Vesicle-associated membrane protein 8: Difference between revisions

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{{Infobox_gene}}
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'''Vesicle-associated membrane protein 8''' is a [[protein]] that in humans is encoded by the ''VAMP8'' [[gene]].<ref name="pmid9878266">{{cite journal |vauthors=Bui TD, Wong SH, Lu L, Hong W | title = Endobrevin maps to chromosome 2 in human and chromosome 6 in mouse | journal = Genomics | volume = 54 | issue = 3 | pages = 579–80 |date=February 1999 | pmid = 9878266 | pmc =  | doi = 10.1006/geno.1998.5596 }}</ref><ref name="pmid9614193">{{cite journal |vauthors=Wong SH, Zhang T, Xu Y, Subramaniam VN, Griffiths G, Hong W | title = Endobrevin, a Novel Synaptobrevin/VAMP-Like Protein Preferentially Associated with the Early Endosome | journal = Mol Biol Cell | volume = 9 | issue = 6 | pages = 1549–63 |date=July 1998 | pmid = 9614193 | pmc = 25382 | doi =  10.1091/mbc.9.6.1549}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: VAMP8 vesicle-associated membrane protein 8 (endobrevin)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8673| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_VAMP8_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gl2.
| PDB = {{PDB2|1gl2}}
| Name = Vesicle-associated membrane protein 8 (endobrevin)
| HGNCid = 12647
| Symbol = VAMP8
| AltSymbols =; EDB; VAMP5
| OMIM = 603177
| ECnumber =
| Homologene = 37846
| MGIid = 1336882
  | GeneAtlas_image1 = PBB_GE_VAMP8_202546_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}  
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005769 |text = early endosome}} {{GNF_GO|id=GO:0008021 |text = synaptic vesicle}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006904 |text = vesicle docking during exocytosis}} {{GNF_GO|id=GO:0016192 |text = vesicle-mediated transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8673
    | Hs_Ensembl = ENSG00000118640
    | Hs_RefseqProtein = NP_003752
    | Hs_RefseqmRNA = NM_003761
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 85658228
    | Hs_GenLoc_end = 85662664
    | Hs_Uniprot = Q9BV40
    | Mm_EntrezGene = 22320
    | Mm_Ensembl = ENSMUSG00000050732
    | Mm_RefseqmRNA = NM_016794
    | Mm_RefseqProtein = NP_058074
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 72315019
    | Mm_GenLoc_end = 72317929
    | Mm_Uniprot = Q3V4C2
  }}
}}
'''Vesicle-associated membrane protein 8 (endobrevin)''', also known as '''VAMP8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: VAMP8 vesicle-associated membrane protein 8 (endobrevin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8673| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =
| summary_text = Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. It is associated with the perinuclear vesicular structures of the early endocytic compartment. It has been found that VAMP8 interacts specifically with the soluble NSF-attachment protein (alpha-SNAP), most likely through an VAMP8-containing SNARE complex.<ref name="entrez">{{cite web | title = Entrez Gene: VAMP8 vesicle-associated membrane protein 8 (endobrevin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8673| accessdate = }}</ref>
| summary_text = Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. It is associated with the perinuclear vesicular structures of the early endocytic compartment. It has been found that VAMP8 interacts specifically with the soluble NSF-attachment protein (alpha-SNAP), most likely through an VAMP8-containing SNARE complex.<ref name="entrez" /> Phosphorylation of VAMP8 inside the conserved SNARE-domain can suppress vesicle fusion.<ref name="pmid27402227">{{cite journal |vauthors=Malmersjö S, Di Palma S, Diao J, Lai Y, Pfuetzner RA, Wang AL, McMahon MA, Hayer A, Porteus M, Bodenmiller B, Brunger AT, Meyer T | title = Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion | journal = EMBO Journal | volume = 35 | issue = 16 | pages = 1721–1843 |date=July 2016 | pmid = 27402227 | pmc = 5010044 | doi = 10.15252/embj.201694071 }}</ref>
}}
}}
==Interactions==
