Henoch-Schönlein purpura other diagnostic studies: Difference between revisions
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{{ | {{Henoch-Schönlein purpura}} | ||
{{CMG}} | {{CMG}} | ||
==Overview== | ==Overview== | ||
Henoch-Schönlein purpura is diagnosed using a biopsy of the skin and kidney. | |||
==Biopsy== | ==Other Diagnostic Studies== | ||
Biopsy<ref name="pmid9366584">{{cite journal |vauthors=Jennette JC, Falk RJ |title=Small-vessel vasculitis |journal=N. Engl. J. Med. |volume=337 |issue=21 |pages=1512–23 |date=November 1997 |pmid=9366584 |doi=10.1056/NEJM199711203372106 |url=}}</ref><ref name="pmid25557596">{{cite journal |vauthors=Chen JY, Mao JH |title=Henoch-Schönlein purpura nephritis in children: incidence, pathogenesis and management |journal=World J Pediatr |volume=11 |issue=1 |pages=29–34 |date=February 2015 |pmid=25557596 |doi=10.1007/s12519-014-0534-5 |url=}}</ref><ref name="pmid23842510">{{cite journal |vauthors=Kawasaki Y, Ono A, Ohara S, Suzuki Y, Suyama K, Suzuki J, Hosoya M |title=Henoch-Schönlein purpura nephritis in childhood: pathogenesis, prognostic factors and treatment |journal=Fukushima J Med Sci |volume=59 |issue=1 |pages=15–26 |date=2013 |pmid=23842510 |doi= |url=}}</ref> | |||
*'''Indications''' | |||
**No rash | |||
**[[Abnormal]] [[renal function tests]] | |||
'''Skin biopsy''' | |||
*Light Microscopy | |||
**[[IgA]] [[Deposition (physics)|deposition]] in postcapillary [[venules]] with [[IgA]] [[Deposition (chemistry)|deposition]] and [[leukocytoclastic vasculitis]] in is a [[pathognomonic]] microscopic feature of Henoch-Schönlein Purpura. | |||
**Skin lesions less than 24 hrs are preferred as the chronic lesion lack the [[immunoglobulin]] isotypes essential for the diagnosis of HSP. | |||
**A biopsy from a different skin site is taken for the [[immunofluorescent]] studies to confirm the [[diagnosis]]. | |||
'''Renal biopsy''' | |||
*[[IgA]] [[Deposition (physics)|deposition]] in the [[mesangium]] on [[immunofluorescence]] microscopy should be differentiated from the [[IgA]] [[nephropathy]]. | |||
*Light microscopic features range from isolated [[Mesangial cell|mesangial]] [[proliferation]] to severe [[Rapidly progressive glomerulonephritis|crescentic glomerulonephritis]]. | |||
==References== | ==References== | ||
Latest revision as of 20:13, 15 April 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Henoch-Schönlein purpura is diagnosed using a biopsy of the skin and kidney.
Other Diagnostic Studies
- Indications
- No rash
- Abnormal renal function tests
Skin biopsy
- Light Microscopy
- IgA deposition in postcapillary venules with IgA deposition and leukocytoclastic vasculitis in is a pathognomonic microscopic feature of Henoch-Schönlein Purpura.
- Skin lesions less than 24 hrs are preferred as the chronic lesion lack the immunoglobulin isotypes essential for the diagnosis of HSP.
- A biopsy from a different skin site is taken for the immunofluorescent studies to confirm the diagnosis.
Renal biopsy
- IgA deposition in the mesangium on immunofluorescence microscopy should be differentiated from the IgA nephropathy.
- Light microscopic features range from isolated mesangial proliferation to severe crescentic glomerulonephritis.
References
- ↑ Jennette JC, Falk RJ (November 1997). "Small-vessel vasculitis". N. Engl. J. Med. 337 (21): 1512–23. doi:10.1056/NEJM199711203372106. PMID 9366584.
- ↑ Chen JY, Mao JH (February 2015). "Henoch-Schönlein purpura nephritis in children: incidence, pathogenesis and management". World J Pediatr. 11 (1): 29–34. doi:10.1007/s12519-014-0534-5. PMID 25557596.
- ↑ Kawasaki Y, Ono A, Ohara S, Suzuki Y, Suyama K, Suzuki J, Hosoya M (2013). "Henoch-Schönlein purpura nephritis in childhood: pathogenesis, prognostic factors and treatment". Fukushima J Med Sci. 59 (1): 15–26. PMID 23842510.