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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''YTH domain-containing protein 1''' is a [[protein]] that in humans is encoded by the ''YTHDC1'' [[gene]].<ref name="pmid12368078">{{cite journal | vauthors = Stoilov P, Rafalska I, Stamm S | title = YTH: a new domain in nuclear proteins | journal = Trends Biochem Sci | volume = 27 | issue = 10 | pages = 495–7 | date = Oct 2002 | pmid = 12368078 | pmc =  | doi = 10.1016/S0968-0004(02)02189-8 }}</ref><ref name="pmid10564280">{{cite journal | vauthors = Hartmann AM, Nayler O, Schwaiger FW, Obermeier A, Stamm S | title = The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn) | journal = Mol Biol Cell | volume = 10 | issue = 11 | pages = 3909–26 | date = Dec 1999 | pmid = 10564280 | pmc = 25688 | doi = 10.1091/mbc.10.11.3909 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: YTHDC1 YTH domain containing 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=91746| accessdate = }}</ref>
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = YTH domain containing 1
| HGNCid = 30626
| Symbol = YTHDC1
| AltSymbols =; KIAA1966; YT521; YT521-B
| OMIM = 
| ECnumber = 
| Homologene = 15796
| MGIid = 
| GeneAtlas_image1 = PBB_GE_YTHDC1_212455_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 91746
    | Hs_Ensembl = ENSG00000083896
    | Hs_RefseqProtein = NP_001026902
    | Hs_RefseqmRNA = NM_001031732
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 68861633
    | Hs_GenLoc_end = 68898402
    | Hs_Uniprot = Q96MU7
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''YTH domain containing 1''', also known as '''YTHDC1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: YTHDC1 YTH domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=91746| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
YTHDC1 has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
* [[Abl gene]],<ref name = pmid15175272/>
| section_title =  
* [[C-src tyrosine kinase]],<ref name = pmid15175272>{{cite journal | vauthors = Rafalska I, Zhang Z, Benderska N, Wolff H, Hartmann AM, Brack-Werner R, Stamm S | title = The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation | journal = Hum. Mol. Genet. | volume = 13 | issue = 15 | pages = 1535–49 | date = Aug 2004 | pmid = 15175272 | doi = 10.1093/hmg/ddh167 }}</ref>  
| summary_text =  
* [[Emerin]],<ref name = pmid12755701>{{cite journal | vauthors = Wilkinson FL, Holaska JM, Zhang Z, Sharma A, Manilal S, Holt I, Stamm S, Wilson KL, Morris GE | title = Emerin interacts in vitro with the splicing-associated factor, YT521-B | journal = Eur. J. Biochem. | volume = 270 | issue = 11 | pages = 2459–66 | date = Jun 2003 | pmid = 12755701 | doi = 10.1046/j.1432-1033.2003.03617.x}}</ref>  and
}}
* [[KHDRBS1]].<ref name = pmid10564280 />


