Maturity onset diabetes of the young: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
No edit summary
 
(10 intermediate revisions by the same user not shown)
Line 1: Line 1:
__NOTOC__
{{Infobox_Disease |
{{Infobox_Disease |
   Name          = {{PAGENAME}} |
   Name          = {{PAGENAME}} |
Line 13: Line 14:
   MeshID        = D003924 |
   MeshID        = D003924 |
}}
}}
{{Maturity onset diabetes of the young}}
{{Maturity onset diabetes of the young}}
{{CMG}}
{{CMG}}


{{SK}} MODY;
{{SK}} MODY;


==Management==
== [[Maturity onset diabetes of the young overview|Overview]] ==
Unfortunately, chronic hyperglycemia of any cause can eventually cause blood vessel damage and the microvascular complications of diabetes. The principal treatment goals for people with MODY — keeping the blood sugars as close to normal as possible ("good [[Diabetes management#Glycemic control|glycemic control]]"), while minimizing other vascular risk factors — are the same for all known forms of diabetes.
 
== [[Maturity onset diabetes of the young historical perspective|Historical Perspective]] ==
 
== [[Maturity onset diabetes of the young classification|Classification]] ==
 
== [[Maturity onset diabetes of the young pathophysiology|Pathophysiology]] ==
 
== [[Maturity onset diabetes of the young causes|Causes]] ==
 
== [[Maturity onset diabetes of the young differential diagnosis|Differentiating Maturity onset diabetes of the young from other Diseases]] ==
 
== [[Maturity onset diabetes of the young epidemiology and demographics|Epidemiology and Demographics]] ==
 
== [[Maturity onset diabetes of the young risk factors|Risk Factors]] ==
 
== [[Maturity onset diabetes of the young screening|Screening]] ==


Tools available for management are also those available for all forms of diabetes: blood testing, changes in [[diet (nutrition)|diet]], physical [[exercise]], oral hypoglycemic agents, and insulin injections. In many cases these goals can be achieved more easily with MODY than with ordinary types 1 and 2 diabetes. Some people with MODY may require insulin injections to achieve the same [[Diabetes management#Glycemic control|glycemic control]] that another person may attain with careful eating or an oral medication.
== [[Maturity onset diabetes of the young natural history, complications and prognosis|Natural History, Complications and Prognosis]] ==


When oral hypoglycemic agents are used in MODY, the sulfonylureas remain the oral medication of first resort. Patients with MODY less often suffer from obesity and [[insulin resistance]] than those with ordinary type 2 diabetes (for whom insulin sensitizers like [[metformin]] or the [[thiazolidinedione]]s are often preferred over the sulfonylureas).
== Diagnosis ==


==References==
[[Maturity onset diabetes of the young history and symptoms|History and Symptoms]] | [[Maturity onset diabetes of the young physical examination|Physical Examination]] | [[Maturity onset diabetes of the young laboratory tests|Laboratory Findings]] | [[Maturity onset diabetes of the young CT|CT]] | [[Maturity onset diabetes of the young MRI|MRI]] | [[Maturity onset diabetes of the young echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Maturity onset diabetes of the young other imaging findings|Other Imaging Findings]] | [[Maturity onset diabetes of the young other diagnostic studies|Other Diagnostic Studies]]
{{reflist|2}}


==Further reading==
== Treatment ==
* {{cite journal |author=Fajans SS |title=Scope and heterogeneous nature of MODY |journal=Diabetes Care |volume=13 |issue=1 |pages=49–64 |year=1990 |pmid=2404717 |doi=10.2337/diacare.13.1.49}} (''For historical perspective, this review covers the concept just before the nature of the first of the specific molecular defects was discovered. It illustrates the significant change in the disease(s) referred to as MODY before and after 1990.'')


* {{cite journal |author=Fajans SS, Bell GI, Polonsky KS |title=Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young |journal=N. Engl. J. Med. |volume=345 |issue=13 |pages=971–80 |year=2001 |pmid=11575290 |doi=10.1056/NEJMra002168|url=http://content.nejm.org/cgi/content/extract/345/13/971?view=extractpmid=11575290}} (''An excellent overview of the modern concept of the 6 types of MODY.'')
[[Maturity onset diabetes of the young medical therapy|Medical Therapy]] | [[Maturity onset diabetes of the young surgery|Surgery]] | [[Maturity onset diabetes of the young primary prevention|Primary Prevention]] | [[Maturity onset diabetes of the young secondary prevention|Secondary Prevention]] | [[Maturity onset diabetes of the young cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Maturity onset diabetes of the young future or investigational therapies|Future or Investigational Therapies]]


*[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowTOC&rid=diabetes.TOC Dean L and McEntyre J, 2004.] '''The Genetic Landscape of Diabetes'''. Bethesda:NCBI, 2004. ''This is an entire online textbook on the complex genetics of the forms of diabetes. The chapter on MODY provides an up-to-date and concise overview of the molecular defects. Little expansion of clinical knowledge of the 6 types since 2001 has occurred.''
== Case Studies ==
 
[[Maturity onset diabetes of the young case study one|Case #1]]
 
== External links ==


==External links==
* [http://www.diabetesgenes.org Andrew Hattersley's Exeter and Oxford research groups]
* [http://www.diabetesgenes.org Andrew Hattersley's Exeter and Oxford research groups]
* [http://www.athenadiagnostics.com/MODY Virtual Grand Rounds: "MODY" by William E. Winter]


[[Category:Diabetes]]
[[Category:Diabetes]]
[[Category:Endocrinology]]
[[Category:Endocrinology]]
[[Category:Disease]]


[[it:Maturity onset diabetes of the young]]
[[it:Maturity onset diabetes of the young]]
{{WikiDoc Help Menu}}
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}
{{WikiDoc Sources}}

Latest revision as of 02:32, 20 September 2012

Maturity onset diabetes of the young
OMIM 606391
DiseasesDB 8330
MeSH D003924

Maturity onset diabetes of the young Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Maturity onset diabetes of the young from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Maturity onset diabetes of the young On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Maturity onset diabetes of the young

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Maturity onset diabetes of the young

CDC on Maturity onset diabetes of the young

Maturity onset diabetes of the young in the news

Blogs on Maturity onset diabetes of the young

Directions to Hospitals Treating Maturity onset diabetes of the young

Risk calculators and risk factors for Maturity onset diabetes of the young

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: MODY;

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Maturity onset diabetes of the young from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

External links

it:Maturity onset diabetes of the young


Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=Maturity_onset_diabetes_of_the_young&oldid=745047"