Vesicle-associated membrane protein 8 has been shown to [[Protein-protein interaction|interact]] with [[STX4]],<ref name=pmid10820264>{{cite journal |last=Paumet |first=F |authorlink= |author2=Le Mao J |author3=Martin S |author4=Galli T |author5=David B |author6=Blank U |author7=Roa M  |date=June 2000 |title=Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment |journal=J. Immunol. |volume=164 |issue=11 |pages=5850–7 | issn = 0022-1767| pmid = 10820264 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | doi=10.4049/jimmunol.164.11.5850}}</ref><ref name=pmid12130530>{{cite journal |last=Polgár |first=János |authorlink= |author2=Chung Sul-Hee |author3=Reed Guy L  |date=August 2002 |title=Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion |journal=Blood |volume=100 |issue=3 |pages=1081–3 | issn = 0006-4971| pmid = 12130530 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1182/blood.V100.3.1081 }}</ref> [[SNAP23]],<ref name=pmid10820264/><ref name=pmid12828989>{{cite journal |last=Imai |first=Akane |authorlink= |author2=Nashida Tomoko |author3=Yoshie Sumio |author4=Shimomura Hiromi  |date=August 2003 |title=Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane |journal=Arch. Oral Biol. |volume=48 |issue=8 |pages=597–604 | issn = 0003-9969| pmid = 12828989 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0003-9969(03)00116-X }}</ref> [[STX1A]],<ref name=pmid11112705>{{cite journal |last=Nagamatsu |first=S |authorlink= |author2=Nakamichi Y |author3=Watanabe T |author4=Matsushima S |author5=Yamaguchi S |author6=Ni J |author7=Itagaki E |author8=Ishida H  |date=January 2001 |title=Localization of cellubrevin-related peptide, endobrevin, in the early endosome in pancreatic beta cells and its physiological function in exo-endocytosis of secretory granules |journal=J. Cell Sci. |volume=114 |issue=Pt 1 |pages=219–227 | issn = 0021-9533| pmid = 11112705 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[STX8]]<ref name=pmid11101518>{{cite journal |last=Antonin |first=W |authorlink= |author2=Holroyd C |author3=Fasshauer D |author4=Pabst S |author5=Von Mollard G F |author6=Jahn R  |date=Dec 2000 |title=A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function |journal=EMBO J. |volume=19 |issue=23 |pages=6453–64 | issn = 0261-4189| pmid = 11101518 |doi = 10.1093/emboj/19.23.6453 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=305878 }}</ref> and [[STX7]].<ref name=pmid11101518/><ref name=pmid11278762>{{cite journal |last=Wade |first=N |authorlink= |author2=Bryant N J |author3=Connolly L M |author4=Simpson R J |author5=Luzio J P |author6=Piper R C |author7=James D E  |date=June 2001 |title=Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells |journal=J. Biol. Chem. |volume=276 |issue=23 |pages=19820–7 | issn = 0021-9258| pmid = 11278762 |doi = 10.1074/jbc.M010838200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{Reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{Refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Wong SH, Zhang T, Xu Y, ''et al.'' |title=Endobrevin, a novel synaptobrevin/VAMP-like protein preferentially associated with the early endosome. |journal=Mol. Biol. Cell |volume=9 |issue= 6 |pages= 1549-63 |year= 1998 |pmid= 9614193 |doi= }}
*{{cite journal  | author=Fasshauer D |title=Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties |journal=J. Biol. Chem. |volume=274 |issue= 22 |pages= 15440–6 |year= 1999 |pmid= 10336434 |doi=10.1074/jbc.274.22.15440 |name-list-format=vanc| author2=Antonin W | author3=Margittai M  | display-authors=3  | last4=Pabst  | first4=S  | last5=Jahn  | first5=R  }}
*{{cite journal | author=Bui TD, Wong SH, Lu L, Hong W |title=Endobrevin maps to chromosome 2 in human and chromosome 6 in mouse. |journal=Genomics |volume=54 |issue= 3 |pages= 579-80 |year= 1999 |pmid= 9878266 |doi= 10.1006/geno.1998.5596 }}
*{{cite journal  | author=Kim PK |title=Identification of the endoplasmic reticulum targeting signal in vesicle-associated membrane proteins |journal=J. Biol. Chem. |volume=274 |issue= 52 |pages= 36876–82 |year= 2000 |pmid= 10601239 |doi=10.1074/jbc.274.52.36876 |name-list-format=vanc| author2=Hollerbach C | author3=Trimble WS | display-authors=3  | last4=Leber  | first4=B  | last5=Andrews  | first5=DW }}
