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__NOTOC__
For Patient Information page click [[Hereditary spherocytosis (patient information)|here]]
{{DiseaseDisorder infobox |
{{DiseaseDisorder infobox |
   Name        = Spherocytosis |
   Name        = Spherocytosis |
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{{Spherocytosis}}
{{Spherocytosis}}
{{CMG}}
{{CMG}}
__NOTOC__


== [[Spherocytosis overview|Overview]] ==
== [[Spherocytosis historical perspective|Historical Perspective]]==
== [[Spherocytosis classification|Classification]] ==
== [[Spherocytosis pathophysiology|Pathophysiology]] ==
== [[Spherocytosis causes|Causes]] ==
== [[Spherocytosis differential diagnosis|Differentiating Spherocytosis from other Diseases]] ==
== [[Spherocytosis epidemiology and demographics|Epidemiology and Demographics]]==
== [[Spherocytosis risk factors|Risk Factors]] ==
== [[Spherocytosis natural history, complications and prognosis|Natural History, Complications and Prognosis]] ==
== Diagnosis ==
[[Spherocytosis history and symptoms|History and Symptoms]] | [[Spherocytosis physical examination|Physical Examination]] | [[Spherocytosis laboratory findings|Laboratory Findings]] |  [[Spherocytosis CT|CT]] | [[Spherocytosis MRI|MRI]] | [[Spherocytosis ultrasound|Ultrasound]] | [[Spherocytosis other imaging findings|Other Imaging Studies]] | [[Spherocytosis other diagnostic studies|Other Diagnostic Studies]]


==Symptoms==
== Treatment ==
The [[spleen]]'s [[hemolysis]] results directly in varying degrees of [[anemia]] and hyperbilirubinemia, which in turn result in symptoms of [[Fatigue (physical)|fatigue]], [[pallor]], and [[jaundice]]. 


Acute cases can threaten [[Hypoxia (medical)|hypoxemia]] through [[anemia]] and acute [[kernicterus]] through hyperbilirubinemia, particularly in newborns.
[[Spherocytosis medical therapy|Medical Therapy]] | [[Spherocytosis surgery|Surgery]] | [[Spherocytosis prevention|Prevention]] | [[Spherocytosis cost-effectiveness of therapy | Cost Effectiveness of Therapy]] | [[Spherocytosis future or investigational therapies|Future or Investigational Therapies]]


Chronic symptoms include [[anemia]] and [[splenomegaly]], or enlargement of the [[spleen]] due to its [[hypersplenism|increased activity]]. In some cases the spleen continues to change sizes.  Yet in other cases the spleen just continues growing which puts the patient at a greater risk for rupture, which can cause death. Furthermore, the detritus of the broken-down blood cells--[[bilirubin]]--accumulates in the [[gallbladder]], and can cause [[gallstones]] or "sludge" to develop.  In chronic patients, an [[infection]] or other illness can cause an increase in the destruction of red blood cells, resulting in the appearance of acute symptoms, a ''hemolytic crisis''.
==Case Studies==
:[[Spherocytosis case study one|Case #1]]


==See also==
==Related Chapters==
* [[Hereditary spherocytosis]]
* [[Hereditary spherocytosis]]
* [[Anemia]]
* [[Anemia]]
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* [[Blood diseases]]
* [[Blood diseases]]
* [[Red blood cells]]
* [[Red blood cells]]
* Hereditary diseases
 


==External links==
==External links==
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*[http://www.nlm.nih.gov/medlineplus/ency/imagepages/1220.htm A picture of spherocytes from Medline]
*[http://www.nlm.nih.gov/medlineplus/ency/imagepages/1220.htm A picture of spherocytes from Medline]


==References==
* Kumar, Vinay, Abul Abbas, and Nelson Fausto. "Robbins and Cotran Pathologic Basis of Disease, 7th edition (2004)."
* Schneider, Arthur S. and Philip A. Stanzo.  "Board Review Series: Pathology, 2nd edition (2002)."





Latest revision as of 16:52, 21 September 2012

For Patient Information page click here

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Overview

Historical Perspective

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Physical Examination

Laboratory Findings

CT

MRI

Ultrasound

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Spherocytosis from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | CT | MRI | Ultrasound | Other Imaging Studies | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Prevention | Cost Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

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