Kallman syndrome epidemiology and demographics: Difference between revisions
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==Overview== | ==Overview== | ||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
===Prevalance=== | |||
Kallmann syndrome occurs at a rate of 1 in 10,000 male births and 1 in 50,000 female births. It may be inherited as an X-linked condition, an autosomal dominant condition or as an autosomal recessive condition. Statistics are sparse, but it seems that autosomal dominant is the most common form of heredity. Even though mutations in the KAL-1 gene on the X chromosome can cause Kallmann syndrome, only 11-14% of patients with Kallmann syndrome have detectable KAL-1 mutations. | |||
There may also be no obvious family history of inheritance (sporadic cases). However, it is possible for Kallmann syndrome genes to be passed on to children of a sporadic case. | |||
===Gender=== | |||
One recent paper <ref name="Quinton">Quinton R. Topical Endocrinology 22. (15-20)</ref> quoted an incidence in males of 0.025%, or 1 in 4,000, with the female incidence being 3 to 5 times less. | One recent paper <ref name="Quinton">Quinton R. Topical Endocrinology 22. (15-20)</ref> quoted an incidence in males of 0.025%, or 1 in 4,000, with the female incidence being 3 to 5 times less. | ||
==References== | ==References== | ||
Latest revision as of 16:31, 19 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Epidemiology and Demographics
Prevalance
Kallmann syndrome occurs at a rate of 1 in 10,000 male births and 1 in 50,000 female births. It may be inherited as an X-linked condition, an autosomal dominant condition or as an autosomal recessive condition. Statistics are sparse, but it seems that autosomal dominant is the most common form of heredity. Even though mutations in the KAL-1 gene on the X chromosome can cause Kallmann syndrome, only 11-14% of patients with Kallmann syndrome have detectable KAL-1 mutations.
There may also be no obvious family history of inheritance (sporadic cases). However, it is possible for Kallmann syndrome genes to be passed on to children of a sporadic case.
Gender
One recent paper [1] quoted an incidence in males of 0.025%, or 1 in 4,000, with the female incidence being 3 to 5 times less.
References
- ↑ Quinton R. Topical Endocrinology 22. (15-20)