*{{cite journal  | author=Fasshauer D, Antonin W, Margittai M, ''et al.'' |title=Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties. |journal=J. Biol. Chem. |volume=274 |issue= 22 |pages= 15440-6 |year= 1999 |pmid= 10336434 |doi=  }}
*{{cite journal  | author=Paumet F |title=Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment |journal=J. Immunol. |volume=164 |issue= 11 |pages= 5850–7 |year= 2000 |pmid= 10820264 |doi=  10.4049/jimmunol.164.11.5850|name-list-format=vanc| author2=Le Mao J | author3=Martin S  | display-authors=3  | last4=Galli  | first4=T  | last5=David  | first5=B  | last6=Blank  | first6=U  | last7=Roa  | first7=M }}
*{{cite journal  | author=Kim PK, Hollerbach C, Trimble WS, ''et al.'' |title=Identification of the endoplasmic reticulum targeting signal in vesicle-associated membrane proteins. |journal=J. Biol. Chem. |volume=274 |issue= 52 |pages= 36876-82 |year= 2000 |pmid= 10601239 |doi=  }}
*{{cite journal  | author=Antonin W |title=The R-SNARE Endobrevin/VAMP-8 Mediates Homotypic Fusion of Early Endosomes and Late Endosomes |journal=Mol. Biol. Cell |volume=11 |issue= 10 |pages= 3289–98 |year= 2000 |pmid= 11029036 |doi= 10.1091/mbc.11.10.3289| pmc=14992 |name-list-format=vanc| author2=Holroyd C  | author3=Tikkanen R  | display-authors=3  | last4=Höning  | first4=S  | last5=Jahn  | first5=R }}
*{{cite journal  | author=Paumet F, Le Mao J, Martin S, ''et al.'' |title=Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment. |journal=J. Immunol. |volume=164 |issue= 11 |pages= 5850-7 |year= 2000 |pmid= 10820264 |doi=  }}
*{{cite journal  | author=Antonin W |title=A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function |journal=EMBO J. |volume=19 |issue= 23 |pages= 6453–64 |year= 2001 |pmid= 11101518 |doi= 10.1093/emboj/19.23.6453  | pmc=305878  |name-list-format=vanc| author2=Holroyd C | author3=Fasshauer D | display-authors=3  | last4=Pabst  | first4=S  | last5=Von Mollard  | first5=GF  | last6=Jahn  | first6=R }}
*{{cite journal | author=Antonin W, Holroyd C, Tikkanen R, ''et al.'' |title=The R-SNARE endobrevin/VAMP-8 mediates homotypic fusion of early endosomes and late endosomes. |journal=Mol. Biol. Cell |volume=11 |issue= 10 |pages= 3289-98 |year= 2000 |pmid= 11029036 |doi=  }}
*{{cite journal  | author=Nagamatsu S |title=Localization of cellubrevin-related peptide, endobrevin, in the early endosome in pancreatic beta cells and its physiological function in exo-endocytosis of secretory granules |journal=J. Cell Sci. |volume=114 |issue= Pt 1 |pages= 219–227 |year= 2001 |pmid= 11112705 |doi=  |name-list-format=vanc| author2=Nakamichi Y  | author3=Watanabe T  | display-authors=3  | last4=Matsushima  | first4=S  | last5=Yamaguchi  | first5=S | last6=Ni  | first6=J  | last7=Itagaki  | first7=E  | last8=Ishida  | first8=H  }}
*{{cite journal  | author=Antonin W, Holroyd C, Fasshauer D, ''et al.'' |title=A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function. |journal=EMBO J. |volume=19 |issue= 23 |pages= 6453-64 |year= 2001 |pmid= 11101518 |doi= 10.1093/emboj/19.23.6453 }}
*{{cite journal  | author=Wade N |title=Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 19820–7 |year= 2001 |pmid= 11278762 |doi= 10.1074/jbc.M010838200 |name-list-format=vanc| author2=Bryant NJ  | author3=Connolly LM  | display-authors=3  | last4=Simpson  | first4=RJ  | last5=Luzio  | first5=JP  | last6=Piper  | first6=RC  | last7=James  | first7=DE }}
*{{cite journal | author=Nagamatsu S, Nakamichi Y, Watanabe T, ''et al.'' |title=Localization of cellubrevin-related peptide, endobrevin, in the early endosome in pancreatic beta cells and its physiological function in exo-endocytosis of secretory granules. |journal=J. Cell. Sci. |volume=114 |issue= Pt 1 |pages= 219-227 |year= 2001 |pmid= 11112705 |doi=  }}
*{{cite journal  | author=Antonin W |title=Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs |journal=Nat. Struct. Biol. |volume=9 |issue= 2 |pages= 107–11 |year= 2002 |pmid= 11786915 |doi= 10.1038/nsb746 |name-list-format=vanc| author2=Fasshauer D  | author3=Becker S  | display-authors=3  | last4=Jahn | first4=Reinhard  | last5=Schneider  | first5=Thomas R. }}
