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'''Thymosin beta-10''' is a [[protein]] that in humans is encoded by the ''TMSB10'' [[gene]].<ref name="pmid3365256">{{cite journal | vauthors = McCreary V, Kartha S, Bell GI, Toback FG | title = Sequence of a human kidney cDNA clone encoding thymosin beta 10 | journal = Biochem Biophys Res Commun | volume = 152 | issue = 2 | pages = 862–6 |date=Jun 1988 | pmid = 3365256 | pmc = | doi =10.1016/S0006-291X(88)80118-9 }}</ref><ref name="pmid10487837">{{cite journal | vauthors = Santelli G, Califano D, Chiappetta G, Vento MT, Bartoli PC, Zullo F, Trapasso F, Viglietto G, Fusco A | title = Thymosin beta-10 gene overexpression is a general event in human carcinogenesis | journal = Am J Pathol | volume = 155 | issue = 3 | pages = 799–804 |date=Oct 1999 | pmid = 10487837 | pmc = 1866886 | doi = 10.1016/s0002-9440(10)65178-4}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TMSB10 thymosin, beta 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9168| accessdate = }}</ref> TMSB10 is a member of the [[Thymosins#Single domain .CE.B2-thymosins|beta-thymosin]] are a family of peptides. | |||
TMSB10 plays an important role in the organization of the [[cytoskeleton]]. Binds to and sequesters [[actin]] monomers ([[ACTG1|G actin]]) and therefore inhibits actin polymerization (By similarity).{{Citation needed|date=August 2010}} | |||
==References== | |||
{{Reflist}} | |||
==Further reading== | |||
{{Refbegin| 2}} | |||
{{PBB_Further_reading | |||
| citations = | |||
*{{cite journal |vauthors=Tsitsiloni OE, Yialouris PP, Echner H, etal |title=Evidence for the extranuclear localization of thymosins in thymus. |journal=Experientia |volume=48 |issue= 4 |pages= 398–402 |year= 1992 |pmid= 1582498 |doi=10.1007/BF01923441 }} | |||
*{{cite journal | vauthors=Condon MR, Hall AK |title=Expression of thymosin beta-4 and related genes in developing human brain. |journal=J. Mol. Neurosci. |volume=3 |issue= 3 |pages= 165–70 |year= 1992 |pmid= 1627460 |doi=10.1007/BF02919408 }} | |||
*{{cite journal | vauthors=Lin SC, Morrison-Bogorad M |title=Cloning and characterization of a testis-specific thymosin beta 10 cDNA. Expression in post-meiotic male germ cells. |journal=J. Biol. Chem. |volume=266 |issue= 34 |pages= 23347–53 |year= 1992 |pmid= 1744129 |doi= }} | |||
*{{cite journal | author=Hall AK |title=Differential expression of thymosin genes in human tumors and in the developing human kidney. |journal=Int. J. Cancer |volume=48 |issue= 5 |pages= 672–7 |year= 1991 |pmid= 2071228 |doi=10.1002/ijc.2910480507 }} | |||
*{{cite journal | vauthors=Hall AK, Hempstead J, Morgan JI |title=Thymosin beta 10 levels in developing human brain and its regulation by retinoic acid in the HTB-10 neuroblastoma. |journal=Brain Res. Mol. Brain Res. |volume=8 |issue= 2 |pages= 129–35 |year= 1990 |pmid= 2169566 |doi=10.1016/0169-328X(90)90057-K }} | |||
*{{cite journal | vauthors=Weterman MA, van Muijen GN, Ruiter DJ, Bloemers HP |title=Thymosin beta-10 expression in melanoma cell lines and melanocytic lesions: a new progression marker for human cutaneous melanoma. |journal=Int. J. Cancer |volume=53 |issue= 2 |pages= 278–84 |year= 1993 |pmid= 8425765 |doi=10.1002/ijc.2910530218 }} | |||
*{{cite journal |vauthors=Lapteva N, Ando Y, Nieda M, etal |title=Profiling of genes expressed in human monocytes and monocyte-derived dendritic cells using cDNA expression array. |journal=Br. J. Haematol. |volume=114 |issue= 1 |pages= 191–7 |year= 2001 |pmid= 11472367 |doi=10.1046/j.1365-2141.2001.02910.x }} | |||
