WIF1: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Wnt inhibitory factor 1''' is a [[protein]] that in humans is encoded by the ''WIF1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: WIF1 WNT inhibitory factor 1 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11197| accessdate = }}</ref> WIF1 is a [[lipid]]-binding protein that binds to [[Wnt signaling pathway|Wnt]] proteins and prevents them from triggering signalling.<ref name="pmid21743455">{{cite journal | vauthors = Malinauskas T, Aricescu AR, Lu W, Siebold C, Jones EY | title = Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1 | journal = Nature Structural & Molecular Biology | volume = 18 | issue = 8 | pages = 886–893 |date=July 2011 | pmid = 21743455 | pmc=3430870 | doi = 10.1038/nsmb.2081 }}</ref><ref name="pmid=18256869">{{cite journal  | author=Malinauskas T |title=Docking of fatty acids into the WIF domain of the human Wnt inhibitory factor-1 |journal=Lipids |volume=43 |issue= 3 |pages=227–30 |year= 2008 |pmid=18256869 |doi=10.1007/s11745-007-3144-3 }}</ref><ref name="pmid10201374">{{cite journal | vauthors = Hsieh JC, Kodjabachian L, Rebbert ML, Rattner A, Smallwood PM, Samos CH, Nusse R, Dawid IB, Nathans J | title = A new secreted protein that binds to Wnt proteins and inhibits their activities | journal = Nature | volume = 398 | issue = 6726 | pages = 431–6 |date=Apr 1999 | pmid = 10201374 | pmc = | doi = 10.1038/18899 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_WIF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2d3j.
| PDB = {{PDB2|2d3j}}
| Name = WNT inhibitory factor 1
| HGNCid = 18081
| Symbol = WIF1
| AltSymbols =; WIF-1
| OMIM = 605186
| ECnumber = 
| Homologene = 31430
| MGIid = 1344332
| GeneAtlas_image1 = PBB_GE_WIF1_204712_at_tn.png
| Function = {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11197
    | Hs_Ensembl = ENSG00000156076
    | Hs_RefseqProtein = NP_009122
    | Hs_RefseqmRNA = NM_007191
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 63730674
    | Hs_GenLoc_end = 63801383
    | Hs_Uniprot = Q9Y5W5
    | Mm_EntrezGene = 24117
    | Mm_Ensembl = ENSMUSG00000020218
    | Mm_RefseqmRNA = XM_983228
    | Mm_RefseqProtein = XP_988322
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 120437064
    | Mm_GenLoc_end = 120503703
    | Mm_Uniprot = Q3TYU1
  }}
}}
'''WNT inhibitory factor 1''', also known as '''WIF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: WIF1 WNT inhibitory factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11197| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
WNT proteins are extracellular signaling molecules involved in the control of [[embryonic development]]. This gene encodes a secreted protein, which binds WNT proteins and inhibits their activities. This protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. It may be involved in [[mesoderm]] segmentation. This protein is found to be present in fish, amphibia and mammals.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = WNT proteins are extracellular signaling molecules involved in the control of embryonic development. This gene encodes a secreted protein, which binds WNT proteins and inhibits their activities. This protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. It may be involved in mesoderm segmentation. This protein is found to be present in fish, amphibia and mammals.<ref name="entrez">{{cite web | title = Entrez Gene: WIF1 WNT inhibitory factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11197| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Shepelev MV, Korobko EV, Korobko IV |title=[WIF1: perspectives of application in oncology] |journal=Mol. Gen. Mikrobiol. Virusol. |volume= |issue= 4 |pages= 3–7 |year= 2006 |pmid= 17094650 |doi=  }}
| citations =
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Shepelev MV, Korobko EV, Korobko IV |title=[WIF1: perspectives of application in oncology] |journal=Mol. Gen. Mikrobiol. Virusol. |volume= |issue= 4 |pages= 3-7 |year= 2006 |pmid= 17094650 |doi=  }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003  | pmc=403697 }}
*{{cite journal | author=Hsieh JC, Kodjabachian L, Rebbert ML, ''et al.'' |title=A new secreted protein that binds to Wnt proteins and inhibits their activities. |journal=Nature |volume=398 |issue= 6726 |pages= 431-6 |year= 1999 |pmid= 10201374 |doi= 10.1038/18899 }}
*{{cite journal   |vauthors=Reguart N, He B, Xu Z, etal |title=Cloning and characterization of the promoter of human Wnt inhibitory factor-1. |journal=Biochem. Biophys. Res. Commun. |volume=323 |issue= 1 |pages= 229–34 |year= 2004 |pmid= 15351726 |doi= 10.1016/j.bbrc.2004.08.075 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Esufali S, Bapat B |title=Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation. |journal=Oncogene |volume=23 |issue= 50 |pages= 8260–71 |year= 2004 |pmid= 15377999 |doi= 10.1038/sj.onc.1208007 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal   |vauthors=Ohigashi T, Mizuno R, Nakashima J, etal |title=Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells. |journal=Prostate |volume=62 |issue= 1 |pages= 61–8 |year= 2005 |pmid= 15389810 |doi= 10.1002/pros.20117 }}
*{{cite journal  | author=Reguart N, He B, Xu Z, ''et al.'' |title=Cloning and characterization of the promoter of human Wnt inhibitory factor-1. |journal=Biochem. Biophys. Res. Commun. |volume=323 |issue= 1 |pages= 229-34 |year= 2004 |pmid= 15351726 |doi= 10.1016/j.bbrc.2004.08.075 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Esufali S, Bapat B |title=Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation. |journal=Oncogene |volume=23 |issue= 50 |pages= 8260-71 |year= 2004 |pmid= 15377999 |doi= 10.1038/sj.onc.1208007 }}
*{{cite journal  | vauthors=Simon M, Grandage VL, Linch DC, Khwaja A |title=Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia. |journal=Oncogene |volume=24 |issue= 14 |pages= 2410–20 |year= 2005 |pmid= 15735743 |doi= 10.1038/sj.onc.1208431 }}
*{{cite journal | author=Ohigashi T, Mizuno R, Nakashima J, ''et al.'' |title=Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells. |journal=Prostate |volume=62 |issue= 1 |pages= 61-8 |year= 2005 |pmid= 15389810 |doi= 10.1002/pros.20117 }}
