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{{Infobox_gene}}
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'''Trafficking protein particle complex subunit 10''' is a [[protein]] that in humans is encoded by the ''TRAPPC10'' [[gene]].<ref name="pmid7633421">{{cite journal |vauthors=Yamakawa K, Mitchell S, Hubert R, Chen XN, Colbern S, Huo YK, Gadomski C, Kim UJ, Korenberg JR | title = Isolation and characterization of a candidate gene for progressive myoclonus epilepsy on 21q22.3 | journal = Hum Mol Genet | volume = 4 | issue = 4 | pages = 709–16 |date=Sep 1995 | pmid = 7633421 | pmc =  | doi =10.1093/hmg/4.4.709 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TMEM1 transmembrane protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7109| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Transmembrane protein 1
| HGNCid = 11868
| Symbol = TMEM1
| AltSymbols =; EHOC-1; EHOC1; GT334; MGC126777
| OMIM = 602103
| ECnumber =
  | Homologene = 37751
| MGIid = 1336209
| GeneAtlas_image1 = PBB_GE_TMEM1_209412_at_tn.png
| GeneAtlas_image2 = PBB_GE_TMEM1_208184_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0004812 |text = aminoacyl-tRNA ligase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0015081 |text = sodium ion transmembrane transporter activity}}
| Component = {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006418 |text = tRNA aminoacylation for protein translation}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0006888 |text = ER to Golgi vesicle-mediated transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7109
    | Hs_Ensembl = ENSG00000160218
    | Hs_RefseqProtein = NP_001001723
    | Hs_RefseqmRNA = NM_001001723
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 21
    | Hs_GenLoc_start = 44256634
    | Hs_GenLoc_end = 44350852
    | Hs_Uniprot = P48553
    | Mm_EntrezGene = 216131
    | Mm_Ensembl = ENSMUSG00000000374
    | Mm_RefseqmRNA = XM_125775
    | Mm_RefseqProtein = XP_125775
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 77590988
    | Mm_GenLoc_end = 77647631
    | Mm_Uniprot = 
  }}
}}
'''Transmembrane protein 1''', also known as '''TMEM1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TMEM1 transmembrane protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7109| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a transmembrane protein found in the cis-Golgi complex. The encoded protein is part of the multisubunit transport protein particle (TRAPP) complex and may be involved in vesicular transport from the endoplasmic reticulum to the Golgi. Mutations in this gene could be responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy, or for autoimmune polyglandular disease type 1. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: TMEM1 transmembrane protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7109| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a transmembrane protein found in the cis-Golgi complex. The encoded protein is part of the multisubunit transport protein particle (TRAPP) complex and may be involved in vesicular transport from the endoplasmic reticulum to the Golgi. Mutations in this gene could be responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy, or for autoimmune polyglandular disease type 1. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Yamakawa K, Mitchell S, Hubert R, ''et al.'' |title=Isolation and characterization of a candidate gene for progressive myoclonus epilepsy on 21q22.3. |journal=Hum. Mol. Genet. |volume=4 |issue= 4 |pages= 709-16 |year= 1995 |pmid= 7633421 |doi=  }}
*{{cite journal  | author=Nagamine K |title=Isolation of cDNA for a novel human protein KNP-I that is homologous to the E. coli SCRP-27A protein from the autoimmune polyglandular disease type I (APECED) region of chromosome 21q22.3 |journal=Biochem. Biophys. Res. Commun. |volume=225 |issue= 2 |pages= 608–16 |year= 1996 |pmid= 8753807 |doi= 10.1006/bbrc.1996.1218 |name-list-format=vanc| author2=Kudoh J  | author3=Minoshima S  | display-authors=3  | last4=Kawasaki  | first4=Kazuhiko  | last5=Asakawa  | first5=Shuichi  | last6=Ito  | first6=Fumiaki  | last7=Shimizu  | first7=Nobuyoshi }}
*{{cite journal  | author=Nagamine K, Kudoh J, Minoshima S, ''et al.'' |title=Isolation of cDNA for a novel human protein KNP-I that is homologous to the E. coli SCRP-27A protein from the autoimmune polyglandular disease type I (APECED) region of chromosome 21q22.3. |journal=Biochem. Biophys. Res. Commun. |volume=225 |issue= 2 |pages= 608-16 |year= 1996 |pmid= 8753807 |doi= 10.1006/bbrc.1996.1218 }}
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | author=Nagamine K |title=Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3 |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 1 |pages= 185–90 |year= 1997 |pmid= 9196060 |doi= 10.1006/bbrc.1997.6758 |name-list-format=vanc| author2=Kudoh J  | author3=Kawasaki K  | display-authors=3  | last4=Minoshima  | first4=Shinsei  | last5=Asakawa  | first5=Shuichi  | last6=Ito  | first6=Fumiaki  | last7=Shimizu  | first7=Nobuyoshi }}
