WNT7A: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Protein Wnt-7a''' is a [[protein]] that in humans is encoded by the ''WNT7A'' [[gene]].<ref name="pmid8893824">{{cite journal | vauthors = Ikegawa S, Kumano Y, Okui K, Fujiwara T, Takahashi E, Nakamura Y | title = Isolation, characterization and chromosomal assignment of the human WNT7A gene | journal = Cytogenet Cell Genet | volume = 74 | issue = 1–2 | pages = 149–52 |date=Dec 1996 | pmid = 8893824 | pmc =  | doi =10.1159/000134404  }}</ref><ref name="pmid9161407">{{cite journal | vauthors = Bui TD, Lako M, Lejeune S, Curtis AR, Strachan T, Lindsay S, Harris AL | title = Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25 | journal = Gene | volume = 189 | issue = 1 | pages = 25–9 |date=Jun 1997 | pmid = 9161407 | pmc = | doi =10.1016/S0378-1119(96)00808-6  }}</ref><ref name="entrez"/>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Wingless-type MMTV integration site family, member 7A
| HGNCid = 12786
| Symbol = WNT7A
| AltSymbols =;
| OMIM = 601570
| ECnumber = 
| Homologene = 20969
| MGIid = 98961
| GeneAtlas_image1 = PBB_GE_WNT7A_210248_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005102 |text = receptor binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007223 |text = Wnt receptor signaling pathway, calcium modulating pathway}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007548 |text = sex differentiation}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7476
    | Hs_Ensembl = ENSG00000154764
    | Hs_RefseqProtein = NP_004616
    | Hs_RefseqmRNA = NM_004625
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 13835085
    | Hs_GenLoc_end = 13896619
    | Hs_Uniprot = O00755
    | Mm_EntrezGene = 22421
    | Mm_Ensembl = ENSMUSG00000030093
    | Mm_RefseqmRNA = NM_009527
    | Mm_RefseqProtein = NP_033553
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 91329487
    | Mm_GenLoc_end = 91376873
    | Mm_Uniprot = Q9DBY3
  }}
}}
'''Wingless-type MMTV integration site family, member 7A''', also known as '''WNT7A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: WNT7A wingless-type MMTV integration site family, member 7A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7476| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The [[Wnt signaling pathway|WNT]] gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in [[oncogenesis]] and in several developmental processes, including regulation of cell fate and patterning during [[embryogenesis]]. This gene is a member of the WNT gene family. It encodes a protein showing 99% amino acid identity to the mouse Wnt7A protein. This gene not only guides the development of the [[Anatomical terms of location#Anterior and posterior|anterior-posterior axis]] in the female reproductive tract but also plays a critical role in [[uterine]] smooth muscle pattering and maintenance of adult uterine function. It is also responsive to changes in the levels of sex steroid hormone in the female reproductive tract. Decreased expression of this gene in human uterine [[leiomyoma]] is found to be inversely associated with the expression of [[estrogen receptor alpha]].<ref name="entrez">{{cite web | title = Entrez Gene: WNT7A wingless-type MMTV integration site family, member 7A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7476| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 99% amino acid identity to the mouse Wnt7A protein. This gene not only guides the development of the anterior-posterior axis in the female reproductive tract, but also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. It is also responsive to changes in the levels of sex steriod hormone in the female reproductive tract. Decreased expression of this gene in human uterine leiomyoma is found to be inversely associated with the expression of estrogen receptor-alpha.<ref name="entrez">{{cite web | title = Entrez Gene: WNT7A wingless-type MMTV integration site family, member 7A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7476| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Smolich BD, McMahon JA, McMahon AP, Papkoff J |title=Wnt family proteins are secreted and associated with the cell surface |journal=Mol. Biol. Cell |volume=4 |issue= 12 |pages= 1267–75 |year= 1994 |pmid= 8167409 |doi= 10.1091/mbc.4.12.1267| pmc=275763 }}