*{{cite journal   |vauthors=Taniguchi H, Yamamoto H, Hirata T, etal |title=Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers. |journal=Oncogene |volume=24 |issue= 53 |pages= 7946–52 |year= 2005 |pmid= 16007117 |doi= 10.1038/sj.onc.1208910 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Lin YC, You L, Xu Z, etal |title=Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines. |journal=Biochem. Biophys. Res. Commun. |volume=341 |issue= 2 |pages= 635–40 |year= 2006 |pmid= 16427602 |doi= 10.1016/j.bbrc.2005.12.220 }}
*{{cite journal | author=Simon M, Grandage VL, Linch DC, Khwaja A |title=Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia. |journal=Oncogene |volume=24 |issue= 14 |pages= 2410-20 |year= 2005 |pmid= 15735743 |doi= 10.1038/sj.onc.1208431 }}
*{{cite journal   |vauthors=Urakami S, Shiina H, Enokida H, etal |title=Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway. |journal=Clin. Cancer Res. |volume=12 |issue= 2 |pages= 383–91 |year= 2006 |pmid= 16428476 |doi= 10.1158/1078-0432.CCR-05-1344 }}
*{{cite journal | author=Taniguchi H, Yamamoto H, Hirata T, ''et al.'' |title=Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers. |journal=Oncogene |volume=24 |issue= 53 |pages= 7946-52 |year= 2005 |pmid= 16007117 |doi= 10.1038/sj.onc.1208910 }}
*{{cite journal  | vauthors=Liepinsh E, Bányai L, Patthy L, Otting G |title=NMR structure of the WIF domain of the human Wnt-inhibitory factor-1. |journal=J. Mol. Biol. |volume=357 |issue= 3 |pages= 942–50 |year= 2006 |pmid= 16476441 |doi= 10.1016/j.jmb.2006.01.047 }}
*{{cite journal | author=Lin YC, You L, Xu Z, ''et al.'' |title=Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines. |journal=Biochem. Biophys. Res. Commun. |volume=341 |issue= 2 |pages= 635-40 |year= 2006 |pmid= 16427602 |doi= 10.1016/j.bbrc.2005.12.220 }}
*{{cite journal   |vauthors=Batra S, Shi Y, Kuchenbecker KM, etal |title=Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma. |journal=Biochem. Biophys. Res. Commun. |volume=342 |issue= 4 |pages= 1228–32 |year= 2006 |pmid= 16516163 |doi= 10.1016/j.bbrc.2006.02.084 }}
*{{cite journal  | author=Urakami S, Shiina H, Enokida H, ''et al.'' |title=Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway. |journal=Clin. Cancer Res. |volume=12 |issue= 2 |pages= 383-91 |year= 2006 |pmid= 16428476 |doi= 10.1158/1078-0432.CCR-05-1344 }}
*{{cite journal  | vauthors=Chim CS, Chan WW, Pang A, Kwong YL |title=Preferential methylation of Wnt inhibitory factor-1 in acute promyelocytic leukemia: an independent poor prognostic factor. |journal=Leukemia |volume=20 |issue= 5 |pages= 907–9 |year= 2006 |pmid= 16525492 |doi= 10.1038/sj.leu.2404176 }}
*{{cite journal | author=Liepinsh E, Bányai L, Patthy L, Otting G |title=NMR structure of the WIF domain of the human Wnt-inhibitory factor-1. |journal=J. Mol. Biol. |volume=357 |issue= 3 |pages= 942-50 |year= 2006 |pmid= 16476441 |doi= 10.1016/j.jmb.2006.01.047 }}
*{{cite journal   |vauthors=Urakami S, Shiina H, Enokida H, etal |title=Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection. |journal=Clin. Cancer Res. |volume=12 |issue= 7 Pt 1 |pages= 2109–16 |year= 2006 |pmid= 16609023 |doi= 10.1158/1078-0432.CCR-05-2468 }}
*{{cite journal  | author=Batra S, Shi Y, Kuchenbecker KM, ''et al.'' |title=Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma. |journal=Biochem. Biophys. Res. Commun. |volume=342 |issue= 4 |pages= 1228-32 |year= 2006 |pmid= 16516163 |doi= 10.1016/j.bbrc.2006.02.084 }}
*{{cite journal  | vauthors=Milutinovic S, D'Alessio AC, Detich N, Szyf M |title=Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes. |journal=Carcinogenesis |volume=28 |issue= 3 |pages= 560–71 |year= 2007 |pmid= 17012225 |doi= 10.1093/carcin/bgl167 }}
*{{cite journal | author=Chim CS, Chan WW, Pang A, Kwong YL |title=Preferential methylation of Wnt inhibitory factor-1 in acute promyelocytic leukemia: an independent poor prognostic factor. |journal=Leukemia |volume=20 |issue= 5 |pages= 907-9 |year= 2006 |pmid= 16525492 |doi= 10.1038/sj.leu.2404176 }}
*{{cite journal  | vauthors=Queimado L, Lopes CS, Reis AM |title=WIF1, an inhibitor of the Wnt pathway, is rearranged in salivary gland tumors. |journal=Genes Chromosomes Cancer |volume=46 |issue= 3 |pages= 215–25 |year= 2007 |pmid= 17171686 |doi= 10.1002/gcc.20402 }}
*{{cite journal  | author=Urakami S, Shiina H, Enokida H, ''et al.'' |title=Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection. |journal=Clin. Cancer Res. |volume=12 |issue= 7 Pt 1 |pages= 2109-16 |year= 2006 |pmid= 16609023 |doi= 10.1158/1078-0432.CCR-05-2468 }}
*{{cite journal   |vauthors=Chan SL, Cui Y, van Hasselt A, etal |title=The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas. |journal=Lab. Invest. |volume=87 |issue= 7 |pages= 644–50 |year= 2007 |pmid= 17384664 |doi= 10.1038/labinvest.3700547 }}
*{{cite journal  | author=Milutinovic S, D'Alessio AC, Detich N, Szyf M |title=Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes. |journal=Carcinogenesis |volume=28 |issue= 3 |pages= 560-71 |year= 2007 |pmid= 17012225 |doi= 10.1093/carcin/bgl167 }}
*{{cite journal   |vauthors=Veeck J, Wild PJ, Fuchs T, etal |title=Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer. |journal=BMC Cancer |volume=9 |pages= 1–13 |year= 2009 |pmid= 19570204 |doi= 10.1186/1471-2407-9-217  | pmc=2717119 }}
*{{cite journal | author=Queimado L, Lopes CS, Reis AM |title=WIF1, an inhibitor of the Wnt pathway, is rearranged in salivary gland tumors. |journal=Genes Chromosomes Cancer |volume=46 |issue= 3 |pages= 215-25 |year= 2007 |pmid= 17171686 |doi= 10.1002/gcc.20402 }}
*{{cite journal | author=Chan SL, Cui Y, van Hasselt A, ''et al.'' |title=The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas. |journal=Lab. Invest. |volume=87 |issue= 7 |pages= 644-50 |year= 2007 |pmid= 17384664 |doi= 10.1038/labinvest.3700547 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=11197}}
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{{gene-12-stub}}

