Thin basement membrane disease history and symptoms: Difference between revisions

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Latest revision as of 09:37, 21 December 2020

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Marufa Marium, M.B.B.S [2]

Overview

Obtaining complete history both for the patient and family is an important aspect of diagnosing TBMD. The hallmark of TBMD is benign hematuria. A positive family history of incidental finding of intermittent or persistent hematuria is suggestive of TBMD. TBMD is mostly asymptomatic. Microscopic hematuria is found incidentally.

History and Symptoms

History

Obtaining complete medical and family history is an important aspect of diagnosing TBMD. It provides insight to cause and differentiation of TBMD with Alport syndrome, IgA nephropathy, Lupus Nephritis and other glomerulopathies. History may be obtained focusing specific areas including:

Past medical history including URTI, Autoimmune Disease, Glomerulopathies.
Positive family history of benign intermittent or persistent hematuria.
Physical properties of urine (color, turbidity).
Nature of micturation (frequency, dysuria)
New onset hypertension or edema.

Symptoms

TBMD is mostly asymptomatic. The following signs are included:

Intermiitent or persistent hematuria is found incidentally.
New onset hypertension.
Proteinuria.
Renal impairment.
Renal failure.

References

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@@ Line 2: / Line 2: @@
 {{Thin basement membrane disease}}
 {{CMG}}
+{{AE}} {{MMT}}
+==Overview==
+Obtaining complete [[History and Physical examination|history]] both for the patient and family is an important aspect of diagnosing [[TBMD]]. The hallmark of TBMD is [[Benign Recurrent Hamaturia|benign hematuria.]] A positive [[Family history|family histor]]<nowiki/>y of incidental finding of intermittent or [[Hematuria|persistent hematuria]] is suggestive of [[TBMD]]. TBMD is mostly asymptomatic. [[Microscopic hematuria]] is found incidentally.
+==History and Symptoms==
+===History===
-==Overview==
+Obtaining complete [[medical]] and [[family history]] is an important aspect of diagnosing TBMD. It provides insight to cause and differentiation of [[TBMD]] with [[Alport syndrome]], [[IgA nephropathy]], [[Lupus]] [[Nephritis]] and other [[Glomerulopathy|glomerulopathies.]] History may be obtained focusing specific areas including:
+*Past [[medical history]] including [[Upper respiratory infection|URTI]], [[Autoimmune disease|Autoimmune Disease]], [[Glomerulopathy|Glomerulopathi]]<nowiki/>es.
+*Positive [[family history]] o[[Benign Recurrent Hamaturia|f benign intermittent or persistent hematuria.]]
+*[[Physical properties]] of [[urine]] ([[color]], [[turbidity]]).
+*Nature of [[micturation]] ([[frequency]], [[dysuria]])
+*New onset [[hypertension]] or [[edema]].
+===Symptoms===
+TBMD is mostly asymptomatic. The following signs are included:
-==History and symptoms==
+*[[Benign Recurrent Hamaturia|Intermiitent or persistent hematuria]] is found incidentally.
-Most patients with thin basement membrane disease are incidentally discovered to have [[microscopic hematuria]] on [[urinalysis]]. The [[blood pressure]], [[kidney function]], and the urinary protein excretion are usually normal. Mild [[proteinuria]] (less than 1.5 g/day) and [[hypertension]] are seen in a small minority of patients. Frank [[hematuria]] and loin pain should prompt a search for another cause, such as  [[kidney stone]]s or [[loin pain-hematuria syndrome]]. Also, there are no systemic manifestations, so presence of [[hearing impairment]] or [[visual impairment]] should prompt a search for [[hereditary]] nephritis such as [[Alport syndrome]].
+*New onset [[hypertension]].
+*[[Proteinuria]].
+*[[Renal impairment]].
+*[[Renal failure]].
-Thin basement membrane disease must be differentiated from the other two common causes of [[glomerulus|glomerular]] [[hematuria]], [[IgA nephropathy]] and [[Alport syndrome]]. The history and presentation are helpful in this regard:
-*In [[Alport syndrome]], there is often a family history of [[kidney failure]], which may be associated with [[hearing impairment]]. Also, males tend to be more affected as Alport syndrome it is [[X-linked]] in most cases.
-*In [[IgA nephropathy]], episodes of frank [[hematuria]] are more common, and a family history is less common.
 ==References==