Sepsis history and symptoms: Difference between revisions

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Latest revision as of 00:08, 30 July 2020

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]

Synonyms and keywords: sepsis syndrome; septic shock; septicemia

Overview

Symptoms of sepsis are often related to the underlying infectious process. When the infection crosses into the bloodstream the resulting symptoms of sepsis occur fever, chills, and rigors, confusion, anxiety, difficulty breathing, fatigue and malaise, nausea and vomiting.^[1]^[2]^[3]

History and Symptoms

Symptoms of sepsis are often related to the underlying infectious process. When the infection crosses into the bloodstream the resulting symptoms of sepsis occur:^[1]^[2]^[3]

Fever
A capillary leak syndrome can develop with severe swelling, edema, and third spacing of fluids.
General symptoms can include flu like symptoms as well as shaking chills or rigors.
If the respiratory system is the primary source for sepsis then sore throat, productive cough, and pleuritic chest pain may be present.

Symptoms due to the focal involvement of organs by the bacteria can give clues to the etiology of sepsis. Such symptoms include the following:

Organ system	Symptoms
Head and Neck	Headache Neck stiffness Altered mental status Earache Sore throat Sinus pain or tenderness Cervical or submandibular lymphadenopathy
Pulmonary	Productive cough Pleuritic chest pain Dyspnea Dullness on percussion Bronchial breath sounds with localized rales or any evidence of consolidation
Cardiac	Onset of new murmur H/O of IV drug use
Abdominal and gastrointestinal	Diarrhea Abdominal pain and distention Guarding or rebound tenderness Rectal tenderness or swelling
Pelvic and genitourinary	Flank pain Adnexal tenderness or masses Vaginal or urethral discharge Dysuria, frequency, and urgency
Musculoskeletal	Localized limb pain or tenderness Focal erythema, edema Swollen joint crepitus in necrotizing infections Joint effusions
Skin	Petechiae Purpura Erythema, ulceration, bullous formation, and fluctuance

References

↑ ^1.0 ^1.1 Lever A, Mackenzie I (2007). "Sepsis: definition, epidemiology, and diagnosis". BMJ. 335 (7625): 879–83. doi:10.1136/bmj.39346.495880.AE. PMC 2043413. PMID 17962288.
↑ ^2.0 ^2.1 Juneja, Deven (2012). "Severe sepsis and septic shock in the elderly: An overview". World Journal of Critical Care Medicine. 1 (1): 23. doi:10.5492/wjccm.v1.i1.23. ISSN 2220-3141.
↑ ^3.0 ^3.1 Karnatovskaia LV, Festic E (2012). "Sepsis: a review for the neurohospitalist". Neurohospitalist. 2 (4): 144–53. doi:10.1177/1941874412453338. PMC 3726110. PMID 23983879.

Template:WikiDoc Sources

[pmid17962288-1] 1.0 ^1.1 Lever A, Mackenzie I (2007). "Sepsis: definition, epidemiology, and diagnosis". BMJ. 335 (7625): 879–83. doi:10.1136/bmj.39346.495880.AE. PMC 2043413. PMID 17962288.

[Juneja2012-2] 2.0 ^2.1 Juneja, Deven (2012). "Severe sepsis and septic shock in the elderly: An overview". World Journal of Critical Care Medicine. 1 (1): 23. doi:10.5492/wjccm.v1.i1.23. ISSN 2220-3141.

[pmid23983879-3] 3.0 ^3.1 Karnatovskaia LV, Festic E (2012). "Sepsis: a review for the neurohospitalist". Neurohospitalist. 2 (4): 144–53. doi:10.1177/1941874412453338. PMC 3726110. PMID 23983879.

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[2]

[3]