Latest revision as of 22:40, 17 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Wnt inhibitory factor 1 is a protein that in humans is encoded by the WIF1 gene.[1] WIF1 is a lipid-binding protein that binds to Wnt proteins and prevents them from triggering signalling.[2][3][4]

Function

WNT proteins are extracellular signaling molecules involved in the control of embryonic development. This gene encodes a secreted protein, which binds WNT proteins and inhibits their activities. This protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. It may be involved in mesoderm segmentation. This protein is found to be present in fish, amphibia and mammals.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: WIF1 WNT inhibitory factor 1".
  2. ↑ Malinauskas T, Aricescu AR, Lu W, Siebold C, Jones EY (July 2011). "Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1". Nature Structural & Molecular Biology. 18 (8): 886–893. doi:10.1038/nsmb.2081. PMC 3430870. PMID 21743455.
  3. ↑ Malinauskas T (2008). "Docking of fatty acids into the WIF domain of the human Wnt inhibitory factor-1". Lipids. 43 (3): 227–30. doi:10.1007/s11745-007-3144-3. PMID 18256869.
  4. ↑ Hsieh JC, Kodjabachian L, Rebbert ML, Rattner A, Smallwood PM, Samos CH, Nusse R, Dawid IB, Nathans J (Apr 1999). "A new secreted protein that binds to Wnt proteins and inhibits their activities". Nature. 398 (6726): 431–6. doi:10.1038/18899. PMID 10201374.

Further reading


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