UCN2: Difference between revisions

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{{Infobox_gene}}
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'''Urocortin-2''' is a [[protein]] that in humans is encoded by the ''UCN2'' [[gene]].<ref name="pmid11329063">{{cite journal | vauthors = Hsu SY, Hsueh AJ | title = Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor | journal = Nat Med | volume = 7 | issue = 5 | pages = 605–11 |date=Apr 2001 | pmid = 11329063 | pmc =  | doi = 10.1038/87936 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UCN2 urocortin 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=90226| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Urocortin 2
| HGNCid = 18414
| Symbol = UCN2
| AltSymbols =; URP; SRP; UCN-II; UCNI
| OMIM = 605902
| ECnumber = 
| Homologene = 50048
| MGIid = 
| Function = {{GNF_GO|id=GO:0001664 |text = G-protein-coupled receptor binding}} {{GNF_GO|id=GO:0005179 |text = hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process = {{GNF_GO|id=GO:0006171 |text = cAMP biosynthetic process}} {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0007586 |text = digestion}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 90226
    | Hs_Ensembl = ENSG00000145040
    | Hs_RefseqProtein = NP_149976
    | Hs_RefseqmRNA = NM_033199
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 48574157
    | Hs_GenLoc_end = 48576205
    | Hs_Uniprot = Q96RP3
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Urocortin 2''', also known as '''UCN2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UCN2 urocortin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=90226| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.<ref name="entrez">{{cite web | title = Entrez Gene: UCN2 urocortin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=90226| accessdate = }}</ref>
| summary_text = This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the [[corticotropin-releasing factor]] (CRF) gene and the encoded product is an endogenous [[ligand]] for CRF type 2 receptors. In the [[brain]] it may be responsible for the effects of [[stress (biology)|stress]] on [[appetite]]. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.<ref name="entrez">{{cite web | title = Entrez Gene: UCN2 urocortin 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=90226| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
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| citations =  
| citations =  
*{{cite journal | author=Hauger RL, Grigoriadis DE, Dallman MF, ''et al.'' |title=International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands. |journal=Pharmacol. Rev. |volume=55 |issue= 1 |pages= 21-6 |year= 2003 |pmid= 12615952 |doi= 10.1124/pr.55.1.3 }}
*{{cite journal   |vauthors=Hauger RL, Grigoriadis DE, Dallman MF, etal |title=International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands. |journal=Pharmacol. Rev. |volume=55 |issue= 1 |pages= 21–6 |year= 2003 |pmid= 12615952 |doi= 10.1124/pr.55.1.3 }}
*{{cite journal | author=Florio P, Torres PB, Torricelli M, ''et al.'' |title=Human endometrium expresses urocortin II and III messenger RNA and peptides. |journal=Fertil. Steril. |volume=86 |issue= 6 |pages= 1766-70 |year= 2006 |pmid= 17074339 |doi= 10.1016/j.fertnstert.2006.05.041 }}
*{{cite journal   |vauthors=Florio P, Torres PB, Torricelli M, etal |title=Human endometrium expresses urocortin II and III messenger RNA and peptides. |journal=Fertil. Steril. |volume=86 |issue= 6 |pages= 1766–70 |year= 2006 |pmid= 17074339 |doi= 10.1016/j.fertnstert.2006.05.041 }}
*{{cite journal | author=Imperatore A, Florio P, Torres PB, ''et al.'' |title=Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes. |journal=Am. J. Obstet. Gynecol. |volume=195 |issue= 1 |pages= 288-95 |year= 2006 |pmid= 16626608 |doi= 10.1016/j.ajog.2005.12.048 }}
*{{cite journal   |vauthors=Imperatore A, Florio P, Torres PB, etal |title=Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes. |journal=Am. J. Obstet. Gynecol. |volume=195 |issue= 1 |pages= 288–95 |year= 2006 |pmid= 16626608 |doi= 10.1016/j.ajog.2005.12.048 }}
*{{cite journal | author=Isfort RJ, Wang F, Tscheiner M, ''et al.'' |title=Modifications of the human urocortin 2 peptide that improve pharmacological properties. |journal=Peptides |volume=27 |issue= 7 |pages= 1806-13 |year= 2006 |pmid= 16476507 |doi= 10.1016/j.peptides.2006.01.003 }}