| citations =
*{{cite journal   |vauthors=Huguet EL, McMahon JA, McMahon AP, etal |title=Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue |journal=Cancer Res. |volume=54 |issue= 10 |pages= 2615–21 |year= 1994 |pmid= 8168088 |doi=  }}
*{{cite journal  | author=Smolich BD, McMahon JA, McMahon AP, Papkoff J |title=Wnt family proteins are secreted and associated with the cell surface. |journal=Mol. Biol. Cell |volume=4 |issue= 12 |pages= 1267-75 |year= 1994 |pmid= 8167409 |doi=  }}
*{{cite journal  | vauthors=Parr BA, McMahon AP |title=Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a |journal=Nature |volume=395 |issue= 6703 |pages= 707–10 |year= 1998 |pmid= 9790192 |doi= 10.1038/27221 }}
*{{cite journal | author=Huguet EL, McMahon JA, McMahon AP, ''et al.'' |title=Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. |journal=Cancer Res. |volume=54 |issue= 10 |pages= 2615-21 |year= 1994 |pmid= 8168088 |doi=  }}
*{{cite journal   |vauthors=Calvo R, West J, Franklin W, etal |title=Altered HOX and WNT7A expression in human lung cancer |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 23 |pages= 12776–81 |year= 2001 |pmid= 11070089 |doi= 10.1073/pnas.97.23.12776 | pmc=18840 }}
*{{cite journal  | author=Ikegawa S, Kumano Y, Okui K, ''et al.'' |title=Isolation, characterization and chromosomal assignment of the human WNT7A gene. |journal=Cytogenet. Cell Genet. |volume=74 |issue= 1-2 |pages= 149-52 |year= 1996 |pmid= 8893824 |doi= }}
*{{cite journal   |vauthors=Li S, Chiang TC, Davis GR, etal |title=Decreased expression of Wnt7a mRNA is inversely associated with the expression of estrogen receptor-alpha in human uterine leiomyoma |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 1 |pages= 454–7 |year= 2001 |pmid= 11232041 |doi=10.1210/jc.86.1.454  }}
*{{cite journal | author=Bui TD, Lako M, Lejeune S, ''et al.'' |title=Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25. |journal=Gene |volume=189 |issue= 1 |pages= 25-9 |year= 1997 |pmid= 9161407 |doi=  }}
*{{cite journal   |vauthors=Couse JF, Dixon D, Yates M, etal |title=Estrogen receptor-alpha knockout mice exhibit resistance to the developmental effects of neonatal diethylstilbestrol exposure on the female reproductive tract |journal=Dev. Biol. |volume=238 |issue= 2 |pages= 224–38 |year= 2002 |pmid= 11784006 |doi= 10.1006/dbio.2001.0413 }}
*{{cite journal | author=Parr BA, McMahon AP |title=Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a. |journal=Nature |volume=395 |issue= 6703 |pages= 707-10 |year= 1998 |pmid= 9790192 |doi= 10.1038/27221 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Calvo R, West J, Franklin W, ''et al.'' |title=Altered HOX and WNT7A expression in human lung cancer. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 23 |pages= 12776-81 |year= 2001 |pmid= 11070089 |doi= 10.1073/pnas.97.23.12776 }}
*{{cite journal   |vauthors=Caricasole A, Ferraro T, Iacovelli L, etal |title=Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins |journal=J. Biol. Chem. |volume=278 |issue= 39 |pages= 37024–31 |year= 2003 |pmid= 12857724 |doi= 10.1074/jbc.M300191200 }}
*{{cite journal | author=Li S, Chiang TC, Davis GR, ''et al.'' |title=Decreased expression of Wnt7a mRNA is inversely associated with the expression of estrogen receptor-alpha in human uterine leiomyoma. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 1 |pages= 454-7 |year= 2001 |pmid= 11232041 |doi=  }}
