Myleofibrosis: Difference between revisions

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{{Myelofibrosis}}  
{{Myleofibrosis}}  
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'''Primary myelofibrosis''', also known as '''Myelofibrosis'''; '''Idiopathic myelofibrosis'''; '''Myeloid metaplasia'''; '''Agnogenic myeloid metaplasia''', is a disorder of the [[bone marrow]], in which the marrow is replaced by fibrous (scar) tissue ([[collagen]]).
==[[Myleofibrosis overview|Overview]]==


== Causes, incidence, and risk factors ==
==[[Myleofibrosis historical perspective|Historical Perspective]]==
In primary myelofibrosis, a progressive scarring ([[fibrosis]]) of the bone marrow occurs. As a result, blood forms in sites other than the bone marrow, such as the [[liver]] and [[spleen]]. This causes an enlargement of these organs. The cause and risk factors are unknown.  It commonly occurs in the spent phase of [[Polycythemia Rubra Vera]], possibly in response to the medication [[hydroxyurea]] poisoning the marrow.


The disorder usually develops slowly, in people over 50 years old. It leads to progressive bone marrow failure with severe [[anemia]]. Low platelet count leads to easy bleeding, and spleen enlargement continues.
==[[Myleofibrosis classification|Classification]]==


== Symptoms == 
==[[Myleofibrosis pathophysiology|Pathophysiology]]==
*Abdominal fullness related to an enlarged spleen
*Bone pain
*Bruising
*Easy bleeding
*Fatigue
*Increased susceptibility to infection
*Pallor
*Shortness of breath while doing physical work
*Uncontrollable [[diarrhea]]


== Treatment ==
==[[Myleofibrosis causes|Causes]]==
Myleofibrosis has no known cure.  [[Lenalidomide]] (brand name Revlimid) and [[Thalidomide]] are drugs that can be used in its treatment, though they can cause [[gout]] and leave the patient susceptible to diseases such as [[pneumonia]].  Frequent [[blood transfusions]] may also be required.


==[[Myleofibrosis differential diagnosis|Differentiating Myleofibrosis from other Diseases]]==


{{SIB}}
==[[Myleofibrosis epidemiology and demographics|Epidemiology and Demographics]]==


==[[Myleofibrosis risk factors|Risk Factors]]==
==[[Myleofibrosis screening|Screening]]==
==[[Myleofibrosis natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
==Diagnosis==
[[Myleofibrosis history and symptoms| History and Symptoms]] | [[Myleofibrosis physical examination | Physical Examination]] |[[Myleofibrosis laboratory findings|Laboratory Findings]] | [[Myleofibrosis x ray|X Ray]] |  [[Myleofibrosis CT|CT]] | [[Myleofibrosis MRI|MRI]] | [[Myleofibrosis ultrasound|Ultrasound]] | [[Myleofibrosis other imaging findings|Other Imaging Findings]] | [[Myleofibrosis other diagnostic studies|Other Diagnostic Studies]]
==Treatment==
[[Myleofibrosis medical therapy|Medical Therapy]] | [[Myleofibrosis surgery|Surgery]] | [[Myleofibrosis primary prevention|Primary Prevention]] | [[Myleofibrosis secondary prevention|Secondary Prevention]] | [[Myleofibrosis cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Myleofibrosis future or investigational therapies|Future or Investigational Therapies]]
==Case Studies==
[[Myleofibrosis case study one|Case#1]]
[[Category:Hematology]]
[[Category:Hematology]]


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{{WikiDoc Sources}}
{{WikiDoc Sources}}

Latest revision as of 15:39, 21 September 2012

Myleofibrosis Microchapters

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Myleofibrosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Myleofibrosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination |Laboratory Findings | X Ray | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case#1

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