IgA nephropathy causes: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{IgA nephropathy}} | |||
{{CMG}} {{AE}}{{Rim}};{{OO}} | |||
==Overview== | |||
The cause of primary [[IgA nephropathy]] is unknown. Additionally, there are no known infectious or environmental associated factors. However, [[IgA nephropathy]] is associated with some [[genetic mutations]] and familial clustering as a postulated cause of primary [[IgAN]]. [[Liver cirrhosis]], [[celiac disease]], [[HIV]] infection are the most common etiologies associated with glomerular [[IgA]] deposits and thus secondary [[IgA nephropathy]]. | |||
==Causes== | |||
===Primary IgA Nephropathy=== | |||
*The cause of primary [[IgA nephropathy]] is unknown. Additionally, there are no known [[infectious]] or environmental associated factors. | |||
*However, [[IgA nephropathy]] is associated with some [[genetic]] [[mutations]] and familial clustering as a postulated cause of primary [[IgAN]] <ref name="pmid10792601">{{cite journal| author=Hsu SI, Ramirez SB, Winn MP, Bonventre JV, Owen WF| title=Evidence for genetic factors in the development and progression of IgA nephropathy. | journal=Kidney Int | year= 2000 | volume= 57 | issue= 5 | pages= 1818-35 | pmid=10792601 | doi=10.1046/j.1523-1755.2000.00032.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10792601 }} </ref>. | |||
*These [[genetic]] associations are poorly studied and are largely inconclusive. There are ongoing studies in this field. | |||
*Primary [[IgA nephropathy]] is caused by a [[genetic predisposition]] in patients who typically present immediately following a [[Respiratory tract infection|respiratory]] or [[gastrointestinal tract]] infections. The environmental exposure to these [[infectious agents]] may thus facilitate the subsequent [[pathogenesis]] of the disease. | |||
{{ | ===Secondary IgA Nephropathy=== | ||
The most common etiologies associated with glomerular IgA deposits and thus secondary IgA nephropathy include: | |||
* [[Liver cirrhosis]]<ref name="pmid22895519">{{cite journal| author=Radhakrishnan J, Cattran DC| title=The KDIGO practice guideline on glomerulonephritis: reading between the (guide)lines--application to the individual patient. | journal=Kidney Int | year= 2012 |volume= 82 | issue= 8 | pages= 840-56 | pmid=22895519 | doi=10.1038/ki.2012.280 | pmc=|url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22895519 }} </ref> | |||
* [[Celiac disease]]<ref name="pmid22895519">{{cite journal| author=Radhakrishnan J, Cattran DC| title=The KDIGO practice guideline on glomerulonephritis: reading between the (guide)lines--application to the individual patient. | journal=Kidney Int | year= 2012 |volume= 82 | issue= 8 | pages= 840-56 | pmid=22895519 | doi=10.1038/ki.2012.280 | pmc=|url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22895519 }} </ref> | |||
* [[HIV]] infection<ref name="pmid22895519">{{cite journal| author=Radhakrishnan J, Cattran DC| title=The KDIGO practice guideline on glomerulonephritis: reading between the (guide)lines--application to the individual patient. | journal=Kidney Int | year= 2012 |volume= 82 | issue= 8 | pages= 840-56 | pmid=22895519 | doi=10.1038/ki.2012.280 | pmc=|url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22895519 }} </ref> | |||
==References== | ==References== | ||
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{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Nephrology]] | [[Category:Nephrology]] | ||
Latest revision as of 13:24, 18 July 2018
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IgA nephropathy Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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IgA nephropathy causes On the Web |
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American Roentgen Ray Society Images of IgA nephropathy causes |
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Risk calculators and risk factors for IgA nephropathy causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2];Olufunmilola Olubukola M.D.[3]
Overview
The cause of primary IgA nephropathy is unknown. Additionally, there are no known infectious or environmental associated factors. However, IgA nephropathy is associated with some genetic mutations and familial clustering as a postulated cause of primary IgAN. Liver cirrhosis, celiac disease, HIV infection are the most common etiologies associated with glomerular IgA deposits and thus secondary IgA nephropathy.
Causes
Primary IgA Nephropathy
- The cause of primary IgA nephropathy is unknown. Additionally, there are no known infectious or environmental associated factors.
- However, IgA nephropathy is associated with some genetic mutations and familial clustering as a postulated cause of primary IgAN [1].
- These genetic associations are poorly studied and are largely inconclusive. There are ongoing studies in this field.
- Primary IgA nephropathy is caused by a genetic predisposition in patients who typically present immediately following a respiratory or gastrointestinal tract infections. The environmental exposure to these infectious agents may thus facilitate the subsequent pathogenesis of the disease.
Secondary IgA Nephropathy
The most common etiologies associated with glomerular IgA deposits and thus secondary IgA nephropathy include:
References
- ↑ Hsu SI, Ramirez SB, Winn MP, Bonventre JV, Owen WF (2000). "Evidence for genetic factors in the development and progression of IgA nephropathy". Kidney Int. 57 (5): 1818–35. doi:10.1046/j.1523-1755.2000.00032.x. PMID 10792601.
- ↑ 2.0 2.1 2.2 Radhakrishnan J, Cattran DC (2012). "The KDIGO practice guideline on glomerulonephritis: reading between the (guide)lines--application to the individual patient". Kidney Int. 82 (8): 840–56. doi:10.1038/ki.2012.280. PMID 22895519.