USP18: Difference between revisions

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{{Infobox_gene}}
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'''Ubiquitin specific peptidase 18''' ('''USP18'''), also known as '''UBP43''', is an [[isopeptidase]] that in human is encoded by the ''USP18'' gene.<ref name="entrez">{{cite web | title = Entrez Gene: USP18 ubiquitin specific peptidase 18| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11274| accessdate = }}</ref> USP18 is a member of the [[Deubiquitinating enzyme|deubiquitinating protease]] family of enzymes. It is thought to remove [[ISG15]] adducts from a broad range of protein substrates, a process known as deISGylation.<ref name="entrez"/> In mice, deletion of this enzyme results in increased inflammatory response to [[type I interferon]]s, suggesting that USP18 may, in part, regulate interferon responsiveness.<ref>{{Cite web|url=https://www.ncbi.nlm.nih.gov/gene/11274|title=USP18 ubiquitin specific peptidase 18 [Homo sapiens (human)] - Gene - NCBI|website=www.ncbi.nlm.nih.gov|access-date=2018-01-03}}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== References ==
{{GNF_Protein_box
{{reflist}}
| image = 
| image_source = 
| PDB =
| Name = Ubiquitin specific peptidase 18
| HGNCid = 12616
| Symbol = USP18
| AltSymbols =; ISG43; UBP43
| OMIM = 607057
| ECnumber = 
| Homologene = 8047
| MGIid = 1344364
| GeneAtlas_image1 = PBB_GE_USP18_219211_at_tn.png
| Function = {{GNF_GO|id=GO:0004221 |text = ubiquitin thiolesterase activity}} {{GNF_GO|id=GO:0008234 |text = cysteine-type peptidase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11274
    | Hs_Ensembl = ENSG00000184979
    | Hs_RefseqProtein = XP_001128928
    | Hs_RefseqmRNA = XM_001128928
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 17012758
    | Hs_GenLoc_end = 17040158
    | Hs_Uniprot = Q9UMW8
    | Mm_EntrezGene = 24110
    | Mm_Ensembl = ENSMUSG00000030107
    | Mm_RefseqmRNA = XM_001002847
    | Mm_RefseqProtein = XP_001002847
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 121211576
    | Mm_GenLoc_end = 121236536
    | Mm_Uniprot = Q3U7P3
  }}
}}
'''Ubiquitin specific peptidase 18''', also known as '''USP18''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: USP18 ubiquitin specific peptidase 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11274| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Further reading ==
{{PBB_Summary
| section_title =
| summary_text = USP18, a member of the deubiquitinating protease family of enzymes, removes ubiquitin adducts from a broad range of protein substrates.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: USP18 ubiquitin specific peptidase 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11274| accessdate = }}</ref>
}}
 