*{{cite journal   |vauthors=Tuli R, Tuli S, Nandi S, etal |title=Transforming growth factor-beta-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen-activated protein kinase and Wnt signaling cross-talk |journal=J. Biol. Chem. |volume=278 |issue= 42 |pages= 41227–36 |year= 2003 |pmid= 12893825 |doi= 10.1074/jbc.M305312200 }}
*{{cite journal | author=Couse JF, Dixon D, Yates M, ''et al.'' |title=Estrogen receptor-alpha knockout mice exhibit resistance to the developmental effects of neonatal diethylstilbestrol exposure on the female reproductive tract. |journal=Dev. Biol. |volume=238 |issue= 2 |pages= 224-38 |year= 2002 |pmid= 11784006 |doi= 10.1006/dbio.2001.0413 }}
*{{cite journal   |vauthors=Ohira T, Gemmill RM, Ferguson K, etal |title=WNT7a induces E-cadherin in lung cancer cells |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 18 |pages= 10429–34 |year= 2003 |pmid= 12937339 |doi= 10.1073/pnas.1734137100  | pmc=193578 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Timmreck LS, Pan HA, Reindollar RH, Gray MR |title=WNT7A mutations in patients with Müllerian duct abnormalities |journal=Journal of pediatric and adolescent gynecology |volume=16 |issue= 4 |pages= 217–21 |year= 2004 |pmid= 14550385 |doi=10.1016/S1083-3188(03)00124-4  }}
*{{cite journal | author=Caricasole A, Ferraro T, Iacovelli L, ''et al.'' |title=Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins. |journal=J. Biol. Chem. |volume=278 |issue= 39 |pages= 37024-31 |year= 2003 |pmid= 12857724 |doi= 10.1074/jbc.M300191200 }}
*{{cite journal   |vauthors=Hwang SG, Ryu JH, Kim IC, etal |title=Wnt-7a causes loss of differentiated phenotype and inhibits apoptosis of articular chondrocytes via different mechanisms |journal=J. Biol. Chem. |volume=279 |issue= 25 |pages= 26597–604 |year= 2004 |pmid= 15082716 |doi= 10.1074/jbc.M401401200 }}
*{{cite journal  | author=Tuli R, Tuli S, Nandi S, ''et al.'' |title=Transforming growth factor-beta-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen-activated protein kinase and Wnt signaling cross-talk. |journal=J. Biol. Chem. |volume=278 |issue= 42 |pages= 41227-36 |year= 2003 |pmid= 12893825 |doi= 10.1074/jbc.M305312200 }}
*{{cite journal   |vauthors=Winn RA, Marek L, Han SY, etal |title=Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation |journal=J. Biol. Chem. |volume=280 |issue= 20 |pages= 19625–34 |year= 2005 |pmid= 15705594 |doi= 10.1074/jbc.M409392200 }}
*{{cite journal | author=Ohira T, Gemmill RM, Ferguson K, ''et al.'' |title=WNT7a induces E-cadherin in lung cancer cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 18 |pages= 10429-34 |year= 2003 |pmid= 12937339 |doi= 10.1073/pnas.1734137100 }}
*{{cite journal  | vauthors=Lyu J, Joo CK |title=Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing |journal=J. Biol. Chem. |volume=280 |issue= 22 |pages= 21653–60 |year= 2005 |pmid= 15802269 |doi= 10.1074/jbc.M500374200 }}
*{{cite journal | author=Timmreck LS, Pan HA, Reindollar RH, Gray MR |title=WNT7A mutations in patients with Müllerian duct abnormalities. |journal=Journal of pediatric and adolescent gynecology |volume=16 |issue= 4 |pages= 217-21 |year= 2004 |pmid= 14550385 |doi= }}
*{{cite journal   |vauthors=Woods CG, Stricker S, Seemann P, etal |title=Mutations in WNT7A Cause a Range of Limb Malformations, Including Fuhrmann Syndrome and Al-Awadi/Raas-Rothschild/Schinzel Phocomelia Syndrome |journal=Am. J. Hum. Genet. |volume=79 |issue= 2 |pages= 402–8 |year= 2006 |pmid= 16826533 |doi= 10.1086/506332  | pmc=1559483 }}
*{{cite journal  | author=Hwang SG, Ryu JH, Kim IC, ''et al.'' |title=Wnt-7a causes loss of differentiated phenotype and inhibits apoptosis of articular chondrocytes via different mechanisms. |journal=J. Biol. Chem. |volume=279 |issue= 25 |pages= 26597-604 |year= 2004 |pmid= 15082716 |doi= 10.1074/jbc.M401401200 }}
