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'''Spermatid nuclear transition protein 1''' is a [[protein]] that in humans is encoded by the ''TNP1'' [[gene]].<ref name="pmid2249851">{{cite journal | vauthors = Luerssen H, Mattei MG, Schroter M, Grzeschik KH, Adham IM, Engel W | title = Nucleotide sequence of the gene for human transition protein 1 and its chromosomal localization on chromosome 2 | journal = Genomics | volume = 8 | issue = 2 | pages = 324–30 |date=Jan 1991 | pmid = 2249851 | pmc =  | doi =10.1016/0888-7543(90)90289-7 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TNP1 transition protein 1 (during histone to protamine replacement)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7141| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Transition protein 1 (during histone to protamine replacement)
| HGNCid = 11951
| Symbol = TNP1
| AltSymbols =; TP1
| OMIM = 190231
| ECnumber =
| Homologene = 2465
| MGIid = 98784
  | GeneAtlas_image1 = PBB_GE_TNP1_206568_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}}
| Component = {{GNF_GO|id=GO:0000786 |text = nucleosome}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
| Process = {{GNF_GO|id=GO:0000012 |text = single strand break repair}} {{GNF_GO|id=GO:0006337 |text = nucleosome disassembly}} {{GNF_GO|id=GO:0006338 |text = chromatin remodeling}} {{GNF_GO|id=GO:0006342 |text = chromatin silencing}} {{GNF_GO|id=GO:0007001 |text = chromosome organization and biogenesis (sensu Eukaryota)}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0007290 |text = spermatid nuclear elongation}} {{GNF_GO|id=GO:0019953 |text = sexual reproduction}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0030317 |text = sperm motility}} {{GNF_GO|id=GO:0035042 |text = fertilization, exchange of chromosomal proteins}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7141
    | Hs_Ensembl = ENSG00000118245
    | Hs_RefseqProtein = NP_003275
    | Hs_RefseqmRNA = NM_003284
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 217432431
    | Hs_GenLoc_end = 217433027
    | Hs_Uniprot = P09430
    | Mm_EntrezGene = 21958
    | Mm_Ensembl = ENSMUSG00000026182
    | Mm_RefseqmRNA = NM_009407
    | Mm_RefseqProtein = NP_033433
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 72948284
    | Mm_GenLoc_end = 72949106
    | Mm_Uniprot = Q545L6
  }}
}}
'''Transition protein 1 (during histone to protamine replacement)''', also known as '''TNP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TNP1 transition protein 1 (during histone to protamine replacement)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7141| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Meistrich ML, Mohapatra B, Shirley CR, Zhao M |title=Roles of transition nuclear proteins in spermiogenesis. |journal=Chromosoma |volume=111 |issue= 8 |pages= 483-8 |year= 2004 |pmid= 12743712 |doi= 10.1007/s00412-002-0227-z }}
*{{cite journal  | vauthors=Meistrich ML, Mohapatra B, Shirley CR, Zhao M |title=Roles of transition nuclear proteins in spermiogenesis. |journal=Chromosoma |volume=111 |issue= 8 |pages= 483–8 |year= 2004 |pmid= 12743712 |doi= 10.1007/s00412-002-0227-z }}
*{{cite journal | author=Chirat F, Martinage A, Briand G, ''et al.'' |title=Nuclear transition protein 1 from ram elongating spermatids. Mass spectrometric characterization, primary structure and phosphorylation sites of two variants. |journal=Eur. J. Biochem. |volume=198 |issue= 1 |pages= 13-20 |year= 1991 |pmid= 2040274 |doi= }}
*{{cite journal   |vauthors=Chirat F, Martinage A, Briand G, etal |title=Nuclear transition protein 1 from ram elongating spermatids. Mass spectrometric characterization, primary structure and phosphorylation sites of two variants. |journal=Eur. J. Biochem. |volume=198 |issue= 1 |pages= 13–20 |year= 1991 |pmid= 2040274 |doi=10.1111/j.1432-1033.1991.tb15980.x }}
*{{cite journal  | author=Luerssen H, Mattei MG, Schröter M, ''et al.'' |title=Nucleotide sequence of the gene for human transition protein 1 and its chromosomal localization on chromosome 2. |journal=Genomics |volume=8 |issue= 2 |pages= 324-30 |year= 1991 |pmid= 2249851 |doi= }}
*{{cite journal  | vauthors=Baskaran R, Rao MR |title=Interaction of spermatid-specific protein TP2 with nucleic acids, in vitro. A comparative study with TP1. |journal=J. Biol. Chem. |volume=265 |issue= 34 |pages= 21039–47 |year= 1991 |pmid= 2250010 |doi=  }}
*{{cite journal  | author=Baskaran R, Rao MR |title=Interaction of spermatid-specific protein TP2 with nucleic acids, in vitro. A comparative study with TP1. |journal=J. Biol. Chem. |volume=265 |issue= 34 |pages= 21039-47 |year= 1991 |pmid= 2250010 |doi=  }}
*{{cite journal   |vauthors=Kleene KC, Borzorgzadeh A, Flynn JF, etal |title=Nucleotide sequence of a cDNA clone encoding mouse transition protein 1. |journal=Biochim. Biophys. Acta |volume=950 |issue= 2 |pages= 215–20 |year= 1988 |pmid= 3382664 |doi=  10.1016/0167-4781(88)90013-9}}
