutations in the ST3GAL3 gene was recently shown to be the cause of autosomal recessive mental retardation 12. Since the mutations disrupt a glycosylation pathway, this disorder may be considererd a [[congenital disorder of glycosylation]]. | |||
{{protein- | == See also == | ||
{{ | * [[Sialyltransferase]] | ||
== References == | |||
{{reflist}} | |||
== Further reading == | |||
{{refbegin|colwidth=30em}} | |||
* {{cite journal | vauthors = Kalyanaraman VS, Rodriguez V, Veronese F, Rahman R, Lusso P, DeVico AL, Copeland T, Oroszlan S, Gallo RC, Sarngadharan MG | title = Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1 | journal = AIDS Research and Human Retroviruses | volume = 6 | issue = 3 | pages = 371–80 | date = Mar 1990 | pmid = 2187500 | doi = 10.1089/aid.1990.6.371 }} | |||
* {{cite journal | vauthors = Pal R, Hoke GM, Sarngadharan MG | title = Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 86 | issue = 9 | pages = 3384–8 | date = May 1989 | pmid = 2541446 | pmc = 287137 | doi = 10.1073/pnas.86.9.3384 }} | |||
* {{cite journal | vauthors = Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP | title = Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport | journal = Journal of Virology | volume = 63 | issue = 6 | pages = 2452–6 | date = Jun 1989 | pmid = 2542563 | pmc = 250699 | doi = }} | |||
* {{cite journal | vauthors = Kozarsky K, Penman M, Basiripour L, Haseltine W, Sodroski J, Krieger M | title = Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein | journal = Journal of Acquired Immune Deficiency Syndromes | volume = 2 | issue = 2 | pages = 163–9 | year = 1989 | pmid = 2649653 | doi = }} | |||
* {{cite journal | vauthors = Robinson WE, Montefiori DC, Mitchell WM | title = Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis | journal = AIDS Research and Human Retroviruses | volume = 3 | issue = 3 | pages = 265–82 | year = 1988 | pmid = 2829950 | doi = 10.1089/aid.1987.3.265 }} | |||
* {{cite journal | vauthors = Kitagawa H, Paulson JC | title = Differential expression of five sialyltransferase genes in human tissues | journal = The Journal of Biological Chemistry | volume = 269 | issue = 27 | pages = 17872–8 | date = Jul 1994 | pmid = 8027041 | doi = }} | |||
* {{cite journal | vauthors = Kitagawa H, Paulson JC | title = Cloning and expression of human Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase | journal = Biochemical and Biophysical Research Communications | volume = 194 | issue = 1 | pages = 375–82 | date = Jul 1993 | pmid = 8333853 | doi = 10.1006/bbrc.1993.1830 }} | |||
* {{cite journal | vauthors = Burger PC, Lötscher M, Streiff M, Kleene R, Kaissling B, Berger EG | title = Immunocytochemical localization of alpha2,3(N)-sialyltransferase (ST3Gal III) in cell lines and rat kidney tissue sections: evidence for golgi and post-golgi localization | journal = Glycobiology | volume = 8 | issue = 3 | pages = 245–57 | date = Mar 1998 | pmid = 9451034 | doi = 10.1093/glycob/8.3.245 }} | |||
* {{cite journal | vauthors = Taniguchi A, Morishima T, Tsujita Y, Matsumoto Y, Matsumoto K | title = Genomic structure, expression, and transcriptional regulation of human Gal beta 1,3 GalNAc alpha 2,3-sialyltransferase gene | journal = Biochemical and Biophysical Research Communications | volume = 300 | issue = 2 | pages = 570–6 | date = Jan 2003 | pmid = 12504121 | doi = 10.1016/S0006-291X(02)02899-1 }} | |||
* {{cite journal | vauthors = Taniguchi A, Saito K, Kubota T, Matsumoto K | title = Characterization of the promoter region of the human Galbeta1,3(4)GlcNAc alpha2,3-sialyltransferase III (hST3Gal III) gene | journal = Biochimica et Biophysica Acta | volume = 1626 | issue = 1–3 | pages = 92–6 | date = Apr 2003 | pmid = 12697334 | doi = 10.1016/s0167-4781(03)00021-6 }} | |||
* {{cite journal | vauthors = Saito S, Aoki H, Ito A, Ueno S, Wada T, Mitsuzuka K, Satoh M, Arai Y, Miyagi T | title = Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase | journal = The Journal of Biological Chemistry | volume = 278 | issue = 29 | pages = 26474–9 | date = Jul 2003 | pmid = 12716912 | doi = 10.1074/jbc.M213223200 }} | |||