*{{cite journal |vauthors=Bani-Yaghoub M, Felker JM, Ozog MA, etal |title=Array analysis of the genes regulated during neuronal differentiation of human embryonal cells. |journal=Biochem. Cell Biol. |volume=79 |issue= 4 |pages= 387–98 |year= 2002 |pmid= 11527208 |doi=10.1139/bcb-79-4-387 }} | |||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | |||
*{{cite journal |vauthors=Santelli G, Bartoli PC, Giuliano A, etal |title=Thymosin beta-10 protein synthesis suppression reduces the growth of human thyroid carcinoma cells in semisolid medium. |journal=Thyroid |volume=12 |issue= 9 |pages= 765–72 |year= 2003 |pmid= 12481941 |doi= 10.1089/105072502760339325 }} | |||
*{{cite journal |vauthors=Johansson U, Olsson A, Gabrielsson S, etal |title=Inflammatory mediators expressed in human islets of Langerhans: implications for islet transplantation. |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 3 |pages= 474–9 |year= 2003 |pmid= 12914774 |doi=10.1016/S0006-291X(03)01392-5 }} | |||
*{{cite journal |vauthors=Rho SB, Chun T, Lee SH, etal |title=The interaction between E-tropomodulin and thymosin beta-10 rescues tumor cells from thymosin beta-10 mediated apoptosis by restoring actin architecture. |journal=FEBS Lett. |volume=557 |issue= 1–3 |pages= 57–63 |year= 2004 |pmid= 14741341 |doi=10.1016/S0014-5793(03)01438-8 }} | |||
*{{cite journal |vauthors=Chiappetta G, Pentimalli F, Monaco M, etal |title=Thymosin beta-10 gene expression as a possible tool in diagnosis of thyroid neoplasias |journal=Oncol. Rep. |volume=12 |issue= 2 |pages= 239–43 |year= 2005 |pmid= 15254683 |doi= 10.3892/or.12.2.239}} | |||
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | |||
*{{cite journal |vauthors=Lee SH, Son MJ, Oh SH, etal |title=Thymosin {beta}(10) inhibits angiogenesis and tumor growth by interfering with Ras function. |journal=Cancer Res. |volume=65 |issue= 1 |pages= 137–48 |year= 2005 |pmid= 15665289 |doi= }} | |||
*{{cite journal |vauthors=Rho SB, Lee KW, Chun T, etal |title=The identification of apoptosis-related residues in human thymosin beta-10 by mutational analysis and computational modeling |journal=J. Biol. Chem. |volume=280 |issue= 40 |pages= 34003–7 |year= 2005 |pmid= 16012174 |doi= 10.1074/jbc.M501629200 }} | |||
*{{cite journal | vauthors=Maelan AE, Rasmussen TK, Larsson LI |title=Localization of thymosin beta10 in breast cancer cells: relationship to actin cytoskeletal remodeling and cell motility |journal=Histochem. Cell Biol. |volume=127 |issue= 1 |pages= 109–13 |year= 2007 |pmid= 16786322 |doi= 10.1007/s00418-006-0208-z }} | |||
*{{cite journal |vauthors=Kim SC, Sprung R, Chen Y, etal |title=Substrate and functional diversity of lysine acetylation revealed by a proteomics survey |journal=Mol. Cell |volume=23 |issue= 4 |pages= 607–18 |year= 2006 |pmid= 16916647 |doi= 10.1016/j.molcel.2006.06.026 }} | |||
}} | |||
{{Refend}} | |||
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Thymosin beta-10 is a protein that in humans is encoded by the TMSB10 gene.[1][2][3] TMSB10 is a member of the beta-thymosin are a family of peptides.
TMSB10 plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).[citation needed]
References
- ↑ McCreary V, Kartha S, Bell GI, Toback FG (Jun 1988). "Sequence of a human kidney cDNA clone encoding thymosin beta 10". Biochem Biophys Res Commun. 152 (2): 862–6. doi:10.1016/S0006-291X(88)80118-9. PMID 3365256.
- ↑ Santelli G, Califano D, Chiappetta G, Vento MT, Bartoli PC, Zullo F, Trapasso F, Viglietto G, Fusco A (Oct 1999). "Thymosin beta-10 gene overexpression is a general event in human carcinogenesis". Am J Pathol. 155 (3): 799–804. doi:10.1016/s0002-9440(10)65178-4. PMC 1866886. PMID 10487837.
- ↑ "Entrez Gene: TMSB10 thymosin, beta 10".