*{{cite journal   |vauthors=Isfort RJ, Wang F, Tscheiner M, etal |title=Modifications of the human urocortin 2 peptide that improve pharmacological properties. |journal=Peptides |volume=27 |issue= 7 |pages= 1806–13 |year= 2006 |pmid= 16476507 |doi= 10.1016/j.peptides.2006.01.003 }}
*{{cite journal  | author=Czimmer J, Million M, Taché Y |title=Urocortin 2 acts centrally to delay gastric emptying through sympathetic pathways while CRF and urocortin 1 inhibitory actions are vagal dependent in rats. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=290 |issue= 3 |pages= G511-8 |year= 2006 |pmid= 16223946 |doi= 10.1152/ajpgi.00289.2005 }}
*{{cite journal  | vauthors=Czimmer J, Million M, Taché Y |title=Urocortin 2 acts centrally to delay gastric emptying through sympathetic pathways while CRF and urocortin 1 inhibitory actions are vagal dependent in rats. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=290 |issue= 3 |pages= G511–8 |year= 2006 |pmid= 16223946 |doi= 10.1152/ajpgi.00289.2005 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Chang CL, Hsu SY |title=Ancient evolution of stress-regulating peptides in vertebrates. |journal=Peptides |volume=25 |issue= 10 |pages= 1681-8 |year= 2005 |pmid= 15476935 |doi= 10.1016/j.peptides.2004.05.022 }}
*{{cite journal  | vauthors=Chang CL, Hsu SY |title=Ancient evolution of stress-regulating peptides in vertebrates. |journal=Peptides |volume=25 |issue= 10 |pages= 1681–8 |year= 2005 |pmid= 15476935 |doi= 10.1016/j.peptides.2004.05.022 }}
*{{cite journal  | author=Karteris E, Hillhouse EW, Grammatopoulos D |title=Urocortin II is expressed in human pregnant myometrial cells and regulates myosin light chain phosphorylation: potential role of the type-2 corticotropin-releasing hormone receptor in the control of myometrial contractility. |journal=Endocrinology |volume=145 |issue= 2 |pages= 890-900 |year= 2004 |pmid= 14592950 |doi= 10.1210/en.2003-1210 }}
*{{cite journal  | vauthors=Karteris E, Hillhouse EW, Grammatopoulos D |title=Urocortin II is expressed in human pregnant myometrial cells and regulates myosin light chain phosphorylation: potential role of the type-2 corticotropin-releasing hormone receptor in the control of myometrial contractility. |journal=Endocrinology |volume=145 |issue= 2 |pages= 890–900 |year= 2004 |pmid= 14592950 |doi= 10.1210/en.2003-1210 }}
*{{cite journal | author=Chanalaris A, Lawrence KM, Stephanou A, ''et al.'' |title=Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes. |journal=J. Mol. Cell. Cardiol. |volume=35 |issue= 10 |pages= 1295-305 |year= 2004 |pmid= 14519439 |doi=  }}
*{{cite journal   |vauthors=Chanalaris A, Lawrence KM, Stephanou A, etal |title=Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes. |journal=J. Mol. Cell. Cardiol. |volume=35 |issue= 10 |pages= 1295–305 |year= 2004 |pmid= 14519439 |doi=10.1016/S0022-2828(03)00244-X }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Lewis K, Li C, Perrin MH, ''et al.'' |title=Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7570-5 |year= 2001 |pmid= 11416224 |doi= 10.1073/pnas.121165198 }}
*{{cite journal   |vauthors=Lewis K, Li C, Perrin MH, etal |title=Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7570–5 |year= 2001 |pmid= 11416224 |doi= 10.1073/pnas.121165198  | pmc=34709 }}
*{{cite journal | author=Hsu SY, Hsueh AJ |title=Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. |journal=Nat. Med. |volume=7 |issue= 5 |pages= 605-11 |year= 2001 |pmid= 11329063 |doi= 10.1038/87936 }}
*{{cite journal   |vauthors=Reyes TM, Lewis K, Perrin MH, etal |title=Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 5 |pages= 2843–8 |year= 2001 |pmid= 11226328 |doi= 10.1073/pnas.051626398 | pmc=30227 }}
*{{cite journal | author=Reyes TM, Lewis K, Perrin MH, ''et al.'' |title=Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 5 |pages= 2843-8 |year= 2001 |pmid= 11226328 |doi= 10.1073/pnas.051626398 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 13:09, 21 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Urocortin-2 is a protein that in humans is encoded by the UCN2 gene.[1][2]

This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.[2]

References

  1. ↑ Hsu SY, Hsueh AJ (Apr 2001). "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor". Nat Med. 7 (5): 605–11. doi:10.1038/87936. PMID 11329063.
  2. ↑ 2.0 2.1 "Entrez Gene: UCN2 urocortin 2".

Further reading



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