* {{cite journal | vauthors = Grahn A, Barkhordar GS, Larson G | title = Cloning and sequencing of nineteen transcript isoforms of the human alpha2,3-sialyltransferase gene, ST3Gal III; its genomic organisation and expression in human tissues | journal = Glycoconjugate Journal | volume = 19 | issue = 3 | pages = 197–210 | date = Mar 2002 | pmid = 12815231 | doi = 10.1023/A:1024253808424 }} | |||
* {{cite journal | vauthors = Gretschel S, Haensch W, Schlag PM, Kemmner W | title = Clinical relevance of sialyltransferases ST6GAL-I and ST3GAL-III in gastric cancer | journal = Oncology | volume = 65 | issue = 2 | pages = 139–45 | year = 2003 | pmid = 12931020 | doi = 10.1159/000072339 }} | |||
* {{cite journal | vauthors = Jeanneau C, Chazalet V, Augé C, Soumpasis DM, Harduin-Lepers A, Delannoy P, Imberty A, Breton C | title = Structure-function analysis of the human sialyltransferase ST3Gal I: role of n-glycosylation and a novel conserved sialylmotif | journal = The Journal of Biological Chemistry | volume = 279 | issue = 14 | pages = 13461–8 | date = Apr 2004 | pmid = 14722111 | doi = 10.1074/jbc.M311764200 }} | |||
* {{cite journal | vauthors = Grahn A, Barkhordar GS, Larson G | title = Identification of seven new alpha2,3-sialyltransferase III, ST3Gal III, transcripts from human foetal brain | journal = Glycoconjugate Journal | volume = 20 | issue = 7–8 | pages = 493–500 | year = 2005 | pmid = 15316282 | doi = 10.1023/B:GLYC.0000038295.87747.0b }} | |||
* {{cite journal | vauthors = Van Dyken SJ, Green RS, Marth JD | title = Structural and mechanistic features of protein O glycosylation linked to CD8+ T-cell apoptosis | journal = Molecular and Cellular Biology | volume = 27 | issue = 3 | pages = 1096–111 | date = Feb 2007 | pmid = 17101770 | pmc = 1800694 | doi = 10.1128/MCB.01750-06 }} | |||
* {{cite journal | vauthors = Hu H, Eggers K, Chen W, Garshasbi M, Motazacker MM, Wrogemann K, Kahrizi K, Tzschach A, Hosseini M, Bahman I, Hucho T, Mühlenhoff M, Gerardy-Schahn R, Najmabadi H, Ropers HH, Kuss AW | title = ST3GAL3 mutations impair the development of higher cognitive functions | journal = American Journal of Human Genetics | volume = 89 | issue = 3 | pages = 407–14 | date = Sep 2011 | doi = 10.1016/j.ajhg.2011.08.008 | pmid = 21907012 | series = 3 | pmc=3169827}} | |||
*{{cite journal |vauthors=Szabo R, Skropeta D, etal |title=Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities. |journal=Med. Res. Rev. |volume=37 |pages= 210–270 |year= 2017 |doi= 10.1002/med.21407 }} | |||
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
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ST3 beta-galactoside alpha-2,3-sialyltransferase 3, also known as ST3GAL3, is a protein which in humans is encoded by the ST3GAL3 gene.[1][2]
Function
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Multiple transcript variants encoding several different isoforms have been found for this gene.[2]
Mutations in the ST3GAL3 gene was recently shown to be the cause of autosomal recessive mental retardation 12. Since the mutations disrupt a glycosylation pathway, this disorder may be considererd a congenital disorder of glycosylation.
See also
References
- ↑ Kitagawa H, Paulson JC (Jul 1993). "Cloning and expression of human Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase". Biochemical and Biophysical Research Communications. 194 (1): 375–82. doi:10.1006/bbrc.1993.1830. PMID 8333853.
- ↑ 2.0 2.1 "Entrez Gene: ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3".
Further reading
- Kalyanaraman VS, Rodriguez V, Veronese F, Rahman R, Lusso P, DeVico AL, Copeland T, Oroszlan S, Gallo RC, Sarngadharan MG (Mar 1990). "Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1". AIDS Research and Human Retroviruses. 6 (3): 371–80. doi:10.1089/aid.1990.6.371. PMID 2187500.
- Pal R, Hoke GM, Sarngadharan MG (May 1989). "Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1". Proceedings of the National Academy of Sciences of the United States of America. 86 (9): 3384–8. doi:10.1073/pnas.86.9.3384. PMC 287137. PMID 2541446.
- Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP (Jun 1989). "Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport". Journal of Virology. 63 (6): 2452–6. PMC 250699. PMID 2542563.
- Kozarsky K, Penman M, Basiripour L, Haseltine W, Sodroski J, Krieger M (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein". Journal of Acquired Immune Deficiency Syndromes. 2 (2): 163–9. PMID 2649653.
- Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis". AIDS Research and Human Retroviruses. 3 (3): 265–82. doi:10.1089/aid.1987.3.265. PMID 2829950.
- Kitagawa H, Paulson JC (Jul 1994). "Differential expression of five sialyltransferase genes in human tissues". The Journal of Biological Chemistry. 269 (27): 17872–8. PMID 8027041.
- Kitagawa H, Paulson JC (Jul 1993). "Cloning and expression of human Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase". Biochemical and Biophysical Research Communications. 194 (1): 375–82. doi:10.1006/bbrc.1993.1830. PMID 8333853.
- Burger PC, Lötscher M, Streiff M, Kleene R, Kaissling B, Berger EG (Mar 1998). "Immunocytochemical localization of alpha2,3(N)-sialyltransferase (ST3Gal III) in cell lines and rat kidney tissue sections: evidence for golgi and post-golgi localization". Glycobiology. 8 (3): 245–57. doi:10.1093/glycob/8.3.245. PMID 9451034.
- Taniguchi A, Morishima T, Tsujita Y, Matsumoto Y, Matsumoto K (Jan 2003). "Genomic structure, expression, and transcriptional regulation of human Gal beta 1,3 GalNAc alpha 2,3-sialyltransferase gene". Biochemical and Biophysical Research Communications. 300 (2): 570–6. doi:10.1016/S0006-291X(02)02899-1. PMID 12504121.
- Taniguchi A, Saito K, Kubota T, Matsumoto K (Apr 2003). "Characterization of the promoter region of the human Galbeta1,3(4)GlcNAc alpha2,3-sialyltransferase III (hST3Gal III) gene". Biochimica et Biophysica Acta. 1626 (1–3): 92–6. doi:10.1016/s0167-4781(03)00021-6. PMID 12697334.
- Saito S, Aoki H, Ito A, Ueno S, Wada T, Mitsuzuka K, Satoh M, Arai Y, Miyagi T (Jul 2003). "Human alpha2,3-sialyltransferase (ST3Gal II) is a stage-specific embryonic antigen-4 synthase". The Journal of Biological Chemistry. 278 (29): 26474–9. doi:10.1074/jbc.M213223200. PMID 12716912.
- Grahn A, Barkhordar GS, Larson G (Mar 2002). "Cloning and sequencing of nineteen transcript isoforms of the human alpha2,3-sialyltransferase gene, ST3Gal III; its genomic organisation and expression in human tissues". Glycoconjugate Journal. 19 (3): 197–210. doi:10.1023/A:1024253808424. PMID 12815231.
- Gretschel S, Haensch W, Schlag PM, Kemmner W (2003). "Clinical relevance of sialyltransferases ST6GAL-I and ST3GAL-III in gastric cancer". Oncology. 65 (2): 139–45. doi:10.1159/000072339. PMID 12931020.
- Jeanneau C, Chazalet V, Augé C, Soumpasis DM, Harduin-Lepers A, Delannoy P, Imberty A, Breton C (Apr 2004). "Structure-function analysis of the human sialyltransferase ST3Gal I: role of n-glycosylation and a novel conserved sialylmotif". The Journal of Biological Chemistry. 279 (14): 13461–8. doi:10.1074/jbc.M311764200. PMID 14722111.
- Grahn A, Barkhordar GS, Larson G (2005). "Identification of seven new alpha2,3-sialyltransferase III, ST3Gal III, transcripts from human foetal brain". Glycoconjugate Journal. 20 (7–8): 493–500. doi:10.1023/B:GLYC.0000038295.87747.0b. PMID 15316282.
- Van Dyken SJ, Green RS, Marth JD (Feb 2007). "Structural and mechanistic features of protein O glycosylation linked to CD8+ T-cell apoptosis". Molecular and Cellular Biology. 27 (3): 1096–111. doi:10.1128/MCB.01750-06. PMC 1800694. PMID 17101770.
- Hu H, Eggers K, Chen W, Garshasbi M, Motazacker MM, Wrogemann K, Kahrizi K, Tzschach A, Hosseini M, Bahman I, Hucho T, Mühlenhoff M, Gerardy-Schahn R, Najmabadi H, Ropers HH, Kuss AW (Sep 2011). "ST3GAL3 mutations impair the development of higher cognitive functions". American Journal of Human Genetics. 3. 89 (3): 407–14. doi:10.1016/j.ajhg.2011.08.008. PMC 3169827. PMID 21907012.
- Szabo R, Skropeta D, et al. (2017). "Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities". Med. Res. Rev. 37: 210–270. doi:10.1002/med.21407.
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