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{{Merkel cell cancer}} | {{Merkel cell cancer}} | ||
{{CMG}} ; {{AE}} {{VKG}} | |||
==Overview== | |||
Other diagnostic studies for merkel cell cancer include [[skin biopsy]], which demonstrates positive [[Keratin 20|cytokeratin-20]] , and [[electron microscopy]], which demonstrates [[granules]], and [[cytoplasmic]] extensions. | |||
==Other Diagnostic Studies== | |||
=== Skin biopsy === | |||
[[Skin biopsy]] may be helpful in the diagnosis of merkel cell cancer. | |||
* Findings diagnostic of merkel cell cancer include: | |||
* The [[histopathological]] diagnosis of merkel cell cancer is difficult, and the majority of cases with merkel cell cancer are often misdiagnosed. | |||
* On skin biopsy, merkel cell cancer is characterized by positive staining on [[Keratin 20|cytokeratin-20]] [[immunohistochemical]] assay.<ref name="pmid18280333">{{cite journal| author=Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF et al.| title=Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. | journal=J Am Acad Dermatol | year= 2008 | volume= 58 | issue= 3 | pages= 375-81 | pmid=18280333 | doi=10.1016/j.jaad.2007.11.020 | pmc=PMC2335370 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18280333 }} </ref> | |||
=== Electron microscopy === | |||
* On [[electron microscopy]], merkel cell cancer is characterized by the presence of: | |||
** Neurosecretory [[granules]] within [[cytoplasmic]] extensions.<ref name="pmid18280333">{{cite journal| author=Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF et al.| title=Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. | journal=J Am Acad Dermatol | year= 2008 | volume= 58 | issue= 3 | pages= 375-81 | pmid=18280333 | doi=10.1016/j.jaad.2007.11.020 | pmc=PMC2335370 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18280333 }} </ref> | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | [[Category:Oncology]] | ||
[[Category:Medicine]] | |||
[[Category:Dermatology]] | |||
[[Category:Surgery]] | |||
Latest revision as of 03:12, 31 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
Other diagnostic studies for merkel cell cancer include skin biopsy, which demonstrates positive cytokeratin-20 , and electron microscopy, which demonstrates granules, and cytoplasmic extensions.
Other Diagnostic Studies
Skin biopsy
Skin biopsy may be helpful in the diagnosis of merkel cell cancer.
- Findings diagnostic of merkel cell cancer include:
- The histopathological diagnosis of merkel cell cancer is difficult, and the majority of cases with merkel cell cancer are often misdiagnosed.
- On skin biopsy, merkel cell cancer is characterized by positive staining on cytokeratin-20 immunohistochemical assay.[1]
Electron microscopy
- On electron microscopy, merkel cell cancer is characterized by the presence of:
- Neurosecretory granules within cytoplasmic extensions.[1]
References
- ↑ 1.0 1.1 Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF; et al. (2008). "Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features". J Am Acad Dermatol. 58 (3): 375–81. doi:10.1016/j.jaad.2007.11.020. PMC 2335370. PMID 18280333.