*{{cite journal  | author=Wade N, Bryant NJ, Connolly LM, ''et al.'' |title=Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells. |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 19820-7 |year= 2001 |pmid= 11278762 |doi= 10.1074/jbc.M010838200 }}
*{{cite journal  |vauthors=Polgár J, Chung SH, Reed GL |title=Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion |journal=Blood |volume=100 |issue= 3 |pages= 1081–3 |year= 2002 |pmid= 12130530 |doi=10.1182/blood.V100.3.1081  }}
*{{cite journal | author=Antonin W, Fasshauer D, Becker S, ''et al.'' |title=Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs. |journal=Nat. Struct. Biol. |volume=9 |issue= 2 |pages= 107-11 |year= 2002 |pmid= 11786915 |doi= 10.1038/nsb746 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M}}
*{{cite journal  | author=Polgár J, Chung SH, Reed GL |title=Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion. |journal=Blood |volume=100 |issue= 3 |pages= 1081-3 |year= 2002 |pmid= 12130530 |doi= }}
*{{cite journal  |vauthors=Imai A, Nashida T, Yoshie S, Shimomura H |title=Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane |journal=Arch. Oral Biol. |volume=48 |issue= 8 |pages= 597–604 |year= 2003 |pmid= 12828989 |doi=10.1016/S0003-9969(03)00116-X  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Imai A, Nashida T, Yoshie S, Shimomura H |title=Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane. |journal=Arch. Oral Biol. |volume=48 |issue= 8 |pages= 597-604 |year= 2003 |pmid= 12828989 |doi= }}
*{{cite journal  | author=Hillier LW |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466  |name-list-format=vanc| author2=Graves TA  | author3=Fulton RS  | display-authors=3  | last4=Fulton  | first4=Lucinda A.  | last5=Pepin  | first5=Kymberlie H.  | last6=Minx  | first6=Patrick  | last7=Wagner-Mcpherson  | first7=Caryn  | last8=Layman  | first8=Dan  | last9=Wylie  | first9=Kristine |bibcode=2005Natur.434..724H}}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Brinkman JF |title=VAMP5 and VAMP8 are most likely not involved in primary open-angle glaucoma |journal=Mol. Vis. |volume=11 |issue=  |pages= 582–6 |year= 2006 |pmid= 16110299 |doi=  |name-list-format=vanc| author2=Ottenheim CP  | author3=de Jong LA  | display-authors=3  | last4=Zegers  | first4=RH  | last5=De Smet  | first5=MD  | last6=De Jong  | first6=PT  | last7=Bergen  | first7=AA  }}
*{{cite journal  | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal  | author=Oishi Y |title=Role of VAMP-2, VAMP-7, and VAMP-8 in constitutive exocytosis from HSY cells |journal=Histochem. Cell Biol. |volume=125 |issue= 3 |pages= 273–81 |year= 2007 |pmid= 16195891 |doi= 10.1007/s00418-005-0068-y  |name-list-format=vanc| author2=Arakawa T  | author3=Tanimura A  | display-authors=3  | last4=Itakura  | first4=Makoto  | last5=Takahashi  | first5=Masami  | last6=Tajima  | first6=Yoshifumi  | last7=Mizoguchi  | first7=Itaru  | last8=Takuma  | first8=Taishin }}
*{{cite journal | author=Brinkman JF, Ottenheim CP, de Jong LA, ''et al.'' |title=VAMP5 and VAMP8 are most likely not involved in primary open-angle glaucoma. |journal=Mol. Vis. |volume=11 |issue=  |pages= 582-6 |year= 2006 |pmid= 16110299 |doi=  }}
*{{cite journal  | author=Shiffman D |title=Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction |journal=Arterioscler. Thromb. Vasc. Biol. |volume=26 |issue= 7 |pages= 1613–8 |year= 2006 |pmid= 16690874 |doi= 10.1161/01.ATV.0000226543.77214.e4  |name-list-format=vanc| author2=Rowland CM  | author3=Louie JZ  | display-authors=3  | last4=Luke  | first4=MM  | last5=Bare  | first5=LA  | last6=Bolonick  | first6=JI  | last7=Young  | first7=BA  | last8=Catanese  | first8=JJ  | last9=Stiggins  | first9=CF }}
*{{cite journal  | author=Oishi Y, Arakawa T, Tanimura A, ''et al.'' |title=Role of VAMP-2, VAMP-7, and VAMP-8 in constitutive exocytosis from HSY cells. |journal=Histochem. Cell Biol. |volume=125 |issue= 3 |pages= 273-81 |year= 2007 |pmid= 16195891 |doi= 10.1007/s00418-005-0068-y }}
*{{cite journal  | author=Shiffman D, Rowland CM, Louie JZ, ''et al.'' |title=Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=26 |issue= 7 |pages= 1613-8 |year= 2006 |pmid= 16690874 |doi= 10.1161/01.ATV.0000226543.77214.e4 }}
}}
}}
{{refend}}
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{{PDB Gallery|geneid=8673}}


