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{{Infobox_gene}}
{{PBB_Controls
'''Tetraspanin-31''' is a [[protein]] that in humans is encoded by the ''TSPAN31'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TSPAN31 tetraspanin 31| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6302| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Tetraspanin 31
| HGNCid = 10539
| Symbol = TSPAN31
| AltSymbols =; SAS
| OMIM = 181035
| ECnumber = 
| Homologene = 4359
| MGIid = 1914375
| GeneAtlas_image1 = PBB_GE_TSPAN31_203226_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TSPAN31_203227_s_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6302
    | Hs_Ensembl = ENSG00000135452
    | Hs_RefseqProtein = NP_005972
    | Hs_RefseqmRNA = NM_005981
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 56425051
    | Hs_GenLoc_end = 56428271
    | Hs_Uniprot = Q12999
    | Mm_EntrezGene = 67125
    | Mm_Ensembl = ENSMUSG00000006736
    | Mm_RefseqmRNA = NM_025982
    | Mm_RefseqProtein = NP_080258
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 126470229
    | Mm_GenLoc_end = 126473213
    | Mm_Uniprot = Q9CQ88
  }}
}}
'''Tetraspanin 31''', also known as '''TSPAN31''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TSPAN31 tetraspanin 31| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6302| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is thought to be involved in growth-related cellular processes. This gene is associated with tumorigenesis and osteosarcoma.<ref name="entrez">{{cite web | title = Entrez Gene: TSPAN31 tetraspanin 31| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6302| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is thought to be involved in growth-related cellular processes. This gene is associated with tumorigenesis and osteosarcoma.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Wright MD, Tomlinson MG |title=The ins and outs of the transmembrane 4 superfamily. |journal=Immunol. Today |volume=15 |issue= 12 |pages= 588-94 |year= 1995 |pmid= 7531445 |doi=  }}
*{{cite journal  |vauthors=Wright MD, Tomlinson MG |title=The ins and outs of the transmembrane 4 superfamily |journal=Immunol. Today |volume=15 |issue= 12 |pages= 588–94 |year= 1995 |pmid= 7531445 |doi=10.1016/0167-5699(94)90222-4 }}
*{{cite journal  | author=Meltzer PS, Jankowski SA, Dal Cin P, ''et al.'' |title=Identification and cloning of a novel amplified DNA sequence in human malignant fibrous histiocytoma derived from a region of chromosome 12 frequently rearranged in soft tissue tumors. |journal=Cell Growth Differ. |volume=2 |issue= 10 |pages= 495-501 |year= 1992 |pmid= 1661131 |doi=  }}
*{{cite journal  | author=Meltzer PS |title=Identification and cloning of a novel amplified DNA sequence in human malignant fibrous histiocytoma derived from a region of chromosome 12 frequently rearranged in soft tissue tumors |journal=Cell Growth Differ. |volume=2 |issue= 10 |pages= 495–501 |year= 1992 |pmid= 1661131 |doi= |name-list-format=vanc| author2=Jankowski SA  | author3=Dal Cin P  | display-authors=3  | last4=Sandberg  | first4=AA  | last5=Paz  | first5=IB  | last6=Coccia  | first6=MA }}
*{{cite journal  | author=Jankowski SA, De Jong P, Meltzer PS |title=Genomic structure of SAS, a member of the transmembrane 4 superfamily amplified in human sarcomas. |journal=Genomics |volume=25 |issue= 2 |pages= 501-6 |year= 1995 |pmid= 7789984 |doi=  }}
*{{cite journal  |vauthors=Jankowski SA, De Jong P, Meltzer PS |title=Genomic structure of SAS, a member of the transmembrane 4 superfamily amplified in human sarcomas |journal=Genomics |volume=25 |issue= 2 |pages= 501–6 |year= 1995 |pmid= 7789984 |doi=10.1016/0888-7543(95)80051-M }}
*{{cite journal  | author=Jankowski SA, Mitchell DS, Smith SH, ''et al.'' |title=SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins. |journal=Oncogene |volume=9 |issue= 4 |pages= 1205-11 |year= 1994 |pmid= 8134123 |doi=  }}
*{{cite journal  | author=Jankowski SA |title=SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins |journal=Oncogene |volume=9 |issue= 4 |pages= 1205–11 |year= 1994 |pmid= 8134123 |doi= |name-list-format=vanc| author2=Mitchell DS  | author3=Smith SH  | display-authors=3  | last4=Trent  | first4=JM  | last5=Meltzer  | first5=PS }}
