Thrombotic thrombocytopenic purpura physical examination: Difference between revisions

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{{Thrombotic thrombocytopenic purpura}}
{{Thrombotic thrombocytopenic purpura}}
{{CMG}}
 
{{CMG}} {{AE}} {{S.G.}}
 
==Overview==
==Overview==
The presence of fever, [[purpura]], [[petechia]]<nowiki/>e, [[paleness]] in  [[physical examination]] is highly suggestive of TTP.
== Physical Examination ==
== Physical Examination ==
A patient may notice dark urine from the hemolytic anemia.  Because of the many small areas of ischemia produced by clots in the microvasculature, symptoms may be diffuse and fluctuating, including the classical bruising, confusion, or headache, but also nausea and vomiting (from ischemia in the GI tract or from central nervous system involvement), chest pain from cardiac ischemia, seizures, muscle and joint pain, etc.
===Skin===
* [[Bruise|Bruising]] may be present even in [[Mucus|mucous]] [[membrane]] called [[purpura]]
* Pinpoint dots on [[skin]] called [[Petechia|petechiae]]
* [[Paleness]]
* [[Jaundice]]
===Heart===
* [[Tachycardia]]
 
* [[Dyspnea]]
* [[Arrhythmia]]
* Severe [[Complication (medicine)|complications]]; [[sudden cardiac death]], [[Myocardial infarctions|myocardial infarction]], [[cardiogenic shock]], [[heart failure]]
 
===Neurologic===
* No [[abnormalities]]
* Moderate [[Medical sign|signs]] <ref name="pmid18637802">{{cite journal| author=Scully M, Yarranton H, Liesner R, Cavenagh J, Hunt B, Benjamin S et al.| title=Regional UK TTP registry: correlation with laboratory ADAMTS 13 analysis and clinical features. | journal=Br J Haematol | year= 2008 | volume= 142 | issue= 5 | pages= 819-26 | pmid=18637802 | doi=10.1111/j.1365-2141.2008.07276.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18637802  }}</ref>; [[speech]] changes, [[confusion]]
* Severe involvement: focal [[Medical sign|signs]], [[seizure]], [[stroke]], [[coma]]
'''<big>Renal</big>'''
===Other===
* [[Fever]]
 
====Urine====
* Dark [[urine]]
 
==References==
==References==
{{reflist|2}}
{{reflist|2}}

Latest revision as of 12:20, 5 October 2018

Thrombotic thrombocytopenic purpura Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]

Overview

The presence of fever, purpura, petechiae, paleness in physical examination is highly suggestive of TTP.

Physical Examination

Skin

Heart

Neurologic

Renal

Other

Urine

References

  1. Scully M, Yarranton H, Liesner R, Cavenagh J, Hunt B, Benjamin S; et al. (2008). "Regional UK TTP registry: correlation with laboratory ADAMTS 13 analysis and clinical features". Br J Haematol. 142 (5): 819–26. doi:10.1111/j.1365-2141.2008.07276.x. PMID 18637802.

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