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| __NOTOC__
| | #Redirect [[Neutropenia medical therapy]] |
| {{Agranulocytosis}}
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| {{CMG}}
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| ==Overview==
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| ==Medical Therapy==
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| In patients that have no symptoms of infection, management consists of close monitoring with serial [[blood counts]], withdrawal of the offending agent (e.g., medication), and general advice on the significance of fever.
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| Infection in patients with low [[white blood cell]] counts is usually treated urgently, and usually includes a broad-spectrum penicillin ([[piperacillin-tazobactam]] or [[Timentin|ticarcillin clavulanate]]) or cephalosporin ([[ceftazidime]]), or [[meropenem]] in combination with [[gentamicin]] or [[amikacin]].{{Citation needed|date=February 2007}}
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| If the patient remains febrile after 4–5 days and no causative organism for the infection has been identified, antibiotics are, in general, changed to a glycopeptide (e.g., [[vancomycin]]), and subsequently an antifungal agent (e.g., [[amphotericin B]]) is added to the regimen.{{Citation needed|date=February 2007}} In agranulocytosis, the use of recombinant G-CSF ([[filgrastim]]) often results in hematologic recovery.{{Citation needed|date=February 2007}}
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| [[Blood transfusion|Transfusion]] of granulocytes would have been a solution to the problem. However, granulocytes live only ~10 hours in the circulation (for days in [[spleen]] or other tissue), which gives a very short-lasting effect. In addition, there are many complications of such a procedure.
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| ==References==
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| {{Reflist|2}}
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| [[Category:Needs content]]
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| [[Category:Disease]]
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| [[Category:Hematology]]
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