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Li XL, Blackford JA, Judge CS, Liu M, Xiao W, Kalvakolanu DV, Hassel BA | title = RNase-L-dependent destabilization of interferon-induced mRNAs. A role for the 2-5A system in attenuation of the interferon response | journal = The Journal of Biological Chemistry | volume = 275 | issue = 12 | pages = 8880–8 | date = March 2000 | pmid = 10722734 | doi = 10.1074/jbc.275.12.8880 }}
| citations =
* {{cite journal | vauthors = Schwer H, Liu LQ, Zhou L, Little MT, Pan Z, Hetherington CJ, Zhang DE | title = Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18) | journal = Genomics | volume = 65 | issue = 1 | pages = 44–52 | date = April 2000 | pmid = 10777664 | doi = 10.1006/geno.2000.6148 }}
*{{cite journal  | author=Puente XS, Sánchez LM, Overall CM, López-Otín C |title=Human and mouse proteases: a comparative genomic approach. |journal=Nat. Rev. Genet. |volume=4 |issue= 7 |pages= 544-58 |year= 2003 |pmid= 12838346 |doi= 10.1038/nrg1111 }}
* {{cite journal | vauthors = Kang D, Jiang H, Wu Q, Pestka S, Fisher PB | title = Cloning and characterization of human ubiquitin-processing protease-43 from terminally differentiated human melanoma cells using a rapid subtraction hybridization protocol RaSH | journal = Gene | volume = 267 | issue = 2 | pages = 233–42 | date = April 2001 | pmid = 11313150 | doi = 10.1016/S0378-1119(01)00384-5 }}
*{{cite journal | author=Li XL, Blackford JA, Judge CS, ''et al.'' |title=RNase-L-dependent destabilization of interferon-induced mRNAs. A role for the 2-5A system in attenuation of the interferon response. |journal=J. Biol. Chem. |volume=275 |issue= 12 |pages= 8880-8 |year= 2000 |pmid= 10722734 |doi= }}
* {{cite journal | vauthors = Malakhov MP, Malakhova OA, Kim KI, Ritchie KJ, Zhang DE | title = UBP43 (USP18) specifically removes ISG15 from conjugated proteins | journal = The Journal of Biological Chemistry | volume = 277 | issue = 12 | pages = 9976–81 | date = March 2002 | pmid = 11788588 | doi = 10.1074/jbc.M109078200 }}
*{{cite journal | author=Schwer H, Liu LQ, Zhou L, ''et al.'' |title=Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18). |journal=Genomics |volume=65 |issue= 1 |pages= 44-52 |year= 2000 |pmid= 10777664 |doi= 10.1006/geno.2000.6148 }}
* {{cite journal | vauthors = Tokarz S, Berset C, La Rue J, Friedman K, Nakayama K, Nakayama K, Zhang DE, Lanker S | title = The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase | journal = The Journal of Biological Chemistry | volume = 279 | issue = 45 | pages = 46424–30 | date = November 2004 | pmid = 15342634 | doi = 10.1074/jbc.M403189200 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = October 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
* {{cite journal | vauthors = Yan M, Luo JK, Ritchie KJ, Sakai I, Takeuchi K, Ren R, Zhang DE | title = Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling | journal = Blood | volume = 110 | issue = 1 | pages = 305–12 | date = July 2007 | pmid = 17374743 | pmc = 1896118 | doi = 10.1182/blood-2006-07-033209 }}
*{{cite journal  | author=Kang D, Jiang H, Wu Q, ''et al.'' |title=Cloning and characterization of human ubiquitin-processing protease-43 from terminally differentiated human melanoma cells using a rapid subtraction hybridization protocol RaSH. |journal=Gene |volume=267 |issue= 2 |pages= 233-42 |year= 2001 |pmid= 11313150 |doi= }}
* {{cite journal | vauthors = Ketscher L, Hannß R, Morales DJ, Basters A, Guerra S, Goldmann T, Hausmann A, Prinz M, Naumann R, Pekosz A, Utermöhlen O, Lenschow DJ, Knobeloch KP | title = Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 112 | issue = 5 | pages = 1577–82 | date = February 2015 | pmid = 25605921 | pmc = 4321242 | doi = 10.1073/pnas.1412881112 | url = https://repositorio.uam.es/bitstream/10486/672352/1/selective_ketscher_PNAS_2015.pdf }}
*{{cite journal | author=Malakhov MP, Malakhova OA, Kim KI, ''et al.'' |title=UBP43 (USP18) specifically removes ISG15 from conjugated proteins. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 9976-81 |year= 2002 |pmid= 11788588 |doi= 10.1074/jbc.M109078200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Tokarz S, Berset C, La Rue J, ''et al.'' |title=The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 46424-30 |year= 2004 |pmid= 15342634 |doi= 10.1074/jbc.M403189200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal  | author=Yan M, Luo JK, Ritchie KJ, ''et al.'' |title=Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling. |journal=Blood |volume=110 |issue= 1 |pages= 305-12 |year= 2007 |pmid= 17374743 |doi= 10.1182/blood-2006-07-033209 }}
}}
{{refend}}
{{refend}}
[[Category:Enzymes]]


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Latest revision as of 12:26, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ubiquitin specific peptidase 18 (USP18), also known as UBP43, is an isopeptidase that in human is encoded by the USP18 gene.[1] USP18 is a member of the deubiquitinating protease family of enzymes. It is thought to remove ISG15 adducts from a broad range of protein substrates, a process known as deISGylation.[1] In mice, deletion of this enzyme results in increased inflammatory response to type I interferons, suggesting that USP18 may, in part, regulate interferon responsiveness.[2]

References

  1. ↑ 1.0 1.1 "Entrez Gene: USP18 ubiquitin specific peptidase 18".
  2. ↑ "USP18 ubiquitin specific peptidase 18 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2018-01-03.

Further reading

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