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__NOTOC__
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{{Merkel cell cancer}}
{{Merkel cell cancer}}
{{CMG}}
{{CMG}} ; {{AE}} {{VKG}} {{AAM}}


==Overview==
==Overview==
The incidence of merkel cell carcinoma ranges from 0.5 per 100,000 individuals. The [[median]] age at diagnosis is approximately 65 years. Merkel cell carcinoma is more common among males and individuals of the caucasian race.


==Epidemiology and Demographics==
==Epidemiology and Demographics==
===Incidence===
* The [[incidence]] of merkel cell carcinoma ranges from 0.5 per 100,000 individuals.<ref name="pmid217113382">{{cite journal |vauthors=Girschik J, Thorn K, Beer TW, Heenan PJ, Fritschi L |title=Merkel cell carcinoma in Western Australia: a population-based study of incidence and survival |journal=Br. J. Dermatol. |volume=165 |issue=5 |pages=1051–7 |date=November 2011 |pmid=21711338 |doi=10.1111/j.1365-2133.2011.10493.x |url=}}</ref><ref name="pmid30194728">{{cite journal |vauthors=Kieny A, Cribier B, Meyer N, Velten M, Jégu J, Lipsker D |title=Epidemiology of Merkel cell carcinoma. A population-based study from 1985 to 2013, in northeastern of France |journal=Int. J. Cancer |volume=144 |issue=4 |pages=741–745 |date=February 2019 |pmid=30194728 |doi=10.1002/ijc.31860 |url=}}</ref>
*The [[incidence]] is thought to have tripled between 1986 and 2001.
*According to the new research [[incidence]] rates are reportedly increasing in Australia and New Zealand.<ref name="pmid21711338">{{cite journal |vauthors=Girschik J, Thorn K, Beer TW, Heenan PJ, Fritschi L |title=Merkel cell carcinoma in Western Australia: a population-based study of incidence and survival |journal=Br. J. Dermatol. |volume=165 |issue=5 |pages=1051–7 |date=November 2011 |pmid=21711338 |doi=10.1111/j.1365-2133.2011.10493.x |url=}}</ref><ref name="pmid24943712">{{cite journal |vauthors=Youlden DR, Soyer HP, Youl PH, Fritschi L, Baade PD |title=Incidence and survival for Merkel cell carcinoma in Queensland, Australia, 1993-2010 |journal=JAMA Dermatol |volume=150 |issue=8 |pages=864–72 |date=August 2014 |pmid=24943712 |doi=10.1001/jamadermatol.2014.124 |url=}}</ref>
*<nowiki/>By 2020, the [[incidence]]<nowiki/> of merkel cell carcinoma was estimated to be 2835 cases in the United States.<ref name="pmid29102486">{{cite journal |vauthors=Paulson KG, Park SY, Vandeven NA, Lachance K, Thomas H, Chapuis AG, Harms KL, Thompson JA, Bhatia S, Stang A, Nghiem P |title=Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics |journal=J. Am. Acad. Dermatol. |volume=78 |issue=3 |pages=457–463.e2 |date=March 2018 |pmid=29102486 |doi=10.1016/j.jaad.2017.10.028 |url=}}</ref>
* By 2035, the [[incidence]]<nowiki/> of merkel cell carcinoma was estimated to be 3284 cases in the United States.<ref name="pmid291024862">{{cite journal |vauthors=Paulson KG, Park SY, Vandeven NA, Lachance K, Thomas H, Chapuis AG, Harms KL, Thompson JA, Bhatia S, Stang A, Nghiem P |title=Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics |journal=J. Am. Acad. Dermatol. |volume=78 |issue=3 |pages=457–463.e2 |date=March 2018 |pmid=29102486 |doi=10.1016/j.jaad.2017.10.028 |url=}}</ref>


===Age===
===Age===
This type of cancer occurs mostly in -- though not restricted to -- Caucasians between 60 and 80 years of age.  
*Merkel cell carcinoma incidence increases progressively with age.<ref name="pmid18280333">{{cite journal| author=Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF et al.| title=Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. | journal=J Am Acad Dermatol | year= 2008 | volume= 58 | issue= 3 | pages= 375-81 | pmid=18280333 | doi=10.1016/j.jaad.2007.11.020 | pmc=PMC2335370 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18280333  }} </ref>
*The majority of patients with merkel cell carcinoma are diagnosed at age > 50 years.<ref name="pmid18280333">{{cite journal| author=Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF et al.| title=Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. | journal=J Am Acad Dermatol | year= 2008 | volume= 58 | issue= 3 | pages= 375-81 | pmid=18280333 | doi=10.1016/j.jaad.2007.11.020 | pmc=PMC2335370 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18280333  }} </ref>
*The [[median]] age at [[diagnosis]] is approximately 65 years.<ref name="cancergov">National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/publications/pdp</ref>
 
