ULBP2: Difference between revisions

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Latest revision as of 14:51, 20 May 2016

UL16 binding protein 2 (ULBP2) is a cell surface glycoprotein encoded by ULBP2 gene located on the chromosome 6.^[1]^[2] ULBP2 is related to MHC class I molecules, but its gene maps outside the MHC locus.^[1]^[2] The domain structure of ULBP2 differs significantly from those of conventional MHC class I molecules. It does not contain the α3 domain and the transmembrane segment. ULBP2 is thus composed of only the α1α2 domain which is linked to the cell membrane by the GPI anchor.^[1]^[2] It functions as a stress-induced ligand for NKG2D receptor.^[2]

References

↑ ^1.0 ^1.1 ^1.2 Cosman D, Müllberg J, Sutherland CL, Chin W, Armitage R, Fanslow W, Kubin M, Chalupny NJ (Feb 2001). "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor". Immunity. 14 (2): 123–33. doi:10.1016/S1074-7613(01)00095-4. PMID 11239445.
↑ ^2.0 ^2.1 ^2.2 ^2.3 Radosavljevic M, Cuillerier B, Wilson MJ, Clément O, Wicker S, Gilfillan S, Beck S, Trowsdale J, Bahram S (Jan 2002). "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3". Genomics. 79 (1): 114–23. doi:10.1006/geno.2001.6673. PMID 11827464.

Cerwenka A, Lanier LL (May 2003). "NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer". Tissue Antigens. 61 (5): 335–43. doi:10.1034/j.1399-0039.2003.00070.x. PMID 12753652.
Onda H, Ohkubo S, Shintani Y, Ogi K, Kikuchi K, Tanaka H, Yamamoto K, Tsuji I, Ishibashi Y, Yamada T, Kitada C, Suzuki N, Sawada H, Nishimura O, Fujino M (Jul 2001). "A novel secreted tumor antigen with a glycosylphosphatidylinositol-anchored structure ubiquitously expressed in human cancers". Biochemical and Biophysical Research Communications. 285 (2): 235–43. doi:10.1006/bbrc.2001.5149. PMID 11444831.
Steinle A, Li P, Morris DL, Groh V, Lanier LL, Strong RK, Spies T (2001). "Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family". Immunogenetics. 53 (4): 279–87. doi:10.1007/s002510100325. PMID 11491531.
Sutherland CL, Chalupny NJ, Schooley K, VandenBos T, Kubin M, Cosman D (Jan 2002). "UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells". Journal of Immunology. 168 (2): 671–9. doi:10.4049/jimmunol.168.2.671. PMID 11777960.
Radosavljevic M, Cuillerier B, Wilson MJ, Clément O, Wicker S, Gilfillan S, Beck S, Trowsdale J, Bahram S (Jan 2002). "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3". Genomics. 79 (1): 114–23. doi:10.1006/geno.2001.6673. PMID 11827464.
Dunn C, Chalupny NJ, Sutherland CL, Dosch S, Sivakumar PV, Johnson DC, Cosman D (Jun 2003). "Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity". The Journal of Experimental Medicine. 197 (11): 1427–39. doi:10.1084/jem.20022059. PMC 2193902. PMID 12782710.
Rölle A, Mousavi-Jazi M, Eriksson M, Odeberg J, Söderberg-Nauclér C, Cosman D, Kärre K, Cerboni C (Jul 2003). "Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein". Journal of Immunology. 171 (2): 902–8. doi:10.4049/jimmunol.171.2.902. PMID 12847260.
Eleme K, Taner SB, Onfelt B, Collinson LM, McCann FE, Chalupny NJ, Cosman D, Hopkins C, Magee AI, Davis DM (Apr 2004). "Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D". The Journal of Experimental Medicine. 199 (7): 1005–10. doi:10.1084/jem.20032194. PMC 2211882. PMID 15051759.
Rohner A, Langenkamp U, Siegler U, Kalberer CP, Wodnar-Filipowicz A (Oct 2007). "Differentiation-promoting drugs up-regulate NKG2D ligand expression and enhance the susceptibility of acute myeloid leukemia cells to natural killer cell-mediated lysis". Leukemia Research. 31 (10): 1393–402. doi:10.1016/j.leukres.2007.02.020. PMID 17391757.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[Cosman_2001-1] 1.0 ^1.1 ^1.2 Cosman D, Müllberg J, Sutherland CL, Chin W, Armitage R, Fanslow W, Kubin M, Chalupny NJ (Feb 2001). "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor". Immunity. 14 (2): 123–33. doi:10.1016/S1074-7613(01)00095-4. PMID 11239445.

[Radosavljevic_2002-2] 2.0 ^2.1 ^2.2 ^2.3 Radosavljevic M, Cuillerier B, Wilson MJ, Clément O, Wicker S, Gilfillan S, Beck S, Trowsdale J, Bahram S (Jan 2002). "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3". Genomics. 79 (1): 114–23. doi:10.1006/geno.2001.6673. PMID 11827464.