*{{cite journal  | author=Nagamine K, Kudoh J, Kawasaki K, ''et al.'' |title=Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3. |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 1 |pages= 185-90 |year= 1997 |pmid= 9196060 |doi= 10.1006/bbrc.1997.6758 }}
*{{cite journal  | author=Nagamine K |title=Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21 |journal=Genomics |volume=42 |issue= 3 |pages= 528–31 |year= 1997 |pmid= 9205129 |doi= 10.1006/geno.1997.4761 |name-list-format=vanc| author2=Kudoh J  | author3=Minoshima S  | display-authors=3  | last4=Kawasaki  | first4=Kazuhiko  | last5=Asakawa  | first5=Shuichi  | last6=Ito  | first6=Fumiaki  | last7=Shimizu  | first7=Nobuyoshi }}
*{{cite journal  | author=Nagamine K, Kudoh J, Minoshima S, ''et al.'' |title=Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21. |journal=Genomics |volume=42 |issue= 3 |pages= 528-31 |year= 1997 |pmid= 9205129 |doi= 10.1006/geno.1997.4761 }}
*{{cite journal  | author=Lafrenière RG |title=Genomic structure of the human GT334 (EHOC-1) gene mapping to 21q22.3 |journal=Gene |volume=198 |issue= 1–2 |pages= 313–21 |year= 1997 |pmid= 9370297 |doi=10.1016/S0378-1119(97)00333-8  |name-list-format=vanc| author2=Kibar Z  | author3=Rochefort DL  | display-authors=3  | last4=Fei-Yu Han  | last5=Fon  | first5=Edward A.  | last6=Dubé  | first6=Marie-Pierre  | last7=Kang  | first7=Xiaolin  | last8=Baird  | first8=Stephen  | last9=Korneluk  | first9=Robert G.  | first4=FY }}
*{{cite journal  | author=Lafrenière RG, Kibar Z, Rochefort DL, ''et al.'' |title=Genomic structure of the human GT334 (EHOC-1) gene mapping to 21q22.3. |journal=Gene |volume=198 |issue= 1-2 |pages= 313-21 |year= 1997 |pmid= 9370297 |doi=  }}
*{{cite journal  | author=Hattori M |title=The DNA sequence of human chromosome 21 |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 |name-list-format=vanc| author2=Fujiyama A  | author3=Taylor TD  | display-authors=3  | last4=Taylor  | first4=T. D.  | last5=Watanabe  | first5=H.  | last6=Yada  | first6=T.  | last7=Park  | first7=H.-S.  | last8=Toyoda  | first8=A.  | last9=Ishii  | first9=K. }}
*{{cite journal  | author=Hattori M, Fujiyama A, Taylor TD, ''et al.'' |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311-9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }}
*{{cite journal  | author=Gavin AC |title=Functional organization of the yeast proteome by systematic analysis of protein complexes |journal=Nature |volume=415 |issue= 6868 |pages= 141–7 |year= 2002 |pmid= 11805826 |doi= 10.1038/415141a |name-list-format=vanc| author2=Bösche M  | author3=Krause R  | display-authors=3  | last4=Grandi  | first4=Paola  | last5=Marzioch  | first5=Martina  | last6=Bauer  | first6=Andreas  | last7=Schultz  | first7=Jörg  | last8=Rick  | first8=Jens M.  | last9=Michon  | first9=Anne-Marie }}
*{{cite journal  | author=Gavin AC, Bösche M, Krause R, ''et al.'' |title=Functional organization of the yeast proteome by systematic analysis of protein complexes. |journal=Nature |volume=415 |issue= 6868 |pages= 141-7 |year= 2002 |pmid= 11805826 |doi= 10.1038/415141a }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Beausoleil SA |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446  |name-list-format=vanc| author2=Jedrychowski M  | author3=Schwartz D  | display-authors=3  | last4=Elias  | first4=JE  | last5=Villén  | first5=J  | last6=Li  | first6=J  | last7=Cohn  | first7=MA  | last8=Cantley  | first8=LC  | last9=Gygi  | first9=SP }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}
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Latest revision as of 11:58, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Trafficking protein particle complex subunit 10 is a protein that in humans is encoded by the TRAPPC10 gene.[1][2]

The protein encoded by this gene is a transmembrane protein found in the cis-Golgi complex. The encoded protein is part of the multisubunit transport protein particle (TRAPP) complex and may be involved in vesicular transport from the endoplasmic reticulum to the Golgi. Mutations in this gene could be responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy, or for autoimmune polyglandular disease type 1. Two transcript variants encoding different isoforms have been found for this gene.[2]

References

  1. ↑ Yamakawa K, Mitchell S, Hubert R, Chen XN, Colbern S, Huo YK, Gadomski C, Kim UJ, Korenberg JR (Sep 1995). "Isolation and characterization of a candidate gene for progressive myoclonus epilepsy on 21q22.3". Hum Mol Genet. 4 (4): 709–16. doi:10.1093/hmg/4.4.709. PMID 7633421.
  2. ↑ 2.0 2.1 "Entrez Gene: TMEM1 transmembrane protein 1".

Further reading



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