==References==
== See also ==
{{reflist|2}}
[[N6-Methyladenosine|''N''<sup>6</sup>-Methyladenosine]]
==Further reading==
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Imai Y, Matsuo N, Ogawa S, Tohyama M, Takagi T | title = Cloning of a gene, YT521, for a novel RNA splicing-related protein induced by hypoxia/reoxygenation. | journal = Brain Res. Mol. Brain Res. | volume = 53 | issue = 1-2 | pages = 33–40 | year = 1998 | pmid = 9473574 | doi = 10.1016/S0169-328X(97)00262-3 }}
| citations =
* {{cite journal | vauthors = Nayler O, Hartmann AM, Stamm S | title = The ER repeat protein YT521-B localizes to a novel subnuclear compartment. | journal = J. Cell Biol. | volume = 150 | issue = 5 | pages = 949–62 | year = 2000 | pmid = 10973987 | pmc = 2175241 | doi = 10.1083/jcb.150.5.949 }}
*{{cite journal  | author=Stoilov P, Rafalska I, Stamm S |title=YTH: a new domain in nuclear proteins. |journal=Trends Biochem. Sci. |volume=27 |issue= 10 |pages= 495-7 |year= 2002 |pmid= 12368078 |doi=  }}
* {{cite journal | vauthors = Stoss O, Olbrich M, Hartmann AM, Konig H, Memmott J, Andreadis A, Stamm S | title = The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites. | journal = J. Biol. Chem. | volume = 276 | issue = 12 | pages = 8665–73 | year = 2001 | pmid = 11118435 | doi = 10.1074/jbc.M006851200 }}
*{{cite journal | author=Imai Y, Matsuo N, Ogawa S, ''et al.'' |title=Cloning of a gene, YT521, for a novel RNA splicing-related protein induced by hypoxia/reoxygenation. |journal=Brain Res. Mol. Brain Res. |volume=53 |issue= 1-2 |pages= 33-40 |year= 1998 |pmid= 9473574 |doi= }}
* {{cite journal | vauthors = Nagase T, Kikuno R, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. | journal = DNA Res. | volume = 8 | issue = 6 | pages = 319–27 | year = 2002 | pmid = 11853319 | doi = 10.1093/dnares/8.6.319 }}
*{{cite journal  | author=Hartmann AM, Nayler O, Schwaiger FW, ''et al.'' |title=The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn). |journal=Mol. Biol. Cell |volume=10 |issue= 11 |pages= 3909-26 |year= 1999 |pmid= 10564280 |doi=  }}
* {{cite journal | vauthors = Wilkinson FL, Holaska JM, Zhang Z, Sharma A, Manilal S, Holt I, Stamm S, Wilson KL, Morris GE | title = Emerin interacts in vitro with the splicing-associated factor, YT521-B. | journal = Eur. J. Biochem. | volume = 270 | issue = 11 | pages = 2459–66 | year = 2003 | pmid = 12755701 | doi = 10.1046/j.1432-1033.2003.03617.x }}
*{{cite journal | author=Nayler O, Hartmann AM, Stamm S |title=The ER repeat protein YT521-B localizes to a novel subnuclear compartment. |journal=J. Cell Biol. |volume=150 |issue= 5 |pages= 949-62 |year= 2000 |pmid= 10973987 |doi= }}
* {{cite journal | vauthors = Rafalska I, Zhang Z, Benderska N, Wolff H, Hartmann AM, Brack-Werner R, Stamm S | title = The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation. | journal = Hum. Mol. Genet. | volume = 13 | issue = 15 | pages = 1535–49 | year = 2005 | pmid = 15175272 | doi = 10.1093/hmg/ddh167 }}
*{{cite journal | author=Stoss O, Olbrich M, Hartmann AM, ''et al.'' |title=The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites. |journal=J. Biol. Chem. |volume=276 |issue= 12 |pages= 8665-73 |year= 2001 |pmid= 11118435 |doi= 10.1074/jbc.M006851200 }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Nagase T, Kikuno R, Ohara O |title=Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. |journal=DNA Res. |volume=8 |issue= 6 |pages= 319-27 |year= 2002 |pmid= 11853319 |doi=  }}
* {{cite journal | vauthors = Stoss O, Novoyatleva T, Gencheva M, Olbrich M, Benderska N, Stamm S | title = p59(fyn)-mediated phosphorylation regulates the activity of the tissue-specific splicing factor rSLM-1. | journal = Mol. Cell. Neurosci. | volume = 27 | issue = 1 | pages = 8–21 | year = 2005 | pmid = 15345239 | doi = 10.1016/j.mcn.2004.04.011 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
*{{cite journal | author=Wilkinson FL, Holaska JM, Zhang Z, ''et al.'' |title=Emerin interacts in vitro with the splicing-associated factor, YT521-B. |journal=Eur. J. Biochem. |volume=270 |issue= 11 |pages= 2459-66 |year= 2003 |pmid= 12755701 |doi= }}
* {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 14 | pages = 5391–6 | year = 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization. | journal = Nat. Biotechnol. | volume = 24 | issue = 10 | pages = 1285–92 | year = 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
*{{cite journal | author=Rafalska I, Zhang Z, Benderska N, ''et al.'' |title=The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation. |journal=Hum. Mol. Genet. |volume=13 |issue= 15 |pages= 1535-49 |year= 2005 |pmid= 15175272 |doi= 10.1093/hmg/ddh167 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal | author=Stoss O, Novoyatleva T, Gencheva M, ''et al.'' |title=p59(fyn)-mediated phosphorylation regulates the activity of the tissue-specific splicing factor rSLM-1. |journal=Mol. Cell. Neurosci. |volume=27 |issue= 1 |pages= 8-21 |year= 2005 |pmid= 15345239 |doi= 10.1016/j.mcn.2004.04.011 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391-6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
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Latest revision as of 12:05, 10 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

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UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

YTH domain-containing protein 1 is a protein that in humans is encoded by the YTHDC1 gene.[1][2][3]

Interactions

YTHDC1 has been shown to interact with:

See also

N6-Methyladenosine

References

  1. ↑ Stoilov P, Rafalska I, Stamm S (Oct 2002). "YTH: a new domain in nuclear proteins". Trends Biochem Sci. 27 (10): 495–7. doi:10.1016/S0968-0004(02)02189-8. PMID 12368078.
  2. ↑ 2.0 2.1 Hartmann AM, Nayler O, Schwaiger FW, Obermeier A, Stamm S (Dec 1999). "The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn)". Mol Biol Cell. 10 (11): 3909–26. doi:10.1091/mbc.10.11.3909. PMC 25688. PMID 10564280.
  3. ↑ "Entrez Gene: YTHDC1 YTH domain containing 1".
  4. ↑ 4.0 4.1 Rafalska I, Zhang Z, Benderska N, Wolff H, Hartmann AM, Brack-Werner R, Stamm S (Aug 2004). "The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation". Hum. Mol. Genet. 13 (15): 1535–49. doi:10.1093/hmg/ddh167. PMID 15175272.
  5. ↑ Wilkinson FL, Holaska JM, Zhang Z, Sharma A, Manilal S, Holt I, Stamm S, Wilson KL, Morris GE (Jun 2003). "Emerin interacts in vitro with the splicing-associated factor, YT521-B". Eur. J. Biochem. 270 (11): 2459–66. doi:10.1046/j.1432-1033.2003.03617.x. PMID 12755701.

Further reading


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