Hashimoto's thyroiditis laboratory findings: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Hashimoto's thyroiditis}} | {{Hashimoto's thyroiditis}} | ||
{{CMG}} | {{CMG}} {{AE}} {{MMF}} | ||
==Overview== | ==Overview== | ||
Laboratory findings consistent with the diagnosis of [[Hashimoto's thyroiditis]] usually include increased [[Thyroid-stimulating hormone|thyroid stimulating hormone]], decreased [[free T3]] and [[free T4]], and [[thyroid peroxidase|anti-thyroid peroxidase antibodies]]. | |||
== Laboratory Findings == | |||
Laboratory findings consistent with the diagnosis of Hashimoto's thyroiditis usually include increased [[Thyroid function tests|thyroid stimulating hormone, decreased free T3 and free T4]], and Anti-[[thyroid peroxidase]] antibodies.<ref name="pmid25535130">{{cite journal |vauthors=Dong YH, Fu DG |title=Autoimmune thyroid disease: mechanism, genetics and current knowledge |journal=Eur Rev Med Pharmacol Sci |volume=18 |issue=23 |pages=3611–8 |year=2014 |pmid=25535130 |doi= |url=}}</ref><ref name="pmid24434360">{{cite journal |vauthors=Caturegli P, De Remigis A, Rose NR |title=Hashimoto thyroiditis: clinical and diagnostic criteria |journal=Autoimmun Rev |volume=13 |issue=4-5 |pages=391–7 |year=2014 |pmid=24434360 |doi=10.1016/j.autrev.2014.01.007 |url=}}</ref> | |||
===Thyroid hormones=== | |||
*Increased [[Thyroid-stimulating hormone]] (TSH) | |||
*Decreased Free [[T3]] and Free [[T4]] | |||
*[[TSH]] may be decreased in the transient hyperthyroid state<ref>{{cite journal|last=Simmons|first=PJ|title=Antigen-presenting dendritic cells as regulators of the growth of thyrocytes: a role of interleukin-1beta and interleukin-6|journal=Endocrinology|year=1998|volume=139|issue=7|pages=3158–3186|pmid=9645688|doi=10.1210/en.139.7.3148}}</ref> | |||
== | ===Thyroid antibodies=== | ||
* [[thyroid peroxidase|Anti-thyroid peroxidase]] antibodies (anti-TPO) (correlates with the disease severity) | |||
* [[thyroglobulin|Anti-thyroglobulin]] antibodies (anti-Tg) | |||
* [[Antimicrosomal antibody|Anti-microsomal antibodies]] can help obtain an accurate diagnosis<ref>{{cite book |last1= Giannini |first1= AJ |authorlink1= |title= The Biological Foundations of Clinical Psychiatry |url= |year= 1986 |publisher= Medical Examination Publishing Company |location= New Hyde Park, NY |language= |isbn= 0-87488-449-7 |oclc= |doi= |id= |page= |pages= 193–198 |quote= |ref= |bibcode= }}</ref> | |||
===Diagnostic findings of Hashimoto's thyroiditis=== | |||
{| class="wikitable" | |||
| rowspan="2" |[[Thyroid function test]] | |||
|'''''↓'''''[[TSH]] '''↑''' [[T3]] and [[T4]] | |||
|In transient hyperthyroidism | |||
|- | |||
|'''↑''' [[TSH]] '''''↓''''' [[T3]] and [[T4]] | |||
|In the hypothyroid state | |||
|- | |||
| rowspan="3" |Antibodies | |||
|[[thyroid peroxidase|Anti-thyroid peroxidase]] antibodies | |||
|Positive | |||
|- | |||
|[[thyroglobulin|Anti-thyroglobulin]] antibodies | |||
|Positive | |||
|- | |||
|[[Antimicrosomal antibody|Anti-microsomal antibodies]] | |||
|Positive | |||
|- | |||
|[[Radioiodine]] reuptake | |||
|[[I-123 thyroid imaging|I-123]] reuptake | |||
|'''''↓''''' | |||
|} | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
{{WH}} | |||
[[Category: | {{WS}} | ||
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[[Category:Medicine]] | |||
[[Category:Endocrinology]] | [[Category:Endocrinology]] | ||
[[Category: | [[Category:Up-To-Date]] | ||
Latest revision as of 21:58, 29 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]
Overview
Laboratory findings consistent with the diagnosis of Hashimoto's thyroiditis usually include increased thyroid stimulating hormone, decreased free T3 and free T4, and anti-thyroid peroxidase antibodies.
Laboratory Findings
Laboratory findings consistent with the diagnosis of Hashimoto's thyroiditis usually include increased thyroid stimulating hormone, decreased free T3 and free T4, and Anti-thyroid peroxidase antibodies.[1][2]
Thyroid hormones
- Increased Thyroid-stimulating hormone (TSH)
- Decreased Free T3 and Free T4
- TSH may be decreased in the transient hyperthyroid state[3]
Thyroid antibodies
- Anti-thyroid peroxidase antibodies (anti-TPO) (correlates with the disease severity)
- Anti-thyroglobulin antibodies (anti-Tg)
- Anti-microsomal antibodies can help obtain an accurate diagnosis[4]
Diagnostic findings of Hashimoto's thyroiditis
| Thyroid function test | ↓TSH ↑ T3 and T4 | In transient hyperthyroidism |
| ↑ TSH ↓ T3 and T4 | In the hypothyroid state | |
| Antibodies | Anti-thyroid peroxidase antibodies | Positive |
| Anti-thyroglobulin antibodies | Positive | |
| Anti-microsomal antibodies | Positive | |
| Radioiodine reuptake | I-123 reuptake | ↓ |
References
- ↑ Dong YH, Fu DG (2014). "Autoimmune thyroid disease: mechanism, genetics and current knowledge". Eur Rev Med Pharmacol Sci. 18 (23): 3611–8. PMID 25535130.
- ↑ Caturegli P, De Remigis A, Rose NR (2014). "Hashimoto thyroiditis: clinical and diagnostic criteria". Autoimmun Rev. 13 (4–5): 391–7. doi:10.1016/j.autrev.2014.01.007. PMID 24434360.
- ↑ Simmons, PJ (1998). "Antigen-presenting dendritic cells as regulators of the growth of thyrocytes: a role of interleukin-1beta and interleukin-6". Endocrinology. 139 (7): 3158–3186. doi:10.1210/en.139.7.3148. PMID 9645688.
- ↑ Giannini, AJ (1986). The Biological Foundations of Clinical Psychiatry. New Hyde Park, NY: Medical Examination Publishing Company. pp. 193–198. ISBN 0-87488-449-7.