[1]

[2]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''UL16 binding protein 2 (ULBP2)''' is a cell surface [[glycoprotein]] encoded by ''ULBP2'' gene located on the chromosome 6.<ref name="Cosman_2001">{{cite journal | vauthors = Cosman D, Müllberg J, Sutherland CL, Chin W, Armitage R, Fanslow W, Kubin M, Chalupny NJ | title = ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor | language = English | journal = Immunity | volume = 14 | issue = 2 | pages = 123–33 | date = Feb 2001 | pmid = 11239445 | doi = 10.1016/S1074-7613(01)00095-4 }}</ref><ref name="Radosavljevic_2002">{{cite journal | vauthors = Radosavljevic M, Cuillerier B, Wilson MJ, Clément O, Wicker S, Gilfillan S, Beck S, Trowsdale J, Bahram S | title = A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3 | journal = Genomics | volume = 79 | issue = 1 | pages = 114–23 | date = Jan 2002 | pmid = 11827464 | doi = 10.1006/geno.2001.6673 }}</ref> ULBP2 is related to [[MHC class I]] molecules, but its gene maps outside the MHC locus.<ref name="Cosman_2001" /><ref name="Radosavljevic_2002" /> The domain structure of ULBP2 differs significantly from those of conventional [[MHC class I]] molecules. It does not contain the α3 domain and the transmembrane segment. ULBP2 is thus composed of only the α1α2 domain which is linked to the cell membrane by the [[Glycophosphatidylinositol|GPI anchor]].<ref name="Cosman_2001" /><ref name="Radosavljevic_2002" /> It functions as a [[Induced-self antigen|stress-induced]] ligand for [[NKG2D]] receptor.<ref name="Radosavljevic_2002" />
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== References ==
-{{GNF_Protein_box
+{{reflist}}
- | image =
- | image_source =
- | PDB =
- | Name = UL16 binding protein 2
- | HGNCid = 14894
- | Symbol = ULBP2
- | AltSymbols =; N2DL2; RAET1H
- | OMIM = 605698
- | ECnumber =
- | Homologene = 88904
- | MGIid =
- | GeneAtlas_image1 = PBB_GE_ULBP2_221291_at_tn.png
- | Function = {{GNF_GO|id=GO:0032393 |text = MHC class I receptor activity}} {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
- | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0042612 |text = MHC class I protein complex}}
- | Process = {{GNF_GO|id=GO:0019882 |text = antigen processing and presentation}} {{GNF_GO|id=GO:0030101 |text = natural killer cell activation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 80328
-    | Hs_Ensembl = ENSG00000131015
-    | Hs_RefseqProtein = NP_079493
-    | Hs_RefseqmRNA = NM_025217
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 6
-    | Hs_GenLoc_start = 150304829
-    | Hs_GenLoc_end = 150312064
-    | Hs_Uniprot = Q9BZM5
-    | Mm_EntrezGene =
-    | Mm_Ensembl =
-    | Mm_RefseqmRNA =
-    | Mm_RefseqProtein =
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr =
-    | Mm_GenLoc_start =
-    | Mm_GenLoc_end =
-    | Mm_Uniprot =
-  }}
-}}
-'''UL16 binding protein 2''', also known as '''ULBP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ULBP2 UL16 binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80328| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Further reading ==
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
-==References==
-{{reflist|2}}
-==Further reading==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Cerwenka A, Lanier LL | title = NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer | journal = Tissue Antigens | volume = 61 | issue = 5 | pages = 335–43 | date = May 2003 | pmid = 12753652 | doi = 10.1034/j.1399-0039.2003.00070.x }}
-| citations =
+* {{cite journal | vauthors = Onda H, Ohkubo S, Shintani Y, Ogi K, Kikuchi K, Tanaka H, Yamamoto K, Tsuji I, Ishibashi Y, Yamada T, Kitada C, Suzuki N, Sawada H, Nishimura O, Fujino M | title = A novel secreted tumor antigen with a glycosylphosphatidylinositol-anchored structure ubiquitously expressed in human cancers | journal = Biochemical and Biophysical Research Communications | volume = 285 | issue = 2 | pages = 235–43 | date = Jul 2001 | pmid = 11444831 | doi = 10.1006/bbrc.2001.5149 }}
-*{{cite journal  | author=Cerwenka A, Lanier LL |title=NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer. |journal=Tissue Antigens |volume=61 |issue= 5 |pages= 335-43 |year= 2004 |pmid= 12753652 |doi=  }}
+* {{cite journal | vauthors = Steinle A, Li P, Morris DL, Groh V, Lanier LL, Strong RK, Spies T | title = Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family | journal = Immunogenetics | volume = 53 | issue = 4 | pages = 279–87 | year = 2001 | pmid = 11491531 | doi = 10.1007/s002510100325 }}
-*{{cite journal  | author=Cosman D, Müllberg J, Sutherland CL, ''et al.'' |title=ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. |journal=Immunity |volume=14 |issue= 2 |pages= 123-33 |year= 2001 |pmid= 11239445 |doi=  }}
