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'''USP26''' is a [[peptidase]] enzyme. | '''USP26''' is a [[peptidase]] enzyme. The USP26 gene is an X-linked gene exclusively expressed in the testis and it codes for the ubiquitin-specific protease 26.<ref name=Possible>{{cite journal | vauthors = Stouffs K, Lissens W, Tournaye H, Van Steirteghem A, Liebaers I | title = Possible role of USP26 in patients with severely impaired spermatogenesis | journal = European Journal of Human Genetics | volume = 13 | issue = 3 | pages = 336–40 | date = March 2005 | pmid = 15562280 | doi = 10.1038/sj.ejhg.5201335 }}</ref> The USP26 gene is found at Xq26.2 on the X-chromosome as a single exon. The enzyme that this gene encodes comprises 913 amino acid residues and it is 104 kilodalton in size, which is transcribed from a sequence of 2794 nucleotide base-pairs on the X-chromosome.<ref>{{cite journal | vauthors = Liu YL, Zheng J, Mi YJ, Zhao J, Tian QB | title = The impacts of nineteen mutations on the enzymatic activity of USP26 | journal = Gene | volume = 641 | pages = 292–296 | date = January 2018 | pmid = 29111204 | doi = 10.1016/j.gene.2017.10.074 | url = http://dx.doi.org/10.1016/j.gene.2017.10.074 }}</ref> The USP26 enzyme is a [[deubiquitinating enzyme]] that places a very significant role in the regulation of protein turnover during spermatogenesis. It is a testis-specific enzyme that is solely express in spermatogonia and can prevent the degradation of ubiquitinated USP26 substrates.<ref>{{Cite journal|last=Lahav-Baratz|first=Shirly|last2=Kravtsova-Ivantsiv|first2=Yelena|last3=Golan|first3=Shay|last4=Ciechanover|first4=Aaron|date=January 2017|title=The testis-specific USP26 is a deubiquitinating enzyme of the ubiquitin ligase Mdm2|url=http://dx.doi.org/10.1016/j.bbrc.2016.10.135|journal=Biochemical and Biophysical Research Communications|volume=482|issue=1|pages=106–111|doi=10.1016/j.bbrc.2016.10.135|issn=0006-291X|via=}}</ref> | ||
Recent research has suggested that defects in USP26 may be involved in some cases of [[male infertility]] | Recent research has suggested that defects in USP26 may be involved in some cases of [[male infertility]],<ref name=Possible /><ref name="pmid17968467">{{cite journal | vauthors = Zhang J, Qiu SD, Li SB, Zhou DX, Tian H, Huo YW, Ge L, Zhang QY | title = Novel mutations in ubiquitin-specific protease 26 gene might cause spermatogenesis impairment and male infertility | journal = Asian Journal of Andrology | volume = 9 | issue = 6 | pages = 809–14 | date = November 2007 | pmid = 17968467 | doi = 10.1111/j.1745-7262.2007.00305.x }}</ref> specifically Sertoli cell-only syndrome, and an absence of sperm in the ejaculate (azoospermia).<ref name=Haplotypes>{{cite journal | vauthors = Ravel C, El Houate B, Chantot S, Lourenço D, Dumaine A, Rouba H, Bandyopadahyay A, Radhakrishna U, Das B, Sengupta S, Mandelbaum J, Siffroi JP, McElreavey K | title = Haplotypes, mutations and male fertility: the story of the testis-specific ubiquitin protease USP26 | journal = Molecular Human Reproduction | volume = 12 | issue = 10 | pages = 643–6 | date = October 2006 | pmid = 16888075 | doi = 10.1093/molehr/gal063 }}</ref> | ||
== | == See also == | ||
*[[Male infertility]] | |||
==External links== | == References == | ||
{{reflist}} | |||
== External links == | |||
* {{MeshName|USP26+protein,+human}} | * {{MeshName|USP26+protein,+human}} | ||
{{biochem-stub}} | {{biochem-stub}} | ||
Latest revision as of 10:48, 12 January 2019
| ubiquitin specific peptidase 26 | |
|---|---|
| Identifiers | |
| Symbol | USP26 |
| Entrez | 83844 |
| HUGO | 13485 |
| OMIM | 300309 |
| RefSeq | NM_031907 |
| UniProt | Q9BXU7 |
| Other data | |
| EC number | 3.1.2.15 |
| Locus | Chr. X q26.2 |
USP26 is a peptidase enzyme. The USP26 gene is an X-linked gene exclusively expressed in the testis and it codes for the ubiquitin-specific protease 26.[1] The USP26 gene is found at Xq26.2 on the X-chromosome as a single exon. The enzyme that this gene encodes comprises 913 amino acid residues and it is 104 kilodalton in size, which is transcribed from a sequence of 2794 nucleotide base-pairs on the X-chromosome.[2] The USP26 enzyme is a deubiquitinating enzyme that places a very significant role in the regulation of protein turnover during spermatogenesis. It is a testis-specific enzyme that is solely express in spermatogonia and can prevent the degradation of ubiquitinated USP26 substrates.[3]
Recent research has suggested that defects in USP26 may be involved in some cases of male infertility,[1][4] specifically Sertoli cell-only syndrome, and an absence of sperm in the ejaculate (azoospermia).[5]
See also
References
- ↑ 1.0 1.1 Stouffs K, Lissens W, Tournaye H, Van Steirteghem A, Liebaers I (March 2005). "Possible role of USP26 in patients with severely impaired spermatogenesis". European Journal of Human Genetics. 13 (3): 336–40. doi:10.1038/sj.ejhg.5201335. PMID 15562280.
- ↑ Liu YL, Zheng J, Mi YJ, Zhao J, Tian QB (January 2018). "The impacts of nineteen mutations on the enzymatic activity of USP26". Gene. 641: 292–296. doi:10.1016/j.gene.2017.10.074. PMID 29111204.
- ↑ Lahav-Baratz, Shirly; Kravtsova-Ivantsiv, Yelena; Golan, Shay; Ciechanover, Aaron (January 2017). "The testis-specific USP26 is a deubiquitinating enzyme of the ubiquitin ligase Mdm2". Biochemical and Biophysical Research Communications. 482 (1): 106–111. doi:10.1016/j.bbrc.2016.10.135. ISSN 0006-291X.
- ↑ Zhang J, Qiu SD, Li SB, Zhou DX, Tian H, Huo YW, Ge L, Zhang QY (November 2007). "Novel mutations in ubiquitin-specific protease 26 gene might cause spermatogenesis impairment and male infertility". Asian Journal of Andrology. 9 (6): 809–14. doi:10.1111/j.1745-7262.2007.00305.x. PMID 17968467.
- ↑ Ravel C, El Houate B, Chantot S, Lourenço D, Dumaine A, Rouba H, Bandyopadahyay A, Radhakrishna U, Das B, Sengupta S, Mandelbaum J, Siffroi JP, McElreavey K (October 2006). "Haplotypes, mutations and male fertility: the story of the testis-specific ubiquitin protease USP26". Molecular Human Reproduction. 12 (10): 643–6. doi:10.1093/molehr/gal063. PMID 16888075.
External links
- USP26+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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