Swyer's syndrome causes: Difference between revisions
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{{Swyer's syndrome}} | {{Swyer's syndrome}} | ||
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==Overview== | |||
==Causes== | |||
Mutations of SRY account for most cases of Swyer syndrome. When this gene is defective, [[testes]] fail to develop in an XY (genetically male) fetus. Without testes, no [[testosterone]] or [[antimullerian hormone]] are produced. Without [[testosterone]] the external [[genitalia]] fail to [[virilization|virilize]], resulting in female genitalia. Without testosterone, the [[wolffian duct]]s fail to develop, so no internal male organs are formed. Without [[antimullerian hormone|AMH]] the [[mullerian duct]]s develop into normal internal female organs ([[uterus]], [[fallopian tube]]s, [[cervix]], [[vagina]]). | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Latest revision as of 12:16, 20 September 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Causes
Mutations of SRY account for most cases of Swyer syndrome. When this gene is defective, testes fail to develop in an XY (genetically male) fetus. Without testes, no testosterone or antimullerian hormone are produced. Without testosterone the external genitalia fail to virilize, resulting in female genitalia. Without testosterone, the wolffian ducts fail to develop, so no internal male organs are formed. Without AMH the mullerian ducts develop into normal internal female organs (uterus, fallopian tubes, cervix, vagina).