Hashimoto's thyroiditis causes: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Hashimoto's thyroiditis}} | {{Hashimoto's thyroiditis}} | ||
{{CMG}} {{AE}} {{MMF}} | |||
==Overview== | |||
Hashimoto's thyroiditis may be caused by [[T cell|T cells]] and [[B cell|B cells]] auto-activation, [[genetic]] factors, and autoimmune antibodies against [[Thyrotropin receptor|thyrotropin receptors]]. | |||
==Causes== | |||
[[Hashimoto's thyroiditis|Hashimoto's thyroidit]]<nowiki/>is usually caused by:<ref name="pmid26361257">{{cite journal |vauthors=Ajjan RA, Weetman AP |title=The Pathogenesis of Hashimoto's Thyroiditis: Further Developments in our Understanding |journal=Horm. Metab. Res. |volume=47 |issue=10 |pages=702–10 |year=2015 |pmid=26361257 |doi=10.1055/s-0035-1548832 |url=}}</ref><ref name="pmid24434360">{{cite journal |vauthors=Caturegli P, De Remigis A, Rose NR |title=Hashimoto thyroiditis: clinical and diagnostic criteria |journal=Autoimmun Rev |volume=13 |issue=4-5 |pages=391–7 |year=2014 |pmid=24434360 |doi=10.1016/j.autrev.2014.01.007 |url=}}</ref> | |||
===Common Causes=== | |||
*Autoantibodies against [[thyroid peroxidase]] and [[thyroglobulin]] | |||
*Abnormalities in the [[suppressor T cells]] and [[Regulatory T cell|regulatory T cells]] | |||
*HLA-B* 46:01, HLA-A* 02:07 and HLA-DRB4 involvement | |||
===Less common cause=== | |||
*[[Immunomodulatory]] drugs (e.g, [[interferon-alpha]]) | |||
*[[Monoclonal antibodies]] that block [[CTLA-4]] | |||
*[[Cancer]] [[vaccines]] | |||
*[[MicroRNA|Micro RNA]] involvement | |||
*[[Polyglandular autoimmune syndrome|Polyglandular Syndrome]] | |||
For the factors involved in the development of Hashimoto's thyroiditis, please '''[[Hashimoto's thyroiditis risk factors|click here]].''' | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
{{WH}} | |||
[[Category: | {{WS}} | ||
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[[Category:Medicine]] | |||
[[Category:Endocrinology]] | [[Category:Endocrinology]] | ||
[[Category: | [[Category:Up-To-Date]] | ||
Latest revision as of 21:58, 29 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]
Overview
Hashimoto's thyroiditis may be caused by T cells and B cells auto-activation, genetic factors, and autoimmune antibodies against thyrotropin receptors.
Causes
Hashimoto's thyroiditis usually caused by:[1][2]
Common Causes
- Autoantibodies against thyroid peroxidase and thyroglobulin
- Abnormalities in the suppressor T cells and regulatory T cells
- HLA-B* 46:01, HLA-A* 02:07 and HLA-DRB4 involvement
Less common cause
- Immunomodulatory drugs (e.g, interferon-alpha)
- Monoclonal antibodies that block CTLA-4
- Cancer vaccines
- Micro RNA involvement
- Polyglandular Syndrome
For the factors involved in the development of Hashimoto's thyroiditis, please click here.
References
- ↑ Ajjan RA, Weetman AP (2015). "The Pathogenesis of Hashimoto's Thyroiditis: Further Developments in our Understanding". Horm. Metab. Res. 47 (10): 702–10. doi:10.1055/s-0035-1548832. PMID 26361257.
- ↑ Caturegli P, De Remigis A, Rose NR (2014). "Hashimoto thyroiditis: clinical and diagnostic criteria". Autoimmun Rev. 13 (4–5): 391–7. doi:10.1016/j.autrev.2014.01.007. PMID 24434360.