Insulin resistance historical perspective: Difference between revisions
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==Overview== | ==Overview== | ||
==Historical Perspective== | |||
The concept that insulin resistance may be the underlying cause of [[diabetes mellitus]] type 2 was first advanced by Sir [[Harold Percival Himsworth]] of the University College Hospital Medical Center in London in 1936.<ref name=Himsworth_1936>{{cite journal | author = Himsworth HP | title = Diabetes mellitus: its differentiation into insulin-sensitive and insulin-insensitive types | journal = Lancet | year = 1936 | volume = 1 | pages = 127–130 | url= }}</ref> | |||
In the 1950's, research scientists Solomon Berson and Rosalyn Yalow developed a technique to measure circulating levels of hormones and other substances in the blood, called radioimmunoassay. Using this technique lead Berson and Yalow to discover that individuals with type 2 diabetes exhibited higher than average levels of circulating insulin than individuals with normal glucose tolerance. | |||
==References== | ==References== | ||
Latest revision as of 05:23, 8 July 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Dayana Davidis, M.D. [2]
Overview
Historical Perspective
The concept that insulin resistance may be the underlying cause of diabetes mellitus type 2 was first advanced by Sir Harold Percival Himsworth of the University College Hospital Medical Center in London in 1936.[1]
In the 1950's, research scientists Solomon Berson and Rosalyn Yalow developed a technique to measure circulating levels of hormones and other substances in the blood, called radioimmunoassay. Using this technique lead Berson and Yalow to discover that individuals with type 2 diabetes exhibited higher than average levels of circulating insulin than individuals with normal glucose tolerance.
References
- ↑ Himsworth HP (1936). "Diabetes mellitus: its differentiation into insulin-sensitive and insulin-insensitive types". Lancet. 1: 127&ndash, 130.