Hepatocellular adenoma medical therapy: Difference between revisions

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__NOTOC__
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{{Hepatocellular adenoma}}
{{Hepatocellular adenoma}}
{{CMG}}; {{AE}} {{ZAS}}
==Overview==
There is no specific [[Medicine|medical]] [[therapy]] for hepatocellular adenoma. The wait-and-watch policy is recommended for hepatocellular adenomas < 5 cm following cessation of offending [[Drug|drugs]] ([[Oral contraceptive|OCPs]]) with no further [[growth]] detected. An annual follow-up with [[Magnetic resonance imaging|MRI]] or [[ultrasound]] is scheduled for [[female]] [[Patient|patients]] untill [[menopause]].


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==Medical Therapy==
* There is no specific [[Medicine|medical]] [[therapy]] for hepatocellular adenoma.<ref name="cde">{{cite journal | author = Toso C, Majno P, Andres A, Rubbia-Brandt L, Berney T, Buhler L, Morel P, Mentha G | title = Management of hepatocellular adenoma: solitary-uncomplicated, multiple and ruptured tumors. | journal = World J Gastroenterol | volume = 11 | issue = 36 | pages = 5691-5 | year = 2005 | id = PMID 16237767}}''[http://www.wjgnet.com/1007-9327/11/5691.asp Full text]''</ref><ref name="pmid8813164">{{cite journal| author=Ault GT, Wren SM, Ralls PW, Reynolds TB, Stain SC| title=Selective management of hepatic adenomas. | journal=Am Surg | year= 1996 | volume= 62 | issue= 10 | pages= 825-9 | pmid=8813164 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8813164  }} </ref>
* Historically, hepatocellular adenomas were treated with a wait-and-watch policy, with [[Surgery|surgical intervention]] recommended for larger (> 5 cm) [[Tumor|tumors]].
* In [[asymptomatic]] [[female]] [[Patient|patients]], the first step is to stop the offending [[drug]] (such as [[Oral contraceptive|OCPs]]) and follow-up to document any change in the size of the [[tumor]].
* The wait-and-watch policy is recommended when the tumor is < 5 cm in size or when it has [[Regression|regressed]] (to < 5 cm) following cessation of the offending [[drug]] ([[Oral contraceptive|OCPs]]) with no further [[growth]] detected.<ref>{{Cite journal
| author = [[Maarten G. Thomeer]], [[Mirelle Broker]], [[Joanne Verheij]], [[Michael Doukas]], [[Turkan Terkivatan]], [[Diederick Bijdevaate]], [[Robert A. De Man]], [[Adriaan Moelker]] & [[Jan N. IJzermans]]
| title = Hepatocellular adenoma: when and how to treat? Update of current evidence
| journal = [[Therapeutic advances in gastroenterology]]
| volume = 9
| issue = 6
| pages = 898–912
| year = 2016
| month = November
| doi = 10.1177/1756283X16663882
| pmid = 27803743
}}</ref>
* An annual follow-up with [[Magnetic resonance imaging|MRI]] or [[ultrasound]] is scheduled for [[female]] [[Patient|patients]] untill [[menopause]].<ref name="pmid18333188">{{cite journal| author=Barthelmes L, Tait IS| title=Liver cell adenoma and liver cell adenomatosis. | journal=HPB (Oxford) | year= 2005 | volume= 7 | issue= 3 | pages= 186-96 | pmid=18333188 | doi=10.1080/13651820510028954 | pmc=PMC2023950 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18333188  }} </ref><ref>{{Cite journal
| author = [[A. F. Mariani]], [[A. S. Livingstone]], [[R. V. Jr Pereiras]], [[P. E. van Zuiden]] & [[E. R. Schiff]]
| title = Progressive enlargement of an hepatic cell adenoma
| journal = [[Gastroenterology]]
  | volume = 77
| issue = 6
| pages = 1319–1325
| year = 1979
| month = December
| pmid = 499719
}}</ref><ref>{{Cite journal
| author = [[P. H. Andersen]] & [[J. T. Packer]]
  | title = Hepatic adenoma. Observations after estrogen withdrawal
  | journal = [[Archives of surgery (Chicago, Ill. : 1960)]]
| volume = 111
| issue = 8
| pages = 898–900
| year = 1976
| month = August
| pmid = 182106
}}</ref><ref>{{Cite journal
| author = [[S. Kay]]
  | title = Nine year follow-up of a case of benign liver cell adenoma related to oral contraceptives
| journal = [[Cancer]]
| volume = 40
| issue = 4
| pages = 1759–1760
| year = 1977
| month = October
| pmid = 198104
}}</ref><ref>{{Cite journal
| author = [[P. Aseni]], [[C. V. Sansalone]], [[C. Sammartino]], [[F. D. Benedetto]], [[G. Carrafiello]], [[A. Giacomoni]], [[C. Osio]], [[M. Vertemati]] & [[D. Forti]]
| title = Rapid disappearance of hepatic adenoma after contraceptive withdrawal
| journal = [[Journal of clinical gastroenterology]]
| volume = 33
| issue = 3
| pages = 234–236
| year = 2001
| month = September
| pmid = 11500616
}}</ref><ref>{{Cite journal
| author = [[H. Buhler]], [[M. Pirovino]], [[A. Akobiantz]], [[J. Altorfer]], [[M. Weitzel]], [[E. Maranta]] & [[M. Schmid]]
| title = Regression of liver cell adenoma. A follow-up study of three consecutive patients after discontinuation of oral contraceptive use
| journal = [[Gastroenterology]]
| volume = 82
| issue = 4
| pages = 775–782
| year = 1982
| month = April
| pmid = 6277724
}}</ref><ref>{{Cite journal
| author = [[B. Heeringa]] & [[A. Sardi]]
| title = Bleeding hepatic adenoma: expectant treatment to limit the extent of liver resection
| journal = [[The American surgeon]]
| volume = 67
| issue = 10
| pages = 927–929
| year = 2001
| month = October
| pmid = 11603546
}}</ref>


