Chronic lymphocytic leukemia differential diagnosis: Difference between revisions

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{{Chronic lymphocytic leukemia}}
[[Image:Home_logo1.png|right|250px|link=https://www.wikidoc.org/index.php/Chronic_lymphocytic_leukemia]]
 
{{CMG}} {{AE}}{{HL}} {{HK}}
{{CMG}}; {{AE}} {{RT}}
 
==Overview==
==Overview==
Chronic lymphocytic leukemia must be differentiated from other diseases that cause [[weight loss]],  [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], [[Prolymphocytic leukemia|prolymphocytic leukaemia]], [[follicular lymphoma]], and [[mantle cell lymphoma]].


==Differential diagnosis==
==Differenting Chronic lymphocytic leukemia from other Diseases==
Hematologic disorders that may resemble [[CLL]] in their clinical presentation, behavior, and microscopic appearance include:
Chronic lymphocytic leukemia must be differentiated from other diseases that cause [[weight loss]], [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], [[Prolymphocytic leukemia|prolymphocytic leukaemia]], [[follicular lymphoma]], and [[mantle cell lymphoma]].
* [[Mantle cell lymphoma]]
* [[Marginal zone lymphoma]]
* [[Lymphoplasmacytic lymphoma]]
* [[B cell prolymphocytic leukemia]] (B PLL), which is a related but more aggressive disorder, has cells with similar phenotype but that are signficantly larger than normal lymphocytes and have a prominent nucleolus suggests a related.
* [[Hairy cell leukemia]] is also a neoplasm of B lymphocytes but differs significantly from CLL by its morphology under the microscope ([[hairy cell leukemia]] cells have delicate, hair-like projections on their surface) and  marker molecule expression.
 
All the B cell malignancies of the blood and [[bone marrow]] can be differentiated from one another by the combination of cellular microscopic morphology, marker molecule expression, and specific tumor-associated gene defects.  This is best accomplished by evaluation of the patient's blood, bone marrow and occasionally lymph node cells by a [[pathologist]] with specific training in blood disorders.  A sophisticated instrument called a [[flow cytometer]] is necessary for cell marker analysis and the detection of genetic problems in the cells may require visualizing the DNA changes with fluorescent probes by [[fluorescent in situ hybridization]] (FISH).
CLL is positive for [[CD5]], [[CD19]] & [[CD23]]; CLL is the only cell type that coexpresses CD5 & 19.  It is negative for CD10 & cyclin D.
[[CD20]] is +/- as is sIg.  90% of B-CLL have [[bcl-2]]. 
The 2 most noteworthy [[lymphoproliferative diseases]] with CD5 positivity are CLL (which is CD23 positive) & mantle zone lymphoma (which is CD23 negative).  Other CD5+ groups include peripheral & cutaneous [[T-cell lymphoma]], [[lymphoblastic lymphoma]], and [[adult T-cell leukemia]]/lymphoma.


==References==
==References==
{{reflist|2}}
{{reflist|2}}
[[Category:Disease]]
[[Category:Hematology]]
[[Category:Oncology]]
[[Category:Mature chapter]]
{{Hematology}}
{{Hematological malignancy histology}}
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Latest revision as of 20:33, 27 February 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2] Syed Hassan A. Kazmi BSc, MD [3]

Overview

Chronic lymphocytic leukemia must be differentiated from other diseases that cause weight loss, night sweats, hepatosplenomegaly, and palpable lymph nodes, such as hairy cell leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.

Differenting Chronic lymphocytic leukemia from other Diseases

Chronic lymphocytic leukemia must be differentiated from other diseases that cause weight loss, night sweats, hepatosplenomegaly, and palpable lymph nodes, such as hairy cell leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.

References

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