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Latest revision as of 10:36, 30 December 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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Wikidata
View/Edit Human

Vesicle-associated membrane protein 8 is a protein that in humans is encoded by the VAMP8 gene.[1][2][3]

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. It is associated with the perinuclear vesicular structures of the early endocytic compartment. It has been found that VAMP8 interacts specifically with the soluble NSF-attachment protein (alpha-SNAP), most likely through an VAMP8-containing SNARE complex.[3] Phosphorylation of VAMP8 inside the conserved SNARE-domain can suppress vesicle fusion.[4]

Interactions

Vesicle-associated membrane protein 8 has been shown to interact with STX4,[5][6] SNAP23,[5][7] STX1A,[8] STX8[9] and STX7.[9][10]

References

  1. ↑ Bui TD, Wong SH, Lu L, Hong W (February 1999). "Endobrevin maps to chromosome 2 in human and chromosome 6 in mouse". Genomics. 54 (3): 579–80. doi:10.1006/geno.1998.5596. PMID 9878266.
  2. ↑ Wong SH, Zhang T, Xu Y, Subramaniam VN, Griffiths G, Hong W (July 1998). "Endobrevin, a Novel Synaptobrevin/VAMP-Like Protein Preferentially Associated with the Early Endosome". Mol Biol Cell. 9 (6): 1549–63. doi:10.1091/mbc.9.6.1549. PMC 25382. PMID 9614193.
  3. ↑ 3.0 3.1 "Entrez Gene: VAMP8 vesicle-associated membrane protein 8 (endobrevin)".
  4. ↑ Malmersjö S, Di Palma S, Diao J, Lai Y, Pfuetzner RA, Wang AL, McMahon MA, Hayer A, Porteus M, Bodenmiller B, Brunger AT, Meyer T (July 2016). "Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion". EMBO Journal. 35 (16): 1721–1843. doi:10.15252/embj.201694071. PMC 5010044. PMID 27402227.
  5. ↑ 5.0 5.1 Paumet, F; Le Mao J; Martin S; Galli T; David B; Blank U; Roa M (June 2000). "Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment". J. Immunol. 164 (11): 5850–7. doi:10.4049/jimmunol.164.11.5850. ISSN 0022-1767. PMID 10820264.
  6. ↑ Polgár, János; Chung Sul-Hee; Reed Guy L (August 2002). "Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion". Blood. 100 (3): 1081–3. doi:10.1182/blood.V100.3.1081. ISSN 0006-4971. PMID 12130530.
  7. ↑ Imai, Akane; Nashida Tomoko; Yoshie Sumio; Shimomura Hiromi (August 2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Arch. Oral Biol. 48 (8): 597–604. doi:10.1016/S0003-9969(03)00116-X. ISSN 0003-9969. PMID 12828989.
  8. ↑ Nagamatsu, S; Nakamichi Y; Watanabe T; Matsushima S; Yamaguchi S; Ni J; Itagaki E; Ishida H (January 2001). "Localization of cellubrevin-related peptide, endobrevin, in the early endosome in pancreatic beta cells and its physiological function in exo-endocytosis of secretory granules". J. Cell Sci. 114 (Pt 1): 219–227. ISSN 0021-9533. PMID 11112705.
  9. ↑ 9.0 9.1 Antonin, W; Holroyd C; Fasshauer D; Pabst S; Von Mollard G F; Jahn R (Dec 2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". EMBO J. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. ISSN 0261-4189. PMC 305878. PMID 11101518.
  10. ↑ Wade, N; Bryant N J; Connolly L M; Simpson R J; Luzio J P; Piper R C; James D E (June 2001). "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells". J. Biol. Chem. 276 (23): 19820–7. doi:10.1074/jbc.M010838200. ISSN 0021-9258. PMID 11278762.

Further reading


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