*{{cite journal | author=Kleene KC, Borzorgzadeh A, Flynn JF, ''et al.'' |title=Nucleotide sequence of a cDNA clone encoding mouse transition protein 1. |journal=Biochim. Biophys. Acta |volume=950 |issue= 2 |pages= 215-20 |year= 1988 |pmid= 3382664 |doi=  }}
*{{cite journal  | vauthors=Luerssen H, Hoyer-Fender S, Engel W |title=The nucleotide sequence of human transition protein 1 cDNA. |journal=Nucleic Acids Res. |volume=16 |issue= 15 |pages= 7723 |year= 1988 |pmid= 3412903 |doi= 10.1093/nar/16.15.7723| pmc=338445 }}
*{{cite journal  | author=Luerssen H, Hoyer-Fender S, Engel W |title=The nucleotide sequence of human transition protein 1 cDNA. |journal=Nucleic Acids Res. |volume=16 |issue= 15 |pages= 7723 |year= 1988 |pmid= 3412903 |doi=  }}
*{{cite journal   |vauthors=Akama K, Kojima S, Nakano M, etal |title=The amino acid sequence and phosphorylation sites of a boar transition protein 1. |journal=Biochem. Mol. Biol. Int. |volume=32 |issue= 2 |pages= 349–57 |year= 1994 |pmid= 8019440 |doi=  }}
*{{cite journal | author=Akama K, Kojima S, Nakano M, ''et al.'' |title=The amino acid sequence and phosphorylation sites of a boar transition protein 1. |journal=Biochem. Mol. Biol. Int. |volume=32 |issue= 2 |pages= 349-57 |year= 1994 |pmid= 8019440 |doi=  }}
*{{cite journal   |vauthors=Steger K, Klonisch T, Gavenis K, etal |title=Expression of mRNA and protein of nucleoproteins during human spermiogenesis. |journal=Mol. Hum. Reprod. |volume=4 |issue= 10 |pages= 939–45 |year= 1999 |pmid= 9809674 |doi=10.1093/molehr/4.10.939 }}
*{{cite journal | author=Steger K, Klonisch T, Gavenis K, ''et al.'' |title=Expression of mRNA and protein of nucleoproteins during human spermiogenesis. |journal=Mol. Hum. Reprod. |volume=4 |issue= 10 |pages= 939-45 |year= 1999 |pmid= 9809674 |doi=  }}
*{{cite journal   |vauthors=Yu YE, Zhang Y, Unni E, etal |title=Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4683–8 |year= 2000 |pmid= 10781074 |doi= 10.1073/pnas.97.9.4683| pmc=18293 }}
*{{cite journal | author=Yu YE, Zhang Y, Unni E, ''et al.'' |title=Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4683-8 |year= 2000 |pmid= 10781074 |doi=  }}
*{{cite journal  | vauthors=Siffroi JP, Alfonsi MF, Dadoune JP |title=Electron microscopic in situ hybridization study of simultaneous expression of TNP1 and PRM1 genes in human spermatids. |journal=Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia |volume=103 |issue= 4 Suppl 1 |pages= 65–74 |year= 2001 |pmid= 11315969 |doi=  }}
*{{cite journal  | author=Siffroi JP, Alfonsi MF, Dadoune JP |title=Electron microscopic in situ hybridization study of simultaneous expression of TNP1 and PRM1 genes in human spermatids. |journal=Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia |volume=103 |issue= 4 Suppl 1 |pages= 65-74 |year= 2001 |pmid= 11315969 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Miyagawa Y, Nishimura H, Tsujimura A, etal |title=Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations. |journal=J. Androl. |volume=26 |issue= 6 |pages= 779–86 |year= 2006 |pmid= 16291974 |doi= 10.2164/jandrol.05069 }}
*{{cite journal | author=Miyagawa Y, Nishimura H, Tsujimura A, ''et al.'' |title=Single-nucleotide polymorphisms and mutation analyses of the TNP1 and TNP2 genes of fertile and infertile human male populations. |journal=J. Androl. |volume=26 |issue= 6 |pages= 779-86 |year= 2006 |pmid= 16291974 |doi= 10.2164/jandrol.05069 }}
*{{cite journal   |vauthors=Jedrzejczak P, Kempisty B, Bryja A, etal |title=Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men. |journal=Arch. Androl. |volume=53 |issue= 4 |pages= 199–205 |year= 2007 |pmid= 17852044 |doi= 10.1080/01485010701426430 }}
*{{cite journal | author=Jedrzejczak P, Kempisty B, Bryja A, ''et al.'' |title=Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men. |journal=Arch. Androl. |volume=53 |issue= 4 |pages= 199-205 |year= 2007 |pmid= 17852044 |doi= 10.1080/01485010701426430 }}
}}
}}
{{refend}}
{{refend}}


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{{Nucleus}}
 
 
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Latest revision as of 12:06, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Spermatid nuclear transition protein 1 is a protein that in humans is encoded by the TNP1 gene.[1][2]


References

  1. ↑ Luerssen H, Mattei MG, Schroter M, Grzeschik KH, Adham IM, Engel W (Jan 1991). "Nucleotide sequence of the gene for human transition protein 1 and its chromosomal localization on chromosome 2". Genomics. 8 (2): 324–30. doi:10.1016/0888-7543(90)90289-7. PMID 2249851.
  2. ↑ "Entrez Gene: TNP1 transition protein 1 (during histone to protamine replacement)".

Further reading



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