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{{Infobox_gene}}
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'''Syntaxin-binding protein 3''' is a [[protein]] that in humans is encoded by the ''STXBP3'' [[gene]].<ref name="pmid10194441">{{cite journal |vauthors=Reed GL, Houng AK, Fitzgerald ML | title = Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion | journal = Blood | volume = 93 | issue = 8 | pages = 2617–26 |date=May 1999 | pmid = 10194441 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STXBP3 syntaxin binding protein 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6814| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_STXBP3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2pjx.
| PDB = {{PDB2|2pjx}}
| Name = Syntaxin binding protein 3
| HGNCid = 11446
| Symbol = STXBP3
| AltSymbols =; PSP; MUNC18-3; MUNC18C; UNC-18C
| OMIM = 608339
| ECnumber = 
| Homologene = 5260
| MGIid = 107362
| GeneAtlas_image1 = PBB_GE_STXBP3_203310_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0006904 |text = vesicle docking during exocytosis}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0015031 |text = protein transport}} {{GNF_GO|id=GO:0016192 |text = vesicle-mediated transport}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6814
    | Hs_Ensembl = ENSG00000116266
    | Hs_RefseqProtein = XP_001129477
    | Hs_RefseqmRNA = XM_001129477
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 109090833
    | Hs_GenLoc_end = 109153671
    | Hs_Uniprot = O00186
    | Mm_EntrezGene = 20912
    | Mm_Ensembl = ENSMUSG00000027882
    | Mm_RefseqmRNA = XM_974673
    | Mm_RefseqProtein = XP_979767
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 108921232
    | Mm_GenLoc_end = 108968567
    | Mm_Uniprot = Q3U2S2
  }}
}}
'''Syntaxin binding protein 3''', also known as '''STXBP3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: STXBP3 syntaxin binding protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6814| accessdate = }}</ref>


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| summary_text =  
| summary_text =  
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==Interactions==
Syntaxin binding protein 3 has been shown to [[Protein-protein interaction|interact]] with [[STX2]]<ref name=pmid12773094>{{cite journal |last=Schraw |first=Todd D |authorlink= |author2=Lemons Paula P |author3=Dean William L |author4=Whiteheart Sidney W  |date=Aug 2003 |title=A role for Sec1/Munc18 proteins in platelet exocytosis |journal=Biochem. J. |volume=374 |issue=Pt 1 |pages=207–17 |publisher= |location = England| issn = 0264-6021| pmid = 12773094 |doi = 10.1042/BJ20030610 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1223584 }}</ref> and [[STX4]].<ref name=pmid12773094/><ref name=pmid12832401>{{cite journal |last=Widberg |first=Charlotte H |authorlink= |author2=Bryant Nia J |author3=Girotti Milena |author4=Rea Shane |author5=James David E  |date=Sep 2003 |title=Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation |journal=J. Biol. Chem. |volume=278 |issue=37 |pages=35093–101 |publisher= |location = United States| issn = 0021-9258| pmid = 12832401 |doi = 10.1074/jbc.M304261200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin|35em}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Gengyo-Ando K, Kitayama H, Mukaida M, Ikawa Y |title=A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants. |journal=J. Neurosci. |volume=16 |issue= 21 |pages= 6695-702 |year= 1996 |pmid= 8824310 |doi=  }}
*{{cite journal  |vauthors=Gengyo-Ando K, Kitayama H, Mukaida M, Ikawa Y |title=A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants. |journal=J. Neurosci. |volume=16 |issue= 21 |pages= 6695–702 |year= 1996 |pmid= 8824310 |doi=  }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Reed GL, Houng AK, Fitzgerald ML |title=Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion. |journal=Blood |volume=93 |issue= 8 |pages= 2617-26 |year= 1999 |pmid= 10194441 |doi= }}
*{{cite journal   |vauthors=Baccon J, Pellizzoni L, Rappsilber J, etal |title=Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31957–62 |year= 2002 |pmid= 12065586 |doi= 10.1074/jbc.M203478200 }}
*{{cite journal | author=Baccon J, Pellizzoni L, Rappsilber J, ''et al.'' |title=Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31957-62 |year= 2002 |pmid= 12065586 |doi= 10.1074/jbc.M203478200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Widberg CH, Bryant NJ, Girotti M, etal |title=Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation. |journal=J. Biol. Chem. |volume=278 |issue= 37 |pages= 35093–101 |year= 2003 |pmid= 12832401 |doi= 10.1074/jbc.M304261200 }}
*{{cite journal | author=Widberg CH, Bryant NJ, Girotti M, ''et al.'' |title=Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation. |journal=J. Biol. Chem. |volume=278 |issue= 37 |pages= 35093-101 |year= 2003 |pmid= 12832401 |doi= 10.1074/jbc.M304261200 }}
*{{cite journal   |vauthors=Brandenberger R, Wei H, Zhang S, etal |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Fu J, Naren AP, Gao X, etal |title=Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression. |journal=J. Biol. Chem. |volume=280 |issue= 5 |pages= 3178–84 |year= 2005 |pmid= 15576373 |doi= 10.1074/jbc.M410044200 }}
*{{cite journal | author=Fu J, Naren AP, Gao X, ''et al.'' |title=Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression. |journal=J. Biol. Chem. |volume=280 |issue= 5 |pages= 3178-84 |year= 2005 |pmid= 15576373 |doi= 10.1074/jbc.M410044200 }}
*{{cite journal  |vauthors=Hodgkinson CP, Mander A, Sale GJ |title=Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking. |journal=Biochem. J. |volume=388 |issue= Pt 3 |pages= 785–93 |year= 2005 |pmid= 15707389 |doi= 10.1042/BJ20041845 | pmc=1183457 }}
*{{cite journal  | author=Hodgkinson CP, Mander A, Sale GJ |title=Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking. |journal=Biochem. J. |volume=388 |issue= Pt 3 |pages= 785-93 |year= 2005 |pmid= 15707389 |doi= 10.1042/BJ20041845 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=6814}}
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{{protein-stub}}
{{gene-1-stub}}

Latest revision as of 19:02, 26 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

n/a

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Syntaxin-binding protein 3 is a protein that in humans is encoded by the STXBP3 gene.[1][2]


Interactions

Syntaxin binding protein 3 has been shown to interact with STX2[3] and STX4.[3][4]

References

  1. ↑ Reed GL, Houng AK, Fitzgerald ML (May 1999). "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion". Blood. 93 (8): 2617–26. PMID 10194441.
  2. ↑ "Entrez Gene: STXBP3 syntaxin binding protein 3".
  3. ↑ 3.0 3.1 Schraw, Todd D; Lemons Paula P; Dean William L; Whiteheart Sidney W (Aug 2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". Biochem. J. England. 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. ISSN 0264-6021. PMC 1223584. PMID 12773094.
  4. ↑ Widberg, Charlotte H; Bryant Nia J; Girotti Milena; Rea Shane; James David E (Sep 2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". J. Biol. Chem. United States. 278 (37): 35093–101. doi:10.1074/jbc.M304261200. ISSN 0021-9258. PMID 12832401.

Further reading



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