*{{cite journal   |vauthors=Winn RA, Van Scoyk M, Hammond M, etal |title=Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma |journal=J. Biol. Chem. |volume=281 |issue= 37 |pages= 26943–50 |year= 2006 |pmid= 16835228 |doi= 10.1074/jbc.M604145200 }}
*{{cite journal | author=Winn RA, Marek L, Han SY, ''et al.'' |title=Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation. |journal=J. Biol. Chem. |volume=280 |issue= 20 |pages= 19625-34 |year= 2005 |pmid= 15705594 |doi= 10.1074/jbc.M409392200 }}
*{{cite journal  | vauthors=Lindberg D, Akerström G, Westin G |title=Mutational analyses of WNT7A and HDAC11 as candidate tumour suppressor genes in sporadic malignant pancreatic endocrine tumours |journal=Clin. Endocrinol. |volume=66 |issue= 1 |pages= 110–4 |year= 2007 |pmid= 17201809 |doi= 10.1111/j.1365-2265.2006.02694.x }}
*{{cite journal | author=Lyu J, Joo CK |title=Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing. |journal=J. Biol. Chem. |volume=280 |issue= 22 |pages= 21653-60 |year= 2005 |pmid= 15802269 |doi= 10.1074/jbc.M500374200 }}
*{{cite journal  | vauthors=Thrasivoulou C, Millar M, Ahmed A | last-author-amp=yes | title=Activation of intracellular calcium by multiple Wnt ligands and translocation of  ß-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/ß-catenin pathways |  journal = J. Biol. Chem. |volume=288 |issue= 50 |pages= 35651–35659 |year= 2013 |pmid= 24158438 |doi=10.1074/jbc.M112.437913 | pmc=3861617}}
*{{cite journal  | author=Woods CG, Stricker S, Seemann P, ''et al.'' |title=Mutations in WNT7A cause a range of limb malformations, including Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome. |journal=Am. J. Hum. Genet. |volume=79 |issue= 2 |pages= 402-8 |year= 2006 |pmid= 16826533 |doi= 10.1086/506332 }}
*{{cite journal  | author=Winn RA, Van Scoyk M, Hammond M, ''et al.'' |title=Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma. |journal=J. Biol. Chem. |volume=281 |issue= 37 |pages= 26943-50 |year= 2006 |pmid= 16835228 |doi= 10.1074/jbc.M604145200 }}
*{{cite journal  | author=Lindberg D, Akerström G, Westin G |title=Mutational analyses of WNT7A and HDAC11 as candidate tumour suppressor genes in sporadic malignant pancreatic endocrine tumours. |journal=Clin. Endocrinol. (Oxf) |volume=66 |issue= 1 |pages= 110-4 |year= 2007 |pmid= 17201809 |doi= 10.1111/j.1365-2265.2006.02694.x }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Wnt signaling pathway}}
{{WikiDoc Sources}}
 
 
{{gene-3-stub}}

Latest revision as of 22:46, 17 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein Wnt-7a is a protein that in humans is encoded by the WNT7A gene.[1][2][3]

Function

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 99% amino acid identity to the mouse Wnt7A protein. This gene not only guides the development of the anterior-posterior axis in the female reproductive tract but also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. It is also responsive to changes in the levels of sex steroid hormone in the female reproductive tract. Decreased expression of this gene in human uterine leiomyoma is found to be inversely associated with the expression of estrogen receptor alpha.[3]

References

  1. ↑ Ikegawa S, Kumano Y, Okui K, Fujiwara T, Takahashi E, Nakamura Y (Dec 1996). "Isolation, characterization and chromosomal assignment of the human WNT7A gene". Cytogenet Cell Genet. 74 (1–2): 149–52. doi:10.1159/000134404. PMID 8893824.
  2. ↑ Bui TD, Lako M, Lejeune S, Curtis AR, Strachan T, Lindsay S, Harris AL (Jun 1997). "Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25". Gene. 189 (1): 25–9. doi:10.1016/S0378-1119(96)00808-6. PMID 9161407.
  3. ↑ 3.0 3.1 "Entrez Gene: WNT7A wingless-type MMTV integration site family, member 7A".

Further reading


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