*{{cite journal  | author=Elkahloun AG, Krizman DB, Wang Z, ''et al.'' |title=Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. |journal=Genomics |volume=42 |issue= 2 |pages= 295-301 |year= 1997 |pmid= 9192850 |doi= 10.1006/geno.1997.4727 }}
*{{cite journal  | author=Elkahloun AG |title=Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers |journal=Genomics |volume=42 |issue= 2 |pages= 295–301 |year= 1997 |pmid= 9192850 |doi= 10.1006/geno.1997.4727 |name-list-format=vanc| author2=Krizman DB  | author3=Wang Z  | display-authors=3  | last4=Hofmann  | first4=Tiffany A.  | last5=Roe  | first5=Bruce  | last6=Meltzer  | first6=Paul S. |url=https://zenodo.org/record/1229731/files/article.pdf}}
*{{cite journal  | author=Wunder JS, Eppert K, Burrow SR, ''et al.'' |title=Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas. |journal=Oncogene |volume=18 |issue= 3 |pages= 783-8 |year= 1999 |pmid= 9989829 |doi= 10.1038/sj.onc.1202346 }}
*{{cite journal  | author=Wunder JS |title=Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas |journal=Oncogene |volume=18 |issue= 3 |pages= 783–8 |year= 1999 |pmid= 9989829 |doi= 10.1038/sj.onc.1202346 |name-list-format=vanc| author2=Eppert K  | author3=Burrow SR  | display-authors=3  | last4=Gogkoz  | first4=Nalan  | last5=Bell  | first5=Robert S  | last6=Andrulis  | first6=Irene L }}
*{{cite journal  | author=Ragazzini P, Gamberi G, Benassi MS, ''et al.'' |title=Analysis of SAS gene and CDK4 and MDM2 proteins in low-grade osteosarcoma. |journal=Cancer Detect. Prev. |volume=23 |issue= 2 |pages= 129-36 |year= 1999 |pmid= 10101594 |doi=  }}
*{{cite journal  | author=Ragazzini P |title=Analysis of SAS gene and CDK4 and MDM2 proteins in low-grade osteosarcoma |journal=Cancer Detect. Prev. |volume=23 |issue= 2 |pages= 129–36 |year= 1999 |pmid= 10101594 |doi=10.1046/j.1525-1500.1999.09907.x  |name-list-format=vanc| author2=Gamberi G  | author3=Benassi MS  | display-authors=3  | last4=Orlando  | last5=Sestini  | last6=Ferrari  | last7=Molendini  | last8=Sollazzo  | last9=Merli  | first4=C  | first5=R  | first6=C  | first7=L  | first8=MR  | first9=M }}
*{{cite journal  | author=Suzuki Y, Tsunoda T, Sese J, ''et al.'' |title=Identification and characterization of the potential promoter regions of 1031 kinds of human genes. |journal=Genome Res. |volume=11 |issue= 5 |pages= 677-84 |year= 2001 |pmid= 11337467 |doi= 10.1101/gr.164001 }}
*{{cite journal  | author=Suzuki Y |title=Identification and Characterization of the Potential Promoter Regions of 1031 Kinds of Human Genes |journal=Genome Res. |volume=11 |issue= 5 |pages= 677–84 |year= 2001 |pmid= 11337467 |doi=   10.1101/gr.gr-1640r| pmc=311086  |name-list-format=vanc| author2=Tsunoda T  | author3=Sese J  | display-authors=3  | last4=Taira  | first4=H  | last5=Mizushima-Sugano  | first5=J  | last6=Hata  | first6=H  | last7=Ota  | first7=T  | last8=Isogai  | first8=T  | last9=Tanaka  | first9=T }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Ragazzini P, Gamberi G, Pazzaglia L, ''et al.'' |title=Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma. |journal=Histol. Histopathol. |volume=19 |issue= 2 |pages= 401-11 |year= 2004 |pmid= 15024701 |doi=  }}
*{{cite journal  | author=Ragazzini P |title=Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma |journal=Histol. Histopathol. |volume=19 |issue= 2 |pages= 401–11 |year= 2004 |pmid= 15024701 |doi= |name-list-format=vanc| author2=Gamberi G  | author3=Pazzaglia L  | display-authors=3  | last4=Serra  | first4=M  | last5=Magagnoli  | first5=G  | last6=Ponticelli  | first6=F  | last7=Ferrari  | first7=C  | last8=Ghinelli  | first8=C  | last9=Alberghini  | first9=M }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
}}
}}
{{refend}}
{{refend}}
{{Membrane proteins}}
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Latest revision as of 17:05, 5 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Tetraspanin-31 is a protein that in humans is encoded by the TSPAN31 gene.[1]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is thought to be involved in growth-related cellular processes. This gene is associated with tumorigenesis and osteosarcoma.[1]

References

  1. 1.0 1.1 "Entrez Gene: TSPAN31 tetraspanin 31".

Further reading