==References==
==References==
{{reflist|2}}
{{reflist|1}}


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Latest revision as of 01:54, 23 August 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]

Overview

There is no specific medical therapy for hepatocellular adenoma. The wait-and-watch policy is recommended for hepatocellular adenomas < 5 cm following cessation of offending drugs (OCPs) with no further growth detected. An annual follow-up with MRI or ultrasound is scheduled for female patients untill menopause.

Medical Therapy

References

  1. ↑ Toso C, Majno P, Andres A, Rubbia-Brandt L, Berney T, Buhler L, Morel P, Mentha G (2005). "Management of hepatocellular adenoma: solitary-uncomplicated, multiple and ruptured tumors". World J Gastroenterol. 11 (36): 5691–5. PMID 16237767.Full text
  2. ↑ Ault GT, Wren SM, Ralls PW, Reynolds TB, Stain SC (1996). "Selective management of hepatic adenomas". Am Surg. 62 (10): 825–9. PMID 8813164.
  3. ↑ Maarten G. Thomeer, Mirelle Broker, Joanne Verheij, Michael Doukas, Turkan Terkivatan, Diederick Bijdevaate, Robert A. De Man, Adriaan Moelker & Jan N. IJzermans (2016). "Hepatocellular adenoma: when and how to treat? Update of current evidence". Therapeutic advances in gastroenterology. 9 (6): 898–912. doi:10.1177/1756283X16663882. PMID 27803743. Unknown parameter |month= ignored (help)
  4. ↑ Barthelmes L, Tait IS (2005). "Liver cell adenoma and liver cell adenomatosis". HPB (Oxford). 7 (3): 186–96. doi:10.1080/13651820510028954. PMC 2023950. PMID 18333188.
  5. ↑ A. F. Mariani, A. S. Livingstone, R. V. Jr Pereiras, P. E. van Zuiden & E. R. Schiff (1979). "Progressive enlargement of an hepatic cell adenoma". Gastroenterology. 77 (6): 1319–1325. PMID 499719. Unknown parameter |month= ignored (help)
  6. ↑ P. H. Andersen & J. T. Packer (1976). "Hepatic adenoma. Observations after estrogen withdrawal". Archives of surgery (Chicago, Ill. : 1960). 111 (8): 898–900. PMID 182106. Unknown parameter |month= ignored (help)
  7. ↑ S. Kay (1977). "Nine year follow-up of a case of benign liver cell adenoma related to oral contraceptives". Cancer. 40 (4): 1759–1760. PMID 198104. Unknown parameter |month= ignored (help)
  8. ↑ P. Aseni, C. V. Sansalone, C. Sammartino, F. D. Benedetto, G. Carrafiello, A. Giacomoni, C. Osio, M. Vertemati & D. Forti (2001). "Rapid disappearance of hepatic adenoma after contraceptive withdrawal". Journal of clinical gastroenterology. 33 (3): 234–236. PMID 11500616. Unknown parameter |month= ignored (help)
  9. ↑ H. Buhler, M. Pirovino, A. Akobiantz, J. Altorfer, M. Weitzel, E. Maranta & M. Schmid (1982). "Regression of liver cell adenoma. A follow-up study of three consecutive patients after discontinuation of oral contraceptive use". Gastroenterology. 82 (4): 775–782. PMID 6277724. Unknown parameter |month= ignored (help)
  10. ↑ B. Heeringa & A. Sardi (2001). "Bleeding hepatic adenoma: expectant treatment to limit the extent of liver resection". The American surgeon. 67 (10): 927–929. PMID 11603546. Unknown parameter |month= ignored (help)


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