Thrombotic thrombocytopenic purpura classification: Difference between revisions
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{{Thrombotic thrombocytopenic purpura}} | {{Thrombotic thrombocytopenic purpura}} | ||
{{CMG}} | {{CMG}}; {{AE}} {{S.G.}} | ||
==Overview== | ==Overview== | ||
== Classification == | TTP may be classified according to ''[[ADAMTS13]]'' [[gene]] [[Mutation|mutations]] and [[autoantibody]] against [[ADAMTS13]] into two subtypes: herditary [[Syndrome|syndromes]], aquired [[Syndrome|syndromes]]. | ||
==Classification== | |||
TTP may be classified into several subtypes based on ''[[ADAMTS13]]'' [[gene]] [[Mutation|mutations]](herditary [[Syndrome|syndromes]]) and [[autoantibody]] against [[ADAMTS13]](aquired [[Syndrome|syndromes]]):<ref name="pmid26581428">{{cite journal |vauthors=Tersteeg C, Verhenne S, Roose E, Schelpe AS, Deckmyn H, De Meyer SF, Vanhoorelbeke K |title=ADAMTS13 and anti-ADAMTS13 autoantibodies in thrombotic thrombocytopenic purpura - current perspectives and new treatment strategies |journal=Expert Rev Hematol |volume=9 |issue=2 |pages=209–21 |date=2016 |pmid=26581428 |doi=10.1586/17474086.2016.1122515 |url=}}</ref><ref>{{Cite journal | |||
| author = [[Yoshihiro Fujimura]], [[Masanori Matsumoto]], [[Hideo Yagi]], [[Akira Yoshioka]], [[Taei Matsui]] & [[Koiti Titani]] | |||
| title = Von Willebrand factor-cleaving protease and Upshaw-Schulman syndrome | |||
| journal = [[International journal of hematology]] | |||
| volume = 75 | |||
| issue = 1 | |||
| pages = 25–34 | |||
| year = 2002 | |||
| month = January | |||
| pmid = 11843286 | |||
}}</ref> | |||
'''1.Hereditary:''' | |||
* [[Congenital disorder|Congenital]] TTP | |||
* [[Inherited]] TTP | |||
* [[Familial]] TTP | |||
* Upshaw-Schulman syndrome (USS) is an [[autosomal]] recessive [[disease]] of [[ADAMTS13]] [[gene]] on [[chromosome]] 9q34 . | |||
'''2.Acquired''' | |||
* Existence of an [[inhibitory]] [[antibody]] against [[ADAMTS13]] due to the variety of [[Condition|conditions.]] | |||
==References== | ==References== | ||
{{ | {{Reflist|2}} | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
Latest revision as of 12:02, 14 March 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]
Overview
TTP may be classified according to ADAMTS13 gene mutations and autoantibody against ADAMTS13 into two subtypes: herditary syndromes, aquired syndromes.
Classification
TTP may be classified into several subtypes based on ADAMTS13 gene mutations(herditary syndromes) and autoantibody against ADAMTS13(aquired syndromes):[1][2]
1.Hereditary:
- Congenital TTP
- Inherited TTP
- Familial TTP
- Upshaw-Schulman syndrome (USS) is an autosomal recessive disease of ADAMTS13 gene on chromosome 9q34 .
2.Acquired
- Existence of an inhibitory antibody against ADAMTS13 due to the variety of conditions.
References
- ↑ Tersteeg C, Verhenne S, Roose E, Schelpe AS, Deckmyn H, De Meyer SF, Vanhoorelbeke K (2016). "ADAMTS13 and anti-ADAMTS13 autoantibodies in thrombotic thrombocytopenic purpura - current perspectives and new treatment strategies". Expert Rev Hematol. 9 (2): 209–21. doi:10.1586/17474086.2016.1122515. PMID 26581428.
- ↑ Yoshihiro Fujimura, Masanori Matsumoto, Hideo Yagi, Akira Yoshioka, Taei Matsui & Koiti Titani (2002). "Von Willebrand factor-cleaving protease and Upshaw-Schulman syndrome". International journal of hematology. 75 (1): 25–34. PMID 11843286. Unknown parameter
|month=ignored (help)