VARS: Difference between revisions

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{{other uses|Vars (disambiguation)}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Valyl-tRNA synthetase''' is an [[enzyme]] that in humans is encoded by the ''VARS'' [[gene]].<ref name="pmid15779907">{{cite journal | vauthors = Bonnefond L, Fender A, Rudinger-Thirion J, Giegé R, Florentz C, Sissler M | title = Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS | journal = Biochemistry | volume = 44 | issue = 12 | pages = 4805–16 | date = March 2005 | pmid = 15779907 | pmc =  | doi = 10.1021/bi047527z }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: VARS valyl-tRNA synthetase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7407| accessdate = }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Valyl-tRNA synthetase
| HGNCid = 12651
| Symbol = VARS
| AltSymbols =; G7A; VARS2
| OMIM = 192150
| ECnumber = 
| Homologene = 4587
| MGIid = 90675
| GeneAtlas_image1 = PBB_GE_VARS_201797_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_VARS_201796_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004832 |text = valine-tRNA ligase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0006414 |text = translational elongation}} {{GNF_GO|id=GO:0006438 |text = valyl-tRNA aminoacylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7407
    | Hs_Ensembl = ENSG00000096171
    | Hs_RefseqProtein = XP_001133527
    | Hs_RefseqmRNA = XM_001133527
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = c6_COX
    | Hs_GenLoc_start = 31879916
    | Hs_GenLoc_end = 31898129
    | Hs_Uniprot = P26640
    | Mm_EntrezGene = 22321
    | Mm_Ensembl = ENSMUSG00000007029
    | Mm_RefseqmRNA = NM_011690
    | Mm_RefseqProtein = NP_035820
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 34609189
    | Mm_GenLoc_end = 34624382
    | Mm_Uniprot = Q3TII4
  }}
}}
'''Valyl-tRNA synthetase''', also known as '''VARS''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: VARS valyl-tRNA synthetase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7407| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Aminoacyl-tRNA synthetase]]s catalyze the aminoacylation of [[tRNA]] by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the [[major histocompatibility complex]].<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex.<ref name="entrez">{{cite web | title = Entrez Gene: VARS valyl-tRNA synthetase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7407| accessdate = }}</ref>
}}