+* {{cite journal | vauthors = Sutherland CL, Chalupny NJ, Schooley K, VandenBos T, Kubin M, Cosman D | title = UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells | journal = Journal of Immunology | volume = 168 | issue = 2 | pages = 671–9 | date = Jan 2002 | pmid = 11777960 | doi = 10.4049/jimmunol.168.2.671 }}
-*{{cite journal  | author=Onda H, Ohkubo S, Shintani Y, ''et al.'' |title=A novel secreted tumor antigen with a glycosylphosphatidylinositol-anchored structure ubiquitously expressed in human cancers. |journal=Biochem. Biophys. Res. Commun. |volume=285 |issue= 2 |pages= 235-43 |year= 2001 |pmid= 11444831 |doi= 10.1006/bbrc.2001.5149 }}
+* {{cite journal | vauthors = Radosavljevic M, Cuillerier B, Wilson MJ, Clément O, Wicker S, Gilfillan S, Beck S, Trowsdale J, Bahram S | title = A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3 | journal = Genomics | volume = 79 | issue = 1 | pages = 114–23 | date = Jan 2002 | pmid = 11827464 | doi = 10.1006/geno.2001.6673 }}
-*{{cite journal  | author=Steinle A, Li P, Morris DL, ''et al.'' |title=Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family. |journal=Immunogenetics |volume=53 |issue= 4 |pages= 279-87 |year= 2001 |pmid= 11491531 |doi=  }}
+* {{cite journal | vauthors = Dunn C, Chalupny NJ, Sutherland CL, Dosch S, Sivakumar PV, Johnson DC, Cosman D | title = Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity | journal = The Journal of Experimental Medicine | volume = 197 | issue = 11 | pages = 1427–39 | date = Jun 2003 | pmid = 12782710 | pmc = 2193902 | doi = 10.1084/jem.20022059 }}
-*{{cite journal  | author=Sutherland CL, Chalupny NJ, Schooley K, ''et al.'' |title=UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells. |journal=J. Immunol. |volume=168 |issue= 2 |pages= 671-9 |year= 2002 |pmid= 11777960 |doi=  }}
+* {{cite journal | vauthors = Rölle A, Mousavi-Jazi M, Eriksson M, Odeberg J, Söderberg-Nauclér C, Cosman D, Kärre K, Cerboni C | title = Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein | journal = Journal of Immunology | volume = 171 | issue = 2 | pages = 902–8 | date = Jul 2003 | pmid = 12847260 | doi = 10.4049/jimmunol.171.2.902 }}
-*{{cite journal  | author=Radosavljevic M, Cuillerier B, Wilson MJ, ''et al.'' |title=A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3. |journal=Genomics |volume=79 |issue= 1 |pages= 114-23 |year= 2002 |pmid= 11827464 |doi= 10.1006/geno.2001.6673 }}
+* {{cite journal | vauthors = Eleme K, Taner SB, Onfelt B, Collinson LM, McCann FE, Chalupny NJ, Cosman D, Hopkins C, Magee AI, Davis DM | title = Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D | journal = The Journal of Experimental Medicine | volume = 199 | issue = 7 | pages = 1005–10 | date = Apr 2004 | pmid = 15051759 | pmc = 2211882 | doi = 10.1084/jem.20032194 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Rohner A, Langenkamp U, Siegler U, Kalberer CP, Wodnar-Filipowicz A | title = Differentiation-promoting drugs up-regulate NKG2D ligand expression and enhance the susceptibility of acute myeloid leukemia cells to natural killer cell-mediated lysis | journal = Leukemia Research | volume = 31 | issue = 10 | pages = 1393–402 | date = Oct 2007 | pmid = 17391757 | doi = 10.1016/j.leukres.2007.02.020 }}
-*{{cite journal  | author=Dunn C, Chalupny NJ, Sutherland CL, ''et al.'' |title=Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity. |journal=J. Exp. Med. |volume=197 |issue= 11 |pages= 1427-39 |year= 2003 |pmid= 12782710 |doi= 10.1084/jem.20022059 }}
-*{{cite journal  | author=Rölle A, Mousavi-Jazi M, Eriksson M, ''et al.'' |title=Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein. |journal=J. Immunol. |volume=171 |issue= 2 |pages= 902-8 |year= 2003 |pmid= 12847260 |doi=  }}
-*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
-*{{cite journal  | author=Eleme K, Taner SB, Onfelt B, ''et al.'' |title=Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D. |journal=J. Exp. Med. |volume=199 |issue= 7 |pages= 1005-10 |year= 2004 |pmid= 15051759 |doi= 10.1084/jem.20032194 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Rohner A, Langenkamp U, Siegler U, ''et al.'' |title=Differentiation-promoting drugs up-regulate NKG2D ligand expression and enhance the susceptibility of acute myeloid leukemia cells to natural killer cell-mediated lysis. |journal=Leuk. Res. |volume=31 |issue= 10 |pages= 1393-402 |year= 2007 |pmid= 17391757 |doi= 10.1016/j.leukres.2007.02.020 }}
-}}
 {{refend}}
-{{protein-stub}}
+{{gene-6-stub}}
-{{WikiDoc Sources}}

ULBP2: Difference between revisions

Latest revision as of 14:51, 20 May 2016

References

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