===Gender===
===Gender===
It occurs about twice as often in males as in females.
*Merkel cell carcinoma<nowiki/> is slightly more common among males than females.<ref name="pmid18280333">{{cite journal| author=Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF et al.| title=Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. | journal=J Am Acad Dermatol | year= 2008 | volume= 58 | issue= 3 | pages= 375-81 | pmid=18280333 | doi=10.1016/j.jaad.2007.11.020 | pmc=PMC2335370 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18280333  }} </ref>


===Incidence===
===Race===
There are roughly 1200 new cases diagnosed a year in the United States, compared to 60,000 new cases of [[melanoma]] and over 1 million new cases of [[skin cancer|nonmelanoma skin cancer]]. <ref>{{cite journal | author = Hodgson NC. | title = Merkel cell carcinoma: Changing incidence trends. | journal = Journal of surgical oncology | volume = 89 | issue = 1 | pages = 1-4 | year = 2005}}</ref>  
*Merkel cell carcinoma is much more common among individuals of the caucasian race compared to individuals of other ethnicities.<ref name="pmid18280333">{{cite journal| author=Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF et al.| title=Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. | journal=J Am Acad Dermatol | year= 2008 | volume= 58 | issue= 3 | pages= 375-81 | pmid=18280333 | doi=10.1016/j.jaad.2007.11.020 | pmc=PMC2335370 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18280333  }} </ref>


==References==
==References==
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Latest revision as of 02:26, 31 January 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2] Ahmad Al Maradni, M.D. [3]

Overview

The incidence of merkel cell carcinoma ranges from 0.5 per 100,000 individuals. The median age at diagnosis is approximately 65 years. Merkel cell carcinoma is more common among males and individuals of the caucasian race.

Epidemiology and Demographics

Incidence

  • The incidence of merkel cell carcinoma ranges from 0.5 per 100,000 individuals.[1][2]
  • The incidence is thought to have tripled between 1986 and 2001.
  • According to the new research incidence rates are reportedly increasing in Australia and New Zealand.[3][4]
  • By 2020, the incidence of merkel cell carcinoma was estimated to be 2835 cases in the United States.[5]
  • By 2035, the incidence of merkel cell carcinoma was estimated to be 3284 cases in the United States.[6]

Age

  • Merkel cell carcinoma incidence increases progressively with age.[7]
  • The majority of patients with merkel cell carcinoma are diagnosed at age > 50 years.[7]
  • The median age at diagnosis is approximately 65 years.[8]

Gender

  • Merkel cell carcinoma is slightly more common among males than females.[7]

Race

  • Merkel cell carcinoma is much more common among individuals of the caucasian race compared to individuals of other ethnicities.[7]

References

  1. ↑ Girschik J, Thorn K, Beer TW, Heenan PJ, Fritschi L (November 2011). "Merkel cell carcinoma in Western Australia: a population-based study of incidence and survival". Br. J. Dermatol. 165 (5): 1051–7. doi:10.1111/j.1365-2133.2011.10493.x. PMID 21711338.
  2. ↑ Kieny A, Cribier B, Meyer N, Velten M, Jégu J, Lipsker D (February 2019). "Epidemiology of Merkel cell carcinoma. A population-based study from 1985 to 2013, in northeastern of France". Int. J. Cancer. 144 (4): 741–745. doi:10.1002/ijc.31860. PMID 30194728.
  3. ↑ Girschik J, Thorn K, Beer TW, Heenan PJ, Fritschi L (November 2011). "Merkel cell carcinoma in Western Australia: a population-based study of incidence and survival". Br. J. Dermatol. 165 (5): 1051–7. doi:10.1111/j.1365-2133.2011.10493.x. PMID 21711338.
  4. ↑ Youlden DR, Soyer HP, Youl PH, Fritschi L, Baade PD (August 2014). "Incidence and survival for Merkel cell carcinoma in Queensland, Australia, 1993-2010". JAMA Dermatol. 150 (8): 864–72. doi:10.1001/jamadermatol.2014.124. PMID 24943712.
  5. ↑ Paulson KG, Park SY, Vandeven NA, Lachance K, Thomas H, Chapuis AG, Harms KL, Thompson JA, Bhatia S, Stang A, Nghiem P (March 2018). "Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics". J. Am. Acad. Dermatol. 78 (3): 457–463.e2. doi:10.1016/j.jaad.2017.10.028. PMID 29102486.
  6. ↑ Paulson KG, Park SY, Vandeven NA, Lachance K, Thomas H, Chapuis AG, Harms KL, Thompson JA, Bhatia S, Stang A, Nghiem P (March 2018). "Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics". J. Am. Acad. Dermatol. 78 (3): 457–463.e2. doi:10.1016/j.jaad.2017.10.028. PMID 29102486.
  7. ↑ 7.0 7.1 7.2 7.3 Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF; et al. (2008). "Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features". J Am Acad Dermatol. 58 (3): 375–81. doi:10.1016/j.jaad.2007.11.020. PMC 2335370. PMID 18280333.
  8. ↑ National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/publications/pdp


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