==References==
== See also ==
{{reflist|2}}
*[[Valine-tRNA ligase]]
==Further reading==
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hsieh SL, Campbell RD | title = Evidence that gene G7a in the human major histocompatibility complex encodes valyl-tRNA synthetase | journal = The Biochemical Journal | volume = 278 ( Pt 3) | issue = 3 | pages = 809–16 | date = September 1991 | pmid = 1898367 | pmc = 1151418 | doi =  }}
| citations =
* {{cite journal | vauthors = Sargent CA, Dunham I, Campbell RD | title = Identification of multiple HTF-island associated genes in the human major histocompatibility complex class III region | journal = The EMBO Journal | volume = 8 | issue = 8 | pages = 2305–12 | date = August 1989 | pmid = 2477242 | pmc = 401163 | doi =  }}
*{{cite journal | author=Hsieh SL, Campbell RD |title=Evidence that gene G7a in the human major histocompatibility complex encodes valyl-tRNA synthetase. |journal=Biochem. J. |volume=278 ( Pt 3) |issue= |pages= 809-16 |year= 1991 |pmid= 1898367 |doi=  }}
* {{cite journal | vauthors = Bec G, Kerjan P, Zha XD, Waller JP | title = Valyl-tRNA synthetase from rabbit liver. I. Purification as a heterotypic complex in association with elongation factor 1 | journal = The Journal of Biological Chemistry | volume = 264 | issue = 35 | pages = 21131–7 | date = December 1989 | pmid = 2556394 | doi =  }}
*{{cite journal | author=Sargent CA, Dunham I, Campbell RD |title=Identification of multiple HTF-island associated genes in the human major histocompatibility complex class III region. |journal=EMBO J. |volume=8 |issue= 8 |pages= 2305-12 |year= 1989 |pmid= 2477242 |doi=  }}
* {{cite journal | vauthors = Wolfson AD, Orlovsky AF, Gladilin KL | title = Mammalian valyl-tRNA synthetase forms a complex with the first elongation factor | journal = FEBS Letters | volume = 238 | issue = 2 | pages = 262–4 | date = October 1988 | pmid = 3169261 | doi = 10.1016/0014-5793(88)80492-7 }}
*{{cite journal | author=Bec G, Kerjan P, Zha XD, Waller JP |title=Valyl-tRNA synthetase from rabbit liver. I. Purification as a heterotypic complex in association with elongation factor 1. |journal=J. Biol. Chem. |volume=264 |issue= 35 |pages= 21131-7 |year= 1990 |pmid= 2556394 |doi=  }}
* {{cite journal | vauthors = Bec G, Kerjan P, Waller JP | title = Reconstitution in vitro of the valyl-tRNA synthetase-elongation factor (EF) 1 beta gamma delta complex. Essential roles of the NH2-terminal extension of valyl-tRNA synthetase and of the EF-1 delta subunit in complex formation | journal = The Journal of Biological Chemistry | volume = 269 | issue = 3 | pages = 2086–92 | date = January 1994 | pmid = 8294461 | doi =  }}
*{{cite journal | author=Motorin YuA , Wolfson AD, Orlovsky AF, Gladilin KL |title=Mammalian valyl-tRNA synthetase forms a complex with the first elongation factor. |journal=FEBS Lett. |volume=238 |issue= 2 |pages= 262-4 |year= 1988 |pmid= 3169261 |doi= }}
* {{cite journal | vauthors = Vilalta A, Donovan D, Wood L, Vogeli G, Yang DC | title = Cloning, sequencing and expression of a cDNA encoding mammalian valyl-tRNA synthetase | journal = Gene | volume = 123 | issue = 2 | pages = 181–6 | date = January 1993 | pmid = 8428657 | doi = 10.1016/0378-1119(93)90122-J }}
*{{cite journal | author=Bec G, Kerjan P, Waller JP |title=Reconstitution in vitro of the valyl-tRNA synthetase-elongation factor (EF) 1 beta gamma delta complex. Essential roles of the NH2-terminal extension of valyl-tRNA synthetase and of the EF-1 delta subunit in complex formation. |journal=J. Biol. Chem. |volume=269 |issue= 3 |pages= 2086-92 |year= 1994 |pmid= 8294461 |doi=  }}
* {{cite journal | vauthors = Motorin Y | title = Two human valyl-tRNA synthetase-encoding cDNA sequences deposited in GenBank display extensive differences | journal = Gene | volume = 170 | issue = 2 | pages = 289–91 | date = May 1996 | pmid = 8666263 | doi = 10.1016/0378-1119(96)84699-3 }}
*{{cite journal | author=Vilalta A, Donovan D, Wood L, ''et al.'' |title=Cloning, sequencing and expression of a cDNA encoding mammalian valyl-tRNA synthetase. |journal=Gene |volume=123 |issue= 2 |pages= 181-6 |year= 1993 |pmid= 8428657 |doi= }}
* {{cite journal | vauthors = Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, Campbell RD, Hood L | title = Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse | journal = Genome Research | volume = 13 | issue = 12 | pages = 2621–36 | date = December 2003 | pmid = 14656967 | pmc = 403804 | doi = 10.1101/gr.1736803 }}
*{{cite journal | author=Motorin Y |title=Two human valyl-tRNA synthetase-encoding cDNA sequences deposited in GenBank display extensive differences. |journal=Gene |volume=170 |issue= 2 |pages= 289-91 |year= 1996 |pmid= 8666263 |doi=  }}
* {{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nature Cell Biology | volume = 6 | issue = 2 | pages = 97–105 | date = February 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
* {{cite journal | vauthors = Jiang S, Wolfe CL, Warrington JA, Norcum MT | title = Three-dimensional reconstruction of the valyl-tRNA synthetase/elongation factor-1H complex and localization of the delta subunit | journal = FEBS Letters | volume = 579 | issue = 27 | pages = 6049–54 | date = November 2005 | pmid = 16229838 | doi = 10.1016/j.febslet.2005.09.062 }}
*{{cite journal | author=Xie T, Rowen L, Aguado B, ''et al.'' |title=Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. |journal=Genome Res. |volume=13 |issue= 12 |pages= 2621-36 |year= 2004 |pmid= 14656967 |doi= 10.1101/gr.1736803 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Bonnefond L, Fender A, Rudinger-Thirion J, ''et al.'' |title=Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. |journal=Biochemistry |volume=44 |issue= 12 |pages= 4805-16 |year= 2005 |pmid= 15779907 |doi= 10.1021/bi047527z }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Jiang S, Wolfe CL, Warrington JA, Norcum MT |title=Three-dimensional reconstruction of the valyl-tRNA synthetase/elongation factor-1H complex and localization of the delta subunit. |journal=FEBS Lett. |volume=579 |issue= 27 |pages= 6049-54 |year= 2005 |pmid= 16229838 |doi= 10.1016/j.febslet.2005.09.062 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 15:28, 17 September 2017

For other uses, see Vars (disambiguation).
VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Valyl-tRNA synthetase is an enzyme that in humans is encoded by the VARS gene.[1][2]

Function

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex.[2]

See also

References

  1. ↑ Bonnefond L, Fender A, Rudinger-Thirion J, Giegé R, Florentz C, Sissler M (March 2005). "Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS". Biochemistry. 44 (12): 4805–16. doi:10.1021/bi047527z. PMID 15779907.
  2. ↑ 2.0 2.1 "Entrez Gene: VARS valyl-tRNA synthetase".

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=VARS&oldid=1421089"