|
|
| (16 intermediate revisions by 3 users not shown) |
| Line 1: |
Line 1: |
| __NOTOC__
| | #REDIRECT [[Goodpasture syndrome]] |
| {{Infobox_Disease |
| |
| | |
| Name = {{PAGENAME}} |
| |
| | |
| Image = |
| |
| | |
| Caption = |
| |
| | |
| DiseasesDB = 5363 |
| |
| | |
| ICD10 = {{ICD10|M|31|0|m|30}} ([[ILDS]] M31.010) |
| |
| | |
| ICD9 = {{ICD9|446.21}} |
| |
| | |
| ICDO = |
| |
| | |
| OMIM = 233450 |
| |
| | |
| MedlinePlus = 142|
| |
| | |
| MeshID = D019867 |
| |
| | |
| }}
| |
| {{Goodpastures syndrome}}
| |
| | |
| '''For patient information click [[Goodpastures_syndrome_(patient_information)|here]]'''
| |
| | |
| {{CMG}}; '''Associate Editor-In-Chief:''' {{CZ}}
| |
| | |
| {{SK}} Anti-GBM nephritis with pulmonary hemorrhage; antiglomerular basement membrane disease; Goodpasture’s syndrome
| |
| == Diagnosis ==
| |
| | |
| Because of the vagueness of early symptoms and rapid progression of the disease, diagnosis is often not reached until very late in the course of the disease. Kidney [[biopsy]] is often the fastest way to secure the diagnosis and gain information about the extent of the disease and likely effect of treatment. Tests for anti-GBM [[antibody|antibodies]] may also be useful, combined with tests for antibodies to neutrophil cytoplasmic antigens, which are also directed against the patient’s own proteins.
| |
| | |
| == Treatment ==
| |
| | |
| Like many autoimmune diseases, Goodpasture’s syndrome responds well to treatment with [[corticosteroid]]s and [[immunosuppressant]]s. These drugs dampen the body's normal immune response. A serious side effect of this is that the patient may become more susceptible to infections. The concentration of anti-GBM antibodies in the blood may be reduced by [[apheresis]] to remove blood plasma and its replacement with an isotonic salt and protein solution. This course of treatment usually lasts between three and six months.
| |
| | |
| [[Antibiotic]] treatment of lung infection and stopping smoking may also help to reduce lung haemorrhaging.
| |
| | |
| However, none of these can reverse permanent kidney damage and so for patients who have suffered this, renal [[organ transplant|transplant]] once the disease has subsided may be the only option.
| |
| | |
| == See also ==
| |
| | |
| [[HLA-DR#DR2]]
| |
| | |
| == References ==
| |
| {{Reflist|2}}
| |
| | |
| == External links ==
| |
| | |
| [http://www.antibodypatterns.com/gbm.php GBM antibodies: immunofluorescence image]
| |
| | |
| {{Diseases of the musculoskeletal system and connective tissue}}
| |
| | |
| [[Category:Autoimmune diseases]]
| |
| [[Category:Kidney diseases]]
| |
| [[Category:Rheumatology]]
| |
| | |
| [[de:Goodpasture-Syndrom]] | |
| | |
| [[es:Síndrome de Goodpasture]]
| |
| | |
| [[ja:グッドパスチャー症候群]]
| |
| | |
| [[ru:Синдром Гудпасчера]]
| |
| | |
| [[fi:Goodpasturen oireyhtymä]]
| |
| | |
| [[sv:Goodpastures syndrom]]
| |
| | |
| {{WikiDoc Help Menu}}
| |
| | |
| {{WikiDoc Sources}}
| |