Further reading
- Tsitsiloni OE, Yialouris PP, Echner H, et al. (1992). "Evidence for the extranuclear localization of thymosins in thymus". Experientia. 48 (4): 398–402. doi:10.1007/BF01923441. PMID 1582498.
- Condon MR, Hall AK (1992). "Expression of thymosin beta-4 and related genes in developing human brain". J. Mol. Neurosci. 3 (3): 165–70. doi:10.1007/BF02919408. PMID 1627460.
- Lin SC, Morrison-Bogorad M (1992). "Cloning and characterization of a testis-specific thymosin beta 10 cDNA. Expression in post-meiotic male germ cells". J. Biol. Chem. 266 (34): 23347–53. PMID 1744129.
- Hall AK (1991). "Differential expression of thymosin genes in human tumors and in the developing human kidney". Int. J. Cancer. 48 (5): 672–7. doi:10.1002/ijc.2910480507. PMID 2071228.
- Hall AK, Hempstead J, Morgan JI (1990). "Thymosin beta 10 levels in developing human brain and its regulation by retinoic acid in the HTB-10 neuroblastoma". Brain Res. Mol. Brain Res. 8 (2): 129–35. doi:10.1016/0169-328X(90)90057-K. PMID 2169566.
- Weterman MA, van Muijen GN, Ruiter DJ, Bloemers HP (1993). "Thymosin beta-10 expression in melanoma cell lines and melanocytic lesions: a new progression marker for human cutaneous melanoma". Int. J. Cancer. 53 (2): 278–84. doi:10.1002/ijc.2910530218. PMID 8425765.
- Lapteva N, Ando Y, Nieda M, et al. (2001). "Profiling of genes expressed in human monocytes and monocyte-derived dendritic cells using cDNA expression array". Br. J. Haematol. 114 (1): 191–7. doi:10.1046/j.1365-2141.2001.02910.x. PMID 11472367.
- Bani-Yaghoub M, Felker JM, Ozog MA, et al. (2002). "Array analysis of the genes regulated during neuronal differentiation of human embryonal cells". Biochem. Cell Biol. 79 (4): 387–98. doi:10.1139/bcb-79-4-387. PMID 11527208.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Santelli G, Bartoli PC, Giuliano A, et al. (2003). "Thymosin beta-10 protein synthesis suppression reduces the growth of human thyroid carcinoma cells in semisolid medium". Thyroid. 12 (9): 765–72. doi:10.1089/105072502760339325. PMID 12481941.
- Johansson U, Olsson A, Gabrielsson S, et al. (2003). "Inflammatory mediators expressed in human islets of Langerhans: implications for islet transplantation". Biochem. Biophys. Res. Commun. 308 (3): 474–9. doi:10.1016/S0006-291X(03)01392-5. PMID 12914774.
- Rho SB, Chun T, Lee SH, et al. (2004). "The interaction between E-tropomodulin and thymosin beta-10 rescues tumor cells from thymosin beta-10 mediated apoptosis by restoring actin architecture". FEBS Lett. 557 (1–3): 57–63. doi:10.1016/S0014-5793(03)01438-8. PMID 14741341.
- Chiappetta G, Pentimalli F, Monaco M, et al. (2005). "Thymosin beta-10 gene expression as a possible tool in diagnosis of thyroid neoplasias". Oncol. Rep. 12 (2): 239–43. doi:10.3892/or.12.2.239. PMID 15254683.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Lee SH, Son MJ, Oh SH, et al. (2005). "Thymosin {beta}(10) inhibits angiogenesis and tumor growth by interfering with Ras function". Cancer Res. 65 (1): 137–48. PMID 15665289.
- Rho SB, Lee KW, Chun T, et al. (2005). "The identification of apoptosis-related residues in human thymosin beta-10 by mutational analysis and computational modeling". J. Biol. Chem. 280 (40): 34003–7. doi:10.1074/jbc.M501629200. PMID 16012174.
- Maelan AE, Rasmussen TK, Larsson LI (2007). "Localization of thymosin beta10 in breast cancer cells: relationship to actin cytoskeletal remodeling and cell motility". Histochem. Cell Biol. 127 (1): 109–13. doi:10.1007/s00418-006-0208-z. PMID 16786322.
- Kim SC, Sprung R, Chen Y, et al. (2006). "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey". Mol. Cell. 23 (4): 607–18. doi:10.1016/j.molcel.2006.06.026. PMID 16916647.
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