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 __NOTOC__
+{| class="infobox" style="float: right;"
+| style="vertical-align: middle; padding: 5px;" align=center | [[File:Siren.gif|30px|link=Sepsis resident survival guide]]
+| style="vertical-align: middle; padding: 5px;" align=center | [[Sepsis resident survival guide|'''Resident'''<br>'''Survival'''<br>'''Guide''']]
+|}
 {{Sepsis}}
-{{CMG}}; '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.D.]] [mailto:psingh@perfuse.org]
+{{CMG}};  '''Associate Editor(s)-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, M.B.B.S.]] [mailto:psingh@perfuse.org]
+{{SK}} sepsis syndrome; septic shock; septicemia
-Please help WikiDoc by adding more content here.  It's easy!  Click  [[Help:How_to_Edit_a_Page|here]]  to learn about editing.
 ==Overview==
+Symptoms of sepsis are often related to the underlying infectious process. When the infection crosses into the bloodstream the resulting symptoms of sepsis occur fever, chills, and rigors, confusion, anxiety, difficulty breathing, fatigue and malaise, nausea and vomiting.<ref name="pmid17962288">{{cite journal |vauthors=Lever A, Mackenzie I |title=Sepsis: definition, epidemiology, and diagnosis |journal=BMJ |volume=335 |issue=7625 |pages=879–83 |year=2007 |pmid=17962288 |pmc=2043413 |doi=10.1136/bmj.39346.495880.AE |url=}}</ref><ref name="Juneja2012">{{cite journal|last1=Juneja|first1=Deven|title=Severe sepsis and septic shock in the elderly: An overview|journal=World Journal of Critical Care Medicine|volume=1|issue=1|year=2012|pages=23|issn=2220-3141|doi=10.5492/wjccm.v1.i1.23}}</ref><ref name="pmid23983879">{{cite journal |vauthors=Karnatovskaia LV, Festic E |title=Sepsis: a review for the neurohospitalist |journal=Neurohospitalist |volume=2 |issue=4 |pages=144–53 |year=2012 |pmid=23983879 |pmc=3726110 |doi=10.1177/1941874412453338 |url=}}</ref>
 ==History and Symptoms==
-===History===
+[[Symptoms]] of sepsis are often related to the underlying [[infectious]] process. When the [[infection]] crosses into the [[bloodstream]] the resulting symptoms of sepsis occur:<ref name="pmid17962288">{{cite journal |vauthors=Lever A, Mackenzie I |title=Sepsis: definition, epidemiology, and diagnosis |journal=BMJ |volume=335 |issue=7625 |pages=879–83 |year=2007 |pmid=17962288 |pmc=2043413 |doi=10.1136/bmj.39346.495880.AE |url=}}</ref><ref name="Juneja2012">{{cite journal|last1=Juneja|first1=Deven|title=Severe sepsis and septic shock in the elderly: An overview|journal=World Journal of Critical Care Medicine|volume=1|issue=1|year=2012|pages=23|issn=2220-3141|doi=10.5492/wjccm.v1.i1.23}}</ref><ref name="pmid23983879">{{cite journal |vauthors=Karnatovskaia LV, Festic E |title=Sepsis: a review for the neurohospitalist |journal=Neurohospitalist |volume=2 |issue=4 |pages=144–53 |year=2012 |pmid=23983879 |pmc=3726110 |doi=10.1177/1941874412453338 |url=}}</ref>
-The patient’s history is important in determining the likely site and cause of the septic process. This, in turn, helps in deciding the appropriate antimicrobial therapy and treatment approach.
-===Symptoms===
-Symptoms of sepsis are often related to the underlying infectious process. When the infection crosses into the bloodstream the resulting symptoms of sepsis occurs:
-**[[Fever]]
-A capillary leak syndrome can develop with severe swelling, [[edema]], and third spacing of fluids. General symptoms can include flu like symptoms as well as shaking chills or [[rigors]].
-The immunological response that causes sepsis is a systemic inflammatory response causing widespread activation of [[inflammation]] and [[coagulation]] pathways. This may progress to dysfunction of the [[septic shock|circulatory system]] and, even under optimal treatment, may result in the [[multiple organ dysfunction syndrome]] and eventually [[death]].
+*[[Fever]]
+*A [[capillary leak syndrome]] can develop with severe [[swelling]], [[edema]], and third spacing of fluids.
+*General [[symptoms]] can include flu like symptoms as well as shaking chills or [[rigors]].
+*If the [[respiratory system]] is the primary source for sepsis then [[sore throat]], productive [[cough]], and [[pleuritic chest pain]] may be present.
+Symptoms due to the focal involvement of organs by the bacteria can give clues to the etiology of sepsis. Such symptoms include the following:
+{| class="wikitable"
+!Organ system
+!Symptoms
+|-
+|Head and Neck
+|
+* [[Headache]]
+* [[Neck stiffness]]
+* [[Altered mental status]]
+* [[Otalgia|Earache]]
+* [[Sore throat]]
+* Sinus pain or tenderness
+* Cervical or submandibular lymphadenopathy
+|-
+|Pulmonary
+|
+* Productive [[cough]]
+* [[Pleuritic chest pain]]
+* [[Dyspnea]]
+* Dullness on percussion
+* Bronchial breath sounds with localized rales or any evidence of consolidation
+|-
+|Cardiac
+|
+* Onset of new murmur
+* H/O of IV drug use
+|-
+|Abdominal and gastrointestinal
+|
+* [[Diarrhea]]
+* Abdominal pain and distention
+* Guarding or rebound tenderness
+* Rectal tenderness or swelling
+|-
+|Pelvic and genitourinary
+|
+* [[Flank pain]]
+* Adnexal tenderness or masses
+* [[Vaginal discharge|Vaginal]] or [[urethral discharge]]
+* [[Dysuria]], frequency, and [[Urinary urgency|urgency]]
+|-
+|Musculoskeletal
+|
+* Localized limb pain or tenderness
+* Focal [[erythema]], edema
+* Swollen joint crepitus in necrotizing infections
+* Joint effusions
+|-
+|Skin
+|
+* [[Petechiae]]
+* [[Purpura]]
+* [[Erythema]], [[ulceration]], bullous formation, and fluctuance
+|}
 ==References==
 {{reflist|2}}
+{{WikiDoc Help Menu}}
+{{WikiDoc Sources}}
+[[Category:Needs overview]]
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+[[Category:Intensive care medicine]]
+[[Category:Causes of death]]
+[[Category:Emergency medicine]]
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+[[Category:Emergency mdicine]]
+[[Category:Up-To-Date]]
 [[Category:Infectious disease]]
-[[Category:Intensive care medicine]]
-[[Category:Emergency medicine]]
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Sepsis history and symptoms: Difference between revisions

Latest revision as of 00:08, 30 July 2020

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History and Symptoms

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